AR034166A1 - Procedimiento para la preparacion de polvos de inhalacion, y los polvos de inhalacion obtenibles con este procedimiento - Google Patents
Procedimiento para la preparacion de polvos de inhalacion, y los polvos de inhalacion obtenibles con este procedimientoInfo
- Publication number
- AR034166A1 AR034166A1 ARP010104784A ARP010104784A AR034166A1 AR 034166 A1 AR034166 A1 AR 034166A1 AR P010104784 A ARP010104784 A AR P010104784A AR P010104784 A ARP010104784 A AR P010104784A AR 034166 A1 AR034166 A1 AR 034166A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- inhalation powders
- preparation
- substance
- size
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
Abstract
Procedimiento para la preparación de polvos de inhalación, que se caracteriza porque N + m porciones de aproximadamente igual tamano de una sustancia con una distribución mayor del tamano de partículas (coadyuvante) y N porciones de igual tamano de una sustancia con una distribución menor del tamano de partículas (principio activo) se anaden de forma intermitente en capas a un recipiente de mezcla adecuado y, después de la adición completa, las 2N + m capas de los dos componentes se mezclan mediante un mezclador adecuado, efectuándose primeramente la adición de una porción de la sustancia con un tamano de partícula mayor, siendo N un número entero > 0, preferiblemente > 5 y representando m el número 0 ó 1. También se describen los polvos de inhalación obtenibles mediante este procedimiento de preparación que se destinan al tratamiento de una pluralidad de enfermedades, en particular, al tratamiento de enfermedades de las vías respiratorias. Estos polvos de inhalación se distinguen por un grado extraordinariamente elevado de homogeneidad en el sentido de una uniformidad en el contenido. Por consiguiente, el procedimiento descrito más arriba permite resolver los problemas de homogeneidad que presentan los procedimientos conocidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10050635 | 2000-10-12 | ||
| DE2001138022 DE10138022A1 (de) | 2001-08-10 | 2001-08-10 | Verfahren zur Herstellung von Pulverformulierungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034166A1 true AR034166A1 (es) | 2004-02-04 |
Family
ID=26007343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104784A AR034166A1 (es) | 2000-10-12 | 2001-10-12 | Procedimiento para la preparacion de polvos de inhalacion, y los polvos de inhalacion obtenibles con este procedimiento |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US6585959B2 (es) |
| EP (1) | EP1326585B2 (es) |
| JP (2) | JP4986369B2 (es) |
| KR (1) | KR100849837B1 (es) |
| CN (1) | CN1269470C (es) |
| AR (1) | AR034166A1 (es) |
| AT (1) | ATE319422T1 (es) |
| AU (2) | AU1822002A (es) |
| BG (1) | BG66194B1 (es) |
| BR (1) | BR0114316A (es) |
| CA (1) | CA2425005C (es) |
| CY (1) | CY1105037T1 (es) |
| CZ (1) | CZ300022B6 (es) |
| DE (1) | DE50109178D1 (es) |
| DK (1) | DK1326585T4 (es) |
| EA (1) | EA004689B1 (es) |
| EE (1) | EE05146B1 (es) |
| EG (1) | EG24478A (es) |
| ES (1) | ES2259046T5 (es) |
| HR (1) | HRP20030277B1 (es) |
| HU (1) | HU229512B1 (es) |
| IL (2) | IL154919A0 (es) |
| ME (1) | ME02762B (es) |
| MX (1) | MXPA03003219A (es) |
| MY (1) | MY155912A (es) |
| NO (1) | NO333719B1 (es) |
| NZ (1) | NZ525781A (es) |
| PE (1) | PE20020424A1 (es) |
| PL (1) | PL204733B1 (es) |
| PT (1) | PT1326585E (es) |
| RS (1) | RS50495B (es) |
| SA (1) | SA01220518B1 (es) |
| SI (1) | SI1326585T2 (es) |
| SK (1) | SK285841B6 (es) |
| TW (1) | TWI283180B (es) |
| UA (1) | UA75375C2 (es) |
| UY (1) | UY26960A1 (es) |
| WO (1) | WO2002030390A2 (es) |
| ZA (1) | ZA200301349B (es) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL200063B1 (pl) * | 2000-10-12 | 2008-12-31 | Boehringer Ingelheim Pharma | Nowe proszki do inhalacji zawierające tiotropium |
| US6443152B1 (en) * | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
| JP2004538267A (ja) * | 2001-05-25 | 2004-12-24 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 閉塞性気道疾患及びその他の炎症性疾患を治療するためのドーパミンｄ２−受容体アゴニスト及びチオトロピウム又はその誘導体の組み合わせ |
| US20030070679A1 (en) * | 2001-06-01 | 2003-04-17 | Boehringer Ingelheim Pharma Kg | Capsules containing inhalable tiotropium |
| US20030008001A1 (en) * | 2001-06-13 | 2003-01-09 | Boehringer Ingelheim Pharma Kg | Process for cleaning hard gelatine capsules |
| US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| DE10141377A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
| DE10141376A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Inhalationspulvern |
