WO2008102127A3 - Gel forming compounds - Google Patents

Gel forming compounds Download PDF

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Publication number
WO2008102127A3
WO2008102127A3 PCT/GB2008/000575 GB2008000575W WO2008102127A3 WO 2008102127 A3 WO2008102127 A3 WO 2008102127A3 GB 2008000575 W GB2008000575 W GB 2008000575W WO 2008102127 A3 WO2008102127 A3 WO 2008102127A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
compounds
gel forming
forming compounds
integer
Prior art date
Application number
PCT/GB2008/000575
Other languages
French (fr)
Other versions
WO2008102127A2 (en
Inventor
Vesna Caplar
Leo Frkanec
Milan Jokic
Janja Makarevic
Tomislav Portada
Mladen Zinic
Zelimir Jelcic
Original Assignee
Pliva Hrvatska D O O
Bucks Teresa Anne
Vesna Caplar
Leo Frkanec
Milan Jokic
Janja Makarevic
Tomislav Portada
Mladen Zinic
Zelimir Jelcic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Hrvatska D O O, Bucks Teresa Anne, Vesna Caplar, Leo Frkanec, Milan Jokic, Janja Makarevic, Tomislav Portada, Mladen Zinic, Zelimir Jelcic filed Critical Pliva Hrvatska D O O
Publication of WO2008102127A2 publication Critical patent/WO2008102127A2/en
Publication of WO2008102127A3 publication Critical patent/WO2008102127A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compounds of general formula (Ia) or (Ib): general formula (Ia) or (Ib): wherein: R1 is C1-6 alkyl, benzyl, phenyl, or indolylmethyl, any of which may be substituted with OH, 0(C1-6 alkyl) or S(C1-6 alkyl); each of X and Xa is independently -O-[CH2]P- or -NH-[CH2]r; p is 1 to 4 except when: R1 is C1-6≤ alkyl, and: n is ≤ 6 in compounds of formula (Ia); or q is ≤ 5 in compounds of formula (Ib); in which case, p is 2 to 4; r is 0 to 4; each of R2 and R2a is independently pyridyl; m is an integer of 4 to 12; n is an integer of 5 to 12; q is an integer of 4 to 11; or salts thereof are capable of forming gels when added to water or to organic solvents, heated and left to cool.
PCT/GB2008/000575 2007-02-21 2008-02-19 Gel forming compounds WO2008102127A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0703328A GB0703328D0 (en) 2007-02-21 2007-02-21 Gel forming compounds
GB0703328.5 2007-02-21

Publications (2)

Publication Number Publication Date
WO2008102127A2 WO2008102127A2 (en) 2008-08-28
WO2008102127A3 true WO2008102127A3 (en) 2008-12-18

Family

ID=37908984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000575 WO2008102127A2 (en) 2007-02-21 2008-02-19 Gel forming compounds

Country Status (2)

Country Link
GB (1) GB0703328D0 (en)
WO (1) WO2008102127A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2516507A1 (en) 2009-12-22 2012-10-31 Dow Global Technologies LLC Poly(bisoxalamides)
CA2792767C (en) 2010-03-12 2014-07-08 The Procter & Gamble Company Ph tuneable amido-gellant for use in consumer product compositions
WO2012174091A2 (en) * 2011-06-13 2012-12-20 The Procter & Gamble Company PERSONAL CARE COMPOSITIONS COMPRISING A pH TUNEABLE GELLANT AND METHODS OF USING
EP2570474B1 (en) * 2011-09-13 2014-11-19 The Procter and Gamble Company Stable water-soluble unit dose articles
BR112014005193A2 (en) 2011-09-13 2017-03-21 Procter & Gamble encapsulated
US20130303427A1 (en) * 2011-09-13 2013-11-14 Susana Fernandez Prieto MICROCAPSULE COMPOSITIONS COMPRISING pH TUNEABLE DI-AMIDO GELLANTS
US10064960B2 (en) 2011-11-25 2018-09-04 Danmarks Tekniske Universitet Formulation of solid nano-sized particles in a gel-forming system
EP2746377A1 (en) * 2012-12-20 2014-06-25 The Procter & Gamble Company Improved structuring using an external structurant and a cosmotrope
WO2017194980A1 (en) * 2016-05-12 2017-11-16 Rudjer Boskovic Institute Low molecular weight organic gelators of vegetable oil
WO2023198878A1 (en) * 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Lipopeptide compound and treatment of pain disorder
WO2024045158A1 (en) * 2022-09-02 2024-03-07 宁德时代新能源科技股份有限公司 Amide compound and preparation method therefor, electrode sheet, secondary battery, and electric device

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANTHONY D'ALÉO ET AL.: "11-AMINOUNDECANOIC ACID: A VERSATILE UNIT FOR THE GENERATION OF LOW MOLECULAR WEIGHT GELATORS FOR WATER AND ORGANIC SOLVENTS", CHEMICAL COMMUNICATIONS, no. 2, 18 November 2003 (2003-11-18), SEINSTITUTE OF INORGANIC AND PHYSICAL CHEMISTRY, STOCKHOLM,, pages 190-191, XP002499110 *
ESTROFF L A ET AL: "WATER GELATION BY SMALL ORGANIC MOLECULES", CHEMICAL REVIEWS, ACS,WASHINGTON, DC, US, vol. 104, no. 3, 1 January 2004 (2004-01-01), pages 1201 - 1218, XP003016413, ISSN: 0009-2665 *
MASAHIRO S ET AL: "New low-molecular-weight hydrogelators based on L-lysine with positively charged pendant chain", NEW JOURNAL OF CHEMISTRY, CNRS-GAUTHIER-VILLARS, MONTROUGE.; FR, vol. 26, 1 January 2002 (2002-01-01), pages 817 - 818, XP009018282, ISSN: 1144-0546 *
MASAHIRO SUZUKI ET AL.: "SUPRAMOLECULAR HYDROGELS AND ORGANOGELS BASED ON NOVEL L-VALINE AND L-ISOLEUCINE AMPHIPHILES", TETRAHEDRON LETTERS, vol. 46, no. 02, 10 January 2005 (2005-01-10), NLELSEVIER, AMSTERDAM, pages 303 - 306, XP002499109 *
SUZUKI ET AL: "Supramolecular hydrogel formed by glucoheptonamide of l-lysine: simple preparation and excellent hydrogelation ability", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 63, no. 31, 20 February 2007 (2007-02-20), pages 7302 - 7308, XP022124595, ISSN: 0040-4020 *
SUZUKI M ET AL: "New l-valine-based hydrogelators: formation of supramolecular hydrogels", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 45, no. 28, 5 July 2004 (2004-07-05), pages 5399 - 5402, XP004518889, ISSN: 0040-4039 *
SUZUKIM ET AL: "A family of low-molecular-weight hydrogelators based on L-lysine", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, vol. 9, no. 1, 1 January 2003 (2003-01-01), pages 348 - 354, XP001155280, ISSN: 0947-6539 *

Also Published As

Publication number Publication date
GB0703328D0 (en) 2007-03-28
WO2008102127A2 (en) 2008-08-28

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