PE20090727A1 - DERIVADOS DE AMIDA COMO INHIBIDORES DE NaV1.7 - Google Patents
DERIVADOS DE AMIDA COMO INHIBIDORES DE NaV1.7Info
- Publication number
- PE20090727A1 PE20090727A1 PE2008000697A PE2008000697A PE20090727A1 PE 20090727 A1 PE20090727 A1 PE 20090727A1 PE 2008000697 A PE2008000697 A PE 2008000697A PE 2008000697 A PE2008000697 A PE 2008000697A PE 20090727 A1 PE20090727 A1 PE 20090727A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridin
- chromen
- benzamide
- dihydro
- amida
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91331207P | 2007-04-23 | 2007-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090727A1 true PE20090727A1 (es) | 2009-07-23 |
Family
ID=39876087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000697A PE20090727A1 (es) | 2007-04-23 | 2008-04-23 | DERIVADOS DE AMIDA COMO INHIBIDORES DE NaV1.7 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8143408B2 (enExample) |
| EP (1) | EP2158198B1 (enExample) |
| JP (1) | JP2010525056A (enExample) |
| KR (1) | KR20100015827A (enExample) |
| CN (1) | CN101687860B (enExample) |
| AR (1) | AR066266A1 (enExample) |
| AU (1) | AU2008241610B2 (enExample) |
| BR (1) | BRPI0810354A2 (enExample) |
| CA (1) | CA2685141A1 (enExample) |
| CL (1) | CL2008001170A1 (enExample) |
| CO (1) | CO6251361A2 (enExample) |
| EC (1) | ECSP099706A (enExample) |
| IL (1) | IL201309A0 (enExample) |
| MX (1) | MX2009011364A (enExample) |
| MY (1) | MY146662A (enExample) |
| NZ (1) | NZ581353A (enExample) |
| PE (1) | PE20090727A1 (enExample) |
| RU (1) | RU2460730C2 (enExample) |
| SA (1) | SA08290245B1 (enExample) |
| TW (1) | TW200848037A (enExample) |
| UY (1) | UY31046A1 (enExample) |
| WO (1) | WO2008130320A2 (enExample) |
| ZA (1) | ZA200907137B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| EP3725775A1 (en) | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
| NZ618135A (en) * | 2009-10-26 | 2015-05-29 | Signal Pharm Llc | Methods of synthesis and purification of heteroaryl compounds |
| UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| JPWO2011093501A1 (ja) | 2010-02-01 | 2013-06-06 | 日本ケミファ株式会社 | Ｇｐｒ１１９作動薬 |
| AU2011293612B2 (en) | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| WO2012039657A1 (en) * | 2010-09-22 | 2012-03-29 | Astrazeneca Ab | Novel chromane compound for the treatment of pain disorders |
| CN102408385B (zh) * | 2011-06-20 | 2014-06-18 | 雅本化学股份有限公司 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
| CN102408386B (zh) * | 2011-07-27 | 2014-05-07 | 雅本化学股份有限公司 | 2,4-二取代-2h-1,2,3-三氮唑衍生物的制备方法 |
| CN102603659B (zh) * | 2012-03-01 | 2014-03-26 | 雅本化学股份有限公司 | 1-取代-4-溴-1h-1,2,3-三氮唑-5-羧酸及其制备方法 |
| CN105073738B (zh) * | 2013-01-31 | 2018-01-05 | 沃泰克斯药物股份有限公司 | 作为钠通道调节剂的喹啉及喹喔啉酰胺类 |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| JP6532474B2 (ja) * | 2014-02-06 | 2019-06-19 | アッヴィ・インコーポレイテッド | ６−ヘテロアリールオキシ−および６−アリールオキシ−キノリン−２−カルボキシアミドならびにその使用 |
| KR102412146B1 (ko) | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
| EP3375782B1 (en) | 2015-11-13 | 2020-07-29 | Daewoong Pharmaceutical Co., Ltd. | Sodium channel blocker |
| CN105541774B (zh) * | 2016-01-13 | 2018-06-15 | 华中师范大学 | 3,4-二氢香豆素类化合物及其制备方法和用途 |
| JP7210483B2 (ja) * | 2017-06-30 | 2023-01-23 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規アザキノリン誘導体 |
| CN117964573B (zh) | 2018-01-19 | 2026-04-14 | 赛特凯恩蒂克公司 | 作为心肌节抑制剂的二氢苯并呋喃和茚类似物 |
| WO2019170543A1 (en) | 2018-03-07 | 2019-09-12 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
| EP3814342B1 (en) | 2018-06-26 | 2022-07-27 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| WO2020005888A1 (en) | 2018-06-26 | 2020-01-02 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| US12421225B2 (en) | 2018-09-10 | 2025-09-23 | Kaken Pharmaceutical Co., Ltd. | Heteroaromatic amide derivative and medicament containing the same |
| US20220227729A1 (en) | 2019-05-21 | 2022-07-21 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| TW202302594A (zh) | 2021-03-04 | 2023-01-16 | 美商胞質動力學公司 | 心臟肌節抑制劑 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8904361D0 (sv) * | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
