BRPI0415015A - certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos - Google Patents

certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos

Info

Publication number
BRPI0415015A
BRPI0415015A BRPI0415015-5A BRPI0415015A BRPI0415015A BR PI0415015 A BRPI0415015 A BR PI0415015A BR PI0415015 A BRPI0415015 A BR PI0415015A BR PI0415015 A BRPI0415015 A BR PI0415015A
Authority
BR
Brazil
Prior art keywords
pharmaceuticals
certain substituted
substituted spirocyclic
spirocyclic lactams
lactams
Prior art date
Application number
BRPI0415015-5A
Other languages
English (en)
Inventor
Yves Auberson
Ralf Glatthar
Rhys Salter
Oliver Simic
Marina Tintelnot-Blomley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0415015A publication Critical patent/BRPI0415015A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"CERTAS LACTAMAS ESPIROCìCLICAS SUBSTITUìDAS E USO DESTAS COMO PRODUTOS FARMACêUTICOS". A presente invenção refere-se a novas 2-(6-oxo-1,7-diaza-espirol¢4,4!non-7-il)-propionamidas da fórmula onde R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, m e p são como definidos na especificação, para sua preparação, para seu uso como produtos farmacêuticos e para suas composições farmacêuticas que contêm estes.
BRPI0415015-5A 2003-10-03 2004-10-04 certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos BRPI0415015A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0323204.8A GB0323204D0 (en) 2003-10-03 2003-10-03 Organic compounds
PCT/EP2004/011054 WO2005035535A1 (en) 2003-10-03 2004-10-04 Certain substituted spirocyclic lactams and use thereof as pharmaceuticals

Publications (1)

Publication Number Publication Date
BRPI0415015A true BRPI0415015A (pt) 2006-11-07

Family

ID=29415468

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415015-5A BRPI0415015A (pt) 2003-10-03 2004-10-04 certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos

Country Status (16)

Country Link
US (2) US20070015781A1 (pt)
EP (1) EP1670803B1 (pt)
JP (1) JP4549350B2 (pt)
CN (1) CN1863804B (pt)
AT (1) ATE388954T1 (pt)
AU (1) AU2004279553C1 (pt)
BR (1) BRPI0415015A (pt)
CA (1) CA2540249A1 (pt)
DE (1) DE602004012426T2 (pt)
ES (1) ES2300815T3 (pt)
GB (1) GB0323204D0 (pt)
HK (1) HK1092472A1 (pt)
MX (1) MXPA06003645A (pt)
PL (1) PL1670803T3 (pt)
PT (1) PT1670803E (pt)
WO (1) WO2005035535A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351738B2 (en) * 2002-11-27 2008-04-01 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates
CN101193892A (zh) * 2005-06-14 2008-06-04 先灵公司 大环杂环天冬氨酰基蛋白酶抑制剂
WO2007011810A1 (en) * 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
US7745484B2 (en) * 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
EP2331571B1 (en) 2008-09-18 2015-08-26 Northwestern University Nmda receptor modulators and uses thereof
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
JP6531042B2 (ja) 2013-01-29 2019-06-12 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
EA201591404A1 (ru) 2013-01-29 2016-01-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение
SI3514158T1 (sl) 2013-01-29 2023-03-31 Aptinyx Inc. Spirolaktamski modulatorji NMDA-receptorja in njihove uporabe
EA201591405A1 (ru) 2013-01-29 2017-05-31 Аптиникс Инк. Спиролактамные модуляторы nmda-рецептора и их применение
KR20150110787A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
PE20190174A1 (es) 2016-05-19 2019-02-01 Aptinyx Inc Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos
BR112019001921A2 (pt) 2016-08-01 2019-05-14 Aptinyx Inc. moduladores do receptor nmda de espiro-lactama e seus usos
IL264496B (en) 2016-08-01 2022-09-01 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
WO2018026798A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda modulators and methods of using same
US10918637B2 (en) 2016-08-01 2021-02-16 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CA3031537A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
AU2019215058A1 (en) 2018-01-31 2020-09-17 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CN114364380A (zh) * 2019-06-24 2022-04-15 诺雷克斯股份有限公司 (s)-2-((2s,3r)-1-氨基-3-羟基-1-氧代丁烷-2-基)-1-氧代-2,5-二氮杂螺[3.4]辛烷-5-甲酸叔丁酯的固体形式及其制备方法
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
US20240174673A1 (en) * 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Pyridine Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
ES2162503T3 (es) * 1998-06-12 2001-12-16 Hoffmann La Roche Derivados diaza-espiro(3,5)nonanos.
DE60027131D1 (de) * 1999-01-06 2006-05-18 Us Gov Health & Human Serv Inhibitoren für asparagin-proteasen
AU2002256418A1 (en) * 2001-04-27 2002-11-11 Vertex Pharmaceuticals Incorporated Inhibitors of bace
KR20070094802A (ko) * 2004-12-20 2007-09-21 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. ＭｙＤ８８ 동종이량체화 억제제

Also Published As

Publication number Publication date
DE602004012426T2 (de) 2009-03-26
CN1863804B (zh) 2010-05-26
WO2005035535A1 (en) 2005-04-21
HK1092472A1 (en) 2007-02-09
EP1670803A1 (en) 2006-06-21
AU2004279553B2 (en) 2009-03-12
JP2007509038A (ja) 2007-04-12
AU2004279553C1 (en) 2009-07-23
JP4549350B2 (ja) 2010-09-22
CA2540249A1 (en) 2005-04-21
PL1670803T3 (pl) 2008-08-29
PT1670803E (pt) 2008-04-23
GB0323204D0 (en) 2003-11-05
DE602004012426D1 (de) 2008-04-24
US7655686B2 (en) 2010-02-02
AU2004279553A1 (en) 2005-04-21
ES2300815T3 (es) 2008-06-16
US20070265328A1 (en) 2007-11-15
ATE388954T1 (de) 2008-03-15
CN1863804A (zh) 2006-11-15
US20070015781A1 (en) 2007-01-18
MXPA06003645A (es) 2006-06-05
EP1670803B1 (en) 2008-03-12

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 487/10; A61P 25/00

Ipc: C07D 487/10 (2011.01), A61P 25/00 (2011.01)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.