| US7309707B2 (en) * | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
| US7244415B2 (en) * | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
| AU2003221531B2 (en) * | 2002-04-04 | 2008-10-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder formulations suitable for inhalation |
| GB0219513D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Inhalation compositions including coarse carrier |
| US20050158248A1 (en) * | 2002-08-21 | 2005-07-21 | Xian-Ming Zeng | Method of preparing dry powder inhalation compositions |
| GB0219511D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
| JP4744876B2 (ja) * | 2002-08-21 | 2011-08-10 | ノートン・ヘルスケアー リミテッド | 乾燥粉末吸入組成物の製造方法 |
| ATE520405T1 (de) * | 2002-08-21 | 2011-09-15 | Norton Healthcare Ltd | Inhalationszusammensetzung |
| DE10255387A1 (de) * | 2002-11-28 | 2004-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Tiotropium-haltige Pulverformulierung für die Inhalation |
| US7763280B2 (en) | 2002-11-28 | 2010-07-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing powder formulation for inhalation |
| UA83813C2 (ru) * | 2002-12-20 | 2008-08-26 | Бёрингер Ингельхайм Фарма Гмбх & Ко. Кг | Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола |
| DE10317461A1 (de) | 2003-04-16 | 2004-10-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung |
| US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
| US7462367B2 (en) | 2003-07-11 | 2008-12-09 | Boehringer Ingelheim International Gmbh | Anticholinergic powder formulations for inhalation |
| DE10331350A1 (de) * | 2003-07-11 | 2005-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverformulierungen für die Inhalation enthaltend ein neues Anticholinergikum |
| CA2575957C (en) | 2003-09-02 | 2010-11-30 | Norton Healthcare Ltd. | Process for preparing a medicament |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| EP2083007B1 (de) | 2003-11-03 | 2013-04-24 | Boehringer Ingelheim International Gmbh | Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen |
| UY28590A1 (es) | 2003-11-03 | 2005-06-30 | Boehringer Ingelheim Int | Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen. |
| PL1691783T3 (pl) * | 2003-12-03 | 2010-05-31 | Boehringer Ingelheim Int | Inhalator suchego proszku ze wstępnym odmierzaniem do leków wrażliwych na wilgoć |
| DE102004048389A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
| RU2007133547A (ru) | 2005-02-10 | 2009-03-20 | Глаксо Груп Лимитед (GB) | Способы получения лактозы с использованием методов предварительной сортировки и приготовляемые из нее фармацевтические композиции |
| GB0507835D0 (en) * | 2005-04-18 | 2005-05-25 | Solexa Ltd | Method and device for nucleic acid sequencing using a planar wave guide |
| JP5227790B2 (ja) | 2005-05-02 | 2013-07-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規結晶性臭化チオトロピウム |
| DE102005059602A1 (de) | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mikronisierung |
| EP2011538B1 (en) | 2007-07-06 | 2016-02-17 | Vectura Delivery Devices Limited | Inhaler |
| BRPI0814175A2 (pt) * | 2007-07-27 | 2015-01-20 | Cargill Inc | Micronização de polióis |
| EP2082768A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082772A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082771A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082766A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Blister Strip Coil Forming |
| EP2082767A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
| CA2723806C (en) | 2008-05-09 | 2022-05-31 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| US8298616B2 (en) * | 2008-07-24 | 2012-10-30 | American Air Liquide, Inc. | Heteroleptic cyclopentadienyl transition metal precursors for deposition of transition metal-containing films |
| TWI491416B (zh) * | 2008-12-24 | 2015-07-11 | Daiichi Sankyo Co Ltd | 吸入用乾燥粉末醫藥組成物 |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| JP5843777B2 (ja) | 2009-10-27 | 2016-01-13 | ホライラ， インコーポレイテッド | 冷却可能なエネルギー放出アセンブリを有する送達デバイス |
| US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| CN102711645B (zh) | 2009-11-11 | 2016-12-28 | 赫莱拉公司 | 用于处理组织和控制狭窄的系统和装置 |
| EP2575786B1 (en) | 2010-06-03 | 2017-11-15 | Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. | Process for dry powder formulations |
| TR201007251A2 (tr) * | 2010-09-01 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Kalsiyum kanal blokörü formülasyonu. |