| WO1994012493A1 (en) * | 1992-11-25 | 1994-06-09 | Sandoz, Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-benzopyr ans, their use as pharmaceuticals |
| JPH0827153A (ja) * | 1994-07-12 | 1996-01-30 | Nippon Kayaku Co Ltd | アザクロマン誘導体及びその用途 |
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| GB9713804D0 (en) * | 1997-06-30 | 1997-09-03 | Novo Nordisk As | Particulate polymeric materials and their use |
| JPH1135569A (ja) | 1997-07-22 | 1999-02-09 | Meiji Milk Prod Co Ltd | ポリフェノール化合物及びこれを含有する医薬 |
| SE9702799D0 (sv) * | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| SE9703378D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| SE9703377D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| TW200524888A (en) * | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| JP2008540443A (ja) * | 2005-05-04 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン |
| CN101490002A (zh) * | 2006-07-12 | 2009-07-22 | 阿斯利康(瑞典)有限公司 | 作为止痛剂的3-氧代异二氢吲哚-1-甲酰胺衍生物 |
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
-
2008
- 2008-04-21 SA SA8290245A patent/SA08290245B1/ar unknown
- 2008-04-22 US US12/596,878 patent/US8143408B2/en not_active Expired - Fee Related
- 2008-04-22 AU AU2008241610A patent/AU2008241610B2/en not_active Ceased
- 2008-04-22 MX MX2009011364A patent/MX2009011364A/es active IP Right Grant
- 2008-04-22 CA CA002685141A patent/CA2685141A1/en not_active Abandoned
- 2008-04-22 EP EP08779260A patent/EP2158198B1/en active Active
- 2008-04-22 KR KR1020097022164A patent/KR20100015827A/ko not_active Withdrawn
- 2008-04-22 RU RU2009138137/04A patent/RU2460730C2/ru not_active IP Right Cessation
- 2008-04-22 NZ NZ581353A patent/NZ581353A/en not_active IP Right Cessation
- 2008-04-22 WO PCT/SE2008/050459 patent/WO2008130320A2/en not_active Ceased
- 2008-04-22 CN CN2008800215491A patent/CN101687860B/zh not_active Expired - Fee Related
- 2008-04-22 JP JP2010506133A patent/JP2010525056A/ja active Pending
- 2008-04-22 MY MYPI20094419A patent/MY146662A/en unknown
- 2008-04-22 BR BRPI0810354-2A2A patent/BRPI0810354A2/pt not_active IP Right Cessation
- 2008-04-23 UY UY31046A patent/UY31046A1/es not_active Application Discontinuation
- 2008-04-23 CL CL2008001170A patent/CL2008001170A1/es unknown
- 2008-04-23 PE PE2008000697A patent/PE20090727A1/es not_active Application Discontinuation
- 2008-04-23 AR ARP080101710A patent/AR066266A1/es not_active Application Discontinuation
- 2008-04-23 TW TW097114910A patent/TW200848037A/zh unknown
-
2009
- 2009-10-01 IL IL201309A patent/IL201309A0/en unknown
- 2009-10-13 ZA ZA200907137A patent/ZA200907137B/xx unknown
- 2009-10-29 CO CO09122476A patent/CO6251361A2/es not_active Application Discontinuation
- 2009-10-29 EC EC2009009706A patent/ECSP099706A/es unknown
-
2012
- 2012-03-23 US US13/427,981 patent/US20120238579A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100137322A1 (en) | 2010-06-03 |
| KR20100015827A (ko) | 2010-02-12 |
| EP2158198A4 (en) | 2012-01-04 |
| WO2008130320A3 (en) | 2008-12-18 |
| AU2008241610B2 (en) | 2011-08-18 |
| EP2158198A2 (en) | 2010-03-03 |
| AR066266A1 (es) | 2009-08-05 |
| CN101687860A (zh) | 2010-03-31 |
| CA2685141A1 (en) | 2008-10-30 |
| TW200848037A (en) | 2008-12-16 |
| US8143408B2 (en) | 2012-03-27 |
| RU2460730C2 (ru) | 2012-09-10 |
| RU2009138137A (ru) | 2011-05-27 |
| MY146662A (en) | 2012-09-14 |
| SA08290245B1 (ar) | 2012-02-12 |
| UY31046A1 (es) | 2008-11-28 |
| CL2008001170A1 (es) | 2009-05-22 |
| BRPI0810354A2 (pt) | 2014-10-21 |
| JP2010525056A (ja) | 2010-07-22 |
| US20120238579A1 (en) | 2012-09-20 |
| AU2008241610A1 (en) | 2008-10-30 |
| NZ581353A (en) | 2012-02-24 |
| IL201309A0 (en) | 2010-05-31 |
| EP2158198B1 (en) | 2013-03-20 |
| ECSP099706A (es) | 2009-11-30 |
| CN101687860B (zh) | 2012-07-04 |
| WO2008130320A2 (en) | 2008-10-30 |
| MX2009011364A (es) | 2009-11-05 |
| ZA200907137B (en) | 2010-07-28 |
| CO6251361A2 (es) | 2011-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |