AR039272A1 - Preparacion liquida que comprende un derivado de camptotecina y una composicion farmaceutica que puede producirse por liofilizacion de la preparacion - Google Patents
Preparacion liquida que comprende un derivado de camptotecina y una composicion farmaceutica que puede producirse por liofilizacion de la preparacionInfo
- Publication number
- AR039272A1 AR039272A1 ARP030101238A ARP030101238A AR039272A1 AR 039272 A1 AR039272 A1 AR 039272A1 AR P030101238 A ARP030101238 A AR P030101238A AR P030101238 A ARP030101238 A AR P030101238A AR 039272 A1 AR039272 A1 AR 039272A1
- Authority
- AR
- Argentina
- Prior art keywords
- glycyl
- group
- glycine
- liquid preparation
- peptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Una preparación líquida estable que comprende un derivado de camptotecina que se prepara uniendo un compuesto de la fórmula (1): donde R1 es un grupo alquilo inferior sustituido o insustituido, X1 es un grupo de la fórmula: -NHR2 (R2 es un átomo de hidrógeno o un grupo alquilo inferior) o un grupo hidroxi y Alk es un grupo alquileno de cadena lineal o ramificada opcionalmente interrumpida por un átomo de oxígeno, y un polisacarido que tiene grupos carboxilo a través de un aminoácido o un péptido, o una sal farmacéuticamente aceptable del mismo, que se ajusta a un valor pH de 5-8, o una composición farmacéutica estable producida por liofilización de dicha preparación líquida. Reivindicación 11: La preparación líquida de acuerdo con la reivindicación 1, donde R1 es un grupo alquilo inferior C1-6 insustituido, X1 es un grupo amino y Alk es un grupo alquileno C1-6 de cadena lineal no interrumpido opr un átomo de oxigeno, un polisacarido es un dextrano o pululano carboximetilado, y un péptido es un péptido que consiste en 2 - 5 aminoácidos. Reivindicación 12: La preparación líquida de acuerdo con la reivindicación 11, donde R1 es un grupo etilo, un grupo de la fórmula: X1-Alk-O- es un grupo 3-aminopropiloxi, y el compuesto de camptotecina [1] está unido en la posición 10 de un núcleo de comptotecina, el polisacárido es dextrano en el cual se introduce un grupo carboxilo, el péptido es glicil-glicil-L- o D-fenilalanil-glicina, glicil-glicina, glicil-glicil-glicina, glicil-glicil-glicil-glicina, glicil-glicil-glicil-glicil-glicina, L o D-fenilalanil-glicina y L- o D-leucilglicina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002112864 | 2002-04-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR039272A1 true AR039272A1 (es) | 2005-02-16 |
Family
ID=29243336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030101238A AR039272A1 (es) | 2002-04-16 | 2003-04-09 | Preparacion liquida que comprende un derivado de camptotecina y una composicion farmaceutica que puede producirse por liofilizacion de la preparacion |
Country Status (21)
Country | Link |
---|---|
US (1) | US20050215485A1 (es) |
EP (1) | EP1501549A2 (es) |
JP (1) | JP3927954B2 (es) |
KR (1) | KR100700963B1 (es) |
CN (1) | CN100544769C (es) |
AR (1) | AR039272A1 (es) |
AU (1) | AU2003223120B2 (es) |
BR (1) | BR0309283A (es) |
CA (1) | CA2480425A1 (es) |
HR (1) | HRP20040894A2 (es) |
ME (1) | MEP31308A (es) |
MX (1) | MXPA04010178A (es) |
MY (1) | MY136696A (es) |
NO (1) | NO20044964L (es) |
PL (1) | PL371677A1 (es) |
RS (1) | RS91204A (es) |
RU (1) | RU2315623C2 (es) |
TW (1) | TW200306314A (es) |
UA (1) | UA77295C2 (es) |
WO (1) | WO2003086471A2 (es) |
ZA (1) | ZA200408008B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602005024923D1 (de) * | 2004-02-13 | 2011-01-05 | Yakult Honsha Kk | Wässrige lösung mit einem camptothecin |
CN1946421B (zh) | 2004-04-27 | 2013-07-17 | 威尔斯达特生物制剂公司 | 使用病毒和喜树碱进行的癌症治疗 |
RU2435586C2 (ru) | 2005-07-14 | 2011-12-10 | Веллстат Байолоджикс Корпорейшн | Лечение рака с применением вирусов, фторпиримидинов и камптотецинов |
JP2007260275A (ja) * | 2006-03-29 | 2007-10-11 | Transcutaneous Technologies Inc | イオントフォレーシス装置及びイオントフォレーシス投与用組成物 |
WO2010151544A1 (en) | 2009-06-22 | 2010-12-29 | Wyeth Llc | Immunogenic compositions of staphylococcus aureus antigens |
