AR070016A1 - Forma cristalina de la sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutano il)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo - Google Patents
Forma cristalina de la sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutano il)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metiloInfo
- Publication number
- AR070016A1 AR070016A1 ARP080103486A ARP080103486A AR070016A1 AR 070016 A1 AR070016 A1 AR 070016A1 AR P080103486 A ARP080103486 A AR P080103486A AR P080103486 A ARP080103486 A AR P080103486A AR 070016 A1 AR070016 A1 AR 070016A1
- Authority
- AR
- Argentina
- Prior art keywords
- pirrolidinil
- imidazol
- salt
- metoxicarbonil
- methylpropil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una forma cristalina de sal diclorhidrato N-2, y también una composicion farmacéutica que comprende la forma cristalina. Forma util en el tratamiento de la hepatitis C. Reivindicacion 5: Forma N-2 de de la formula (1) caracterizada por uno o más de los siguientes: a) una celda unitaria con parámetros sustancialmente iguales a los siguientes: dimensiones de celda: a = 7,5680 L; b= 9,5848 L, c = 16,2864L, a = 74,132 grados, b= 84,132 grados, g = 70,646 grados, grupo espacial P1, moléculas/celda unitaria 1 en la que la medida de dicha forma cristalina es a una temperatura entre aproximadamente 20°C y aproximadamente 25°C; b) picos característicos en el patron de difraccion de rayos X en polvo a valores de dos theta de 10,3+- 0,1, 12,4+- 0,1, 12,8+- 0,1, 13,3+- 0,1, 13,6+- 01, 15,5+- 0,1, 20,3 +- 0,1, 21,2 +- 0,1, 22,4 +- 0,1, 22,7 +- 0,1 y 23,7 +- 0,1 a una temperatura entre aproximadamente 20°C y aproximadamente 25°C; y/o c) una mezcla fundida con endotermia de descomposicion con inicio típicamente en el intervalo de 225-245°C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95459207P | 2007-08-08 | 2007-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070016A1 true AR070016A1 (es) | 2010-03-10 |
Family
ID=39739413
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080103486A AR070016A1 (es) | 2007-08-08 | 2008-08-08 | Forma cristalina de la sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutano il)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo |
ARP160101320A AR104566A2 (es) | 2007-08-08 | 2016-05-06 | Forma cristalina de la sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160101320A AR104566A2 (es) | 2007-08-08 | 2016-05-06 | Forma cristalina de la sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo |
Country Status (21)
Country | Link |
---|---|
US (1) | US8629171B2 (es) |
EP (1) | EP2183244B1 (es) |
JP (1) | JP5244179B2 (es) |
KR (1) | KR101508022B1 (es) |
CN (1) | CN101778840B (es) |
AR (2) | AR070016A1 (es) |
AU (1) | AU2008284100B2 (es) |
BR (1) | BRPI0815142B8 (es) |
CA (1) | CA2695729C (es) |
CL (1) | CL2008002354A1 (es) |
CO (1) | CO6160327A2 (es) |
EA (1) | EA018152B1 (es) |
ES (1) | ES2402791T3 (es) |
HK (1) | HK1144089A1 (es) |
IL (1) | IL203684A (es) |
MX (1) | MX2010001368A (es) |
NZ (1) | NZ583148A (es) |
PE (1) | PE20090940A1 (es) |
TW (1) | TWI359813B (es) |
WO (1) | WO2009020828A1 (es) |
