AR082509A1 - Derivados de imidazopiridina, composiciones farmaceuticas y usos - Google Patents
Derivados de imidazopiridina, composiciones farmaceuticas y usosInfo
- Publication number
- AR082509A1 AR082509A1 ARP110103038A ARP110103038A AR082509A1 AR 082509 A1 AR082509 A1 AR 082509A1 AR P110103038 A ARP110103038 A AR P110103038A AR P110103038 A ARP110103038 A AR P110103038A AR 082509 A1 AR082509 A1 AR 082509A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- groups
- cycloalkyl
- fluorine atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Sus usos como inhibidores de la prostaglandina E2 sintasa-1 microsomal (mPGES-1), composiciones farmacéuticas que los contienen y sus usos como medicamentos para el tratamiento y/o prevención de enfermedades inflamatorias y afecciones asociadas. A, M, W, R1, R2, R6, R7 tiene los significados dados en la descripción.Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) en la que R1 representa halo, -alquilo C1-3, donde este último grupo alquilo está opcionalmente sustituido con uno o más átomos de flúor; R2 representa hidrógeno, halo, -alquilo C1-3, donde este último grupo alquilo está opcionalmente sustituido con uno o más átomos de flúor; W representa -C(O)-, -C(O)O-, donde estos grupos están unidos al nitrógeno del resto -NH- a través del átomo de carbono; M representa -alquilo C1-6, -cicloalquilo C3-7, donde los dos grupos están opcionalmente sustituidos con uno o más grupos seleccionados entre -F, -OH, -CN, -NH2, -NH(alquilo C1-2), -N(alquilo C1-2)2, -O-alquilo C1-3, -alquilo C1-5, -cicloalquilo C3-4, donde en estos tres últimos grupos los grupos alquilo o cicloalquilo están opcionalmente sustituidos con uno o más átomos de flúor; u oxetanil-, tetrahidrofuranil-, tetrahidropiranil-, azetidinil-, pirrolidinil-, piperidinil-, estando todos estos grupos opcionalmente sustituidos con uno o más sustituyentes seleccionados entre flúor, -CN, -alquilo C1-3, donde este último grupo alquilo está opcionalmente sustituido con uno o más átomos de flúor; o fenil-, piridil-, tienil-, pirrolil-, pirazolil-, imidazolil-, tiazolil-, oxazolil-, o isoxazolil-, estando todos estos grupos opcionalmente sustituidos con uno o más sustituyentes seleccionados entre halo, -CN o -alquilo C1-3, donde este último grupo alquilo está opcionalmente sustituido adicionalmente con uno o más átomos de flúor; R6 representa -H, -alquilo C1-5, -alquil C0-2-cicloalquilo C3-5, donde en estos dos últimos grupos los fragmentos alquilo o cicloalquilo están opcionalmente sustituidos con uno o más átomos de flúor; R7 representa alquil C1-5-O-, cicloalquil C3-7-alquil C0-2-O-, heterocicloalquil de 4 - 7 miembros-alquil C0-2-O-, donde en estos tres últimos grupos los fragmentos alquilo, cicloalquilo o heterocicloalquilo están opcionalmente sustituidos con uno o más sustituyentes seleccionados entre -F y -O-alquilo C1-3, donde este último grupo alquilo está opcionalmente sustituido con uno o más átomos de flúor; A representa alquil C1-8, fenil-, piridil-, tienil-, pirrolil-, pirazolil-, tiazolil-, oxazolil-, isoxazolil-, fenil-alquil C1-3-, tienil-alquil C1-3-, piridil-alquil C1-3-, cicloalquil C3-7-alquil C0-3-, oxetanil-alquil C0-3, tetrahidrofuranil-alquilo C0-3, tetrahidropiranil-alquilo C0-3, grupos en los que los fragmentos alquil-, cicloalquil- y heterocicloalquilo están opcionalmente sustituidos con uno o más sustituyentes seleccionados entre R9a y los fragmentos arilo y heteroarilo están opcionalmente sustituidos con uno o más sustituyentes seleccionados entre R9b; cada R9a representa independientemente -F, -Cl, -alquilo C1-3 que está opcionalmente sustituido con uno o más sustituyentes seleccionados entre -F, -O-alquilo C1-3; cada R9b representa independientemente -halo, -CN; -alquilo C1-3 que está opcionalmente sustituido con uno o más átomos de flúor; o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10173502 | 2010-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082509A1 true AR082509A1 (es) | 2012-12-12 |
Family
ID=44474976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103038A AR082509A1 (es) | 2010-08-20 | 2011-08-19 | Derivados de imidazopiridina, composiciones farmaceuticas y usos |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8586604B2 (es) |
| EP (1) | EP2606046A1 (es) |
| JP (1) | JP5554450B2 (es) |
| KR (1) | KR20130098305A (es) |
| CN (1) | CN103097382A (es) |
| AR (1) | AR082509A1 (es) |
| AU (1) | AU2011290724B2 (es) |
| BR (1) | BR112013003843A2 (es) |
| CA (1) | CA2807089A1 (es) |
| CL (1) | CL2013000351A1 (es) |
| EA (1) | EA201201663A1 (es) |
| MX (1) | MX2013001805A (es) |
| NZ (1) | NZ605432A (es) |
| TW (1) | TW201302741A (es) |
| WO (1) | WO2012022792A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| CN101645797B (zh) | 2009-08-25 | 2011-04-13 | 华为技术有限公司 | 自动保护倒换方法、设备和系统 |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| CA3142513A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| KR102711104B1 (ko) * | 2019-08-26 | 2024-09-27 | 국제약품 주식회사 | 인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물 |