| US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| ES2701525T3 (es) | 2014-07-09 | 2019-02-22 | Arven Ilac Sanayi Ve Ticaret As | Un procedimiento para la preparación de formulaciones para inhalación |
| PT3175842T (pt) * | 2015-12-03 | 2020-03-04 | Tiefenbacher Alfred E Gmbh & Co Kg | Processo de mistura de pó seco |
| EP3826620A4 (en) * | 2018-07-12 | 2023-03-08 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising dopamine agonists |
| WO2022146255A1 (en) * | 2020-12-31 | 2022-07-07 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for the preparation of dry powder compositions for inhalation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| US3957965A (en) | 1967-08-08 | 1976-05-18 | Fisons Limited | Sodium chromoglycate inhalation medicament |
| US3860618A (en) | 1967-08-08 | 1975-01-14 | Philip Saxton Hartley | Chromone |
| BE891013A (fr) † | 1980-11-05 | 1982-05-05 | Fisons Ltd | Compositions pharmaceutique |
| JPS60150823A (ja) * | 1984-01-17 | 1985-08-08 | Satake Eng Co Ltd | 穀物混合装置 |
| JPH0439388A (ja) * | 1990-06-04 | 1992-02-10 | Teijin Ltd | 土砂と繊維状物との混合方法 |
| DE4140689B4 (de) * | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| JPH06198156A (ja) * | 1993-01-06 | 1994-07-19 | Nagasaki Pref Gov | 噴霧積層混合器 |
| IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| DE4425255A1 (de) | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| DK1283036T3 (da) | 1998-11-13 | 2008-03-25 | Jagotec Ag | Törpulver til inhalation |
| GB9902689D0 (en) | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
-
2001
- 2001-09-10 UA UA2003054184A patent/UA75375C2/uk unknown
- 2001-10-09 EE EEP200300170A patent/EE05146B1/xx unknown
- 2001-10-09 AU AU1822002A patent/AU1822002A/xx active Pending
- 2001-10-09 MX MXPA03003219A patent/MXPA03003219A/es active IP Right Grant
- 2001-10-09 KR KR1020037005039A patent/KR100849837B1/ko not_active Expired - Lifetime
- 2001-10-09 AT AT01986599T patent/ATE319422T1/de active
- 2001-10-09 BR BR0114316-6A patent/BR0114316A/pt not_active Application Discontinuation
- 2001-10-09 CA CA 2425005 patent/CA2425005C/en not_active Expired - Lifetime
- 2001-10-09 ES ES01986599T patent/ES2259046T5/es not_active Expired - Lifetime
- 2001-10-09 IL IL15491901A patent/IL154919A0/xx active IP Right Grant
- 2001-10-09 EA EA200300429A patent/EA004689B1/ru not_active IP Right Cessation
- 2001-10-09 JP JP2002533833A patent/JP4986369B2/ja not_active Expired - Lifetime
- 2001-10-09 SK SK437-2003A patent/SK285841B6/sk not_active IP Right Cessation
- 2001-10-09 NZ NZ525781A patent/NZ525781A/en not_active IP Right Cessation
- 2001-10-09 TW TW090124981A patent/TWI283180B/zh not_active IP Right Cessation
- 2001-10-09 CZ CZ20031024A patent/CZ300022B6/cs not_active IP Right Cessation
- 2001-10-09 PL PL362511A patent/PL204733B1/pl unknown
- 2001-10-09 AU AU2002218220A patent/AU2002218220B2/en not_active Expired
- 2001-10-09 HR HR20030277A patent/HRP20030277B1/xx not_active IP Right Cessation
- 2001-10-09 CN CNB01817146XA patent/CN1269470C/zh not_active Expired - Lifetime
- 2001-10-09 WO PCT/EP2001/011636 patent/WO2002030390A2/de not_active Ceased
- 2001-10-09 PT PT01986599T patent/PT1326585E/pt unknown
- 2001-10-09 DE DE50109178T patent/DE50109178D1/de not_active Expired - Lifetime
- 2001-10-09 RS YUP-274/03A patent/RS50495B/sr unknown
- 2001-10-09 EP EP01986599A patent/EP1326585B2/de not_active Expired - Lifetime
- 2001-10-09 HU HU0301268A patent/HU229512B1/hu unknown
- 2001-10-09 DK DK01986599.7T patent/DK1326585T4/da active
- 2001-10-09 ME MEP-2008-427A patent/ME02762B/me unknown
- 2001-10-09 SI SI200130509T patent/SI1326585T2/sl unknown
- 2001-10-10 UY UY26960A patent/UY26960A1/es not_active IP Right Cessation
- 2001-10-10 PE PE2001001002A patent/PE20020424A1/es active IP Right Grant
- 2001-10-10 EG EG2001101063A patent/EG24478A/xx active
- 2001-10-10 MY MYPI20014704A patent/MY155912A/en unknown
- 2001-10-11 US US09/977,911 patent/US6585959B2/en not_active Ceased
- 2001-10-12 AR ARP010104784A patent/AR034166A1/es unknown
- 2001-11-11 SA SA01220518A patent/SA01220518B1/ar unknown
-
2003
- 2003-02-19 ZA ZA2003/01349A patent/ZA200301349B/en unknown
- 2003-03-13 IL IL154919A patent/IL154919A/en unknown
- 2003-03-26 BG BG107673A patent/BG66194B1/bg unknown
- 2003-04-11 NO NO20031692A patent/NO333719B1/no not_active IP Right Cessation
-
2004
- 2004-01-28 US US10/766,748 patent/USRE38912E1/en not_active Expired - Lifetime
-
2006
- 2006-05-19 CY CY20061100654T patent/CY1105037T1/el unknown
-
2009
- 2009-06-08 JP JP2009136927A patent/JP2009197025A/ja active Pending
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