CN102408385A - 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 - Google Patents
一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 Download PDFInfo
- Publication number
- CN102408385A CN102408385A CN2011101660679A CN201110166067A CN102408385A CN 102408385 A CN102408385 A CN 102408385A CN 2011101660679 A CN2011101660679 A CN 2011101660679A CN 201110166067 A CN201110166067 A CN 201110166067A CN 102408385 A CN102408385 A CN 102408385A
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- CN
- China
- Prior art keywords
- triazole
- compound
- replacement
- preparation
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GUQUYKTWVBJKFL-UHFFFAOYSA-N Brc1n[nH]nc1Br Chemical compound Brc1n[nH]nc1Br GUQUYKTWVBJKFL-UHFFFAOYSA-N 0.000 description 2
- NLNDFFUTWBPIJM-UHFFFAOYSA-N Brc1n[n](C2CCCC2)nc1Br Chemical compound Brc1n[n](C2CCCC2)nc1Br NLNDFFUTWBPIJM-UHFFFAOYSA-N 0.000 description 1
- IMHZJWRJYADLHS-UHFFFAOYSA-N Brc1n[n](Cc(cc2)ccc2Br)nc1Br Chemical compound Brc1n[n](Cc(cc2)ccc2Br)nc1Br IMHZJWRJYADLHS-UHFFFAOYSA-N 0.000 description 1
- ZPGJRZKBZGFONG-XVNBXDOJSA-N C=C(/C(/Br)=N\NN)Br Chemical compound C=C(/C(/Br)=N\NN)Br ZPGJRZKBZGFONG-XVNBXDOJSA-N 0.000 description 1
- 0 CBrc1n[n](*)nc1* Chemical compound CBrc1n[n](*)nc1* 0.000 description 1
- MEEKMZNPDDHRHE-UHFFFAOYSA-N C[n](nc1C(O)=O)nc1Br Chemical compound C[n](nc1C(O)=O)nc1Br MEEKMZNPDDHRHE-UHFFFAOYSA-N 0.000 description 1
- BSHWJBSHZPLXDB-UHFFFAOYSA-N C[n](nc1C(OC)=O)nc1Br Chemical compound C[n](nc1C(OC)=O)nc1Br BSHWJBSHZPLXDB-UHFFFAOYSA-N 0.000 description 1
- NVNPLEPBDPJYRZ-UHFFFAOYSA-N Fc1ccc(CBr)cc1 Chemical compound Fc1ccc(CBr)cc1 NVNPLEPBDPJYRZ-UHFFFAOYSA-N 0.000 description 1
- QQSQBZBJNVZQJE-UHFFFAOYSA-N Fc1ccc(C[n](nc2Br)nc2Br)cc1 Chemical compound Fc1ccc(C[n](nc2Br)nc2Br)cc1 QQSQBZBJNVZQJE-UHFFFAOYSA-N 0.000 description 1
- SEIVTCQGRGIMCN-UHFFFAOYSA-N OC(c1n[n](Cc(cc2)ccc2Br)nc1Br)=O Chemical compound OC(c1n[n](Cc(cc2)ccc2Br)nc1Br)=O SEIVTCQGRGIMCN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (16)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110166067.9A CN102408385B (zh) | 2011-06-20 | 2011-06-20 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
PCT/CN2011/001101 WO2012174685A1 (zh) | 2011-06-20 | 2011-07-04 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
Applications Claiming Priority (1)
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CN201110166067.9A CN102408385B (zh) | 2011-06-20 | 2011-06-20 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102408385A true CN102408385A (zh) | 2012-04-11 |
CN102408385B CN102408385B (zh) | 2014-06-18 |
Family
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Family Applications (1)
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CN201110166067.9A Active CN102408385B (zh) | 2011-06-20 | 2011-06-20 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
Country Status (2)
Country | Link |
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CN (1) | CN102408385B (zh) |
WO (1) | WO2012174685A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102786485A (zh) * | 2012-08-24 | 2012-11-21 | 苏州雅本化学股份有限公司 | 2-取代-2h-1,2,3-三氮唑衍生物及其制备方法 |
CN103058940A (zh) * | 2012-12-14 | 2013-04-24 | 雅本化学股份有限公司 | 1-取代-4-溴-2h-1,2,3-三氮唑衍生物及其制备方法 |
CN103073513A (zh) * | 2012-12-14 | 2013-05-01 | 雅本化学股份有限公司 | 1-取代-5-氯-2h-1,2,3-三氮唑-4-羧酸衍生物及其制备方法 |
WO2019209693A1 (en) * | 2018-04-23 | 2019-10-31 | Corcept Therapeutics, Inc. | Methods of preparing regioselective n-alkyl triazoles |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101687860A (zh) * | 2007-04-23 | 2010-03-31 | 阿斯利康(瑞典)有限公司 | 用于治疗疼痛的新颖n-(8-杂芳基四氢萘-2-基)或n-(5-杂芳基色满-3-基)甲酰胺衍生物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU46200A (sh) * | 1998-02-27 | 2003-02-28 | Pfizer Products Inc. | N-(supstituisani peto-članog di-ili triaza dinezasićenog prstena)karbonil/guanidin derivati za tretiranje ishemije |
