AR013584A1 - Metodo para reducir la cantidad de una proteina de reserva de semilla de soja y la expresion de dos genes en dichas semillas, planta de soja y semillas transgenicas - Google Patents
Metodo para reducir la cantidad de una proteina de reserva de semilla de soja y la expresion de dos genes en dichas semillas, planta de soja y semillas transgenicasInfo
- Publication number
- AR013584A1 AR013584A1 ARP970102604A ARP970102604A AR013584A1 AR 013584 A1 AR013584 A1 AR 013584A1 AR P970102604 A ARP970102604 A AR P970102604A AR P970102604 A ARP970102604 A AR P970102604A AR 013584 A1 AR013584 A1 AR 013584A1
- Authority
- AR
- Argentina
- Prior art keywords
- seeds
- soy
- expression
- genes
- transgenical
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 108010073771 Soybean Proteins Proteins 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 229940001941 soy protein Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pretreatment Of Seeds And Plants (AREA)
Abstract
Esta invencion se relaciona con la construccion de líneas de soja trangénicas donde la expresion de los genes que codifican proteínas de reservade semilla están moduladas para efectuar un cambio en el perfil de proteínas de reserva dese millas de plantas transgénicas. La modificacion del perfil deproteínas de reserva de semilla puede dar como resultado la produccion de nuevos productos de proteínas de soja con características funcionalesvaliosas y unicas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1994096P | 1996-06-14 | 1996-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR013584A1 true AR013584A1 (es) | 2001-01-10 |
Family
ID=21795898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970102604A AR013584A1 (es) | 1996-06-14 | 1997-06-13 | Metodo para reducir la cantidad de una proteina de reserva de semilla de soja y la expresion de dos genes en dichas semillas, planta de soja y semillas transgenicas |
Country Status (13)
Country | Link |
---|---|
US (6) | US6362399B1 (es) |
EP (2) | EP0912749B1 (es) |
JP (2) | JP3928811B2 (es) |
KR (2) | KR100354633B1 (es) |
AR (1) | AR013584A1 (es) |
AT (1) | ATE347604T1 (es) |
AU (1) | AU736671B2 (es) |
BR (1) | BR9709697A (es) |
CA (1) | CA2257198C (es) |
DE (1) | DE69737059D1 (es) |
NZ (1) | NZ332703A (es) |
WO (1) | WO1997047731A2 (es) |
ZA (1) | ZA975205B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6326527B1 (en) * | 1993-08-25 | 2001-12-04 | Dekalb Genetics Corporation | Method for altering the nutritional content of plant seed |
WO1997047731A2 (en) * | 1996-06-14 | 1997-12-18 | E.I. Du Pont De Nemours And Company | Suppression of specific classes of soybean seed protein genes |
US7109392B1 (en) | 1996-10-09 | 2006-09-19 | Cargill, Incorporated | Methods for increasing oleic acid content in seeds from transgenic plants containing a mutant delta 12 desaturase |
US6171640B1 (en) | 1997-04-04 | 2001-01-09 | Monsanto Company | High beta-conglycinin products and their use |
AU761152B2 (en) * | 1998-03-17 | 2003-05-29 | Cargill Incorporated | Genes for mutant microsomal delta-12 fatty acid desaturases and related enzymes from plants |
US6864362B2 (en) | 2000-03-16 | 2005-03-08 | E. I. Du Pont De Nemours And Company | Hypoallergenic transgenic soybeans |
WO2002000904A2 (en) | 2000-06-23 | 2002-01-03 | E. I. Du Pont De Nemours And Company | Recombinant constructs and their use in reducing gene expression |
