AR046977A1 - Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimioquina - Google Patents
Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimioquinaInfo
- Publication number
- AR046977A1 AR046977A1 ARP040104828A ARP040104828A AR046977A1 AR 046977 A1 AR046977 A1 AR 046977A1 AR P040104828 A ARP040104828 A AR P040104828A AR P040104828 A ARP040104828 A AR P040104828A AR 046977 A1 AR046977 A1 AR 046977A1
- Authority
- AR
- Argentina
- Prior art keywords
- pain
- aryl
- groups
- chemioquine
- isotiazol
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 208000013875 Heart injury Diseases 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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| US53169303P | 2003-12-22 | 2003-12-22 |
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| AR046977A1 true AR046977A1 (es) | 2006-01-04 |
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| ARP040104828A AR046977A1 (es) | 2003-12-22 | 2004-12-21 | Dioxidos de isotiazol como ligandos del receptor cxc y cc-quimioquina |
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| EP (1) | EP1697354B1 (enExample) |
| JP (2) | JP4851943B2 (enExample) |
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| AR (1) | AR046977A1 (enExample) |
| CA (1) | CA2550540A1 (enExample) |
| MX (1) | MXPA06007205A (enExample) |
| TW (1) | TW200530231A (enExample) |
| WO (1) | WO2005068460A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE422203T1 (de) * | 2002-10-09 | 2009-02-15 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
| JP4939229B2 (ja) * | 2003-12-19 | 2012-05-23 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール |
| CN1984899B (zh) | 2004-05-12 | 2011-07-27 | 先灵公司 | Cxcr1和cxcr2趋化因子拮抗剂 |
| EP1758580A4 (en) | 2004-06-24 | 2008-01-16 | Incyte Corp | N-SUBSTITUTED PIPERIDINE AND ITS USE AS A MEDICAMENT |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| EP1912971A2 (en) * | 2005-06-29 | 2008-04-23 | Shering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
| JP2009500328A (ja) * | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン |
| HRP20161260T1 (hr) * | 2005-11-24 | 2016-11-18 | Dompé Farmaceutici S.P.A. | Derivati (r)-arilkilamina i farmaceutski pripravci koji ih sadrže |
| JP2009526065A (ja) * | 2006-02-08 | 2009-07-16 | ワイス | C型肝炎ウイルスによる感染を治療するためのスルホンアミド誘導体 |
| EP2178826B1 (en) * | 2007-07-03 | 2017-05-17 | Merck Sharp & Dohme Corp. | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
| US8790714B2 (en) * | 2007-08-03 | 2014-07-29 | Nucitec, S.A. De C.V. | Compositions and methods for treatment and prevention of osteoarthritis |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| JP5569397B2 (ja) | 2009-01-16 | 2014-08-13 | ダイソー株式会社 | 2−ヒドロキシメチルモルホリン塩の製造方法 |
| WO2011071995A2 (en) | 2009-12-08 | 2011-06-16 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
| KR20130089232A (ko) | 2010-06-15 | 2013-08-09 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 안트라닐산 디아미드 유도체 |
| CN102060811A (zh) * | 2011-01-19 | 2011-05-18 | 山西大学 | 单磺酰哌嗪的合成方法 |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| EP3117835A1 (en) | 2015-07-14 | 2017-01-18 | Dompé farmaceutici s.p.a. | Il-8 inhibitors for use in the treatment of certain urological disorders |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| WO2020106704A2 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN119264082A (zh) * | 2024-09-29 | 2025-01-07 | 中国科学技术大学 | 一种含氟呋喃基化合物、其制备方法及其应用 |
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| MXPA04003439A (es) | 2001-10-12 | 2004-07-08 | Schering Corp | Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc. |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| BR0308739A (pt) | 2002-03-18 | 2005-01-11 | Schering Corp | Tratamentos em combinação para doenças mediadas por quimiocina |
| ATE422203T1 (de) | 2002-10-09 | 2009-02-15 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
| JP4939229B2 (ja) | 2003-12-19 | 2012-05-23 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール |
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2004
- 2004-12-20 TW TW093139590A patent/TW200530231A/zh unknown
- 2004-12-20 CN CN2004800417940A patent/CN1918156B/zh not_active Expired - Fee Related
- 2004-12-20 CA CA002550540A patent/CA2550540A1/en not_active Abandoned
- 2004-12-20 JP JP2006547206A patent/JP4851943B2/ja not_active Expired - Fee Related
- 2004-12-20 MX MXPA06007205A patent/MXPA06007205A/es unknown
- 2004-12-20 US US11/017,505 patent/US7671212B2/en not_active Expired - Fee Related
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- 2004-12-20 WO PCT/US2004/042720 patent/WO2005068460A1/en not_active Ceased
- 2004-12-21 AR ARP040104828A patent/AR046977A1/es not_active Application Discontinuation
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2011
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Also Published As
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| CN1918156B (zh) | 2010-10-27 |
| MXPA06007205A (es) | 2006-08-31 |
| CA2550540A1 (en) | 2005-07-28 |
| EP1697354B1 (en) | 2013-08-07 |
| US20060025453A1 (en) | 2006-02-02 |
| WO2005068460A1 (en) | 2005-07-28 |
| CN1918156A (zh) | 2007-02-21 |
| JP2007515489A (ja) | 2007-06-14 |
| EP1697354A1 (en) | 2006-09-06 |
| JP2011098984A (ja) | 2011-05-19 |
| JP4851943B2 (ja) | 2012-01-11 |
| US7671212B2 (en) | 2010-03-02 |
| TW200530231A (en) | 2005-09-16 |
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