AR051596A1 - Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios - Google Patents
Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentariosInfo
- Publication number
- AR051596A1 AR051596A1 ARP050104440A ARP050104440A AR051596A1 AR 051596 A1 AR051596 A1 AR 051596A1 AR P050104440 A ARP050104440 A AR P050104440A AR P050104440 A ARP050104440 A AR P050104440A AR 051596 A1 AR051596 A1 AR 051596A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- substituted
- alkoxy
- hydroxyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000003814 drug Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 22
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000005843 halogen group Chemical group 0.000 abstract 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 9
- 150000002367 halogens Chemical class 0.000 abstract 9
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 7
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical group 0.000 abstract 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical class 0.000 abstract 4
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- 125000006655 (C3-C8) heteroaryl group Chemical group 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- -1 hydroxy, phenyl Chemical group 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D473/00—Heterocyclic compounds containing purine ring systems
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- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62250804P | 2004-10-26 | 2004-10-26 | |
| US67267005P | 2005-04-18 | 2005-04-18 |
Publications (1)
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| JP (2) | JP2008518016A (enExample) |
| KR (1) | KR100919524B1 (enExample) |
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| BR (1) | BRPI0517015A (enExample) |
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| WO (1) | WO2006047516A2 (enExample) |
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| CN102558155A (zh) | 2003-01-14 | 2012-07-11 | 阿伦纳药品公司 | 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗 |
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| BRPI0812504B8 (pt) * | 2007-06-21 | 2021-05-25 | Cara Therapeutics Inc | composto para profilaxia ou tratamento de doença ou condição associada a receptor de canabinoides em sujeito mamífero |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CA2697551C (en) | 2007-09-20 | 2013-03-12 | Irm Llc | Piperidine derivatives as modulators of gpr119 activity |
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| WO2009149347A1 (en) * | 2008-06-05 | 2009-12-10 | President And Fellows Of Harvard College | High-valent palladium fluoride complexes and uses thereof |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
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| WO2010059943A2 (en) | 2008-11-20 | 2010-05-27 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2011014520A2 (en) | 2009-07-29 | 2011-02-03 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| DK2470552T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi Sa | NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE |
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| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
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| MX2013003184A (es) | 2010-09-22 | 2013-06-07 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo. |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
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| US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
| WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
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| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
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| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| KR101326557B1 (ko) * | 2011-03-31 | 2013-11-08 | 주식회사종근당 | 카나비노이드 수용체〔ｃｂｉ〕길항제로서의 벤즈아미드 유도체 |
| EP2697204B1 (en) | 2011-04-12 | 2017-03-08 | President and Fellows of Harvard College | Fluorination of organic compounds |
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| WO2014052622A1 (en) | 2012-09-26 | 2014-04-03 | President And Fellows Of Harvard College | Nickel fluorinating complexes and uses thereof |
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| KR20160002857A (ko) | 2013-05-02 | 2016-01-08 | 에프. 호프만-라 로슈 아게 | CB2 수용체 작용제로서의 피롤로[2,3-d]피리미딘 유도체 |
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| US11944626B2 (en) * | 2016-06-20 | 2024-04-02 | The Regents Of The University Of Michigan | Small molecule inhibitors of ALDH and uses thereof |
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| CN106632069A (zh) * | 2016-11-18 | 2017-05-10 | 山东友帮生化科技有限公司 | 3‑氯‑6‑肼基哒嗪的合成方法 |
