AR048484A1 - Derivados de diacilhidrazina, su uso como inhibidor de raf quinasa y composiciones farmaceuticas que los contienen - Google Patents

Derivados de diacilhidrazina, su uso como inhibidor de raf quinasa y composiciones farmaceuticas que los contienen

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Publication number
AR048484A1
AR048484A1 ARP040104607A ARP040104607A AR048484A1 AR 048484 A1 AR048484 A1 AR 048484A1 AR P040104607 A ARP040104607 A AR P040104607A AR P040104607 A ARP040104607 A AR P040104607A AR 048484 A1 AR048484 A1 AR 048484A1
Authority
AR
Argentina
Prior art keywords
halogen
group
atoms
substituted
optionally
Prior art date
Application number
ARP040104607A
Other languages
English (en)
Inventor
Dirk Finsinger
Hans-Peter Buchstaller
Lars Thore Burgdorf
Christiane Amendt
Matthias Grell
Christian Sirrenberg
Frank Zenke
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR048484A1 publication Critical patent/AR048484A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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Abstract

Reivindicacion 1: Derivados de diacilhidrazina de la formula: A-D-B en donde D es un resto de diacilhidrazina bivalente o uno de sus derivados; A es un resto insustituido o sustituido de hasta 40 átomos se C de la formula -L-(M-L')a, en donde L es una estructura cíclica de 5, 6 o 7 miembros seleccionada, con preferencia, del grupo integrado por arilo, heteroarilo, arileno y heteroarileno, unida directamente con D, L' comprende un resto cíclico opcionalmente sustituido que tiene al menos 5 miembros seleccionado, con preferencia, del grupo integrado por arilo, heteroarilo, aralquilo, cicloalquilo y heterociclilo, M es un enlace o un grupo puente que tiene al menos un átomo, a es un numero entero de 1-4; y cada estructura cíclica de L y L' contiene 0-4 miembros del grupo integrado por N, O y S, donde L' está sustituido, con preferencia, por al menos un sustituyente del grupo integrado por -SObRx, -C(O)Rx y -C(NRy)Rz; B es un resto de arilo o heteroarilo hasta tricíclico sustituido o insustituido de hasta 30 átomos de C, que comprende al menos una estructura cíclica de 5, 6 o 7 miembros, unida directamente con D que contiene 0-4 miembros del grupo integrado por N, O y S, donde dicha estructura cíclica directamente unida a D está seleccionada, con preferencia, del grupo integrado por arilo, heteroarilo y heterociclilo, Ry es H o un resto carbonado de hasta 24 átomos de C que opcionalmente contiene heteroátomos seleccionados de N, S y O y que está opcionalmente halosustituido, hasta perhalo, Rz es H o un resto carbonado de hasta 30 átomos de C que opcionalmente contiene heteroátomos seleccionados de N, S y O y que está opcionalmente sustituido con halogeno, hidroxi y sustituyentes carbonados de hasta 24 átomos de C, que opcionalmente contienen heteroátomos seleccionados de N, S y O y que están opcionalmente sustituidos con halogeno; Rx es Rz o NRaRb, donde Ra y Rb son a) de forma independiente, H, un resto carbonado de hasta 30 átomos de C que opcionalmente contiene heteroátomos seleccionados de N, S y O y que está opcionalmente sustituido con halogeno, hidroxi y sustituyentes carbonados de hasta 24 átomos de C, que opcionalmente contienen heteroátomos seleccionados de N, S y O y que están opcionalmente sustituidos con halogeno, u -OSi(Rf)3, donde Rf es H o un resto carbonado de hasta 24 átomos de C que opcionalmente contiene heteroátomos seleccionados de N, S y O y que está opcionalmente sustituido con halogeno, hidroxi y sustituyentes carbonados de hasta 24 átomos de C que opcionalmente contienen heteroátomos seleccionados de N, S y O y que están opcionalmente sustituidos con halogeno; o b) Ra y Rb forman juntos una estructura heterocíclica de 5-7 miembros de 1-3 heteroátomos seleccionados de N, S y O, o una estructura heterocíclica sustituida de 5-7 miembros de 1-3 heteroátomos seleccionados de N, S y O sustituida con halogeno, hidroxi o sustituyentes carbonados de hasta 24 átomos de C, que opcionalmente contienen heteroátomos de N, S y O y que están opcionalmente sustituidos con halogeno; o c) uno de Ra o Rb es -C(O)-, un grupo alquileno divalente C1-5 o un grupo alquileno divalente C1-5 sustituido unido con el resto L para formar una estructura cíclica con al menos 5 miembros, en donde los sustituyentes del grupo alquileno divalente C1-5 sustituido están seleccionados del grupo integrado por halogeno, hidroxi y sustituyentes carbonados de hasta 24 átomos de C, que opcionalmente contienen heteroátomos seleccionados de N, S y O y que están opcionalmente sustituidos con halogeno; en donde B está sustituido, L está sustituido o L' está adicionalmente sustituido, los sustituyentes están seleccionados del grupo integrado