AU2002225729A1 (en) | 2000-11-14 | 2002-05-27 | E.I. Du Pont De Nemours And Company | Modification of a plant disease resistance gene specificity and method for engineering altered specificity |
WO2003020016A2 (en) * | 2001-09-05 | 2003-03-13 | Monsanto Technology, Llc | SEED SPECIFIC 7S α PROMOTER FOR EXPRESSING GENES IN PLANTS |
ITMI20020147A1 (it) * | 2002-01-29 | 2003-07-29 | Indena Spa | Estrazione purificazione e modificazione di polipeptidi da seme di soia |
DE10212892A1 (de) | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
AU2003298548A1 (en) * | 2002-08-12 | 2004-05-25 | Monsanto Technology Llc | Methods for increasing total oil levels in plants |
AU2003290582A1 (en) * | 2002-11-04 | 2004-06-07 | Florida State University Research Foundation | NUCLEIC ACID AND ALLERGENIC POLYPEPTIDES ENCODED THEREBY IN CASHEW NUTS (Anacardium occidentale) |
US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
WO2005047480A2 (en) | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast |
MX2007004026A (es) * | 2004-10-06 | 2007-06-04 | Sembiosys Genetics Inc | Metodos para la modulacipn de la expresion de oleosina en plantas. |
EP2980220A1 (en) | 2005-09-20 | 2016-02-03 | BASF Plant Science GmbH | Improved methods controlling gene expression |
US7589257B2 (en) | 2006-02-09 | 2009-09-15 | Pioneer Hi-Bred International Inc. | Genes for enhancing nitrogen utilization efficiency in crop plants |
EP2730656A1 (en) | 2007-05-24 | 2014-05-14 | E. I. du Pont de Nemours and Company | Soybean meal from beans having DGAT genes from yarrowia lipolytica for increased seed storage lipid production and altered fatty acid profiles in soybean |
EP2152733A2 (en) | 2007-05-25 | 2010-02-17 | CropDesign N.V. | Yield enhancement in plants by modulation of maize alfins |
US20090106163A1 (en) * | 2007-10-19 | 2009-04-23 | Pioneer Hi-Bred International, Inc. | Electronic forum based on grain quality |
CN101932712B (zh) | 2007-11-20 | 2014-05-14 | 先锋国际良种公司 | 用于改善植物应激耐性的玉米乙烯信号转导基因及其调节 |
BRPI0908642A2 (pt) | 2008-05-23 | 2020-06-23 | E.I. Du Pont De Mours And Company | Polinucleotídeo recombinante, construção de dna recombinante, método para aumentar o teor total de ácido graxo de uma semente, produto ou subproduto, método para produzir uma semente de oleaginosa com um teor total de ácidos graxos aumentado e método para produzir um produto a partir de uma semente de oleaginosa |
US20100313307A1 (en) * | 2008-06-28 | 2010-12-09 | Donald Danforth Plant Science Center | Protein production and storage in plants |
US8779239B2 (en) | 2009-05-04 | 2014-07-15 | Pioneeri Hi-Bred International, Inc. | Yield enhancement in plants by modulation of AP2 transcription factor |
BRPI1008189A2 (pt) | 2009-06-30 | 2015-08-25 | Du Pont | Planta transgenica semente transgenica obtida a partir da planta transgencia semente transgencia metodo de produção de uma planta transgenica metodo de produção de sementes transgenicas metodo de produto e ou subproduto da semente transgenica e semente transgenica obtida pelo metodo |
WO2011017492A2 (en) | 2009-08-05 | 2011-02-10 | Pioneer Hi-Bred International, Inc. | Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants |
US20110061132A1 (en) | 2009-08-20 | 2011-03-10 | Pioneer Hi-Bred International, Inc. | Functional expression of yeast nitrate transporter (ynt1) in maize to improve nitrate uptake |
