AR005044A1 - Compuesto benzazepina, procedimiento para preparar dicho compuesto benzazepina opticamente activo y un compuesto benzazepina útil como intermediario para su preparacion, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion - Google Patents

Compuesto benzazepina, procedimiento para preparar dicho compuesto benzazepina opticamente activo y un compuesto benzazepina útil como intermediario para su preparacion, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion

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Publication number
AR005044A1
AR005044A1 ARP960105628A ARP960105628A AR005044A1 AR 005044 A1 AR005044 A1 AR 005044A1 AR P960105628 A ARP960105628 A AR P960105628A AR P960105628 A ARP960105628 A AR P960105628A AR 005044 A1 AR005044 A1 AR 005044A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
alkyl group
optionally
substituent
Prior art date
Application number
ARP960105628A
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English (en)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26505504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR005044(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR005044A1 publication Critical patent/AR005044A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un derivado de benzazepina de formula (I), en donde R1 es un atomo de hidrogeno o un atomo de halogeno; A es un grupo alquileno inferior; R2y R3 son iguales o diferentes y cada uno es un atomo de hidrogeno, un grupo alcoxiloinferi or, un grupo alquilo inferior que opcionalmente posee unsustituyente alcoxilo inferior, un grupo alquilo inferior sustituido por hidroxilo, un grupo alquilo inferior sustituido por amino que opcionalmenteposee un sustituyente alquiloinferior, un grupo alquilo inferior sustituido por carbamoilo, un grupo alquilo inferior sustituido por adamantilo, un grupoalquilsulfonilo inferior, un grupo tiazolilo, un grupo fenoxialquilo inferior, un grupo piridilo, un grupo piridilalquiloinferior, un grupo imidazolilalquiloinferior, un grupo fenilo que opcionalmente posee un sustituyente de halogeno o un grupo imidazolilo que opcionalmente posee un sustituyente alquilo inferior oR2 y R3 pueden combinarse junto con el atomo denitrogeno al que estos se enlazan para formar un grupo heterociclico saturado de 5- a 7- miembros quepuede intervenirse o no con otro atomo de nitrogeno o un atomo de oxigeno, en donde dicho grupo heterociclico puede opcionalmente sersustituido por ungrupo alquilo inferior o un grupo fenilalquilo inferior; R4 es un atomo de hidrogeno, un grupo alquilo inferior, un grupo hidroxilo, un grupo amino queopcionalmente posee un sustituyente alcanoilo inferior, un grupo nitro, unatomo de halogeno o un grupo alcoxilo inferior; y R5 es un grupo de la formula:-NHR6 (en donde R6 es un grupo alquilo inferior) o un grupo pirrolidinilo, o una sal del mismo, util para preparar formas de dosificacion que demuestra unaoptimaactividad antivasopresina, actividad antagonica de oxitocina y actividad depresora de vasopresina. Se describe tambien un proceso para preparar un
ARP960105628A 1995-12-15 1996-12-12 Compuesto benzazepina, procedimiento para preparar dicho compuesto benzazepina opticamente activo y un compuesto benzazepina útil como intermediario para su preparacion, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion AR005044A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP32613695 1995-12-15
JP18950096 1996-07-18

Publications (1)

Publication Number Publication Date
AR005044A1 true AR005044A1 (es) 1999-04-07

Family

ID=26505504

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105628A AR005044A1 (es) 1995-12-15 1996-12-12 Compuesto benzazepina, procedimiento para preparar dicho compuesto benzazepina opticamente activo y un compuesto benzazepina útil como intermediario para su preparacion, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion

Country Status (15)

Country Link
US (1) US6096736A (es)
EP (1) EP0877736B1 (es)
KR (1) KR100493503B1 (es)
CN (1) CN1104419C (es)
AR (1) AR005044A1 (es)
AT (1) ATE264845T1 (es)
BR (1) BR9612126A (es)
DE (1) DE69632268T2 (es)
DK (1) DK0877736T3 (es)
ES (1) ES2219703T3 (es)
HK (1) HK1016973A1 (es)
MX (1) MX9804849A (es)
PT (1) PT877736E (es)
TW (1) TW359669B (es)
WO (1) WO1997022591A1 (es)

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US8138342B2 (en) * 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR055054A1 (es) * 2005-04-22 2007-08-01 Wyeth Corp Cristales formados de clorhidrato de (((2r)-7-(2,6-diclorofenil)-5-fluoro-2,3- dihidro-1-benzofurano-2-il) metil ) amina
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WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
JP2008538572A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
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EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
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JP5243455B2 (ja) * 2007-02-23 2013-07-24 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー 新規化合物
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Also Published As

Publication number Publication date
KR20000064406A (ko) 2000-11-06
BR9612126A (pt) 1999-02-17
MX9804849A (es) 1998-09-30
CN1209121A (zh) 1999-02-24
PT877736E (pt) 2004-09-30
DK0877736T3 (da) 2004-08-16
DE69632268T2 (de) 2005-04-21
CN1104419C (zh) 2003-04-02
TW359669B (en) 1999-06-01
EP0877736B1 (en) 2004-04-21
ATE264845T1 (de) 2004-05-15
HK1016973A1 (en) 1999-11-12
WO1997022591A1 (en) 1997-06-26
EP0877736A1 (en) 1998-11-18
KR100493503B1 (ko) 2005-09-30
US6096736A (en) 2000-08-01
ES2219703T3 (es) 2004-12-01
DE69632268D1 (de) 2004-05-27

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