por halogeno, hasta perhalo, y Wg, en donde g es 0-3; en donde cada W está seleccionado, de forma independiente, del grupo integrado por -CN, -CO2R, C(O)NR5R5, -C(O)-R5, -NO2, -OR5, -SR5, -NR5R5, NR5C(O)OR5, -NR5C(O)R5, -Q-Ar, y restos carbonados de hasta 24 átomos de C, que opcionalmente contienen heteroátomos seleccionados de N, S y O y que están opcionalmente sustituidos con uno o varios sustituyentes seleccionados, de forma independiente, del grupo integrado por -CN, -CO2R, C(O)NR5R5, -C(O)-R5, - NO2, -OR5, -SR5, -NR5R5, NR5C(O)OR5, -NR5C(O)R5, y halogeno hasta perhalo; con cada R5 seleccionado, de forma independiente, de H o un resto carbonado de hasta 24 átomos de C, que opcionalmente contiene heteroátomos seleccionados de N, S y O y que opcionalmente está sustituido con halogeno, en donde Q es -O-, -S-, N(R5)-, -(CH2)b, -C(O)-, -CH(OH)-, -(CH2)b-, -(CH2)bS-, -(CH2)bN(R5)-, -O-(CH2)b-CHHal-, -CHal2-, S-(CH2)- y N(R5)(CH2)b-, donde b = 1-3 y Hal es halogeno; y Ar es una estructura aromática de 5 o 6 miembros que contiene 0-2 miembros seleccionados del grupo integrado por N, O y S, que está opcionalmente sustituida con halogeno, hasta perhalo y opcionalmente sustituida con Zd1, donde d1 es 0 a 3 y cada Z está seleccionado, de forma independiente, del grupo integrado por -CN, -CO2R5, C(O)NR5R5, -C(O)-R5, -NO2, -OR5, -SR5, SO2R5, -SO3H, NR5R5, NR5C(O)OR5, -NR5C(O)R5, y un resto carbonado de hasta 24 átomos de C, que opcionalmente contiene heteroátomos seleccionados de N, S y O y que está opcionalmente sustituido con uno o varios sustituyentes seleccionados del grupo integrado por -CN, -CO2R5, -C(O)NR5R5, -C(O)-R5, -NO2, -OR5, -SR5, -SO2R5, -SO3H, -NR5R5, -NR5C(O)OR5, -NR5C(O)R5, y sus derivados, sales y solvatos farmacéuticamente aceptables
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
JP4777887B2 (ja) 2003-07-23 2011-09-21 バイエル、ファーマシューテイカルズ、コーポレイション 病気および状態の処置および防止のためのフロロ置換オメガカルボキシアリールジフェニル尿素
WO2008153801A1 (en) 2007-05-29 2008-12-18 Intrexon Corporation Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
CN103087054B (zh) * 2013-02-27 2015-12-23 山东大学 4-吡啶苯基醚类化合物及其制备方法与应用
CA2940272C (en) * 2014-02-28 2022-03-29 Tohoku University Amide derivative
CN107001329B (zh) * 2014-09-12 2020-09-01 诺华股份有限公司 作为激酶抑制剂的化合物和组合物
WO2016044390A1 (en) * 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds
CN112778156B (zh) * 2019-11-08 2023-03-14 中国科学院上海药物研究所 双酰肼结构类化合物、其制备方法及其应用
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
EP4323362A1 (en) 2021-04-16 2024-02-21 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61222790A (ja) * 1984-12-10 1986-10-03 Canon Inc 記録媒体
JPS61156119A (ja) * 1984-12-28 1986-07-15 Canon Inc 記録媒体
US5354762A (en) * 1986-07-14 1994-10-11 Rohm And Haas Company Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines
EP0253468B1 (en) * 1986-07-14 1991-11-06 Rohm And Haas Company Six-membered heterocyclic derivatives of n'substituted-n,n'-diacylhydrazines
JPH06107648A (ja) * 1992-09-29 1994-04-19 Ricoh Co Ltd 新規なオキサジアゾール化合物
WO1993024468A1 (en) * 1992-06-02 1993-12-09 Ciba-Geigy Ag Pyrimidinyl- and triazinyl- salicyl- and picolylamides and the use, as herbicides, and preparation thereof
JP3341090B2 (ja) * 1992-07-27 2002-11-05 株式会社リコー オキサジアゾール誘導体ならびにその製造法
JPH06199853A (ja) * 1992-11-27 1994-07-19 Ricoh Co Ltd チアジアゾール誘導体及びその製造方法
JPH06184125A (ja) * 1992-12-24 1994-07-05 Idemitsu Kosan Co Ltd １，３，４−ジアゾール誘導体
EP0704436B1 (en) * 1994-03-16 1998-09-16 Sumitomo Electric Industries, Ltd. Triazole derivative and organic electroluminescent element produced therefrom
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP2001018533A (ja) * 1999-07-09 2001-01-23 Ricoh Co Ltd 感熱記録材料
JP2001105741A (ja) * 1999-10-08 2001-04-17 Oki Electric Ind Co Ltd 熱可逆性記録材料および熱可逆性記録媒体
US20030207914A1 (en) * 2001-04-20 2003-11-06 Bayer Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
WO2002085857A2 (en) * 2001-04-20 2002-10-31 Bayer Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
WO2003037864A1 (fr) * 2001-10-29 2003-05-08 Japan Tobacco Inc. Compose indolique, et utilisation a des fins therapeutiques
BR0307409A (pt) * 2002-02-01 2004-12-28 Dainippon Pharmaceutical Co Compostos de hidrazida de ácido 2-furanocarboxìlico, composições farmacêuticas contendo os mesmos e uso dos mesmos para preparação de um agente preventivo ou terapêutico
MXPA04010379A (es) * 2002-04-23 2005-02-17 Squibb Bristol Myers Co Compuestos de pirrolo-triazina anilina utiles como inhibidores de cinasa.
ATE402700T1 (de) * 2002-08-27 2008-08-15 Merck Patent Gmbh Glycinamid-derivate als raf-kinase-hemmer
CN1705645A (zh) * 2002-10-24 2005-12-07 默克专利有限公司 作为raf－激酶抑制剂的亚甲基脲衍生物
CN1764645A (zh) * 2003-03-24 2006-04-26 默克专利有限公司 作为raf－激酶抑制剂的草酰胺衍生物

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