ES2629306T3 - Tratamiento y prevención de la mucositis mediante derivados de antocianidina - Google Patents

Tratamiento y prevención de la mucositis mediante derivados de antocianidina Download PDF

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Publication number
ES2629306T3
ES2629306T3 ES07804655.4T ES07804655T ES2629306T3 ES 2629306 T3 ES2629306 T3 ES 2629306T3 ES 07804655 T ES07804655 T ES 07804655T ES 2629306 T3 ES2629306 T3 ES 2629306T3
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Spain
Prior art keywords
mucositis
prevention
treatment
extract
anthocyanidin
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ES07804655.4T
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Ezio Bombardelli
Paolo Morazzoni
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Indena SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición farmacéutica para su uso en la prevención o el tratamiento de la mucositis que comprende al menos un extracto derivado de Vaccinium myrtillus; un extracto lipófilo de Echinacea angustofolia y un extracto de Sanguinaria canadensis, Macleaya cordata o Macleaya microcarpa.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
Ejemplo V -Gel vaginal
1.
Proantocianidina A2 1,0 g
2.
Alcaloides de Sanguinaria canadensis 0,003 g
3.
Propilenglicol 10,0 g
4.
Etoxidiglicol 10,0 g
5.
Softigen 767 10,0 g
6.
Polisorbato 80 4,0 g
7.
Carbómero 2,0 g
8.
Solución de trietanolamina al 20 % 2,0 g
9.
Metilparabeno 0,2 g
10.
Propilparabeno 0,1 g
11.
Agua purificada c.s. para 100,0 g
Se añadieron proantocianidina A2 y alcaloide de Sanguinaria canadensis a una mezcla de propilenglicol y etoxidiglicol. La solución se calentó, y se añadió Softigen 767 en agitación. La solución se dejó enfriar, y se añadieron Polisorbato 80, metilparabeno y propilparabeno. Se añadió agua purificada a la solución, y el carbómero se dispersó en agitación intensa. La solución se desaireó al vacío, y se gelificó en agitación con solución de trietanolamina al 20 %.
7

Claims (1)

  1. imagen1
ES07804655.4T 2006-07-28 2007-07-27 Tratamiento y prevención de la mucositis mediante derivados de antocianidina Active ES2629306T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06015732 2006-07-28
EP06015732A EP1882473A1 (en) 2006-07-28 2006-07-28 Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs
PCT/IB2007/002147 WO2008012666A2 (en) 2006-07-28 2007-07-27 Treatment and prevention mucositis by anthocyanidin derivatives

Publications (1)

Publication Number Publication Date
ES2629306T3 true ES2629306T3 (es) 2017-08-08

Family

ID=37309334

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12177486.3T Active ES2602786T3 (es) 2006-07-28 2007-07-27 Procedimientos para prevenir y tratar la mucositis
ES07804655.4T Active ES2629306T3 (es) 2006-07-28 2007-07-27 Tratamiento y prevención de la mucositis mediante derivados de antocianidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES12177486.3T Active ES2602786T3 (es) 2006-07-28 2007-07-27 Procedimientos para prevenir y tratar la mucositis

Country Status (20)

Country Link
US (3) US20080026058A1 (es)
EP (4) EP1882473A1 (es)
JP (1) JP5433415B2 (es)
KR (1) KR20090052852A (es)
CN (1) CN101495114A (es)
AU (1) AU2007278959B2 (es)
BR (1) BRPI0715364A2 (es)
CA (2) CA2935902C (es)
DK (2) DK2520295T3 (es)
ES (2) ES2602786T3 (es)
HU (2) HUE031941T2 (es)
IL (1) IL196737A (es)
MX (1) MX2009001064A (es)
NO (1) NO341742B1 (es)
PL (2) PL2520295T3 (es)
PT (2) PT2520295T (es)
RU (1) RU2438693C2 (es)
SG (1) SG172745A1 (es)
SI (2) SI2520295T1 (es)
WO (1) WO2008012666A2 (es)

Families Citing this family (19)

