AR004708A1 - Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion de dicho derivado. - Google Patents

Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion de dicho derivado.

Info

Publication number
AR004708A1
AR004708A1 ARP960105098A ARP960105098A AR004708A1 AR 004708 A1 AR004708 A1 AR 004708A1 AR P960105098 A ARP960105098 A AR P960105098A AR P960105098 A ARP960105098 A AR P960105098A AR 004708 A1 AR004708 A1 AR 004708A1
Authority
AR
Argentina
Prior art keywords
group
derivative
phenyl
piperidin
alkyl
Prior art date
Application number
ARP960105098A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9513252A external-priority patent/FR2741069B1/fr
Priority claimed from FR9513253A external-priority patent/FR2741070B1/fr
Priority claimed from FR9602663A external-priority patent/FR2745574B1/fr
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR004708A1 publication Critical patent/AR004708A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-3(3H)-ona que responde a la formula general (I): en la cual: R1 representa al grupo (C1-C4)alquilo o (C3-C7) ciclometilo, X1 representa un atomo de hidrogeno o de halogeno o ungru po (C1-C4) alcoxi o bien OR1 y X1 representan conjuntamenteun grupo de formula -OCH2O-, -O(CH2)2-, -O(CH2)3-, -O(CH2)2O- o -O(CH2)3O-, X2 representa un atomo de hidrogeno o un grupo amino, X3 representa un atomo dehidrogeno o de halogeno, yR2 re presenta ya sea un atomo de hidrogeno, ya sea un grupo (C1-C6)alquilo eventualmente sustituido, ya sea un grupo fenil (C1-C4)alquilo eventualmente sustituido sobre el nucleo fenilo, o bien un grupo fenil (C2-C3)alquenilo, o bien un grupofenoxi (C 2-C4)alquilo, o bien un grupo ciclo(C3-C7)alquilmetilo, o bien un grupo 2,3-dihidro-1H-inden1-ilo o 2,3-dihidro- 1H-inden-2-ilo, o bien un grupo de formula general -(CH2)nCO-Z en la cual nrepresenta un numero de 1 a 6 y Z representa ungrupo piperi den-1-ilo o 4- (dimetilamino)-piperidin-1-ilo- en estado de base libre o de sal de adicion conun acido. Un medicamento y una composicion farmaceutica que lo comprende y a un procedimiento de preparacion de dicho derivado. Loscompuestos pueden s erutilizados para el tratamiento y la prevencion de los desordenes en los cuales estan implicados los receptores 5HT4 y/o H4, en especial a nivel del sistemanervioso central, del sistema intestinal, del sistema del aparatourinario inferior o d el sistema cardiovascular.
ARP960105098A 1995-11-09 1996-11-08 Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion de dicho derivado. AR004708A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9513252A FR2741069B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9513253A FR2741070B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9602663A FR2745574B1 (fr) 1996-03-04 1996-03-04 Derives de 5-phenyl-3-(piperidin-4-yl)-1, 3, 4-oxadiazol-2 (3h)-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR004708A1 true AR004708A1 (es) 1999-03-10

Family

ID=27253120

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105098A AR004708A1 (es) 1995-11-09 1996-11-08 Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion de dicho derivado.

Country Status (30)

