AR024517A1 - Compuestos 2-fenilbenzimidazoles sustituidos, medicamentos que los contienen, su uso para preparar dichos medicamentos, compuestos 2,3-diaminobenzamidas deutilidad como intermediarios para su preparacion, procedimiento para la obtencion de estos ultimos y procedimiento de comprobacion in vitro para - Google Patents

Compuestos 2-fenilbenzimidazoles sustituidos, medicamentos que los contienen, su uso para preparar dichos medicamentos, compuestos 2,3-diaminobenzamidas deutilidad como intermediarios para su preparacion, procedimiento para la obtencion de estos ultimos y procedimiento de comprobacion in vitro para

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AR024517A1
AR024517A1 ARP990105543A ARP990105543A AR024517A1 AR 024517 A1 AR024517 A1 AR 024517A1 AR P990105543 A ARP990105543 A AR P990105543A AR P990105543 A ARP990105543 A AR P990105543A AR 024517 A1 AR024517 A1 AR 024517A1
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AR
Argentina
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alkyl
hydrogen
phenyl
compounds
meaning
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ARP990105543A
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English (en)
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Basf Se
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Publication of AR024517A1 publication Critical patent/AR024517A1/es

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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Abstract

Compuestos 2-fenilbenzimidazoles sustituidos de la formula general (1) o (2) donde: R1 significa hidrogeno, alquilo C1-6 ramificado y sin ramificar,pudiendo un átomo de C del radical alquilo llevar aun OR11 o un grupo R5, significando R11 hidrogeno oalquilo C1-4; y R2 significa hidrogeno, cloro, bromo,yodo, fluoro, CF3, nitro, NHCOR21, NR22R23, OH, O-C1-4-alquilo, O-C1-4-alquilfenilo, NH2, fenilo, pudiendo los anillos fenilo estar aun sustituidos por, comomáximo, dos radicales R24, y significando R21 y R22 independientemente hidrogeno o alquilo C1-4, y significando R23, hidrogeno, alquilo C1-4 o fenilo, ysignificando R24, OH, alquilo C1-6, O-alquilo C1-4, cloro, bromo, yodo, fluoro, CF3, nitro, NH2, y x puede ser 0, 1 y 2; y R3 significa -D-(F1)p-(E)q-(F2)r-G,donde p, q y r no pueden significar a la vez 0, o -E-(D)u-(F2)s-(G)v, donde el radical E puede estar sustituido aun por uno o dos radicales A, o R3 es igual aB; y R4 significa hidrogeno, cloro, fluoro, bromo, yodo, alquilo C1-6 ramificado o sin ramificar, OH, nitro, CF3, CN, NR41R42, NH-CO-R43, O-alquilo C1-4, dondeR41 y R42 significan, cada uno independientemente del otro, hidrogeno o alquilo C1-4,y R43 significa hidrogeno, alquilo C1-4, alquil-C1-4-fenilo o fenilo, y endonde D, E, F1, F2, p, q, r, s, u, v, G, A, B y R5 tienen el mismo significado provisto en la memoria descriptiva; y así como sus formas tautomeras,enantiomeras y diastereomeros posibles, y sus prodrogas y sales farmacologicamente toleradas. Medicamentos que contienen junto con los excipientes y auxiliareshabituales un compuesto segun los anteriormente descriptos. Uso de compuestos de la formula (1) para la obtencion de medicamentos para el tratamiento deenfermedades, en las que se presentan actividades patologicamente altas de PARP. Dichas enfermedades pueden ser neurodegenerativas; danos neuronales causadospor isquemias, traumas o hemorragias masivas; apoplejía y trauma cráneo-cerebral; enfermedad de Alzheimer, enfermedad de Parkinson y enfermedad de Huntington.Los medicamentos son de utilidad para el tratamiento o la profilaxis de danos causados por isquemias; para el tratamiento de epilepsias, especialmente ataques
ARP990105543A 1998-11-03 1999-11-02 Compuestos 2-fenilbenzimidazoles sustituidos, medicamentos que los contienen, su uso para preparar dichos medicamentos, compuestos 2,3-diaminobenzamidas deutilidad como intermediarios para su preparacion, procedimiento para la obtencion de estos ultimos y procedimiento de comprobacion in vitro para AR024517A1 (es)

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Application Number Priority Date Filing Date Title
DE19850709 1998-11-03
DE19852801 1998-11-16
DE19908733 1999-03-01

Publications (1)

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AR024517A1 true AR024517A1 (es) 2002-10-16

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Country Status (26)

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US (1) US7781596B1 (es)
EP (2) EP1391457B1 (es)
JP (4) JP2002528531A (es)
KR (1) KR20010100977A (es)
CN (1) CN1331682A (es)
AR (1) AR024517A1 (es)
AT (1) ATE284392T1 (es)
AU (1) AU765224B2 (es)
BG (1) BG105515A (es)
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NO20012158L (no) 2001-06-26
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