MX362478B - Derivado de benzoazepina novedoso y uso medico del mismo. - Google Patents
Derivado de benzoazepina novedoso y uso medico del mismo.Info
- Publication number
- MX362478B MX362478B MX2015008399A MX2015008399A MX362478B MX 362478 B MX362478 B MX 362478B MX 2015008399 A MX2015008399 A MX 2015008399A MX 2015008399 A MX2015008399 A MX 2015008399A MX 362478 B MX362478 B MX 362478B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- lower alkyl
- alkyl group
- substituted
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un objetivo de la invención actual es a proporcionar un compuesto que tenga una actividad agonista del receptor V2. Se proporciona una composición farmacéutica que contiene, como un ingrediente activo, un compuesto representado por la fórmula general (I) descrita enseguida: Fórmula 1 (ver Fórmula) en donde R1 es la fórmula descrita enseguida: Fórmula 2 (ver Fórmula) (en donde A es un grupo alquileno inferior que puede sustituirse con un grupo alquilo inferior, o similares; R6 es un átomo de hidrógeno, o similares; R7 es un grupo hidroxilo, un grupo heterocíclico aromático que puede sustituirse con un grupo alquilo inferior, un grupo carbamoilo, o similares); R2 es un átomo de hidrógeno o un grupo alquilo inferior; R3 es un grupo alquilo inferior que puede sustituirse con 1 hasta 3 átomos de flúor, o un átomo de halógeno; R4 es un grupo heterocíclico monocíclico aromático de cinco miembros, un grupo heterocíclico monocíclico no aromático de cinco miembros, o similares, (con la condición de que cada uno de estos grupos heterocíclicos contiene al menos un átomo de nitrógeno y puede sustituirse con un grupo alquilo inferior); y R5 es un grupo alquilo inferior, un átomo de halógeno, o similares, o una sal farmacológicamente aceptable del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012281908 | 2012-12-26 | ||
PCT/JP2013/084937 WO2014104209A1 (ja) | 2012-12-26 | 2013-12-26 | 新規ベンゾアゼピン誘導体及びその医薬用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015008399A MX2015008399A (es) | 2015-09-23 |
MX362478B true MX362478B (es) | 2019-01-11 |
Family
ID=51021283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015008399A MX362478B (es) | 2012-12-26 | 2013-12-26 | Derivado de benzoazepina novedoso y uso medico del mismo. |
Country Status (15)
Country | Link |
---|---|
US (1) | US9586905B2 (es) |
EP (1) | EP2940008B1 (es) |
JP (2) | JP5968466B2 (es) |
KR (1) | KR101983880B1 (es) |
CN (1) | CN104884436B (es) |
AU (1) | AU2013367084B2 (es) |
BR (1) | BR112015015663A2 (es) |
CA (1) | CA2889239C (es) |
DK (1) | DK2940008T3 (es) |
ES (1) | ES2633981T3 (es) |
HK (1) | HK1208676A1 (es) |
MX (1) | MX362478B (es) |
PL (1) | PL2940008T3 (es) |
RU (1) | RU2642783C2 (es) |
WO (1) | WO2014104209A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX362478B (es) * | 2012-12-26 | 2019-01-11 | Sanwa Kagaku Kenkyusho Co | Derivado de benzoazepina novedoso y uso medico del mismo. |
JP2022055368A (ja) * | 2019-02-19 | 2022-04-08 | 株式会社三和化学研究所 | ベンゾアゼピン誘導体の製造方法及びその中間体 |
JPWO2020171055A1 (es) * | 2019-02-19 | 2020-08-27 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952573A (en) | 1988-03-23 | 1990-08-28 | Laboratoirs Alcon S.A. | Compounds having GABA like activity, and use of same in tissue irrigating solutions |
US5258510A (en) | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
US5753677A (en) * | 1989-10-20 | 1998-05-19 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
US5985869A (en) | 1989-10-20 | 1999-11-16 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
JP2905909B2 (ja) * | 1991-04-19 | 1999-06-14 | 大塚製薬株式会社 | バソプレシン拮抗剤 |
DE69026708T2 (de) | 1989-10-20 | 1997-04-03 | Otsuka Pharma Co Ltd | Benzoheterozyklische verbindungen |
WO1995034540A1 (en) | 1994-06-15 | 1995-12-21 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic derivatives useful as vasopressin or oxytocin modulators |