ZA (1) | ZA201000843B (es) |
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CN106496199A (zh) * | 2016-10-19 | 2017-03-15 | 上海博志研新药物技术有限公司 | 达卡他韦及其中间体的制备方法 |
CN109305962B (zh) * | 2017-07-28 | 2022-01-18 | 扬子江药业集团有限公司 | 一种盐酸达拉他韦的精制方法 |
WO2019030387A1 (en) | 2017-08-11 | 2019-02-14 | Sandoz Ag | SOLID COMPOSITION COMPRISING AMORPHOUS SOFOSBUVIR AND AMORPHOUS DACLATASVIR |
CN108675998B (zh) * | 2018-06-28 | 2019-08-13 | 北京凯因格领生物技术有限公司 | 一种结晶性氨基甲酸甲酯类化合物 |
KR20210098504A (ko) | 2018-12-04 | 2021-08-10 | 브리스톨-마이어스 스큅 컴퍼니 | 다중 동위원소체 반응 모니터링에 의한 샘플내 보정 곡선을 사용한 분석 방법 |
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US5654451B1 (en) | 1993-01-14 | 2000-02-22 | Magainin Pharma | Amino acids and peptides having modified c-terminals and modified n-terminals |
JPH08505854A (ja) | 1993-01-14 | 1996-06-25 | マガイニン ファーマシューティカルズ,インク. | 修飾された末端を有するアミノ酸及びペプチド |
WO2004005264A2 (en) | 2002-07-05 | 2004-01-15 | Axxima Pharmaceuticals Ag | Imidazole compounds for the treatment of hepatitis c virus infections |
WO2006093867A1 (en) | 2005-02-28 | 2006-09-08 | The Rockefeller University | Structure of the hepatitits c virus ns5a protein |
US8143288B2 (en) | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
JP2009508835A (ja) | 2005-09-16 | 2009-03-05 | アロー セラピューティクス リミテッド | ビフェニル誘導体及びc型肝炎の治療におけるその使用 |
WO2007058384A1 (en) | 2005-11-17 | 2007-05-24 | Osaka University | Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same |
SG133452A1 (en) | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
AU2007266915A1 (en) | 2006-05-30 | 2007-12-06 | Arrow Therapeutics Limited | Biphenyl derivatives and their use in treating hepatitis C |
US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7759495B2 (en) | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2008133753A2 (en) | 2006-12-20 | 2008-11-06 | Abbott Laboratories | Anti-viral compounds |
US7728027B2 (en) * | 2007-08-08 | 2010-06-01 | Bristol-Myers Squibb Company | Process for synthesizing compounds useful for treating hepatitis C |
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EA018152B1 (ru) | 2013-05-30 |
JP5244179B2 (ja) | 2013-07-24 |
AU2008284100B2 (en) | 2014-01-16 |
CN101778840A (zh) | 2010-07-14 |
NZ583148A (en) | 2011-04-29 |
PE20090940A1 (es) | 2009-07-13 |
JP2010535785A (ja) | 2010-11-25 |
CN101778840B (zh) | 2013-11-13 |
AU2008284100A1 (en) | 2009-02-12 |
TWI359813B (en) | 2012-03-11 |
MX2010001368A (es) | 2010-03-01 |
EP2183244A1 (en) | 2010-05-12 |
BRPI0815142B1 (pt) | 2018-09-25 |
BRPI0815142A2 (pt) | 2015-02-03 |
WO2009020828A1 (en) | 2009-02-12 |
ZA201000843B (en) | 2011-04-28 |
CA2695729C (en) | 2015-03-31 |
KR101508022B1 (ko) | 2015-04-08 |
ES2402791T3 (es) | 2013-05-09 |
CO6160327A2 (es) | 2010-05-20 |
EP2183244B1 (en) | 2013-01-23 |
HK1144089A1 (en) | 2011-01-28 |
EA201000196A1 (ru) | 2010-06-30 |
BRPI0815142B8 (pt) | 2021-05-25 |
CA2695729A1 (en) | 2009-02-12 |
AR104566A2 (es) | 2017-08-02 |
US8629171B2 (en) | 2014-01-14 |
US20090041716A1 (en) | 2009-02-12 |
TW200911790A (en) | 2009-03-16 |
CL2008002354A1 (es) | 2009-01-02 |
IL203684A (en) | 2014-12-31 |
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