AR066266A1 - DERIVADOS DE CROMENO Y DE TETRAHIDRONAFTALENO uTILES PARA EL TRATAMIENTO DEL DOLOR - Google Patents
DERIVADOS DE CROMENO Y DE TETRAHIDRONAFTALENO uTILES PARA EL TRATAMIENTO DEL DOLORInfo
- Publication number
- AR066266A1 AR066266A1 ARP080101710A ARP080101710A AR066266A1 AR 066266 A1 AR066266 A1 AR 066266A1 AR P080101710 A ARP080101710 A AR P080101710A AR P080101710 A ARP080101710 A AR P080101710A AR 066266 A1 AR066266 A1 AR 066266A1
- Authority
- AR
- Argentina
- Prior art keywords
- 6alkyl
- 6alkoxy
- acid
- 6haloalkyl
- phenyl
- Prior art date
Links
- QZHPTGXQGDFGEN-UHFFFAOYSA-N chromene Chemical compound C1=CC=C2C=C[CH]OC2=C1 QZHPTGXQGDFGEN-UHFFFAOYSA-N 0.000 title 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 3
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000005494 pyridonyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91331207P | 2007-04-23 | 2007-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066266A1 true AR066266A1 (es) | 2009-08-05 |
Family
ID=39876087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101710A AR066266A1 (es) | 2007-04-23 | 2008-04-23 | DERIVADOS DE CROMENO Y DE TETRAHIDRONAFTALENO uTILES PARA EL TRATAMIENTO DEL DOLOR |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8143408B2 (enExample) |
| EP (1) | EP2158198B1 (enExample) |
| JP (1) | JP2010525056A (enExample) |
| KR (1) | KR20100015827A (enExample) |
| CN (1) | CN101687860B (enExample) |
| AR (1) | AR066266A1 (enExample) |
| AU (1) | AU2008241610B2 (enExample) |
| BR (1) | BRPI0810354A2 (enExample) |
| CA (1) | CA2685141A1 (enExample) |
| CL (1) | CL2008001170A1 (enExample) |
| CO (1) | CO6251361A2 (enExample) |
| EC (1) | ECSP099706A (enExample) |
| IL (1) | IL201309A0 (enExample) |
| MX (1) | MX2009011364A (enExample) |
| MY (1) | MY146662A (enExample) |
| NZ (1) | NZ581353A (enExample) |
| PE (1) | PE20090727A1 (enExample) |
| RU (1) | RU2460730C2 (enExample) |
| SA (1) | SA08290245B1 (enExample) |
| TW (1) | TW200848037A (enExample) |
| UY (1) | UY31046A1 (enExample) |
| WO (1) | WO2008130320A2 (enExample) |
| ZA (1) | ZA200907137B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| EP2942346B1 (en) | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
| CA2778615C (en) * | 2009-10-26 | 2019-04-23 | Signal Pharmaceuticals, Llc | Methods of synthesis and purification of heteroaryl compounds |
| UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| CN102971304A (zh) | 2010-02-01 | 2013-03-13 | 日本化学医药株式会社 | Gpr119激动剂 |
| WO2012027289A1 (en) | 2010-08-23 | 2012-03-01 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators |
| WO2012039657A1 (en) * | 2010-09-22 | 2012-03-29 | Astrazeneca Ab | Novel chromane compound for the treatment of pain disorders |
| CN102408385B (zh) * | 2011-06-20 | 2014-06-18 | 雅本化学股份有限公司 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
| CN102408386B (zh) * | 2011-07-27 | 2014-05-07 | 雅本化学股份有限公司 | 2,4-二取代-2h-1,2,3-三氮唑衍生物的制备方法 |
| CN102603659B (zh) * | 2012-03-01 | 2014-03-26 | 雅本化学股份有限公司 | 1-取代-4-溴-1h-1,2,3-三氮唑-5-羧酸及其制备方法 |
| RU2683788C2 (ru) * | 2013-01-31 | 2019-04-02 | Вертекс Фармасьютикалз Инкорпорейтед | Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| WO2015119998A1 (en) * | 2014-02-06 | 2015-08-13 | Abbvie, Inc. | 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof |
| KR102412146B1 (ko) | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
| PL3375782T3 (pl) | 2015-11-13 | 2021-02-22 | iN Therapeutics Co., Ltd. | Bloker kanału sodowego |
| CN105541774B (zh) * | 2016-01-13 | 2018-06-15 | 华中师范大学 | 3,4-二氢香豆素类化合物及其制备方法和用途 |
| CR20190595A (es) * | 2017-06-30 | 2020-03-03 | Bayer Animal Health Gmbh | Nuevos derivados de azaquinolina |
| DK3740481T5 (da) | 2018-01-19 | 2025-05-05 | Cytokinetics Inc | Dihydrobenzofuran- og indenanaloger som hjertesarkomerinhibitorer |
| AU2019232437A1 (en) | 2018-03-07 | 2020-10-08 | Bayer Aktiengesellschaft | Identification and use of ERK5 inhibitors |
| EP3814342B1 (en) | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7610985B2 (ja) | 2018-06-26 | 2025-01-09 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| BR112021001608A2 (pt) | 2018-09-10 | 2021-04-27 | Kaken Pharmaceutical Co., Ltd. | derivado de amida heteroaromático inovador e medicamento contendo o mesmo |
| US20220227729A1 (en) | 2019-05-21 | 2022-07-21 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| EP4301760A1 (en) | 2021-03-04 | 2024-01-10 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8904361D0 (sv) * | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
| WO1994012493A1 (en) * | 1992-11-25 | 1994-06-09 | Sandoz, Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-benzopyr ans, their use as pharmaceuticals |
| JPH0827153A (ja) * | 1994-07-12 | 1996-01-30 | Nippon Kayaku Co Ltd | アザクロマン誘導体及びその用途 |
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| GB9713804D0 (en) * | 1997-06-30 | 1997-09-03 | Novo Nordisk As | Particulate polymeric materials and their use |
| JPH1135569A (ja) | 1997-07-22 | 1999-02-09 | Meiji Milk Prod Co Ltd | ポリフェノール化合物及びこれを含有する医薬 |
| SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| SE9703377D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| SE9703378D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| AR045238A1 (es) * | 2003-08-08 | 2005-10-19 | Vertex Pharma | Compuestos utiles como inhibidores de canales ionicos regulados por voltaje |
| WO2006119451A1 (en) * | 2005-05-04 | 2006-11-09 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyrazines useful as modulators of ion channels |
| US20090291983A1 (en) * | 2006-07-12 | 2009-11-26 | Astrazeneca Ab | 3-Oxoisoindoline-1-Carboxamide Derivatives as Analgesic Agents |
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
-
2008
- 2008-04-21 SA SA8290245A patent/SA08290245B1/ar unknown
- 2008-04-22 CA CA002685141A patent/CA2685141A1/en not_active Abandoned
- 2008-04-22 KR KR1020097022164A patent/KR20100015827A/ko not_active Withdrawn
- 2008-04-22 AU AU2008241610A patent/AU2008241610B2/en not_active Ceased
- 2008-04-22 US US12/596,878 patent/US8143408B2/en not_active Expired - Fee Related
- 2008-04-22 NZ NZ581353A patent/NZ581353A/en not_active IP Right Cessation
- 2008-04-22 MY MYPI20094419A patent/MY146662A/en unknown
- 2008-04-22 JP JP2010506133A patent/JP2010525056A/ja active Pending
- 2008-04-22 MX MX2009011364A patent/MX2009011364A/es active IP Right Grant
- 2008-04-22 RU RU2009138137/04A patent/RU2460730C2/ru not_active IP Right Cessation
- 2008-04-22 CN CN2008800215491A patent/CN101687860B/zh not_active Expired - Fee Related
- 2008-04-22 BR BRPI0810354-2A2A patent/BRPI0810354A2/pt not_active IP Right Cessation
- 2008-04-22 EP EP08779260A patent/EP2158198B1/en active Active
- 2008-04-22 WO PCT/SE2008/050459 patent/WO2008130320A2/en not_active Ceased
- 2008-04-23 PE PE2008000697A patent/PE20090727A1/es not_active Application Discontinuation
- 2008-04-23 AR ARP080101710A patent/AR066266A1/es not_active Application Discontinuation
- 2008-04-23 UY UY31046A patent/UY31046A1/es not_active Application Discontinuation
- 2008-04-23 CL CL2008001170A patent/CL2008001170A1/es unknown
- 2008-04-23 TW TW097114910A patent/TW200848037A/zh unknown
-
2009
- 2009-10-01 IL IL201309A patent/IL201309A0/en unknown
- 2009-10-13 ZA ZA200907137A patent/ZA200907137B/xx unknown
- 2009-10-29 CO CO09122476A patent/CO6251361A2/es not_active Application Discontinuation
- 2009-10-29 EC EC2009009706A patent/ECSP099706A/es unknown
-
2012
- 2012-03-23 US US13/427,981 patent/US20120238579A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MY146662A (en) | 2012-09-14 |
| CA2685141A1 (en) | 2008-10-30 |
| NZ581353A (en) | 2012-02-24 |
| AU2008241610A1 (en) | 2008-10-30 |
| KR20100015827A (ko) | 2010-02-12 |
| CL2008001170A1 (es) | 2009-05-22 |
| EP2158198A4 (en) | 2012-01-04 |
| EP2158198A2 (en) | 2010-03-03 |
| US20100137322A1 (en) | 2010-06-03 |
| IL201309A0 (en) | 2010-05-31 |
| SA08290245B1 (ar) | 2012-02-12 |
| UY31046A1 (es) | 2008-11-28 |
| JP2010525056A (ja) | 2010-07-22 |
| CN101687860A (zh) | 2010-03-31 |
| EP2158198B1 (en) | 2013-03-20 |
| US20120238579A1 (en) | 2012-09-20 |
| TW200848037A (en) | 2008-12-16 |
| ZA200907137B (en) | 2010-07-28 |
| AU2008241610B2 (en) | 2011-08-18 |
| ECSP099706A (es) | 2009-11-30 |
| MX2009011364A (es) | 2009-11-05 |
| CO6251361A2 (es) | 2011-02-21 |
| RU2009138137A (ru) | 2011-05-27 |
| WO2008130320A3 (en) | 2008-12-18 |
| BRPI0810354A2 (pt) | 2014-10-21 |
| RU2460730C2 (ru) | 2012-09-10 |
| CN101687860B (zh) | 2012-07-04 |
| US8143408B2 (en) | 2012-03-27 |
| WO2008130320A2 (en) | 2008-10-30 |
| PE20090727A1 (es) | 2009-07-23 |
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