AR042702A1 - Proceso para preparar aripiprazola - Google Patents

Proceso para preparar aripiprazola

Info

Publication number
AR042702A1
AR042702A1 ARP040100006A ARP040100006A AR042702A1 AR 042702 A1 AR042702 A1 AR 042702A1 AR P040100006 A ARP040100006 A AR P040100006A AR P040100006 A ARP040100006 A AR P040100006A AR 042702 A1 AR042702 A1 AR 042702A1
Authority
AR
Argentina
Prior art keywords
aripiprazole
group
compound represented
aripiprazola
prepare
Prior art date
Application number
ARP040100006A
Other languages
English (en)
Inventor
H Tsujimori
T Yamaguchi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32652780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR042702(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR042702A1 publication Critical patent/AR042702A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)

Abstract

La presente comprende proceso para preparar aripiprazola con una pureza más elevada y un mayor rendimiento. De acuerdo con el proceso de la presente, la aripiprazola se prepara mediante la reacción de un compuesto carboestirilo representado por la fórmula general (1) (en donde X es un átomo de halógeno, grupo alcanosulfoniloxi inferior, grupo arilsulfoniloxi o un grupo aralquilsulfoniloxi, con un compuesto de piperazina representado por la fórmula (2), y/o una sal del mismo en agua, en presencia de 0,5 a 10 mol de un compuesto básico, inorgánico, por mol de compuesto carboestirilo (2). La aripiprazola se utiliza como agente antisicótico, en el tratamiento de la esquizofrenia.
ARP040100006A 2003-01-09 2004-01-05 Proceso para preparar aripiprazola AR042702A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003002996 2003-01-09

Publications (1)

Publication Number Publication Date
AR042702A1 true AR042702A1 (es) 2005-06-29

Family

ID=32652780

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100006A AR042702A1 (es) 2003-01-09 2004-01-05 Proceso para preparar aripiprazola

Country Status (20)

Country Link
US (1) US6995264B2 (es)
EP (1) EP1480953B2 (es)
JP (2) JP5797090B2 (es)
KR (1) KR100583667B1 (es)
CN (1) CN1263742C (es)
AR (1) AR042702A1 (es)
AT (1) ATE308524T1 (es)
AU (1) AU2003288755C1 (es)
BR (2) BRPI0305500B1 (es)
CA (2) CA2458929C (es)
DE (1) DE60302139T3 (es)
DK (1) DK1480953T4 (es)
EG (1) EG23557A (es)
ES (1) ES2250919T5 (es)
HK (1) HK1073110A1 (es)
MX (1) MXPA04002519A (es)
MY (1) MY129831A (es)
SI (1) SI1480953T2 (es)
TW (1) TWI258470B (es)
WO (1) WO2004063162A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714129B2 (en) * 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
PT1613598E (pt) * 2003-12-16 2012-01-13 Teva Pharma Métodos para preparar formas cristalinas de aripiprazol
WO2005077904A1 (en) * 2004-02-05 2005-08-25 Teva Pharmaceutical Industries, Ltd. Process for preparing aripiprazole
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
US7872132B2 (en) * 2004-10-08 2011-01-18 Suven Life Sciences Limited Intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
EP1812397A1 (en) * 2004-11-18 2007-08-01 Synthon B.V. Process of making crystalline aripiprazole
CN1303068C (zh) * 2005-01-11 2007-03-07 中国人民解放军第二军医大学 一种阿立哌唑的制备方法
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
JP2009508859A (ja) 2005-09-15 2009-03-05 エラン ファーマ インターナショナル リミテッド ナノ粒子アリピプラゾール製剤
EP1919453A2 (en) * 2005-12-22 2008-05-14 Teva Pharmaceutical Industries Ltd Processes for reducing particle size of aripiprazole
US20070149782A1 (en) * 2005-12-23 2007-06-28 Michael Brand Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole
US20070238876A1 (en) * 2006-04-10 2007-10-11 Neera Tewari Process for the preparation of aripiprazole
EP2162135A4 (en) 2007-05-21 2012-02-22 Reviva Pharmaceuticals Inc COMPOSITIONS, SYNTHESIS AND METHOD FOR THE APPLICATION OF ATTAINED CHINOLINONE-BASED ANTIPSYCHOTICS
WO2009154993A1 (en) 2008-05-27 2009-12-23 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using piperazine based antipsychotic agents
CN101781246B (zh) * 2009-01-15 2012-02-29 成都康弘药业集团股份有限公司 一种合成阿立哌唑的改进方法
AU2010217772B2 (en) 2009-02-26 2014-10-23 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
WO2016181406A1 (en) * 2015-05-08 2016-11-17 Davuluri Ramamohan Rao Improved process for the preparation of aripiprazole with reduced particle size

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE3034237A1 (de) † 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
JP4060523B2 (ja) † 1999-11-24 2008-03-12 大塚製薬株式会社 カルボスチリル誘導体の製造法
AR033485A1 (es) † 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma

Also Published As

Publication number Publication date
DK1480953T4 (da) 2010-11-15
HK1073110A1 (en) 2005-09-23
JP2012031203A (ja) 2012-02-16
US20040192915A1 (en) 2004-09-30
AU2003288755B2 (en) 2005-08-25
TWI258470B (en) 2006-07-21
KR20040093655A (ko) 2004-11-06
DE60302139T3 (de) 2011-02-24
ATE308524T1 (de) 2005-11-15
CA2458929C (en) 2009-09-08
DE60302139T2 (de) 2006-07-20
EP1480953B1 (en) 2005-11-02
EP1480953A1 (en) 2004-12-01
SI1480953T2 (sl) 2010-12-31
ES2250919T3 (es) 2006-04-16
MY129831A (en) 2007-05-31
BRPI0305500B1 (pt) 2018-01-23
DK1480953T3 (da) 2005-12-19
CA2458929A1 (en) 2004-07-09
EG23557A (en) 2006-06-05
JP5797090B2 (ja) 2015-10-21
CN1590377A (zh) 2005-03-09
AU2003288755C1 (en) 2015-02-19
KR100583667B1 (ko) 2006-05-26
TW200418840A (en) 2004-10-01
JP2014148511A (ja) 2014-08-21
MXPA04002519A (es) 2005-04-04
US6995264B2 (en) 2006-02-07
ES2250919T5 (es) 2010-12-03
CN1263742C (zh) 2006-07-12
BR0305500A (pt) 2004-11-03
CA2676216A1 (en) 2004-07-09
AU2003288755A1 (en) 2004-08-10
WO2004063162A1 (en) 2004-07-29
DE60302139D1 (de) 2005-12-08
EP1480953B2 (en) 2010-08-18
SI1480953T1 (sl) 2006-04-30

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee