AR087684A1 - Cepa bacteriana aislada del genero burkholderia y metabolitos plaguicidas derivados, formulaciones y usos - Google Patents
Cepa bacteriana aislada del genero burkholderia y metabolitos plaguicidas derivados, formulaciones y usosInfo
- Publication number
- AR087684A1 AR087684A1 ARP120103151A ARP120103151A AR087684A1 AR 087684 A1 AR087684 A1 AR 087684A1 AR P120103151 A ARP120103151 A AR P120103151A AR P120103151 A ARP120103151 A AR P120103151A AR 087684 A1 AR087684 A1 AR 087684A1
- Authority
- AR
- Argentina
- Prior art keywords
- burkholderia
- residue
- compound
- carbons
- nitrogen
- Prior art date
Links
- 241001453380 Burkholderia Species 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- UDPGUMQDCGORJQ-UHFFFAOYSA-N (2-chloroethyl)phosphonic acid Chemical compound OP(O)(=O)CCCl UDPGUMQDCGORJQ-UHFFFAOYSA-N 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 238000004690 coupled electron pair approximation Methods 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
- 239000000575 pesticide Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 241000195493 Cryptophyta Species 0.000 abstract 3
- 230000000361 pesticidal effect Effects 0.000 abstract 3
- 241000239223 Arachnida Species 0.000 abstract 2
- 241000589513 Burkholderia cepacia Species 0.000 abstract 2
- 241001508395 Burkholderia sp. Species 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 229930014626 natural product Natural products 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 241000894007 species Species 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 abstract 1
- 108020004465 16S ribosomal RNA Proteins 0.000 abstract 1
- 238000005160 1H NMR spectroscopy Methods 0.000 abstract 1
- AMMUUKRRJMWLGJ-UHFFFAOYSA-N 2-(1h-indol-2-yl)-1,3-oxazole Chemical group C1=COC(C=2NC3=CC=CC=C3C=2)=N1 AMMUUKRRJMWLGJ-UHFFFAOYSA-N 0.000 abstract 1
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 241001135516 Burkholderia gladioli Species 0.000 abstract 1
- 241000020731 Burkholderia multivorans Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 abstract 1
- 241000244206 Nematoda Species 0.000 abstract 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical group 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 125000003700 epoxy group Chemical group 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 abstract 1
- 229960002182 imipenem Drugs 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- -1 oxazolyl-benzyl structure Chemical group 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000007918 pathogenicity Effects 0.000 abstract 1
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 abstract 1
- 229960002292 piperacillin Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
- 229940006995 sulfamethoxazole and trimethoprim Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C12P21/00—Preparation of peptides or proteins
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- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
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- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
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Abstract
Se proporcionan una especie de Burkholderia sp sin patogenicidad conocida para vertebrados pero con actividad plaguicida (por ejemplo, plantes, algas, arácnidos, insectos, hongos, malezas y nematodos) así los métodos para controlar las algas usando dichas especies de Burkholderia. También se proporcionan productos naturales derivados de un cultivo de dicha especies y los métodos para controlar algas y/o arácnidos usando dichos productos naturales. Reivindicación 1: Una formulación que comprende: (A) una cepa aislada o caldo de fermentación que comprende células y medio de cultivo de una no Burkholderia cepacia, no Burkholderia plantari, no Burkholderia gladioli, Burkholderia sp. no Burkholderia cepacia, no Burkholderia multivorans, Burkholderia sp. que tiene las siguientes características: (1) secuencia del gen de ARNr 16S que comprende la secuencia delantera que tiene al menos 99% de identidad con la secuencia expuesta en la SEQ ID Nº 8, 11, 12 y una secuencia inversa que tiene al menos 99% de identidad con la secuencia expuesta en la SEQ ID Nº 9, 10, 13, 14 y 15; (2) actividad plaguicida; (3) produce un compuesto plaguicida seleccionado del grupo que consiste en: (a) un compuesto que tiene las siguientes propiedades: (i) un peso molecular de aproximadamente 525 - 555 determinado por cromatografía líquida/Espectroscopia de masa (LC/MS); (ii) ¹H RMN valores d de 6,22, 5,81, 5,69, 5,66, 5,65, 4,64, 4,31, 3,93, 3,22, 3,21, 3,15, 3,10, 2,69, 2,62, 2,26, 2,23, 1,74, 1,15, 1,12, 1,05, 1,02; (iii) tiene ¹³C RMN valores d de 172,99, 172,93, 169,57, 169,23, 167,59, 130,74, 130,12, 129,93, 128,32, 73,49, 62,95, 59,42, 57,73, 38,39, 38,00, 35,49, 30,90, 30,36, 29,26, 18,59, 18,38, 18,09, 17,93, 12,51; y (iv) un tiempo de retención de la cromatografía líquida de alta presión (HPLC) de aproximadamente 10 - 15 minutos, en una columna C-18 de HPLC de fase inversa usando un gradiente de agua:acetonitrilo (CH₃CN); (b) un compuesto que tiene una estructura oxazolil-indol que comprende al menos un residuo indol, al menos un residuo oxazol, al menos un grupo alquilo sustituido y al menos un grupo éster carboxílico, al menos 17 carbonos, al menos 3 oxígenos y al menos 2 nitrógenos; (c) un compuesto que tiene una estructura oxazolil-bencilo que comprende al menos un residuo bencilo, al menos une residuo oxazol, al menos un grupo alquilo sustituido y al menos un grupo amida, al menos 15 carbonos, al menos 2 oxígenos y al menos 2 nitrógenos; (d) un compuesto que tiene al menos un éster, al menos una amida, al menos tres grupos metileno, al menos un residuo tetrahidropiranosa, al menos tres enlaces dobles olefínicos, al menos seis grupos metilo, al menos tres grupos hidroxilo, al menos veinticinco carbonos, al menos ocho oxígeno y al menos un nitrógeno; y (e) un compuesto que tiene al menos un éster, al menos una amida, un grupo epóxido de metileno, al menos un residuo tetrahidropiranosa, al menos tres enlaces dobles olefínicos, al menos seis grupos metilo, al menos tres grupos hidroxilo, al menos 25 carbonos, al menos 8 oxígenos y al menos 1 nitrógeno; (4) es no patogénica para los animales vertebrados; (5) es susceptible a kanamicina, cloranfenicol, ciprofloxacina, piperacilina, imipenem, y una combinación de sulfametoxazol y trimetoprima; y (6) contiene los ácidos grasos 16:0, ciclo 17:0, 16:0 3-OH, 14:0, ciclo 19:0 w8c, 18:0; y (B) parabeno C₁₋₇, alcohol C₂₋₁₇ y detergente.
Applications Claiming Priority (2)
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US201161528153P | 2011-08-27 | 2011-08-27 | |
US201161528149P | 2011-08-27 | 2011-08-27 |
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AR087684A1 true AR087684A1 (es) | 2014-04-09 |
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ID=47757117
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Application Number | Title | Priority Date | Filing Date |
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ARP120103151A AR087684A1 (es) | 2011-08-27 | 2012-08-24 | Cepa bacteriana aislada del genero burkholderia y metabolitos plaguicidas derivados, formulaciones y usos |
Country Status (16)
Country | Link |
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US (2) | US20140221207A1 (es) |
EP (1) | EP2748304A4 (es) |
JP (2) | JP5961693B2 (es) |
KR (2) | KR20160054627A (es) |
AR (1) | AR087684A1 (es) |
AU (1) | AU2012301466B2 (es) |
BR (1) | BR112014004386A2 (es) |
CA (1) | CA2845732C (es) |
CL (2) | CL2014000467A1 (es) |
CO (1) | CO7020854A2 (es) |
CR (1) | CR20140097A (es) |
IN (1) | IN2014MN00242A (es) |
MA (1) | MA35445B1 (es) |
MX (1) | MX347407B (es) |
TW (1) | TW201322924A (es) |
WO (1) | WO2013032693A2 (es) |
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KR101632806B1 (ko) | 2016-06-23 |
CA2845732C (en) | 2019-07-16 |
EP2748304A4 (en) | 2015-02-11 |
EP2748304A2 (en) | 2014-07-02 |
CL2014000467A1 (es) | 2014-09-05 |
JP2016183157A (ja) | 2016-10-20 |
IN2014MN00242A (es) | 2015-09-25 |
CA2845732A1 (en) | 2013-03-07 |
US20170208817A1 (en) | 2017-07-27 |
MX2014002329A (es) | 2014-08-22 |
NZ620640A (en) | 2015-09-25 |
TW201322924A (zh) | 2013-06-16 |
JP5961693B2 (ja) | 2016-08-02 |
KR20160054627A (ko) | 2016-05-16 |
MX347407B (es) | 2017-04-25 |
JP2014527069A (ja) | 2014-10-09 |
WO2013032693A3 (en) | 2013-05-02 |
CR20140097A (es) | 2014-05-02 |
US20140221207A1 (en) | 2014-08-07 |
AU2012301466A1 (en) | 2013-05-02 |
MA35445B1 (fr) | 2014-09-01 |
CO7020854A2 (es) | 2014-08-11 |
BR112014004386A2 (pt) | 2017-03-21 |
WO2013032693A2 (en) | 2013-03-07 |
AU2012301466B2 (en) | 2015-07-23 |
CL2016001235A1 (es) | 2016-11-25 |
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