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| KR20190116416A (ko) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법 |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
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| US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
| JP7526673B2 (ja) | 2018-02-20 | 2024-08-01 | インサイト・コーポレイション | がんを治療するためのｈｐｋ１阻害剤としてのｎ－（フェニル）－２－（フェニル）ピリミジン－４－カルボキサミド誘導体及び関連化合物 |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
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| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| KR20220059480A (ko) | 2019-08-06 | 2022-05-10 | 인사이트 코포레이션 | 고체 형태의 hpk1 억제제 |
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| JP2631139B2 (ja) | 1988-10-06 | 1997-07-16 | ライオン株式会社 | １Ｈ−ピラゾロ〔３，４−ｂ〕ピラジン誘導体 |
| KR0151816B1 (ko) | 1994-02-08 | 1998-10-15 | 강박광 | 신규의 치환된 피리딜 이미다졸 유도체 및 그의 제조방법 |
| CN1466577A (zh) * | 2000-08-01 | 2004-01-07 | СҰҩƷ��ҵ��ʽ���� | 3,4-二氢异喹啉衍生物化合物以及将该化合物作为有效成分的药剂 |
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| US20040132732A1 (en) * | 2002-10-21 | 2004-07-08 | Wei Han | Quinazolinones and derivatives thereof as factor Xa inhibitors |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| CA2518465A1 (en) * | 2003-03-25 | 2004-10-14 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US7141669B2 (en) * | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| CN1809351A (zh) * | 2003-04-24 | 2006-07-26 | 麦克公司 | Akt活性抑制剂 |
| CA2545725A1 (en) * | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| AR051596A1 (es) * | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
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2005
- 2005-10-24 AR ARP050104440A patent/AR051596A1/es not_active Application Discontinuation
- 2005-10-25 TW TW094137369A patent/TW200630096A/zh unknown
- 2005-10-25 PE PE2005001251A patent/PE20060599A1/es not_active Application Discontinuation
- 2005-10-26 CA CA2730374A patent/CA2730374A1/en not_active Abandoned
- 2005-10-26 JP JP2007539039A patent/JP2008518016A/ja not_active Withdrawn
- 2005-10-26 WO PCT/US2005/038361 patent/WO2006047516A2/en not_active Ceased
- 2005-10-26 RU RU2007119449/04A patent/RU2431635C2/ru not_active IP Right Cessation
- 2005-10-26 US US11/718,016 patent/US8158634B2/en not_active Expired - Fee Related
- 2005-10-26 AU AU2005299421A patent/AU2005299421B2/en not_active Ceased
- 2005-10-26 MX MX2007004936A patent/MX2007004936A/es not_active Application Discontinuation
- 2005-10-26 BR BRPI0517015-0A patent/BRPI0517015A/pt not_active IP Right Cessation
- 2005-10-26 IN IN2514DEN2007 patent/IN2007DN02514A/en unknown
- 2005-10-26 CN CN2011101210450A patent/CN102241680A/zh active Pending
- 2005-10-26 CN CN2005800368900A patent/CN101048408B/zh not_active Expired - Fee Related
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- 2005-10-26 EP EP05813001A patent/EP1807429A4/en not_active Withdrawn
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2007
- 2007-04-12 IL IL182527A patent/IL182527A0/en unknown
- 2007-04-18 MA MA29834A patent/MA28937B1/fr unknown
- 2007-04-25 TN TNP2007000161A patent/TNSN07161A1/fr unknown
- 2007-04-25 KR KR1020077009370A patent/KR100919524B1/ko not_active Expired - Fee Related
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- 2007-05-07 NO NO20072352A patent/NO20072352L/no not_active Application Discontinuation
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2009
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2011
- 2011-06-22 JP JP2011138840A patent/JP2011190281A/ja active Pending
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2012
- 2012-03-08 US US13/415,565 patent/US20120225869A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101048408A (zh) | 2007-10-03 |
| NO20072352L (no) | 2007-05-31 |
| CN101048408B (zh) | 2011-07-06 |
| KR100919524B1 (ko) | 2009-10-01 |
| JP2011190281A (ja) | 2011-09-29 |
| WO2006047516A2 (en) | 2006-05-04 |
| EP1807429A4 (en) | 2010-03-24 |
| AU2005299421B2 (en) | 2010-01-28 |
| CN102241680A (zh) | 2011-11-16 |
| US20120225869A1 (en) | 2012-09-06 |
| MA28937B1 (fr) | 2007-10-01 |
| AU2009251216A1 (en) | 2010-01-28 |
| WO2006047516A3 (en) | 2006-10-12 |
| TNSN07161A1 (en) | 2008-11-21 |
| BRPI0517015A (pt) | 2008-09-30 |
| US8158634B2 (en) | 2012-04-17 |
| CA2730374A1 (en) | 2006-05-04 |
| RU2007119449A (ru) | 2008-12-10 |
| IN2007DN02514A (enExample) | 2007-08-03 |
| ECSP077421A (es) | 2007-05-30 |
| CA2581225C (en) | 2011-10-25 |
| JP2008518016A (ja) | 2008-05-29 |
| AU2005299421A1 (en) | 2006-05-04 |
| US20090247517A1 (en) | 2009-10-01 |
| PE20060599A1 (es) | 2006-08-22 |
| IL182527A0 (en) | 2007-09-20 |
| MX2007004936A (es) | 2007-06-25 |
| EP1807429A2 (en) | 2007-07-18 |
| KR20070057980A (ko) | 2007-06-07 |
| CA2581225A1 (en) | 2006-05-04 |
| TW200630096A (en) | 2006-09-01 |
| RU2431635C2 (ru) | 2011-10-20 |
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