AR076164A1 - Inhibidores de anillos fusionados de hepatitis c - Google Patents
Inhibidores de anillos fusionados de hepatitis cInfo
- Publication number
- AR076164A1 AR076164A1 ARP100101000A ARP100101000A AR076164A1 AR 076164 A1 AR076164 A1 AR 076164A1 AR P100101000 A ARP100101000 A AR P100101000A AR P100101000 A ARP100101000 A AR P100101000A AR 076164 A1 AR076164 A1 AR 076164A1
- Authority
- AR
- Argentina
- Prior art keywords
- heterocycle
- heteroaryl
- group
- cycloalkyl
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Composiciones farmacéuticas y terapias de combinacion para el tratamiento de la hepatitis C. Reivindicacion 1: Un compuesto que tiene la formula (1) donde D o bien está presente o ausente, y si está presente, se selecciona del grupo que consiste en -CR2CR2-, -CR2-, -NRN-, -O- y -S-, donde RN es H, -OH, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoílo, carbamoilo, sulfonilo sustituido, sulfonato y sulfonamida, y cada R se selecciona de manera independiente del grupo que consiste en hidrogeno, -OH, -CN, -NO2, halogeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoilo, sulfonilo sustituido, sulfonato, sulfonamida y amino; A y E son, de manera independiente, -CR2-, -CR=, -CR2-CR2, -CR=CR-, -N=CR-, -(CR2)a-N(RN)-(CR2)a, -(CR2)a-C(O)-N(RN)-(CR2)a-, -CR2)a-N(RN)-C(O)-(CR2)a- o -(CR2)b-O-(CR2)b-, donde RN se selecciona del grupo que consiste en H, -OH, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoilo, sulfonilo sustituido, sulfonato y sulfonamida; cada R se selecciona de modo independiente del grupo que consiste en hidrogeno, -OH, -CN, -NO2, halogeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoílo, sulfonilo sustituido, sulfonato, sulfonamida y amino, donde dos R' , ya sea ambos en un solo C, ya sea en C adjuntos, junto con el C o los C a los cuales están unidos, forman, opcionalmente, un ciclo; y donde son posibles dos R en un C, el C puede estar opcionalmente ligado a un solo R con un doble enlace; cada a y b son, de manera independiente, 0; 1; 2; o 3, con la condicion de que si D está presente, ambos b no son 0; y RN y R pueden estar reemplazados por un enlace a D si D está presente; si D está ausente, A y E, además pueden ser, independientemente, un enlace, -O-, -S-, -S(O2)-, -S(O)-, -C(O)- o -N=; y con la condicion de que si W y W' son ambos anillos de 5 miembros, A y E o bien son ambos un enlace, o ambos son diferentes de un enlace; cada Ra se selecciona de manera independiente del grupo que consiste en -OH, -CN, -NO2, halogeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoílo, sulfonilo sustituido, sulfonato, sulfonamida y amino; cada r es, independientemente, 0; 1; 2 o 3; W y W' se seleccionan de manera independiente del grupo que consiste en formulas (2) donde X1 es CH2, NR, O o S; Y1, Y2 y Z1 son, de modo independiente, CH o N; X2 es NH, O o S; W y W', de manera independiente, están opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste en -OH, -CN, -NO2, halogeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoílo, sulfonilo sustituido, sulfonato, sulfonamida y amino; y Cy es un grupo monocíclico, bicíclico o tricíclico de 5 a 12 miembros cicloalquilo, heterociclo, arilo, o heteroarilo donde hasta tres heteroátomos son, independientemente, N, S u O, y está opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste en -OH, -CN, -NO2, halogeno, alquilo C1-12, heteroalquilo C1-12, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, alcoxi, alcoxicarbonilo, alcanoilo, carbamoílo, sulfonilo sustituido, sulfonato, sulfonamida y amino; cada Rc, Rd, Re y Rf se seleccionan de manera independiente del grupo que consiste en: hidrogeno, alquilo C1-8, heteroalquilo C1-8, aralquilo y un anillo de 4 a 8 miembros que puede ser cicloalquilo, heterociclo, heteroarilo o arilo, donde: cada heteroátomo, si se presenta, es de manera independiente N, O o S; cada Rc, Rd, Re y Rf pueden estar opcionalmente sustituidos con alquilo C1-8, heteroalquilo C1-8, aralquilo, o un anillo de 4 a 8 miembros que puede ser cicloalquilo, heterociclo, heteroarilo o arilo, y donde cada heteroátomo, si se presenta, es, de modo independiente, N, O o S; Rc y Rd están opcionalmente unidos para formar un heterociclo de 4 a 8 miembros, que, en forma opcional, está fusionado