CN102408385B - 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 - Google Patents
一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 Download PDFInfo
- Publication number
- CN102408385B CN102408385B CN201110166067.9A CN201110166067A CN102408385B CN 102408385 B CN102408385 B CN 102408385B CN 201110166067 A CN201110166067 A CN 201110166067A CN 102408385 B CN102408385 B CN 102408385B
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- Prior art keywords
- triazole
- replacement
- bromo
- preparation
- formula
- Prior art date
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- BSHWJBSHZPLXDB-UHFFFAOYSA-N C[n](nc1C(OC)=O)nc1Br Chemical compound C[n](nc1C(OC)=O)nc1Br BSHWJBSHZPLXDB-UHFFFAOYSA-N 0.000 description 3
- NLNDFFUTWBPIJM-UHFFFAOYSA-N Brc1n[n](C2CCCC2)nc1Br Chemical compound Brc1n[n](C2CCCC2)nc1Br NLNDFFUTWBPIJM-UHFFFAOYSA-N 0.000 description 1
- AXCCFSAPICGOBI-UHFFFAOYSA-N CCC[n](nc1Br)nc1Br Chemical compound CCC[n](nc1Br)nc1Br AXCCFSAPICGOBI-UHFFFAOYSA-N 0.000 description 1
- IFYOMOGCOQLUJF-UHFFFAOYSA-N CCC[n](nc1C(O)=O)nc1Br Chemical compound CCC[n](nc1C(O)=O)nc1Br IFYOMOGCOQLUJF-UHFFFAOYSA-N 0.000 description 1
- HSRUCDVHLCXDBM-UHFFFAOYSA-N CC[n](nc1Br)nc1Br Chemical compound CC[n](nc1Br)nc1Br HSRUCDVHLCXDBM-UHFFFAOYSA-N 0.000 description 1
- HXADUESUEHSHNP-UHFFFAOYSA-N CC[n](nc1C(O)=O)nc1Br Chemical compound CC[n](nc1C(O)=O)nc1Br HXADUESUEHSHNP-UHFFFAOYSA-N 0.000 description 1
- 0 CCc1n[n](*)nc1* Chemical compound CCc1n[n](*)nc1* 0.000 description 1
- OOUZSCRZUSMYSS-XBXARRHUSA-N CN(N)/N=C(\C(Br)=C)/Br Chemical compound CN(N)/N=C(\C(Br)=C)/Br OOUZSCRZUSMYSS-XBXARRHUSA-N 0.000 description 1
- MEEKMZNPDDHRHE-UHFFFAOYSA-N C[n](nc1C(O)=O)nc1Br Chemical compound C[n](nc1C(O)=O)nc1Br MEEKMZNPDDHRHE-UHFFFAOYSA-N 0.000 description 1
- YDWOKVAUBAKSGT-UHFFFAOYSA-N C[n](nc1C(OC)=O)nc1-c1ccccc1 Chemical compound C[n](nc1C(OC)=O)nc1-c1ccccc1 YDWOKVAUBAKSGT-UHFFFAOYSA-N 0.000 description 1
- JIDALGMYRJWVST-UHFFFAOYSA-N OC(c1n[n](C2CCCC2)nc1Br)=O Chemical compound OC(c1n[n](C2CCCC2)nc1Br)=O JIDALGMYRJWVST-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (14)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110166067.9A CN102408385B (zh) | 2011-06-20 | 2011-06-20 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
PCT/CN2011/001101 WO2012174685A1 (zh) | 2011-06-20 | 2011-07-04 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201110166067.9A CN102408385B (zh) | 2011-06-20 | 2011-06-20 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102408385A CN102408385A (zh) | 2012-04-11 |
CN102408385B true CN102408385B (zh) | 2014-06-18 |
Family
ID=45910775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201110166067.9A Active CN102408385B (zh) | 2011-06-20 | 2011-06-20 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
Country Status (2)
Country | Link |
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CN (1) | CN102408385B (zh) |
WO (1) | WO2012174685A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102786485B (zh) * | 2012-08-24 | 2014-11-26 | 雅本化学股份有限公司 | 2-取代-2h-1,2,3-三氮唑衍生物及其制备方法 |
