AR018452A1 - Compuestos antibioticos de oxazolidinona sustituida, proceso para su preparacion, metodo para producir un efecto antibacteriano, composicionesfarmaceuticas que los contienen y su uso para preparar medicamentos - Google Patents

Compuestos antibioticos de oxazolidinona sustituida, proceso para su preparacion, metodo para producir un efecto antibacteriano, composicionesfarmaceuticas que los contienen y su uso para preparar medicamentos

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Publication number
AR018452A1
AR018452A1 ARP990102657A ARP990102657A AR018452A1 AR 018452 A1 AR018452 A1 AR 018452A1 AR P990102657 A ARP990102657 A AR P990102657A AR P990102657 A ARP990102657 A AR P990102657A AR 018452 A1 AR018452 A1 AR 018452A1
Authority
AR
Argentina
Prior art keywords
carbon
ring
alkyl
linked
nitrogen
Prior art date
Application number
ARP990102657A
Other languages
English (en)
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9812021.5A external-priority patent/GB9812021D0/en
Priority claimed from GBGB9820164.3A external-priority patent/GB9820164D0/en
Priority claimed from GBGB9826066.4A external-priority patent/GB9826066D0/en
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of AR018452A1 publication Critical patent/AR018452A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un compuesto antibiotico de oxazolidinona sustituido de formula (I), o una de sus sales aceptables para uso farmacéutico, o un éster hidrolizableen vivo del mismo, formula (I), donde X es -O-, -S-, -SO- o -SO2-; Het es un anillo heteroarilo de 5 miembros con enlace en C que contiene entre 2 y 4heteroátomos seleccionados independientemente entre N, O y S, cuyo anillo está opcionalmente sustituido en un átomo de carbono disponible por 1 o 2sustituyentes seleccionados independientemente entre C1-4alquilo, amino, alquilamino C1-4, alcoxi C1-4, alcoxicarbonilo C1-4 y halogeno, y/o en un átomode nitrogeno disponible (con la condicion de que el anillo no se cuaternice) por alquilo C1-4; Q se selecciona del grupo Q1 a Q9, donde R2 y R3 sonindependientemente hidrogeno o fluoro; donde A1 es carbono o nitrogeno; B1 es O o S (o, en Q9 solamente, NH); Xq es O, S o N-R1 (donde R1 es hidrogeno,alquilo C1-4 o hidroxi-alquilo C1-4; y donde en Q7 cada A1 es seleccionado independientemente entre carbonoo nitrogeno, con un máximo de 2 heteroátomosde nitrogeno en el anillo de 6 miembros, y q7 está unido a T a través de cualquiera de los átomos de A1 (cuando A1 es carbono), y ligado en el anillo de5 miembros a través del átomo de carboo especificado,o a través de A1 cuando A1 es carbono; Q8 está ligado a T a través de ya sea del átomo de carbonoespecificado en el anillo de 5 miembros, y ligado en el anillo benzo a través de ya sea los dos átomos de carbono especificados en cualquier lado de laligadura que se muestra; y Q9 está ligado a través de ya sea los dos átomos de carbono especificados en cualquier lado de la ligadura que se muestra;donde T se seleciona entre los grupos en (TA) a (TD), (donde AR1, AR2, AR2a, AR3, AR3a, AR3b, AR4, AR4a, CY1 y CY2 se definen más adelante); (TA) T seselecciona entre los grupos siguientes: (TAa) AR1, AR1-(C1-4)alquil-, AR2 (ligado al carbono), AR3; (TAb) AR1-CH(OH), AR2-CH(OH)-, AR3-CH(OH)-; (TAc) AR1-CO-,AR2-CO-, AR3-CO-, AR4-CO-; (TAd) AR1-O-, AR2-O-, AR3-O-; (TAe) AR1-S(O)q-, AR2-S(O)q-, AR3-S(O)q-, (q es 0, 1 o 2); (TAf) un sistema de anillo heteroarilo
ARP990102657A 1998-06-05 1999-06-04 Compuestos antibioticos de oxazolidinona sustituida, proceso para su preparacion, metodo para producir un efecto antibacteriano, composicionesfarmaceuticas que los contienen y su uso para preparar medicamentos AR018452A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9812021.5A GB9812021D0 (en) 1998-06-05 1998-06-05 Chemical compounds
GBGB9820164.3A GB9820164D0 (en) 1998-09-17 1998-09-17 Chemical compounds
GBGB9826066.4A GB9826066D0 (en) 1998-11-28 1998-11-28 Chemical compounds

Publications (1)

Publication Number Publication Date
AR018452A1 true AR018452A1 (es) 2001-11-14

Family

ID=27269342

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102657A AR018452A1 (es) 1998-06-05 1999-06-04 Compuestos antibioticos de oxazolidinona sustituida, proceso para su preparacion, metodo para producir un efecto antibacteriano, composicionesfarmaceuticas que los contienen y su uso para preparar medicamentos

Country Status (22)

Country Link
US (2) US6617339B1 (es)
EP (1) EP1082323A2 (es)
JP (1) JP2002517498A (es)
KR (1) KR20010052615A (es)
CN (1) CN1311787A (es)
AR (1) AR018452A1 (es)
AU (1) AU753988B2 (es)
BG (1) BG105001A (es)
BR (1) BR9910971A (es)
CA (1) CA2333332A1 (es)
EE (1) EE200000707A (es)
HU (1) HUP0103082A3 (es)
ID (1) ID30299A (es)
IL (1) IL140084A0 (es)
IS (1) IS5747A (es)
MX (1) MXPA00011536A (es)
NO (1) NO20006152L (es)
NZ (1) NZ508174A (es)
PL (1) PL345162A1 (es)
SK (1) SK18362000A3 (es)
TR (1) TR200003595T2 (es)
WO (1) WO1999064417A2 (es)

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JP2002517498A (ja) 2002-06-18
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NO20006152L (no) 2001-02-02
US20030144263A1 (en) 2003-07-31
ID30299A (id) 2001-11-22
TR200003595T2 (tr) 2001-07-23
CN1311787A (zh) 2001-09-05
SK18362000A3 (sk) 2001-06-11
EP1082323A2 (en) 2001-03-14
AU753988B2 (en) 2002-10-31
IS5747A (is) 2000-11-30
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BG105001A (en) 2001-09-28
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AU4157199A (en) 1999-12-30
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US6617339B1 (en) 2003-09-09
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