JP2012530785A (ja) | 2009-06-22 | 2012-12-06 | ワイス・エルエルシー | 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法 |
CN102764260B (zh) * | 2011-04-30 | 2014-07-30 | 正大天晴药业集团股份有限公司 | 一种喜树碱衍生物的药物组合物及其制备方法 |
WO2013011598A1 (ja) * | 2011-07-15 | 2013-01-24 | コニカミノルタホールディングス株式会社 | 溶解助剤を利用したリポソーム含有製剤およびその製造方法 |
AU2015369185B2 (en) | 2014-12-26 | 2020-10-22 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical preparation of camptothecin-containing polymer derivative |
KR20180039628A (ko) | 2015-09-03 | 2018-04-18 | 니폰 가야꾸 가부시끼가이샤 | 캄프토테신류 고분자 유도체를 함유하는 의약 조성물 |
AU2016326747A1 (en) | 2015-09-25 | 2018-03-01 | Zy Therapeutics Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
CN108697806A (zh) * | 2016-03-01 | 2018-10-23 | 日本化药株式会社 | 含有喜树碱类高分子衍生物的药物制剂 |
CN109481691A (zh) * | 2018-11-20 | 2019-03-19 | 珠海天香苑生物科技发展股份有限公司 | 吉西他滨-羧甲基多糖共轭物、制备方法及其用途 |
AU2022396967A1 (en) * | 2021-11-26 | 2024-06-13 | Astellas Pharma Inc. | Indocyanine compound-containing solid pharmaceutical composition |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5340817A (en) * | 1987-04-14 | 1994-08-23 | Research Triangle Institute | Method of treating tumors with anti-tumor effective camptothecin compounds |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
AR030207A1 (es) * | 2000-04-07 | 2003-08-13 | Daiichi Seiyaku Co | Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma |
AU2001271037A1 (en) * | 2000-07-13 | 2002-01-30 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compounds |
TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
-
2003
- 2003-04-01 TW TW092107354A patent/TW200306314A/zh unknown
- 2003-04-09 AR ARP030101238A patent/AR039272A1/es unknown
- 2003-04-11 MY MYPI20031367A patent/MY136696A/en unknown
- 2003-04-15 AU AU2003223120A patent/AU2003223120B2/en not_active Ceased
- 2003-04-15 PL PL03371677A patent/PL371677A1/xx not_active Application Discontinuation
- 2003-04-15 BR BR0309283-6A patent/BR0309283A/pt not_active IP Right Cessation
- 2003-04-15 JP JP2003587152A patent/JP3927954B2/ja not_active Expired - Fee Related
- 2003-04-15 MX MXPA04010178A patent/MXPA04010178A/es active IP Right Grant
- 2003-04-15 CA CA002480425A patent/CA2480425A1/en not_active Abandoned
- 2003-04-15 US US10/509,912 patent/US20050215485A1/en not_active Abandoned
- 2003-04-15 WO PCT/JP2003/004745 patent/WO2003086471A2/en active Application Filing
- 2003-04-15 CN CNB038082292A patent/CN100544769C/zh not_active Expired - Fee Related
- 2003-04-15 ME MEP-313/08A patent/MEP31308A/xx unknown
- 2003-04-15 RS YU91204A patent/RS91204A/sr unknown
- 2003-04-15 RU RU2004133349/15A patent/RU2315623C2/ru not_active IP Right Cessation
- 2003-04-15 KR KR1020047016514A patent/KR100700963B1/ko not_active IP Right Cessation
- 2003-04-15 UA UA20041109367A patent/UA77295C2/uk unknown
- 2003-04-15 EP EP03719110A patent/EP1501549A2/en not_active Withdrawn
-
2004
- 2004-09-29 HR HR20040894A patent/HRP20040894A2/xx not_active Application Discontinuation
- 2004-10-05 ZA ZA200408008A patent/ZA200408008B/en unknown
- 2004-11-15 NO NO20044964A patent/NO20044964L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MY136696A (en) | 2008-11-28 |
CA2480425A1 (en) | 2003-10-23 |
RU2004133349A (ru) | 2005-05-27 |
AU2003223120A1 (en) | 2003-10-27 |
CN1646172A (zh) | 2005-07-27 |
BR0309283A (pt) | 2005-02-15 |
JP3927954B2 (ja) | 2007-06-13 |
MEP31308A (en) | 2010-10-10 |
NO20044964L (no) | 2004-11-15 |
RU2315623C2 (ru) | 2008-01-27 |
KR20050000516A (ko) | 2005-01-05 |
US20050215485A1 (en) | 2005-09-29 |
AU2003223120B2 (en) | 2006-10-05 |
PL371677A1 (en) | 2005-06-27 |
EP1501549A2 (en) | 2005-02-02 |
TW200306314A (en) | 2003-11-16 |
ZA200408008B (en) | 2005-06-13 |
KR100700963B1 (ko) | 2007-03-28 |
AU2003223120A2 (en) | 2003-10-27 |
RS91204A (en) | 2006-12-15 |
JP2005523329A (ja) | 2005-08-04 |
WO2003086471A3 (en) | 2004-04-15 |
WO2003086471A2 (en) | 2003-10-23 |
MXPA04010178A (es) | 2005-06-08 |
CN100544769C (zh) | 2009-09-30 |
HRP20040894A2 (en) | 2005-10-31 |
UA77295C2 (en) | 2006-11-15 |
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Legal Events
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