CA2770854A1 (en) | 2009-08-20 | 2011-02-24 | Pioneer Hi-Bred International, Inc. | Functional expression of shuffled yeast nitrate transporter (ynt1) in maize to improve nitrate uptake under low nitrate environment |
AR078829A1 (es) | 2009-10-30 | 2011-12-07 | Du Pont | Plantas y semillas con niveles alterados de compuesto de almacenamiento, construcciones relacionadas y metodos relacionados con genes que codifican proteinas similares a las aldolasas bacterianas de la clase ii del acido 2,4- dihidroxi-hept-2-eno-1,7-dioico |
EP2860254A1 (en) * | 2010-03-03 | 2015-04-15 | E. I. du Pont de Nemours and Company | Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding oxidoreductase motif polypeptides |
BR112012033668A2 (pt) | 2010-07-01 | 2017-06-13 | Du Pont | planta e semente transgênica, método para a produção de um planta transgênica, produto e/ou subproduto obtido a partir da semente transgênica, polinucleotídeo isolado e planta ou semente compreendendo uma cosntrução de dna recombinante |
US20150159166A1 (en) | 2011-10-31 | 2015-06-11 | Pioneer Hi Bred International Inc | Plant drought tolerance and nitrogen use efficiency by reducing plant sensitivity to ethylene |
KR101493981B1 (ko) | 2011-12-28 | 2015-02-24 | 대한민국 | 콩 베타-콘글리시닌의 3 서브유닛들을 포함한 콩 품종 선별용 프라이머 및 이를 이용한 콩 품종 선별 방법 |
JP6034053B2 (ja) * | 2012-04-26 | 2016-11-30 | トヨタ自動車株式会社 | 植物の種子総量の増産方法 |
WO2013184768A1 (en) | 2012-06-05 | 2013-12-12 | University Of Georgia Research Foundation, Inc. | Compositions and methods of gene silencing in plants |
CN103937750B (zh) * | 2014-03-26 | 2015-04-08 | 北京龙科方舟生物工程技术有限公司 | 抗大豆球蛋白的单克隆抗体及其应用 |
KR101855321B1 (ko) | 2016-11-23 | 2018-06-08 | 주식회사 쓰리에이치굿스 | 무지향성 음향 및 360도 전방위 영상용 스피커 |
Family Cites Families (17)
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US4267118A (en) * | 1979-09-07 | 1981-05-12 | John R. Hersh | Process for producing food grade soybean oil |
US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
US5283323A (en) | 1985-08-07 | 1994-02-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing immune response |
US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
NZ225044A (en) | 1987-06-19 | 1990-01-29 | Plant Cell Res Inst | Bertholletia excelsa dna molecule; sulphur rich storage protein |
EP0318341B1 (en) | 1987-10-20 | 1996-07-31 | Plant Genetic Systems, N.V. | A process for the production of transgenic plants with increased nutritional value via the expression of modified 2S storage albumins in said plants |
US5416011A (en) * | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
JPH02156889A (ja) * | 1988-12-08 | 1990-06-15 | Natl Food Res Inst | グリシニン生産細胞及びグリシニン生産植物の育種方法並びに育種増殖方法 |
AU7583691A (en) | 1990-03-05 | 1991-10-10 | Upjohn Company, The | Protein expression via seed specific regulatory sequences |
DE69233118T2 (de) | 1991-12-04 | 2004-04-15 | E.I. Du Pont De Nemours And Co., Wilmington | Fettsäure-desaturase gene aus pflanzen |
JP3149951B2 (ja) | 1992-03-24 | 2001-03-26 | 株式会社加工米育種研究所 | イネ種子中のグルテリン量の低減方法 |
US6372965B1 (en) * | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
DK0668919T3 (da) * | 1992-11-17 | 2003-09-15 | Du Pont | Gener for mikorsomale delta-12-fedtsyredesaturaser og beslægtede enzymer fra planter |