JPH09221476A (ja) | 1995-12-15 | 1997-08-26 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
JP2964031B2 (ja) * | 1995-12-15 | 1999-10-18 | 大塚製薬株式会社 | ベンゾアゼピン誘導体 |
TW359669B (en) * | 1995-12-15 | 1999-06-01 | Otsuka Pharma Co Ltd | Benzazepine derivatives |
JPH111456A (ja) | 1997-06-13 | 1999-01-06 | Otsuka Pharmaceut Co Ltd | アミド誘導体 |
JP2926335B2 (ja) | 1997-06-13 | 1999-07-28 | 大塚製薬株式会社 | 医薬組成物 |
DE60233251D1 (de) * | 2001-11-16 | 2009-09-17 | Astellas Pharma Inc | 4,4-difluor-1,2,3,4-tetrahydro-5h-1-benzazepinderivate und deren salze |
JP4238978B2 (ja) * | 2003-04-22 | 2009-03-18 | 大塚製薬株式会社 | ベンゾアゼピン化合物及びその製造法 |
ES2366641T3 (es) * | 2003-04-28 | 2011-10-24 | Astellas Pharma Inc. | Derivado de 4,4-difluoro-1,2,3,4-tetrahidro-5h-1-benzazepina o sal del mismo. |
WO2005037795A2 (en) | 2003-06-17 | 2005-04-28 | Janssen Pharmaceutica N.V. | Substituted spirobenzazepines |
EP1867639A1 (en) * | 2005-03-25 | 2007-12-19 | Kissei Pharmaceutical Co., Ltd. | Urea derivative, medicinal composition containing the same, and medicinal use of these |
JP2010504352A (ja) * | 2006-09-22 | 2010-02-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | バソプレッシン拮抗薬としてのスピロベンズアゼピン類 |
US8987252B2 (en) * | 2007-05-10 | 2015-03-24 | Albany Molecular Research, Inc. | Aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
PL2860175T3 (pl) * | 2012-06-11 | 2018-07-31 | Tacurion | Sposób wytwarzania związku 4,4,7-trifluoro-1,2,3,4-tetrahydro-5h-1-benzazepinowego i związku pośredniego do jego syntezy |
MX362478B (es) * | 2012-12-26 | 2019-01-11 | Sanwa Kagaku Kenkyusho Co | Derivado de benzoazepina novedoso y uso medico del mismo. |
-
2013
- 2013-12-26 MX MX2015008399A patent/MX362478B/es active IP Right Grant
- 2013-12-26 JP JP2014554554A patent/JP5968466B2/ja not_active Expired - Fee Related
- 2013-12-26 PL PL13867980T patent/PL2940008T3/pl unknown
- 2013-12-26 CA CA2889239A patent/CA2889239C/en not_active Expired - Fee Related
- 2013-12-26 US US14/438,920 patent/US9586905B2/en active Active
- 2013-12-26 DK DK13867980.8T patent/DK2940008T3/en active
- 2013-12-26 AU AU2013367084A patent/AU2013367084B2/en not_active Ceased
- 2013-12-26 EP EP13867980.8A patent/EP2940008B1/en active Active
- 2013-12-26 WO PCT/JP2013/084937 patent/WO2014104209A1/ja active Application Filing
- 2013-12-26 RU RU2015131020A patent/RU2642783C2/ru active
- 2013-12-26 CN CN201380067762.7A patent/CN104884436B/zh not_active Expired - Fee Related
- 2013-12-26 KR KR1020157014600A patent/KR101983880B1/ko active IP Right Grant
- 2013-12-26 BR BR112015015663A patent/BR112015015663A2/pt not_active Application Discontinuation
- 2013-12-26 ES ES13867980.8T patent/ES2633981T3/es active Active
-
2015
- 2015-09-24 HK HK15109366.0A patent/HK1208676A1/xx not_active IP Right Cessation
-
2016
- 2016-07-05 JP JP2016133380A patent/JP6231621B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN104884436B (zh) | 2017-06-13 |
DK2940008T3 (en) | 2017-08-07 |
JPWO2014104209A1 (ja) | 2017-01-19 |
KR20150098614A (ko) | 2015-08-28 |
CA2889239A1 (en) | 2014-07-03 |
JP5968466B2 (ja) | 2016-08-10 |
WO2014104209A1 (ja) | 2014-07-03 |
EP2940008A4 (en) | 2016-05-18 |
EP2940008B1 (en) | 2017-05-17 |
JP2016199575A (ja) | 2016-12-01 |
BR112015015663A2 (pt) | 2017-07-11 |
AU2013367084B2 (en) | 2017-06-08 |
US20150291533A1 (en) | 2015-10-15 |
JP6231621B2 (ja) | 2017-11-15 |
MX2015008399A (es) | 2015-09-23 |
HK1208676A1 (en) | 2016-03-11 |
CA2889239C (en) | 2020-10-27 |
KR101983880B1 (ko) | 2019-05-29 |
RU2015131020A (ru) | 2017-01-30 |
CN104884436A (zh) | 2015-09-02 |
PL2940008T3 (pl) | 2017-10-31 |
EP2940008A1 (en) | 2015-11-04 |
ES2633981T3 (es) | 2017-09-26 |
RU2642783C2 (ru) | 2018-01-26 |
AU2013367084A1 (en) | 2015-05-28 |
US9586905B2 (en) | 2017-03-07 |
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Legal Events
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FG | Grant or registration |