AR092858A1 - Procedimiento para una sintesis mejorada de opioide - Google Patents
Procedimiento para una sintesis mejorada de opioideInfo
- Publication number
- AR092858A1 AR092858A1 ARP130102525A ARP130102525A AR092858A1 AR 092858 A1 AR092858 A1 AR 092858A1 AR P130102525 A ARP130102525 A AR P130102525A AR P130102525 A ARP130102525 A AR P130102525A AR 092858 A1 AR092858 A1 AR 092858A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halo
- cycloalkyl
- compositions
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- -1 -C2−4 alkenyl Chemical group 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940005483 opioid analgesics Drugs 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 229960005118 oxymorphone Drugs 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000006370 trihalo methyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672260P | 2012-07-16 | 2012-07-16 | |
| US201261741480P | 2012-07-19 | 2012-07-19 | |
| US201361762637P | 2013-02-08 | 2013-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092858A1 true AR092858A1 (es) | 2015-05-06 |
Family
ID=48916127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130102525A AR092858A1 (es) | 2012-07-16 | 2013-07-15 | Procedimiento para una sintesis mejorada de opioide |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10316042B2 (OSRAM) |
| EP (1) | EP2872516B1 (OSRAM) |
| JP (1) | JP6236447B2 (OSRAM) |
| KR (1) | KR101946103B1 (OSRAM) |
| CN (1) | CN104470928B (OSRAM) |
| AR (1) | AR092858A1 (OSRAM) |
| AU (2) | AU2013291725B2 (OSRAM) |
| BR (1) | BR112015000944A2 (OSRAM) |
| CA (2) | CA2974010A1 (OSRAM) |
| CO (1) | CO7180188A2 (OSRAM) |
| EA (1) | EA028092B1 (OSRAM) |
| ES (1) | ES2647949T3 (OSRAM) |
| IL (1) | IL236710B (OSRAM) |
| IN (1) | IN2015DN01165A (OSRAM) |
| MX (1) | MX363610B (OSRAM) |
| NZ (1) | NZ628699A (OSRAM) |
| PH (1) | PH12015500089A1 (OSRAM) |
| SG (1) | SG11201407988UA (OSRAM) |
| TW (2) | TWI643860B (OSRAM) |
| UA (1) | UA117225C2 (OSRAM) |
| WO (1) | WO2014013313A1 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5923827B2 (ja) * | 1981-12-16 | 1984-06-05 | フエザ−安全剃刀株式会社 | 安全かみそり刃 |
| TWI588147B (zh) * | 2012-07-16 | 2017-06-21 | 羅德科技公司 | 改良之類鴉片合成方法 |
| EP3027622B8 (en) * | 2013-08-02 | 2019-06-12 | Johnson Matthey Public Limited Company | Process for the preparation of oxymorphone |
| AU2015207734B2 (en) | 2014-01-15 | 2017-02-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
| AU2015207733A1 (en) | 2014-01-15 | 2016-07-14 | Rhodes Technologies | Process for improved oxycodone synthesis |
| MA40332A (fr) * | 2014-07-09 | 2021-04-28 | Rhodes Tech | Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane |
| US20160052932A1 (en) * | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
| US20160340362A1 (en) * | 2015-05-20 | 2016-11-24 | Noramco, Inc. | Process For The Preparation Of Oxymorphone Freebase |
| ES2701855T3 (es) | 2016-05-31 | 2019-02-26 | Alcaliber Investig Desarrollo E Innovacion Slu | Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina |
| US10935314B2 (en) * | 2019-03-21 | 2021-03-02 | Evan Prout | Heating values of cellulosic waste |
| CN113493460A (zh) * | 2020-03-20 | 2021-10-12 | 江苏恩华药业股份有限公司 | 盐酸羟考酮杂质b的制备方法 |
| JP2023548356A (ja) | 2020-11-02 | 2023-11-16 | ローズ テクノロジーズ | ノルオキシモルホンを精製するための方法 |
| US11247999B1 (en) | 2021-07-02 | 2022-02-15 | Joseph DeGraw | Facile conversion of morphine to normorphine |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2772270A (en) * | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
| US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (OSRAM) | 1960-11-29 | |||
| US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| NL6714885A (OSRAM) | 1967-11-02 | 1969-05-06 | ||
| US3541006A (en) | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
| US3541005A (en) | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4077407A (en) | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4063064A (en) | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US4285987A (en) | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| DE3812567A1 (de) | 1988-04-15 | 1989-10-26 | Basf Ag | Verfahren zur herstellung pharmazeutischer mischungen |
| US5215758A (en) | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
| US5286493A (en) | 1992-01-27 | 1994-02-15 | Euroceltique, S.A. | Stabilized controlled release formulations having acrylic polymer coating |
| US5273760A (en) | 1991-12-24 | 1993-12-28 | Euroceltigue, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5472712A (en) | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5324351A (en) | 1992-08-13 | 1994-06-28 | Euroceltique | Aqueous dispersions of zein and preparation thereof |
