AR030207A1 - Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma - Google Patents

Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma

Info

Publication number
AR030207A1
AR030207A1 ARP010101614A ARP010101614A AR030207A1 AR 030207 A1 AR030207 A1 AR 030207A1 AR P010101614 A ARP010101614 A AR P010101614A AR P010101614 A ARP010101614 A AR P010101614A AR 030207 A1 AR030207 A1 AR 030207A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
camptothecin
solution
composition containing
indolizino
Prior art date
Application number
ARP010101614A
Other languages
English (en)
Inventor
Shuichi Ando
Shuichi Sugie
Masami Morita
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of AR030207A1 publication Critical patent/AR030207A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Una composicion farmacéutica que contiene (9S)-1-amino-9-etil-5-fluoro-2,3-dihidro-9-hidroxi-4-metil-1H,12H-benzo[de]pirano[3',4':6,7]indolizino[1,2-b]quinolina-10,13(9H,15H)-diona o una sal de la misma y una sustancia que ajusta el pH. La composicion farmacéutica asegura estabilidad y solubilidad de un derivado de camptotecina hexacíclico preparado agregando un anillo que tiene un grupo soluble en agua a la camptotecina cuando se formula agregando una sustancia que ajusta el pH. La composicion puede contener una o más azucares o alcoholes de azucar seleccionados del grupo consistente en maltosa, glucosa, lactosa, sacarosa, manitol, inositol, galactosa, ribosa, xilosa, manosa, sucrosa, celobiosa, raffinosa y maltrotriosa. Una preparacion secada por congelacion que contiene dicha composicion farmacéutica y una preparacion acuosa preparada disolviendo la preparacion secada por congelacion. Un proceso para producir dicha composicion farmacéutica que comprende preparar una solucion acuosa que contiene (9S)-1-amino-9-etil-5-fluoro-2,3-dihidro-9-hidroxi-4-metil-1H,12H-benzo[de]pirano[3',4':6,7]indolizino[1,2-b]quinolina-10,13(9H, 15H)-diona o una sal de la misma donde la solucion es una solucion débilmente ácida, y luego secar por congelacion la solucion resultante. Los derivados de camptotecina son utiles como agentes antitumorales.
ARP010101614A 2000-04-07 2001-04-05 Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma AR030207A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000111919 2000-04-07
JP2000169082 2000-06-01

Publications (1)

Publication Number Publication Date
AR030207A1 true AR030207A1 (es) 2003-08-13

Family

ID=26590030

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101614A AR030207A1 (es) 2000-04-07 2001-04-05 Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma

Country Status (12)

Country Link
US (1) US20030109460A1 (es)
EP (1) EP1310254A4 (es)
KR (1) KR20030009426A (es)
CN (1) CN1433310A (es)
AR (1) AR030207A1 (es)
AU (1) AU4874301A (es)
BR (1) BR0109891A (es)
CA (1) CA2405453A1 (es)
MX (1) MXPA02009901A (es)
NO (1) NO20024823L (es)
RU (1) RU2002126558A (es)
WO (1) WO2001076603A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
JP2006151808A (ja) * 2002-12-24 2006-06-15 Dai Ichi Seiyaku Co Ltd 抗菌性水性製剤
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
CN110448533B (zh) * 2014-12-05 2022-03-29 天津键凯科技有限公司 一种聚乙二醇修饰的喜树碱类衍生物的药物组合物及其制备方法
PT3946464T (pt) 2019-03-29 2022-11-16 Medimmune Ltd Compostos e seus conjugados
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693760A (en) * 1988-04-14 1997-12-02 Incyte Pharmaceuticals, Inc. Method of causing selective immunosuppression using HL-60 related lectins
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JPH0770195A (ja) * 1993-08-23 1995-03-14 Yutaka Mizushima 糖修飾インターフェロン
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
JP2000044567A (ja) * 1998-07-29 2000-02-15 Dai Ichi Seiyaku Co Ltd 六環性化合物

Also Published As

Publication number Publication date
RU2002126558A (ru) 2004-03-20
CA2405453A1 (en) 2002-10-03
KR20030009426A (ko) 2003-01-29
EP1310254A1 (en) 2003-05-14
WO2001076603A1 (fr) 2001-10-18
MXPA02009901A (es) 2003-05-27
NO20024823D0 (no) 2002-10-04
AU4874301A (en) 2001-10-23
EP1310254A4 (en) 2006-05-10
US20030109460A1 (en) 2003-06-12
NO20024823L (no) 2002-12-06
BR0109891A (pt) 2002-12-31
CN1433310A (zh) 2003-07-30

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