AR046920A1 - Hidroxamatos conectados a acilurea y conectado a sulfonilurea - Google Patents
Hidroxamatos conectados a acilurea y conectado a sulfonilureaInfo
- Publication number
- AR046920A1 AR046920A1 ARP040103893A ARP040103893A AR046920A1 AR 046920 A1 AR046920 A1 AR 046920A1 AR P040103893 A ARP040103893 A AR P040103893A AR P040103893 A ARP040103893 A AR P040103893A AR 046920 A1 AR046920 A1 AR 046920A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- arylamino
- alkyl
- heterocycloalkyl
- Prior art date
Links
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51401303P | 2003-10-27 | 2003-10-27 |
Publications (1)
Publication Number | Publication Date |
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AR046920A1 true AR046920A1 (es) | 2006-01-04 |
Family
ID=34520162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040103893A AR046920A1 (es) | 2003-10-27 | 2004-10-26 | Hidroxamatos conectados a acilurea y conectado a sulfonilurea |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1685094A4 (fr) |
JP (1) | JP2007509930A (fr) |
AR (1) | AR046920A1 (fr) |
AU (1) | AU2004284030A1 (fr) |
CA (1) | CA2543570A1 (fr) |
MX (1) | MXPA06004735A (fr) |
TW (1) | TW200530166A (fr) |
WO (1) | WO2005040101A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04008796A (es) | 2002-03-13 | 2004-11-26 | Janssen Pharmaceutica Nv | Derivados de carbonilamino como novedosos inhibidores de desacetilasa de histona. |
ES2306880T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa. |
KR20040093692A (ko) | 2002-03-13 | 2004-11-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로서의 피페라지닐-,피페리디닐- 및 모르폴리닐-유도체 |
ATE473005T1 (de) | 2002-03-13 | 2010-07-15 | Janssen Pharmaceutica Nv | Histone-deacetylase-inhibitoren |
US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
EA010652B1 (ru) | 2004-07-28 | 2008-10-30 | Янссен Фармацевтика Н.В. | Замещенные индолильные алкиламинопроизводные в качестве новых ингибиторов гистондеацетилазы |
ME01058B (fr) | 2004-07-28 | 2012-10-20 | Janssen Pharmaceutica Nv | Derives de piperazine de propenyle substituee comme nouveaux inhibiteurs de l'histone deacetylase |
ITMI20041869A1 (it) | 2004-10-01 | 2005-01-01 | Dac Srl | Nuovi inibitori delle istone deacetilasi |
US8242175B2 (en) | 2004-10-01 | 2012-08-14 | Dac S.R.L. | Class of histone deacetylase inhibitors |
ITMI20060621A1 (it) * | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
ITFI20050041A1 (it) * | 2005-03-15 | 2006-09-16 | Menarini Internat Operations Luxembourg Sa | Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono |
CN101163471A (zh) | 2005-04-20 | 2008-04-16 | 默克公司 | 含有氨基甲酸酯、脲、酰胺和磺酰胺取代的苯并噻吩异羟肟酸衍生物 |
AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
WO2007011626A2 (fr) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Inhibiteurs de l'histone deacetylase |
CA2623360C (fr) | 2005-10-27 | 2014-04-22 | Janssen Pharmaceutica N.V. | Derives d'acide squarique en tant qu'inhibiteurs d'histone desacetylase |
DK1979326T3 (da) | 2006-01-19 | 2013-01-07 | Janssen Pharmaceutica Nv | Pyridin- og pyrimidinderivater som inhibitorer af histondeacetylase |
EP1979327A1 (fr) | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Dérivés de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone désacétylase |
US7834025B2 (en) | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
AU2007206946B2 (en) | 2006-01-19 | 2011-12-15 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
AU2007206948B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
ATE539073T1 (de) | 2006-01-19 | 2012-01-15 | Janssen Pharmaceutica Nv | Heterocyclylalkylderivate als neue inhibitoren von histondeacetylase |
KR20100016171A (ko) * | 2007-05-04 | 2010-02-12 | 노파르티스 아게 | 위장관암의 치료를 위한 hdac 억제제의 용도 |
CN101417967A (zh) * | 2007-10-26 | 2009-04-29 | 浙江海正药业股份有限公司 | 组蛋白去乙酰酶抑制剂、其组合物及其应用 |
US8476289B2 (en) | 2008-03-27 | 2013-07-02 | Janssen Pharmaceutica Nv | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace |
WO2011009059A2 (fr) * | 2009-07-17 | 2011-01-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Méthode de traitement ou de prévention du cancer |
WO2013041407A1 (fr) * | 2011-09-19 | 2013-03-28 | Cellzome Ag | Acides hydroxamiques et récepteurs hdac6 |
US9409858B2 (en) | 2012-03-07 | 2016-08-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
WO2013134467A1 (fr) * | 2012-03-07 | 2013-09-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Inhibiteurs sélectifs d'histone désacétylase 6 |
AU2014260605B2 (en) * | 2013-04-29 | 2016-07-14 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
US9751832B2 (en) | 2013-07-30 | 2017-09-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
WO2015058106A1 (fr) * | 2013-10-18 | 2015-04-23 | The General Hospital Corporation | Imagerie d'histone désacétylases au moyen d'un radiotraceur à l'aide de la tomographie par émission de positrons |
WO2015137750A1 (fr) * | 2014-03-12 | 2015-09-17 | Chong Kun Dang Pharmaceutical Corp. | Nouveaux composés en tant qu'inhibiteurs de l'histone désacétylase 6 et compositions pharmaceutiques les comprenant |
CN113288888B (zh) * | 2021-05-28 | 2023-02-03 | 烟台邦杰生物科技有限公司 | 具有血管舒张活性的化合物 |
WO2023020412A1 (fr) * | 2021-08-16 | 2023-02-23 | 中国科学院上海药物研究所 | Composé de sulfonylurée, son procédé de préparation et son utilisation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004143053A (ja) * | 2002-10-22 | 2004-05-20 | Senju Pharmaceut Co Ltd | β−アミノヒドロキサム酸誘導体およびその用途 |
-
2004
- 2004-10-26 EP EP04775672A patent/EP1685094A4/fr not_active Withdrawn
- 2004-10-26 AR ARP040103893A patent/AR046920A1/es unknown
- 2004-10-26 AU AU2004284030A patent/AU2004284030A1/en not_active Abandoned
- 2004-10-26 MX MXPA06004735A patent/MXPA06004735A/es not_active Application Discontinuation
- 2004-10-26 JP JP2006537946A patent/JP2007509930A/ja active Pending
- 2004-10-26 WO PCT/SG2004/000353 patent/WO2005040101A1/fr active Application Filing
- 2004-10-26 CA CA002543570A patent/CA2543570A1/fr not_active Abandoned
- 2004-10-26 TW TW093132561A patent/TW200530166A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004284030A1 (en) | 2005-05-06 |
MXPA06004735A (es) | 2006-12-14 |
CA2543570A1 (fr) | 2005-05-06 |
JP2007509930A (ja) | 2007-04-19 |
EP1685094A4 (fr) | 2007-08-22 |
EP1685094A1 (fr) | 2006-08-02 |
TW200530166A (en) | 2005-09-16 |
WO2005040101A1 (fr) | 2005-05-06 |
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