AR049965A1 - Moduladores de androgenos - Google Patents

Moduladores de androgenos

Info

Publication number
AR049965A1
AR049965A1 ARP050102808A ARP050102808A AR049965A1 AR 049965 A1 AR049965 A1 AR 049965A1 AR P050102808 A ARP050102808 A AR P050102808A AR P050102808 A ARP050102808 A AR P050102808A AR 049965 A1 AR049965 A1 AR 049965A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
aryl
cycloalkyl
group
Prior art date
Application number
ARP050102808A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35079243&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR049965(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR049965A1 publication Critical patent/AR049965A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

La presente está dirigida a una nueva clase de 4-cicloalcoxibenzonitrilos y a su uso con modulares del receptor de androgenos. Otros aspectos de la presente están dirigidos al uso de estos compuestos para disminuir la secrecion de sebo y para estimular el crecimiento capilar. Reivindicacion 1: Un compuesto de formula (1), o su sal, en donde: a) X' representa halogeno, ciano, alcoxi C1-6, haloalcoxi o haloalquilo; b) A representa un anillo cicloalquilo o cicloalquelino como se representa en el grupo de formulas (2); c) n, m y p representan cada uno independientemente un numero entero de 1 a 8; d) el símbolo U indica la presencia opcional de uno a más dobles enlaces carbono-carbono dentro del anillo; e) R1, R1' y R2 representan cada uno independientemente un sustituyente seleccionado del grupo que consiste en: hidrogeno; halogeno; ciano; hidroxi; alquilo C1-12 opcionalmente sustituido; alquenilo C2-12 opcionalmente sustituido; alquinilo C2-12 opcionalmente sustituido; cicloalquilo C3-10 opcionalmente sustituido; cicloalquil C3-10-alquilo C1-6, en donde los restos alquilo y cicloalquilo pueden estar cada uno opcionalmente sustituidos; arilo C6-10 opcionalmente sustituido; aril C6-10-alquilo C1-6, en donde los restos alquilo y arilo pueden estar cada uno opcionalmente sustituidos; (CH2)z-SR3; (CH2)z-OR3; (CH2)z-NR3R4; (CH2)z-COOR3; (CH2)z-CONR4; (CH2)z-NCOR3; y (CH2)zOCOR3; f) z representa un numero entero de 0 a 6; g) R3 representa un sustituyente seleccionado del grupo que consiste en hidrogeno, alquilo C1-12, alquelino C1-12, alquilino C2-12, arilo C6-10 opcionalmente sustituido, y aril C6-10-alquilo C1-6, en donde los restos alquilo y arilo pueden estar cada uno opcionalmente sustituidos; y h) R4 representa un sustituyente seleccionado del grupo que consiste en hidrogeno o alquilo C1-12.
ARP050102808A 2004-07-08 2005-07-06 Moduladores de androgenos AR049965A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58616004P 2004-07-08 2004-07-08
US59803304P 2004-08-02 2004-08-02

Publications (1)

Publication Number Publication Date
AR049965A1 true AR049965A1 (es) 2006-09-20

Family

ID=35079243

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050102808A AR049965A1 (es) 2004-07-08 2005-07-06 Moduladores de androgenos

Country Status (15)

Country Link
US (2) US7670613B2 (es)
EP (1) EP1781598A1 (es)
JP (1) JP4874965B2 (es)
AR (1) AR049965A1 (es)
BR (1) BRPI0513020A (es)
CA (1) CA2570047C (es)
GT (1) GT200500187A (es)
MX (1) MXPA06015169A (es)
NL (1) NL1029457C2 (es)
PA (1) PA8639001A1 (es)
PE (1) PE20060379A1 (es)
SV (1) SV2006002169A (es)
TW (1) TW200605876A (es)
UY (1) UY29008A1 (es)
WO (1) WO2006006065A1 (es)

Families Citing this family (17)

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CA2573457A1 (en) * 2004-08-18 2006-02-23 Warner-Lambert Company Llc 4-(2-methoxy-phenoxy)-2-trifluoromethyl-benzonitrile as an androgen modulator
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PE20060379A1 (es) 2006-05-27
CA2570047C (en) 2010-09-28
PA8639001A1 (es) 2006-06-02
NL1029457A1 (nl) 2006-01-10
SV2006002169A (es) 2006-02-15
US7670613B2 (en) 2010-03-02
BRPI0513020A (pt) 2008-04-22
TW200605876A (en) 2006-02-16
US20060009427A1 (en) 2006-01-12
JP4874965B2 (ja) 2012-02-15
UY29008A1 (es) 2006-03-31
US20100048517A1 (en) 2010-02-25
CA2570047A1 (en) 2006-01-19
WO2006006065A1 (en) 2006-01-19
EP1781598A1 (en) 2007-05-09
NL1029457C2 (nl) 2006-08-02
MXPA06015169A (es) 2007-08-21
GT200500187A (es) 2006-02-17

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