AR091044A1 - Derivados dipeptidos de lisina-acido glutamico - Google Patents

Derivados dipeptidos de lisina-acido glutamico

Info

Publication number
AR091044A1
AR091044A1 ARP130101662A ARP130101662A AR091044A1 AR 091044 A1 AR091044 A1 AR 091044A1 AR P130101662 A ARP130101662 A AR P130101662A AR P130101662 A ARP130101662 A AR P130101662A AR 091044 A1 AR091044 A1 AR 091044A1
Authority
AR
Argentina
Prior art keywords
synthesis
lisina
glutamic acid
peptide
compounds
Prior art date
Application number
ARP130101662A
Other languages
English (en)
Inventor
Puentener Kurt
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48430764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR091044(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR091044A1 publication Critical patent/AR091044A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/32—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C271/34—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Un proceso de obtención de los mismos y al uso de los productos para la síntesis de péptidos en fase sólida. Los compuestos de la fórmula (1) son compuestos intermedios peptídicos versátiles para la síntesis de fármacos peptídicos en fase sólida (SPPS), que contienen un bloque de síntesis de cadena lateral alquilo graso-Glu unido a la parte Lys de la cadena peptídica. Reivindicación 1: Compuestos de la fórmula (1) en la que: R¹ y R² son iguales o diferentes e indican hidrógeno o un grupo protector de éster, R³ es hidrógeno o un grupo protector de amino y R⁴ es alquilo C₁₂₋₂₀, y sus enantiómeros, diastereómeros y sales.
ARP130101662A 2012-05-15 2013-05-14 Derivados dipeptidos de lisina-acido glutamico AR091044A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12168119.1A EP2664374A1 (en) 2012-05-15 2012-05-15 Lysin-glutamic acid dipeptide derivatives

Publications (1)

Publication Number Publication Date
AR091044A1 true AR091044A1 (es) 2014-12-30

Family

ID=48430764

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130101662A AR091044A1 (es) 2012-05-15 2013-05-14 Derivados dipeptidos de lisina-acido glutamico

Country Status (22)

Country Link
US (3) US9522874B2 (es)
EP (3) EP2664374A1 (es)
JP (1) JP6162795B2 (es)
KR (2) KR102094928B1 (es)
CN (1) CN104271227B (es)
AR (1) AR091044A1 (es)
AU (1) AU2013261894B2 (es)
BR (1) BR112014028334B1 (es)
CA (2) CA3096624C (es)
ES (2) ES2637415T3 (es)
HK (1) HK1200753A1 (es)
HR (2) HRP20171058T1 (es)
IL (1) IL235425B (es)
MX (2) MX349822B (es)
MY (2) MY184184A (es)
NZ (1) NZ631215A (es)
PL (2) PL3127604T3 (es)
RU (1) RU2640812C2 (es)
SG (1) SG11201406888QA (es)
SI (2) SI3127604T1 (es)
WO (1) WO2013171135A1 (es)
ZA (1) ZA201407528B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
EP2934569A1 (en) 2012-12-21 2015-10-28 Sanofi Exendin-4 derivatives
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TW201609795A (zh) 2013-12-13 2016-03-16 賽諾菲公司 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
CN109641946A (zh) 2016-03-23 2019-04-16 巴切姆股份公司 胰高血糖素样肽的制备方法
WO2020208409A1 (en) * 2019-04-10 2020-10-15 Dr. Reddy’S Laboratories Limited Improved processes for the preparation of peptide intermediates/modifiers
CN111454180A (zh) * 2020-04-10 2020-07-28 大连阿拉宁生物技术有限公司 一种索马鲁肽侧链中间体及其制备方法
CN113004370B (zh) * 2021-02-09 2022-06-17 宁波绿之健药业有限公司 一种具有缓解高尿酸血症和调节肠道菌群的二肽及其应用
EP4345104A1 (en) 2022-09-30 2024-04-03 Bachem Holding AG Method for preparing liraglutide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122009000079I2 (de) * 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle Glp-1 derivate
WO2001066135A1 (en) * 2000-03-08 2001-09-13 Novo Nordisk A/S Lowering serum lipids
US20060258580A1 (en) * 2003-05-14 2006-11-16 Regents Of The University Of Michigan Modulators of Nod1 signaling
JP2006233405A (ja) * 2005-08-16 2006-09-07 Asahi Kasei Chemicals Corp 繊維処理剤
IE20060841A1 (en) * 2006-11-21 2008-05-28 Ipsen Mfg Ireland Ltd Boc and fmoc solid phase peptide synthesis
JP2008290987A (ja) * 2007-05-28 2008-12-04 Shiseido Co Ltd Ｃｍｃ修復剤、毛髪化粧料およびｃｍｃ修復方法
JP5127316B2 (ja) * 2007-06-22 2013-01-23 旭化成ケミカルズ株式会社 化学機械研磨用組成物
AU2008365555B2 (en) * 2008-12-15 2016-01-14 Zealand Pharma A/S Glucagon analogues
ME02220B (me) * 2009-07-13 2016-02-20 Zealand Pharma As Analozi acilovanog glukagona
JP2011057663A (ja) * 2009-08-11 2011-03-24 Sumitomo Chemical Co Ltd 化合物及びフォトレジスト組成物
CN102286092B (zh) * 2011-09-14 2014-01-01 深圳翰宇药业股份有限公司 利拉鲁肽的固相合成方法
CN104144696A (zh) * 2011-12-23 2014-11-12 西兰制药公司 胰高血糖素类似物