| CN114555123B (zh) | 2019-10-18 | 2024-04-02 | 四十七公司 | 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法 |
| AU2020374947A1 (en) | 2019-10-31 | 2022-03-31 | Forty Seven, Inc. | Anti-CD47 and anti-CD20 based treatment of blood cancer |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| US11845723B2 (en) | 2019-12-24 | 2023-12-19 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| TWI832035B (zh) | 2020-02-14 | 2024-02-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| MX2022013619A (es) | 2020-05-01 | 2022-11-16 | Gilead Sciences Inc | Compuestos de 2,4-dioxopirimidina que inhiben cd73. |
| EP4146639A1 (en) | 2020-05-06 | 2023-03-15 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| EP4267574A1 (en) | 2020-12-23 | 2023-11-01 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| CN113304154B (zh) * | 2021-05-10 | 2024-06-21 | 澳门科技大学 | 嘧啶二酮类化合物作为微粒体前列腺素e2合酶抑制剂的应用 |
| TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用ＦＬＴ３Ｌ—Ｆｃ融合蛋白之方法 |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| US11976072B2 (en) | 2021-06-23 | 2024-05-07 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
| WO2022271677A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN118139858A (zh) | 2021-10-28 | 2024-06-04 | 吉利德科学公司 | 吡地嗪-3(2h)-酮衍生物 |
| KR20240097895A (ko) | 2021-10-29 | 2024-06-27 | 길리애드 사이언시즈, 인코포레이티드 | Cd73 화합물 |
| TW202334139A (zh) | 2021-11-09 | 2023-09-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳氧基苯并咪唑及氮雜苯并咪唑 |
| CA3237577A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| CA3239528A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| AU2022424478A1 (en) | 2021-12-28 | 2024-07-04 | Nippon Shinyaku Co., Ltd. | Indazole compound and pharmaceutical |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| AU2023233730A1 (en) | 2022-03-17 | 2024-09-26 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| US20230355796A1 (en) | 2022-03-24 | 2023-11-09 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| TW202345806A (zh) | 2022-03-31 | 2023-12-01 | 美商艾伯維有限公司 | 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑 |
| TW202345901A (zh) | 2022-04-05 | 2023-12-01 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| WO2023205719A1 (en) | 2022-04-21 | 2023-10-26 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20240116928A1 (en) | 2022-07-01 | 2024-04-11 | Gilead Sciences, Inc. | Cd73 compounds |
| US20240091351A1 (en) | 2022-09-21 | 2024-03-21 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY |
| WO2024137852A1 (en) | 2022-12-22 | 2024-06-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
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| DE3006671A1 (de) | 1980-02-22 | 1981-08-27 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel |
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| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
-
2011
- 2011-08-17 US US13/211,471 patent/US8586604B2/en not_active Expired - Fee Related
- 2011-08-19 TW TW100129864A patent/TW201302741A/zh unknown
- 2011-08-19 AR ARP110103038A patent/AR082509A1/es unknown
- 2011-08-19 BR BR112013003843A patent/BR112013003843A2/pt not_active IP Right Cessation
- 2011-08-19 MX MX2013001805A patent/MX2013001805A/es unknown
- 2011-08-19 CN CN2011800390100A patent/CN103097382A/zh active Pending
- 2011-08-19 NZ NZ60543211A patent/NZ605432A/en not_active IP Right Cessation
- 2011-08-19 CA CA2807089A patent/CA2807089A1/en not_active Abandoned
- 2011-08-19 WO PCT/EP2011/064257 patent/WO2012022792A1/en active Application Filing
- 2011-08-19 JP JP2013524454A patent/JP5554450B2/ja not_active Expired - Fee Related
- 2011-08-19 EA EA201201663A patent/EA201201663A1/ru unknown
- 2011-08-19 AU AU2011290724A patent/AU2011290724B2/en not_active Expired - Fee Related
- 2011-08-19 KR KR1020137004207A patent/KR20130098305A/ko not_active Application Discontinuation
- 2011-08-19 EP EP11751853.0A patent/EP2606046A1/en not_active Withdrawn
-
2013
- 2013-02-04 CL CL2013000351A patent/CL2013000351A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130098305A (ko) | 2013-09-04 |
| CN103097382A (zh) | 2013-05-08 |
| MX2013001805A (es) | 2013-04-29 |
| JP5554450B2 (ja) | 2014-07-23 |
| CL2013000351A1 (es) | 2013-06-21 |
| NZ605432A (en) | 2015-04-24 |
| US8586604B2 (en) | 2013-11-19 |
| TW201302741A (zh) | 2013-01-16 |
| JP2013534235A (ja) | 2013-09-02 |
| BR112013003843A2 (pt) | 2016-06-28 |
| US20120208839A1 (en) | 2012-08-16 |
| AU2011290724B2 (en) | 2015-11-05 |
| CA2807089A1 (en) | 2012-02-23 |
| WO2012022792A1 (en) | 2012-02-23 |
| EP2606046A1 (en) | 2013-06-26 |
| AU2011290724A1 (en) | 2013-01-10 |
| EA201201663A1 (ru) | 2013-08-30 |
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