a otro anillo heteroarilo o heterociclo de 3 a 5 miembros; y Re y Rf están opcionalmente unidos para formar un heterociclo de 4 a 8 miembros, que, en forma opcional, está fusionado a otro anillo heteroarilo o heterociclo de 3 a 5 miembros; Y e Y' son, de manera independiente, carbono o nitrogeno; y Z y Z1 se seleccionan de manera independiente del grupo que consiste en hidrogeno, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, 1-3 aminoácidos, -[U-(CR42)t-NR5-C(R42)t]u-U- (CR42)t-NR7-(CR42)t-R8, -U-(CR42) t-R8, y -[U-(CR42)t-NR5-(CR42)t]u-U-(CR42)t-O-(CR42)t-R8, donde U se selecciona del grupo que consiste en -C(O)-, -C(S)- y -S(O)2-, cada R4, R5 y R7 se seleccionan de manera independiente del grupo que consiste en hidrogeno, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclo, arilo, heteroarilo y aralquilo; R8 se selecciona del grupo que consiste en hidrogeno, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclo, arilo, heteroarilo, aralquilo, -C(O)-R81, -C(S)-R81, -C(O)-O-R81, -C(O)-N-R812, -S(O)2-R81 y -S(O)2-N-R812, donde cada R81 se selecciona de modo independiente del grupo que consiste en hidrogeno, alquilo C1-8, heteroalquilo C1-8, cicloalquilo, heterociclo, arilo, heteroarilo y aralquilo; opcionalmente, R7 y R8 juntos forman un anillo de 4-7 miembros; cada t es, independientemente, 0; 1; 2; 3; o 4; y u es 0; 1; o 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16434209P | 2009-03-27 | 2009-03-27 | |
| US21488309P | 2009-04-28 | 2009-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076164A1 true AR076164A1 (es) | 2011-05-26 |
Family
ID=42781523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101000A AR076164A1 (es) | 2009-03-27 | 2010-03-29 | Inhibidores de anillos fusionados de hepatitis c |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9150554B2 (es) |
| EP (1) | EP2410843A4 (es) |
| JP (1) | JP5735482B2 (es) |
| KR (1) | KR20110131312A (es) |
| CN (1) | CN102427726B (es) |
| AR (1) | AR076164A1 (es) |
| AU (1) | AU2010229795A1 (es) |
| BR (1) | BRPI1012282A2 (es) |
| CA (1) | CA2755658A1 (es) |
| CL (1) | CL2011002377A1 (es) |
| CO (1) | CO6450600A2 (es) |
| EA (1) | EA201190224A1 (es) |
| HK (1) | HK1166446A1 (es) |
| IL (1) | IL215202A0 (es) |
| MX (1) | MX2011010132A (es) |
| PE (1) | PE20120773A1 (es) |
| SG (1) | SG174883A1 (es) |
| TW (1) | TW201038560A (es) |
| WO (1) | WO2010111534A1 (es) |
| ZA (1) | ZA201107753B (es) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2505539C2 (ru) | 2008-12-23 | 2014-01-27 | Эбботт Лэборетриз | Антивирусные соединения |
| CN102264737A (zh) | 2008-12-23 | 2011-11-30 | 雅培制药有限公司 | 抗病毒化合物 |
| US8314135B2 (en) | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
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| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
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- 2010-03-25 EP EP10756872A patent/EP2410843A4/en not_active Withdrawn
- 2010-03-25 SG SG2011067683A patent/SG174883A1/en unknown
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- 2010-03-25 EA EA201190224A patent/EA201190224A1/ru unknown
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- 2010-03-25 CA CA2755658A patent/CA2755658A1/en not_active Abandoned
- 2010-03-25 BR BRPI1012282A patent/BRPI1012282A2/pt not_active IP Right Cessation
- 2010-03-25 AU AU2010229795A patent/AU2010229795A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| US20120040962A1 (en) | 2012-02-16 |
| EP2410843A1 (en) | 2012-02-01 |
| HK1166446A1 (en) | 2012-11-02 |
| CN102427726A (zh) | 2012-04-25 |
| BRPI1012282A2 (pt) | 2015-09-22 |
| ZA201107753B (en) | 2012-07-25 |
| WO2010111534A1 (en) | 2010-09-30 |
| CA2755658A1 (en) | 2010-09-30 |
| JP5735482B2 (ja) | 2015-06-17 |
| US9150554B2 (en) | 2015-10-06 |
| JP2012522003A (ja) | 2012-09-20 |
| EP2410843A4 (en) | 2012-08-08 |
| TW201038560A (en) | 2010-11-01 |
| AU2010229795A1 (en) | 2011-10-13 |
| PE20120773A1 (es) | 2012-07-19 |
| SG174883A1 (en) | 2011-11-28 |
| CO6450600A2 (es) | 2012-05-31 |
| IL215202A0 (en) | 2011-12-29 |
| EA201190224A1 (ru) | 2012-03-30 |
| KR20110131312A (ko) | 2011-12-06 |
| MX2011010132A (es) | 2011-10-14 |
| CN102427726B (zh) | 2014-10-08 |
| CL2011002377A1 (es) | 2012-01-20 |
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