EP0620281A3 (en) * | 1993-03-31 | 1995-05-03 | Mitsubishi Corp | Oilseed plants producing valuable seeds with modified amino acid and fatty acid compositions. |
EP0754236B1 (en) * | 1994-04-04 | 2004-10-06 | Pioneer Hi-Bred International Inc. | Reduction of endogenous seed protein levels in plants |
AR002176A1 (es) * | 1995-06-02 | 1998-01-07 | Pioneer Hi Bred Int | Metodos mejorados destinados a la produccion de alimentos para animales, mediante la reduccion de los niveles proteinicos endogenados en el poroto. |
WO1997047731A2 (en) * | 1996-06-14 | 1997-12-18 | E.I. Du Pont De Nemours And Company | Suppression of specific classes of soybean seed protein genes |
-
1997
- 1997-06-10 WO PCT/US1997/009743 patent/WO1997047731A2/en active IP Right Grant
- 1997-06-10 AU AU32313/97A patent/AU736671B2/en not_active Ceased
- 1997-06-10 EP EP97927987A patent/EP0912749B1/en not_active Expired - Lifetime
- 1997-06-10 JP JP50168398A patent/JP3928811B2/ja not_active Expired - Fee Related
- 1997-06-10 EP EP10176258A patent/EP2253708A1/en not_active Withdrawn
- 1997-06-10 CA CA2257198A patent/CA2257198C/en not_active Expired - Fee Related
- 1997-06-10 AT AT97927987T patent/ATE347604T1/de not_active IP Right Cessation
- 1997-06-10 KR KR1020017001201A patent/KR100354633B1/ko not_active IP Right Cessation
- 1997-06-10 NZ NZ332703A patent/NZ332703A/xx not_active IP Right Cessation
- 1997-06-10 KR KR1019980710210A patent/KR100316496B1/ko not_active IP Right Cessation
- 1997-06-10 DE DE69737059T patent/DE69737059D1/de not_active Expired - Lifetime
- 1997-06-10 BR BR9709697-0A patent/BR9709697A/pt not_active Application Discontinuation
- 1997-06-12 ZA ZA975205A patent/ZA975205B/xx unknown
- 1997-06-13 AR ARP970102604A patent/AR013584A1/es unknown
-
1998
- 1998-06-30 US US09/108,010 patent/US6362399B1/en not_active Expired - Lifetime
-
2001
- 2001-01-11 US US09/758,652 patent/US6703544B2/en not_active Expired - Lifetime
-
2002
- 2002-02-28 JP JP2002053791A patent/JP3928848B2/ja not_active Expired - Fee Related
-
2003
- 2003-10-14 US US10/684,651 patent/US6828491B2/en not_active Expired - Fee Related
-
2004
- 2004-01-14 US US10/757,074 patent/US20040139502A1/en not_active Abandoned
- 2004-01-14 US US10/757,667 patent/US20040139504A1/en not_active Abandoned
- 2004-01-14 US US10/757,155 patent/US7365242B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2253708A1 (en) | 2010-11-24 |
US7365242B2 (en) | 2008-04-29 |
US20040139502A1 (en) | 2004-07-15 |
AU736671B2 (en) | 2001-08-02 |
KR100354633B1 (ko) | 2002-10-04 |
EP0912749B1 (en) | 2006-12-06 |
BR9709697A (pt) | 1999-10-05 |
EP0912749A1 (en) | 1999-05-06 |
US20040139504A1 (en) | 2004-07-15 |
ATE347604T1 (de) | 2006-12-15 |
AU3231397A (en) | 1998-01-07 |
JP2000515729A (ja) | 2000-11-28 |
CA2257198A1 (en) | 1997-12-18 |
KR100316496B1 (ko) | 2002-08-13 |
DE69737059D1 (de) | 2007-01-18 |
CA2257198C (en) | 2012-10-30 |
US20010011377A1 (en) | 2001-08-02 |
ZA975205B (en) | 1999-01-25 |
US20040064858A1 (en) | 2004-04-01 |
KR20000016614A (ko) | 2000-03-25 |
NZ332703A (en) | 2000-05-26 |
WO1997047731A2 (en) | 1997-12-18 |
JP3928811B2 (ja) | 2007-06-13 |
US20040139503A1 (en) | 2004-07-15 |
JP3928848B2 (ja) | 2007-06-13 |
US6362399B1 (en) | 2002-03-26 |
WO1997047731A3 (en) | 1999-09-30 |
US6828491B2 (en) | 2004-12-07 |
JP2002262894A (ja) | 2002-09-17 |
US6703544B2 (en) | 2004-03-09 |
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