HK1073110A1 - Process for preparing aripiprazole - Google Patents

Process for preparing aripiprazole

Info

Publication number
HK1073110A1
HK1073110A1 HK05105804A HK05105804A HK1073110A1 HK 1073110 A1 HK1073110 A1 HK 1073110A1 HK 05105804 A HK05105804 A HK 05105804A HK 05105804 A HK05105804 A HK 05105804A HK 1073110 A1 HK1073110 A1 HK 1073110A1
Authority
HK
Hong Kong
Prior art keywords
preparing aripiprazole
aripiprazole
preparing
Prior art date
Application number
HK05105804A
Other languages
English (en)
Inventor
Hisayuki Tsujimori
Tatsuya Yamaguchi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32652780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1073110(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of HK1073110A1 publication Critical patent/HK1073110A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
HK05105804A 2003-01-09 2005-07-11 Process for preparing aripiprazole HK1073110A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003002996 2003-01-09

Publications (1)

Publication Number Publication Date
HK1073110A1 true HK1073110A1 (en) 2005-09-23

Family

ID=32652780

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05105804A HK1073110A1 (en) 2003-01-09 2005-07-11 Process for preparing aripiprazole

Country Status (20)

Country Link
US (1) US6995264B2 (xx)
EP (1) EP1480953B2 (xx)
JP (2) JP5797090B2 (xx)
KR (1) KR100583667B1 (xx)
CN (1) CN1263742C (xx)
AR (1) AR042702A1 (xx)
AT (1) ATE308524T1 (xx)
AU (1) AU2003288755C1 (xx)
BR (2) BR0305500A (xx)
CA (2) CA2458929C (xx)
DE (1) DE60302139T3 (xx)
DK (1) DK1480953T4 (xx)
EG (1) EG23557A (xx)
ES (1) ES2250919T5 (xx)
HK (1) HK1073110A1 (xx)
MX (1) MXPA04002519A (xx)
MY (1) MY129831A (xx)
SI (1) SI1480953T2 (xx)
TW (1) TWI258470B (xx)
WO (1) WO2004063162A1 (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058835A2 (en) * 2003-12-16 2005-06-30 Teva Pharmaceutical Industries Ltd. Methods of preparing aripiprazole crystalline forms
US7714129B2 (en) * 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
MXPA06008828A (es) * 2004-02-05 2007-04-25 Teva Pharma Proceso para preparar aripiprazol.
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
KR101041551B1 (ko) * 2004-10-08 2011-06-15 수벤 라이프 사이언시스 리미티드 아리피프라졸 제조를 위해 유용한 신규 중간체와 신규중간체 및 아리피프라졸 제조 방법
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
EP1812397A1 (en) * 2004-11-18 2007-08-01 Synthon B.V. Process of making crystalline aripiprazole
CN1303068C (zh) * 2005-01-11 2007-03-07 中国人民解放军第二军医大学 一种阿立哌唑的制备方法
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
JP2009508859A (ja) * 2005-09-15 2009-03-05 エラン ファーマ インターナショナル リミテッド ナノ粒子アリピプラゾール製剤
EP1919453A2 (en) * 2005-12-22 2008-05-14 Teva Pharmaceutical Industries Ltd Processes for reducing particle size of aripiprazole
US20070149782A1 (en) * 2005-12-23 2007-06-28 Michael Brand Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole
US20070238876A1 (en) * 2006-04-10 2007-10-11 Neera Tewari Process for the preparation of aripiprazole
RU2497819C2 (ru) 2007-05-21 2013-11-10 Ривайва Фармасьютикалс, Инк. Композиции, синтез и способы применения атипичных нейролептиков на основе хинолина
EP2299814A4 (en) 2008-05-27 2011-06-15 Reviva Pharmaceuticals Inc COMPOSITIONS, SYNTHESIS AND METHOD FOR USE OF ANTIPSYCHOTICS ON PIPERAZINE BASIS
CN101781246B (zh) * 2009-01-15 2012-02-29 成都康弘药业集团股份有限公司 一种合成阿立哌唑的改进方法
KR101705727B1 (ko) 2009-02-26 2017-02-10 레비바 파마슈티칼스, 아이엔씨. 아릴피페라진 유도체의 조성물, 합성, 및 사용 방법
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
WO2016181406A1 (en) * 2015-05-08 2016-11-17 Davuluri Ramamohan Rao Improved process for the preparation of aripiprazole with reduced particle size

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE3034237A1 (de) † 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
JP4060523B2 (ja) † 1999-11-24 2008-03-12 大塚製薬株式会社 カルボスチリル誘導体の製造法
AR033485A1 (es) † 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma

Also Published As

Publication number Publication date
ES2250919T5 (es) 2010-12-03
SI1480953T2 (sl) 2010-12-31
AR042702A1 (es) 2005-06-29
AU2003288755C1 (en) 2015-02-19
DK1480953T4 (da) 2010-11-15
CA2458929A1 (en) 2004-07-09
DK1480953T3 (da) 2005-12-19
DE60302139T2 (de) 2006-07-20
BRPI0305500B1 (pt) 2018-01-23
BR0305500A (pt) 2004-11-03
MXPA04002519A (es) 2005-04-04
EP1480953B2 (en) 2010-08-18
JP5797090B2 (ja) 2015-10-21
DE60302139D1 (de) 2005-12-08
AU2003288755B2 (en) 2005-08-25
CA2458929C (en) 2009-09-08
DE60302139T3 (de) 2011-02-24
ATE308524T1 (de) 2005-11-15
ES2250919T3 (es) 2006-04-16
US6995264B2 (en) 2006-02-07
KR100583667B1 (ko) 2006-05-26
JP2014148511A (ja) 2014-08-21
EG23557A (en) 2006-06-05
CN1590377A (zh) 2005-03-09
EP1480953B1 (en) 2005-11-02
WO2004063162A1 (en) 2004-07-29
CA2676216A1 (en) 2004-07-09
JP2012031203A (ja) 2012-02-16
CN1263742C (zh) 2006-07-12
EP1480953A1 (en) 2004-12-01
TWI258470B (en) 2006-07-21
AU2003288755A1 (en) 2004-08-10
KR20040093655A (ko) 2004-11-06
US20040192915A1 (en) 2004-09-30
TW200418840A (en) 2004-10-01
MY129831A (en) 2007-05-31
SI1480953T1 (sl) 2006-04-30

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20240108