AR051662A1 - Proceso para l a preparacion de compuestos a base de quinolina y productos obtenidos de los mismos - Google Patents

Proceso para l a preparacion de compuestos a base de quinolina y productos obtenidos de los mismos

Info

Publication number
AR051662A1
AR051662A1 ARP050104640A ARP050104640A AR051662A1 AR 051662 A1 AR051662 A1 AR 051662A1 AR P050104640 A ARP050104640 A AR P050104640A AR P050104640 A ARP050104640 A AR P050104640A AR 051662 A1 AR051662 A1 AR 051662A1
Authority
AR
Argentina
Prior art keywords
alkyl
formula
reaction
independently hydrogen
carboalkoxy
Prior art date
Application number
ARP050104640A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35985415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR051662(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR051662A1 publication Critical patent/AR051662A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reivindicacion 1: Un método para preparar un compuesto de la formula (1), en la que: R1 es alquil, alcanoil, aroil, carboalcoxi o carboalcoxiaril; R2 y R3 son, independientemente, hidrogeno, hidroxi, alquil, alcoxi, halogeno, carboxamido, carboalcoxi, perfluoroalquil, ciano, alcanosulfonamido, alcanosulfonil, alcanamido, amino, alquilamino, dialquilamino, perfluoroalcoxi, alcanoiloxi, alcanoil, aroil, aril, arilalquil, heteroaril o heteroarilalquil; R6 y R7 son, independientemente, hidrogeno o alquil; n es 1 o 2; R4 y R5 son, independientemente, hidrogeno o alquil o se toman juntos con los carbonos a los que están unidos, forman un grupo cíclico que es cicloalquil, cicloalquenil, alquil con enlace de dos ciclos, alquenil con enlace de dos ciclos, piranil o tiopiranil en el que el átomo de sulfuro es opcionalmente oxidado para sulfoxida o sulfona; y la línea punteada representa un enlace doble opcional, que comprende la reaccion de un compuesto de la formula (1), en la que: n, R1, R2, R3, R6 y R7 son como se definio precedentemente, con un equivalente de formaldehído equivalente como mínimo y un reactivo con la formula R4-CH=CH-R5 o la formula R4-C:::C-R5, donde R4 y R5 son como se define aquí, en presencia de un ácido de Lewis y un solvente de reaccion para formar un componente de la formula (1), teniendo en cuenta que el equivalente del formaldehído está en forma de solido, al menos antes de la reaccion.
ARP050104640A 2004-11-05 2005-11-04 Proceso para l a preparacion de compuestos a base de quinolina y productos obtenidos de los mismos AR051662A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62530004P 2004-11-05 2004-11-05

Publications (1)

Publication Number Publication Date
AR051662A1 true AR051662A1 (es) 2007-01-31

Family

ID=35985415

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104640A AR051662A1 (es) 2004-11-05 2005-11-04 Proceso para l a preparacion de compuestos a base de quinolina y productos obtenidos de los mismos

Country Status (18)

Country Link
US (2) US7781427B2 (es)
EP (1) EP1807428A2 (es)
JP (1) JP2008519046A (es)
KR (1) KR20070102665A (es)
CN (1) CN101146809A (es)
AR (1) AR051662A1 (es)
AU (1) AU2005304915A1 (es)
CA (1) CA2586623A1 (es)
CL (1) CL2009001681A1 (es)
GT (1) GT200500317A (es)
IL (1) IL182996A0 (es)
NI (1) NI200700118A (es)
NO (1) NO20072473L (es)
PA (1) PA8651801A1 (es)
RU (1) RU2007117509A (es)
SG (1) SG156695A1 (es)
TW (1) TW200617011A (es)
WO (1) WO2006052768A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
US20070225278A1 (en) * 2006-03-24 2007-09-27 Wyeth Methods for treating cognitive and other disorders
CN101410118A (zh) * 2006-03-24 2009-04-15 惠氏公司 疼痛的治疗
CA2644662A1 (en) * 2006-03-24 2007-10-04 Wyeth New therapeutic combinations for the treatment of depression
CL2008002777A1 (es) * 2007-09-21 2010-01-22 Wyeth Corp Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
CN102549027B (zh) * 2009-12-18 2015-02-11 雪佛龙奥伦耐有限责任公司 羰基-烯官能化的聚烯烃
CA3109210A1 (en) * 2018-09-28 2020-04-02 Celltrion, Inc. Novel method for preparing (-)-cibenzoline succinate
WO2020067683A1 (en) * 2018-09-28 2020-04-02 Celltrion Inc. Novel process for the preparation of (+)-cibenzoline succinate

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Also Published As

Publication number Publication date
PA8651801A1 (es) 2006-07-03
CA2586623A1 (en) 2006-05-18
WO2006052768A2 (en) 2006-05-18
CL2009001681A1 (es) 2010-01-22
SG156695A1 (en) 2009-11-26
AU2005304915A1 (en) 2006-05-18
US7781427B2 (en) 2010-08-24
JP2008519046A (ja) 2008-06-05
GT200500317A (es) 2006-10-27
EP1807428A2 (en) 2007-07-18
NO20072473L (no) 2007-07-24
WO2006052768A3 (en) 2006-08-17
IL182996A0 (en) 2007-08-19
RU2007117509A (ru) 2008-12-10
CN101146809A (zh) 2008-03-19
NI200700118A (es) 2008-05-09
US20100196714A1 (en) 2010-08-05
US20060122385A1 (en) 2006-06-08
TW200617011A (en) 2006-06-01
KR20070102665A (ko) 2007-10-19

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