CN103073513B (zh) * | 2012-12-14 | 2015-12-02 | 雅本化学股份有限公司 | 1-取代-5-氯-2h-1,2,3-三氮唑-4-羧酸衍生物及其制备方法 |
CN103058940B (zh) * | 2012-12-14 | 2015-12-23 | 雅本化学股份有限公司 | 1-取代-4-溴-2h-1,2,3-三氮唑衍生物及其制备方法 |
KR102524518B1 (ko) | 2018-04-23 | 2023-04-20 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 위치선택적 n-알킬 트리아졸을 제조하는 방법 |
CA3179700A1 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
WO2023056405A1 (en) | 2021-10-01 | 2023-04-06 | Nuvalent, Inc. | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101687860A (zh) * | 2007-04-23 | 2010-03-31 | 阿斯利康(瑞典)有限公司 | 用于治疗疼痛的新颖n-(8-杂芳基四氢萘-2-基)或n-(5-杂芳基色满-3-基)甲酰胺衍生物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1289326A (zh) * | 1998-02-27 | 2001-03-28 | 辉瑞产品公司 | 用于治疗局部缺血的n-[(取代的五元二氮杂或三氮杂二不饱和环)羰基]胍衍生物 |
GB0603891D0 (en) * | 2006-02-27 | 2006-04-05 | Syngenta Ltd | Novel herbicides |
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2011
- 2011-06-20 CN CN201110166067.9A patent/CN102408385B/zh active Active
- 2011-07-04 WO PCT/CN2011/001101 patent/WO2012174685A1/zh active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101687860A (zh) * | 2007-04-23 | 2010-03-31 | 阿斯利康(瑞典)有限公司 | 用于治疗疼痛的新颖n-(8-杂芳基四氢萘-2-基)或n-(5-杂芳基色满-3-基)甲酰胺衍生物 |
Non-Patent Citations (4)
Title |
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Brian Iddon 等.Azoles. Part 13.",2 Synthesis and bromine -lithium exchange reactions of some 1-substituted 4,5-dibromo-lH-l,2,3-triazoles and 2-substituted 4,5-dibromo=2H-l,2,3=triazole.《J. Chem. Soc., Perkin Trans. 1》.1996,第1卷(第12期),第1341-1347页. |
Brian Iddon 等.Azoles. Part 13.",2 Synthesis and bromine-lithium exchange reactions of some 1-substituted 4,5-dibromo-lH-l,2,3-triazoles and 2-substituted 4,5-dibromo=2H-l,2,3=triazole.《J. Chem. Soc., Perkin Trans. 1》.1996,第1卷(第12期),第1341-1347页. * |
GeneralSolutiontotheSynthesisof N-2-Substituted1,2,3-Triazoles;Xiao-junWang 等;《ORGANIC LETTERS》;20100923;第12卷(第20期);4632-4635 * |
Xiao-junWang 等.GeneralSolutiontotheSynthesisof N-2-Substituted1,2,3-Triazoles.《ORGANIC LETTERS》.2010,第12卷(第20期),4632-4635. |
Also Published As
Publication number | Publication date |
---|---|
CN102408385A (zh) | 2012-04-11 |
WO2012174685A1 (zh) | 2012-12-27 |
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Address after: 215433, Dongfang East Road, Taicang Port Development Zone, Taicang port, Suzhou, Jiangsu 18, China Applicant after: Aba Chemicals Corporation Address before: 215433, Dongfang East Road, Taicang Port Development Zone, Taicang port, Suzhou, Jiangsu 18, China Applicant before: ABA Chemicals (Suzhou) Co., Ltd. |
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Owner name: NANTONG ABACHEM CO., LTD Free format text: FORMER OWNER: ABA CHEMICALS CO., LTD Effective date: 20141106 |
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Effective date of registration: 20141106 Address after: 226400, Jiangsu, Nantong province Rudong County mouth chemical gathering area Patentee after: NANTONG YABEN CHEMICAL CO., LTD. Address before: 215433, Dongfang East Road, Taicang Port Development Zone, Taicang port, Suzhou, Jiangsu 18, China Patentee before: Aba Chemicals Corporation |