CN1918156B - 作为cxc-和cc-趋化因子受体配体的异噻唑二氧化物 - Google Patents
作为cxc-和cc-趋化因子受体配体的异噻唑二氧化物 Download PDFInfo
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- CN1918156B CN1918156B CN2004800417940A CN200480041794A CN1918156B CN 1918156 B CN1918156 B CN 1918156B CN 2004800417940 A CN2004800417940 A CN 2004800417940A CN 200480041794 A CN200480041794 A CN 200480041794A CN 1918156 B CN1918156 B CN 1918156B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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| PCT/US2004/042720 WO2005068460A1 (en) | 2003-12-22 | 2004-12-20 | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
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| CN1918156B true CN1918156B (zh) | 2010-10-27 |
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| MX (1) | MXPA06007205A (enExample) |
| TW (1) | TW200530231A (enExample) |
| WO (1) | WO2005068460A1 (enExample) |
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| EP1551818B1 (en) * | 2002-10-09 | 2009-02-04 | Schering Corporation | Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands |
| DE602004016211D1 (en) * | 2003-12-19 | 2008-10-09 | Schering Corp | Thiadiazole als cxc- und cc-chemokinrezeptorliganden |
| WO2005113534A2 (en) * | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| BRPI0512535A (pt) | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| DE602006017849D1 (de) * | 2005-06-29 | 2010-12-09 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors |
| US7718678B2 (en) * | 2005-06-29 | 2010-05-18 | Schering Corporation | Di-substituted oxadiazoles as CXC-chemokine receptor ligands |
| PL1951663T3 (pl) * | 2005-11-24 | 2017-01-31 | Dompé Farmaceutici S.P.A. | Pochodne (R)-aryloalkiloaminowe i zawierające je kompozycje farmaceutyczne |
| WO2007092558A2 (en) * | 2006-02-08 | 2007-08-16 | Wyeth | Sulfonamide derivatives to treat infection with hepatitis c virus |
| CA2692269A1 (en) * | 2007-07-03 | 2009-01-08 | Schering Corporation | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
| EP2182810B1 (en) * | 2007-08-03 | 2017-11-08 | Nucitec S.A. de C.V. | Compositions and methods for treatment and prevention of osteoarthritis |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| WO2010050445A1 (ja) | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
| JP5569397B2 (ja) | 2009-01-16 | 2014-08-13 | ダイソー株式会社 | 2−ヒドロキシメチルモルホリン塩の製造方法 |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| MX2012014958A (es) | 2010-06-15 | 2013-02-12 | Bayer Ip Gmbh | Derivados de diamida antranilica. |
| CN102060811A (zh) * | 2011-01-19 | 2011-05-18 | 山西大学 | 单磺酰哌嗪的合成方法 |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| EP3117835A1 (en) | 2015-07-14 | 2017-01-18 | Dompé farmaceutici s.p.a. | Il-8 inhibitors for use in the treatment of certain urological disorders |
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| CN116726361A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| CN119264082A (zh) * | 2024-09-29 | 2025-01-07 | 中国科学技术大学 | 一种含氟呋喃基化合物、其制备方法及其应用 |
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2004
- 2004-12-20 WO PCT/US2004/042720 patent/WO2005068460A1/en not_active Ceased
- 2004-12-20 US US11/017,505 patent/US7671212B2/en not_active Expired - Fee Related
- 2004-12-20 TW TW093139590A patent/TW200530231A/zh unknown
- 2004-12-20 EP EP04814856.3A patent/EP1697354B1/en not_active Expired - Lifetime
- 2004-12-20 CA CA002550540A patent/CA2550540A1/en not_active Abandoned
- 2004-12-20 JP JP2006547206A patent/JP4851943B2/ja not_active Expired - Fee Related
- 2004-12-20 MX MXPA06007205A patent/MXPA06007205A/es unknown
- 2004-12-20 CN CN2004800417940A patent/CN1918156B/zh not_active Expired - Fee Related
- 2004-12-21 AR ARP040104828A patent/AR046977A1/es not_active Application Discontinuation
-
2011
- 2011-02-15 JP JP2011030287A patent/JP2011098984A/ja not_active Withdrawn
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| EP0067436A2 (en) * | 1981-06-15 | 1982-12-22 | Merck & Co. Inc. | Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors |
| WO2001028987A1 (en) * | 1999-10-15 | 2001-04-26 | Du Pont Pharmaceuticals Company | Benzylcycloalkyl amines as modulators of chemokine receptor activity |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011098984A (ja) | 2011-05-19 |
| CN1918156A (zh) | 2007-02-21 |
| US7671212B2 (en) | 2010-03-02 |
| MXPA06007205A (es) | 2006-08-31 |
| EP1697354B1 (en) | 2013-08-07 |
| JP4851943B2 (ja) | 2012-01-11 |
| JP2007515489A (ja) | 2007-06-14 |
| TW200530231A (en) | 2005-09-16 |
| WO2005068460A1 (en) | 2005-07-28 |
| US20060025453A1 (en) | 2006-02-02 |
| EP1697354A1 (en) | 2006-09-06 |
| AR046977A1 (es) | 2006-01-04 |
| CA2550540A1 (en) | 2005-07-28 |
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