GB0603891D0 (en) * | 2006-02-27 | 2006-04-05 | Syngenta Ltd | Novel herbicides |
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2011
- 2011-06-20 CN CN201110166067.9A patent/CN102408385B/zh active Active
- 2011-07-04 WO PCT/CN2011/001101 patent/WO2012174685A1/zh active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101687860A (zh) * | 2007-04-23 | 2010-03-31 | 阿斯利康(瑞典)有限公司 | 用于治疗疼痛的新颖n-(8-杂芳基四氢萘-2-基)或n-(5-杂芳基色满-3-基)甲酰胺衍生物 |
Non-Patent Citations (3)
Title |
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《J. Chem. Soc., Perkin Trans. 1》 19960101 Brian Iddon 等 Azoles. Part 13.",2 Synthesis and bromine -lithium exchange reactions of some 1-substituted 4,5-dibromo-lH-l,2,3-triazoles and 2-substituted 4,5-dibromo=2H-l,2,3=triazole 第1341-1347页 2-16 第1卷, 第12期 * |
BRIAN IDDON 等: "Azoles. Part 13.",2 Synthesis and bromine -lithium exchange reactions of some 1-substituted 4,5-dibromo-lH-l,2,3-triazoles and 2-substituted 4,5-dibromo=2H-l,2,3=triazole", 《J. CHEM. SOC., PERKIN TRANS. 1》, vol. 1, no. 12, 1 January 1996 (1996-01-01), pages 1341 - 1347 * |
XIAO-JUNWANG 等: "GeneralSolutiontotheSynthesisof N-2-Substituted1,2,3-Triazoles", 《ORGANIC LETTERS》, vol. 12, no. 20, 23 September 2010 (2010-09-23), pages 4632 - 4635 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102786485A (zh) * | 2012-08-24 | 2012-11-21 | 苏州雅本化学股份有限公司 | 2-取代-2h-1,2,3-三氮唑衍生物及其制备方法 |
CN102786485B (zh) * | 2012-08-24 | 2014-11-26 | 雅本化学股份有限公司 | 2-取代-2h-1,2,3-三氮唑衍生物及其制备方法 |
CN103058940A (zh) * | 2012-12-14 | 2013-04-24 | 雅本化学股份有限公司 | 1-取代-4-溴-2h-1,2,3-三氮唑衍生物及其制备方法 |
CN103073513A (zh) * | 2012-12-14 | 2013-05-01 | 雅本化学股份有限公司 | 1-取代-5-氯-2h-1,2,3-三氮唑-4-羧酸衍生物及其制备方法 |
CN103073513B (zh) * | 2012-12-14 | 2015-12-02 | 雅本化学股份有限公司 | 1-取代-5-氯-2h-1,2,3-三氮唑-4-羧酸衍生物及其制备方法 |
CN103058940B (zh) * | 2012-12-14 | 2015-12-23 | 雅本化学股份有限公司 | 1-取代-4-溴-2h-1,2,3-三氮唑衍生物及其制备方法 |
WO2019209693A1 (en) * | 2018-04-23 | 2019-10-31 | Corcept Therapeutics, Inc. | Methods of preparing regioselective n-alkyl triazoles |
US10494349B2 (en) | 2018-04-23 | 2019-12-03 | Corcept Therapeutics, Inc. | Methods of preparing regioselective N-alkyl triazoles |
CN112004803A (zh) * | 2018-04-23 | 2020-11-27 | 科赛普特治疗公司 | 区域选择的n-烷基三唑的制备方法 |
CN112004803B (zh) * | 2018-04-23 | 2023-11-03 | 科赛普特治疗公司 | 区域选择的n-烷基三唑的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2012174685A1 (zh) | 2012-12-27 |
CN102408385B (zh) | 2014-06-18 |
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Address after: 215433, Dongfang East Road, Taicang Port Development Zone, Taicang port, Suzhou, Jiangsu 18, China Applicant after: Aba Chemicals Corporation Address before: 215433, Dongfang East Road, Taicang Port Development Zone, Taicang port, Suzhou, Jiangsu 18, China Applicant before: ABA Chemicals (Suzhou) Co., Ltd. |
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Owner name: NANTONG ABACHEM CO., LTD Free format text: FORMER OWNER: ABA CHEMICALS CO., LTD Effective date: 20141106 |
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Effective date of registration: 20141106 Address after: 226400, Jiangsu, Nantong province Rudong County mouth chemical gathering area Patentee after: NANTONG YABEN CHEMICAL CO., LTD. Address before: 215433, Dongfang East Road, Taicang Port Development Zone, Taicang port, Suzhou, Jiangsu 18, China Patentee before: Aba Chemicals Corporation |