| JP4256259B2 (ja) | 2001-07-18 | 2009-04-22 | ユーロ−セルティーク エス．エイ． | オキシコドン及びナロキソンの医薬配合物 |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| US20050203115A1 (en) * | 2004-03-10 | 2005-09-15 | Sancilio Frederick D. | Narcotic-NSAID ion pairs |
| TWI483944B (zh) * | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| SK286087B6 (sk) * | 2004-08-18 | 2008-03-05 | Zentiva, A. S. | Spôsob prípravy oxykodonu |
| GB0421149D0 (en) | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
| WO2006091885A2 (en) * | 2005-02-24 | 2006-08-31 | Dr Pharma Nova, Llc | A registry method and control system for dea schedule ii-v medicines |
| EP1893616B1 (en) | 2005-06-16 | 2010-12-29 | Mallinckrodt, Inc. | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
| KR100753432B1 (ko) | 2005-11-08 | 2007-08-31 | 경희대학교 산학협력단 | 다결정 실리콘 및 그의 결정화 방법 |
| US20070117826A1 (en) * | 2005-11-23 | 2007-05-24 | Forest Laboratories, Inc. | Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone |
| ES2392594T3 (es) * | 2006-10-17 | 2012-12-12 | Penick Corporation | Procedimiento para preparar oximorfona |
| US7875719B2 (en) * | 2006-12-04 | 2011-01-25 | Cox D Phillip | Process for reducing impurities in oxycodone base |
| JP2010511726A (ja) | 2006-12-04 | 2010-04-15 | ノランコ・インコーポレーテツド | １４−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法 |
| GB0624880D0 (en) | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
| CA2681740A1 (en) | 2007-03-23 | 2008-10-02 | Mallinckrodt Inc. | Improved preparation of oxymorphone from oripavine |
| CA2684458A1 (en) * | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
| JP5663791B2 (ja) | 2009-06-03 | 2015-02-04 | 高砂香料工業株式会社 | 不斉水素化触媒 |
| WO2011032214A1 (en) | 2009-09-16 | 2011-03-24 | Monash University | A method for the n-demethylation of n-methyl heterocycles |
| EP2377866B1 (en) * | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
| CA2802294C (en) | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| ES2659168T3 (es) * | 2010-07-02 | 2018-03-14 | Johnson Matthey Public Limited Company | Proceso para la síntesis y purificación de oxicodona |
| US20120010412A1 (en) | 2010-07-08 | 2012-01-12 | Alkermes, Inc. | Process for the Synthesis of Substituted Morphinans |
| JP5780933B2 (ja) | 2010-12-01 | 2015-09-16 | 高砂香料工業株式会社 | 光学活性メントールの製造方法 |
| AU2013274407B2 (en) | 2012-06-11 | 2017-06-22 | Siegfried Ag | Improved method of preparing oxymorphone |
| TWI588147B (zh) * | 2012-07-16 | 2017-06-21 | 羅德科技公司 | 改良之類鴉片合成方法 |
| CN103113378B (zh) | 2013-02-20 | 2016-04-06 | 北京华素制药股份有限公司 | 一种盐酸羟吗啡酮的合成方法 |
| CN103433076B (zh) | 2013-09-02 | 2015-06-24 | 浙江新和成股份有限公司 | 一种固载型不对称催化剂及其在不对称氢化反应中的应用 |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| CN106164078A (zh) | 2013-12-18 | 2016-11-23 | 科迪实验室公司 | 氧可酮盐酸盐的合成 |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| AU2015207734B2 (en) | 2014-01-15 | 2017-02-23 | Rhodes Technologies | Process for improved oxymorphone synthesis |
| AU2015207733A1 (en) | 2014-01-15 | 2016-07-14 | Rhodes Technologies | Process for improved oxycodone synthesis |
-
2013
- 2013-07-15 UA UAA201501303A patent/UA117225C2/uk unknown
- 2013-07-15 US US14/413,362 patent/US10316042B2/en active Active
- 2013-07-15 TW TW105114709A patent/TWI643860B/zh active
- 2013-07-15 SG SG11201407988UA patent/SG11201407988UA/en unknown
- 2013-07-15 BR BR112015000944A patent/BR112015000944A2/pt not_active Application Discontinuation
- 2013-07-15 CA CA2974010A patent/CA2974010A1/en not_active Abandoned
- 2013-07-15 JP JP2015522183A patent/JP6236447B2/ja active Active
- 2013-07-15 EA EA201590222A patent/EA028092B1/ru not_active IP Right Cessation
- 2013-07-15 CN CN201380037932.7A patent/CN104470928B/zh active Active
- 2013-07-15 AR ARP130102525A patent/AR092858A1/es not_active Application Discontinuation
- 2013-07-15 TW TW102125210A patent/TWI643859B/zh active
- 2013-07-15 NZ NZ628699A patent/NZ628699A/en unknown
- 2013-07-15 AU AU2013291725A patent/AU2013291725B2/en active Active
- 2013-07-15 WO PCT/IB2013/001541 patent/WO2014013313A1/en active Application Filing
- 2013-07-15 ES ES13745178.7T patent/ES2647949T3/es active Active
- 2013-07-15 MX MX2015000879A patent/MX363610B/es unknown
- 2013-07-15 EP EP13745178.7A patent/EP2872516B1/en active Active
- 2013-07-15 CA CA2879270A patent/CA2879270C/en active Active
- 2013-07-15 KR KR1020157003907A patent/KR101946103B1/ko active Active
-
2015
- 2015-01-13 IL IL236710A patent/IL236710B/en active IP Right Grant
- 2015-01-14 PH PH12015500089A patent/PH12015500089A1/en unknown
- 2015-01-29 CO CO15018243A patent/CO7180188A2/es unknown
- 2015-02-12 IN IN1165DEN2015 patent/IN2015DN01165A/en unknown
-
2016
- 2016-07-14 AU AU2016204926A patent/AU2016204926A1/en not_active Abandoned
-
2019
- 2019-04-17 US US16/386,532 patent/US20190367526A1/en not_active Abandoned
-
2022
- 2022-09-21 US US17/949,681 patent/US20230130617A1/en active Pending
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