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ITMI20042414A1 (it) * 2004-12-17 2005-03-17 Indena Spa Formulazione per il trattamento di affezioni delle prime vie respiratorie
ITMI20080038A1 (it) 2008-01-11 2009-07-12 Indena Spa Formulazioni per il trattamento di mucositi indotte da terapia antitumorale o immunosoppressiva
ITMI20080395A1 (it) * 2008-03-10 2009-09-11 Indena Spa Formulazioni per il trattamento delle verruche e delle placche psoriatiche
US20110104313A1 (en) * 2008-04-24 2011-05-05 Indena S.P.A Compositions for the treatment of vaginal infections with chronic inflammation
US8496975B2 (en) * 2008-04-24 2013-07-30 Indena S.P.A. Compositions for the treatment and prevention of infections of the oral cavity
ATE526968T1 (de) * 2008-06-12 2011-10-15 Indena Spa Zusammensetzungen zur behandlung von vaginalen infektionen mit chronischer entzündung
ES2334746B1 (es) * 2008-07-23 2011-01-28 Feedback Trayer, S.L. Producto para la higiene intima a base de mirtillo rojo y procedimiento para su preparacion.
JP2010215532A (ja) * 2009-03-13 2010-09-30 Ands Corporation コラーゲンゲル収縮促進剤
EP2344154B1 (en) 2009-10-21 2016-12-07 Maqui New Life S.A. Compositions that include anthocyanidins and methods of use
IT1402749B1 (it) * 2010-10-28 2013-09-18 Indena Spa Composizioni per il trattamento di ulcere periferiche di varia origine
FR2979241B1 (fr) 2011-08-30 2014-05-09 Nutrialys Medical Nutrition Sa Utilisation de compositions a faible teneur en polyamines dans la prevention ou le traitement des effets indesirables lies a un traitement anti-cancereux
ITMI20111671A1 (it) * 2011-09-16 2013-03-17 Indena Spa Composizioni per il trattamento di ulcere periferiche di varia origine
CN104145966B (zh) * 2014-07-23 2016-09-07 中国人民解放军第二军医大学 白屈菜红碱在制备抗真菌生物被膜药物中的应用
JP6700083B2 (ja) * 2016-03-30 2020-05-27 株式会社ファンケル 口腔内速崩壊錠
JP6700084B2 (ja) * 2016-03-30 2020-05-27 株式会社ファンケル コーティング顆粒
CN106361755A (zh) * 2016-10-23 2017-02-01 徐州诺克非医药科技有限公司 含Zoarenone用于治疗溃疡性结肠炎的药物
JP7011885B2 (ja) * 2016-10-27 2022-01-27 エヌエスイー プロダクツ、インク． 腸の健康を促す組成物
CN108721276B (zh) * 2018-06-29 2020-01-07 佛山科学技术学院 一种小白菊内酯和原花青素复方药物组合物及其用途
CN109549946B (zh) * 2019-01-08 2020-12-18 牡丹江医学院 一种治疗咽炎的药物及其制备方法

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ITMI20042414A1 (it) 2004-12-17 2005-03-17 Indena Spa Formulazione per il trattamento di affezioni delle prime vie respiratorie
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Also Published As

Publication number Publication date
US20170304341A1 (en) 2017-10-26
EP2046324A2 (en) 2009-04-15
EP2520295B1 (en) 2016-08-17
CA2935902A1 (en) 2008-01-31
US20080026058A1 (en) 2008-01-31
KR20090052852A (ko) 2009-05-26
EP2522345A1 (en) 2012-11-14
AU2007278959B2 (en) 2013-03-28
EP2046324B1 (en) 2017-04-05
JP2009544687A (ja) 2009-12-17
PT2046324T (pt) 2017-07-03
PL2046324T3 (pl) 2017-09-29
US9730952B2 (en) 2017-08-15
CA2659211C (en) 2016-08-16
BRPI0715364A2 (pt) 2013-06-18
RU2438693C2 (ru) 2012-01-10
IL196737A (en) 2014-05-28
DK2520295T3 (en) 2016-12-12
PT2520295T (pt) 2016-11-21
RU2009102649A (ru) 2010-08-10
CN101495114A (zh) 2009-07-29
EP1882473A1 (en) 2008-01-30
AU2007278959A1 (en) 2008-01-31
ES2602786T3 (es) 2017-02-22
CA2935902C (en) 2019-02-19
WO2008012666A2 (en) 2008-01-31
IL196737A0 (en) 2009-11-18
MX2009001064A (es) 2009-02-05
HUE031034T2 (en) 2017-06-28
SI2520295T1 (sl) 2016-11-30
NO20090887L (no) 2009-02-26
EP2520295A1 (en) 2012-11-07
HUE031941T2 (en) 2017-08-28
NO341742B1 (no) 2018-01-15
JP5433415B2 (ja) 2014-03-05
DK2046324T3 (en) 2017-06-12
PL2520295T3 (pl) 2017-02-28
SI2046324T1 (sl) 2017-06-30
WO2008012666A3 (en) 2008-09-04
SG172745A1 (en) 2011-07-28
CA2659211A1 (en) 2008-01-31
US20100310684A1 (en) 2010-12-09

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