Also Published As

Publication number Publication date
SI2849882T1 (sl) 2017-09-29
JP6162795B2 (ja) 2017-07-12
CA3096624C (en) 2022-09-20
US20150073173A1 (en) 2015-03-12
CA3096624A1 (en) 2013-11-21
PL3127604T3 (pl) 2019-05-31
IL235425B (en) 2018-07-31
NZ631215A (en) 2016-06-24
HRP20181696T1 (hr) 2018-12-14
SI3127604T1 (sl) 2018-11-30
CA2868144A1 (en) 2013-11-21
MX349822B (es) 2017-08-15
AU2013261894B2 (en) 2017-02-02
CN104271227B (zh) 2016-12-28
KR20150008875A (ko) 2015-01-23
RU2014148530A (ru) 2016-07-10
EP3127604A1 (en) 2017-02-08
KR20190057437A (ko) 2019-05-28
MY184184A (en) 2021-03-24
SG11201406888QA (en) 2015-01-29
MY172395A (en) 2019-11-22
CN104271227A (zh) 2015-01-07
EP3127604B1 (en) 2018-08-22
CA2868144C (en) 2021-06-29
ZA201407528B (en) 2016-05-25
HK1200753A1 (en) 2015-08-14
BR112014028334B1 (pt) 2020-02-27
ES2637415T3 (es) 2017-10-13
EP2664374A1 (en) 2013-11-20
EP2849882B1 (en) 2017-06-14
ES2692364T3 (es) 2018-12-03
US20170057912A1 (en) 2017-03-02
PL2849882T3 (pl) 2017-10-31
US9522874B2 (en) 2016-12-20
WO2013171135A1 (en) 2013-11-21
HRP20171058T1 (hr) 2017-10-06
US9802886B2 (en) 2017-10-31
KR102018160B1 (ko) 2019-09-04
MX363728B (es) 2019-04-01
JP2015518821A (ja) 2015-07-06
KR102094928B1 (ko) 2020-03-31
RU2640812C2 (ru) 2018-01-12
EP2849882A1 (en) 2015-03-25
AU2013261894A1 (en) 2015-01-22
US20180029978A1 (en) 2018-02-01
MX2014013505A (es) 2015-02-10
BR112014028334A2 (pt) 2018-05-29

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