Country Link
US (1) US5929089A (es)
EP (1) EP0863897B1 (es)
JP (1) JP4263240B2 (es)
CN (1) CN1077891C (es)
AR (1) AR004708A1 (es)
AT (1) ATE181328T1 (es)
AU (1) AU707325B2 (es)
BG (1) BG63463B1 (es)
BR (1) BR9611311A (es)
CA (1) CA2236357C (es)
CO (1) CO4770968A1 (es)
CZ (1) CZ287268B6 (es)
DE (1) DE69602970T2 (es)
EE (1) EE03487B1 (es)
ES (1) ES2135934T3 (es)
GR (1) GR3030823T3 (es)
HK (1) HK1016165A1 (es)
HU (1) HUP0001168A3 (es)
IL (1) IL124364A (es)
MX (1) MX9803696A (es)
NO (1) NO309606B1 (es)
NZ (1) NZ321626A (es)
PL (1) PL186204B1 (es)
RU (1) RU2167160C2 (es)
SI (1) SI0863897T1 (es)
SK (1) SK282335B6 (es)
TR (1) TR199800827T2 (es)
TW (1) TW371303B (es)
UA (1) UA50748C2 (es)
WO (1) WO1997017345A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW467902B (en) 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
FR2762316B1 (fr) * 1997-04-18 1999-12-17 Sanofi Synthelabo Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
FR2763068B1 (fr) * 1997-05-06 1999-06-04 Synthelabo Derives de 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
WO1998050383A1 (fr) * 1997-05-06 1998-11-12 Sanofi-Synthelabo Derives de 5-phenyl-1,3,4-oxadiazol-2(3h)-one et leur utilisation comme ligands 5-ht4
GB9715816D0 (en) * 1997-07-25 1997-10-01 Black James Foundation Histamine H receptor ligands
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
EP1112106B1 (en) 1998-09-18 2005-11-23 Alcon Manufacturing Ltd. Serotonergic 5ht2 agonists for treating glaucoma
WO2000064441A2 (en) * 1999-04-28 2000-11-02 Respiratorius Ab Compound for use as a medicament for treatment of disorders involving bronchocontraction
WO2000076500A2 (en) * 1999-06-15 2000-12-21 Respiratorius Ab Compound for use as a medicament for treatment of disorders involving bronchocontraction
DE60118754T2 (de) * 2000-08-08 2007-01-11 Ortho-Mcneil Pharmaceutical, Inc. Bicyclische verbindungen als h3 rezeptor liganden
CZ2003685A3 (cs) 2000-08-08 2003-08-13 Ortho Mcneil Pharmaceutical Inc. Neimidazolové aryloxypiperidiny
DK1311482T3 (da) 2000-08-08 2007-05-07 Ortho Mcneil Pharm Inc Ikke-imidazolaryloxypiperidiner som H3-receptorligander
ATE449090T1 (de) 2001-07-02 2009-12-15 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
EP1430027B1 (en) 2001-09-14 2010-09-01 High Point Pharmaceuticals, LLC Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
JP2005508907A (ja) * 2001-09-14 2005-04-07 ノボ　ノルディスク　アクティーゼルスカブ ヒスタミンｈ３受容体に選択的に結合する置換されたピペリジン
WO2003031432A1 (en) 2001-10-12 2003-04-17 Novo Nordisk A/S Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
JP2005511764A (ja) 2001-12-14 2005-04-28 アルコン，インコーポレイテッド 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
WO2005123718A2 (en) 2004-06-15 2005-12-29 Pfizer Japan Inc. Benzimidazolone carboxylic acid derivatives
EP2233470B1 (en) * 2005-07-04 2011-12-07 High Point Pharmaceuticals, LLC Histamine H3 receptor antagonists
SG163547A1 (en) 2006-05-29 2010-08-30 High Point Pharmaceuticals Llc 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
MX337721B (es) * 2011-09-19 2016-03-16 Suven Life Sciences Ltd Compuestos de heteroarilo como ligandos del receptor 5-ht4.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243993A (en) * 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
ES2135414T3 (es) * 1991-09-12 1999-11-01 Smithkline Beecham Plc Antagonistas del receptor 5-ht4.
AU667874B2 (en) * 1992-02-06 1996-04-18 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
JPH06157518A (ja) * 1992-11-27 1994-06-03 Yamanouchi Pharmaceut Co Ltd 新規なオキサジアゾール誘導体又はその塩

Also Published As

Publication number Publication date
BG63463B1 (bg) 2002-02-28
WO1997017345A1 (fr) 1997-05-15
BR9611311A (pt) 1999-06-29
CZ287268B6 (en) 2000-10-11
CN1202169A (zh) 1998-12-16
HK1016165A1 (en) 1999-10-29
MX9803696A (es) 1998-09-30
US5929089A (en) 1999-07-27
HUP0001168A3 (en) 2001-07-30
EE9800155A (et) 1998-12-15
JP4263240B2 (ja) 2009-05-13
IL124364A (en) 2001-08-08
HUP0001168A2 (hu) 2001-04-28
TR199800827T2 (xx) 1999-02-22
CN1077891C (zh) 2002-01-16
PL326671A1 (en) 1998-10-12
SK282335B6 (sk) 2002-01-07
TW371303B (en) 1999-10-01
CA2236357A1 (en) 1997-05-15
EP0863897B1 (fr) 1999-06-16
NO982092L (no) 1998-06-29
BG102412A (en) 1999-08-31
CZ142198A3 (cs) 1998-08-12
SK59998A3 (en) 1998-11-04
NO982092D0 (no) 1998-05-07
EE03487B1 (et) 2001-08-15
UA50748C2 (uk) 2002-11-15
ATE181328T1 (de) 1999-07-15
GR3030823T3 (en) 1999-11-30
RU2167160C2 (ru) 2001-05-20
CA2236357C (en) 2006-10-17
JP2000500125A (ja) 2000-01-11
NZ321626A (en) 1998-10-28
DE69602970T2 (de) 2000-01-20
AU7500196A (en) 1997-05-29
AU707325B2 (en) 1999-07-08
NO309606B1 (no) 2001-02-26
ES2135934T3 (es) 1999-11-01
PL186204B1 (pl) 2003-11-28
SI0863897T1 (en) 1999-10-31
CO4770968A1 (es) 1999-04-30
DE69602970D1 (de) 1999-07-22
EP0863897A1 (fr) 1998-09-16
IL124364A0 (en) 1998-12-06

Similar Documents

Publication Publication Date Title
AR004708A1 (es) Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion de dicho derivado.
AR016604A1 (es) Uso de compuestos derivados de eteres vinilicos heterociclicos, compuestos derivados de eteres vinilicos heterociclicos, un procedimiento para laelaboracion de dichos compuestos y medicamentos que contienen uno o mas compuestos derivados de eteres vinilicos heterociclicos
AR018197A1 (es) Compuestos de piperidina, un procedimiento para su preparacion, una composicion y uso del mismo para la preparacion de un medicamento
AR021355A1 (es) Derivados de quinolina. procedimiento para su preparacion, composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de unmedicamento
HUP0302157A2 (hu) 4-(2-Fenil-tiazol-5-il)-1,4-diazabiciklo[3.2.2]nonán-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
AR031526A1 (es) Nuevas fenilpiperazinas, composiciones farmaceuticas que las contienen, metodos para preparar los compuestos y las composiciones y uso de los compuestos en la preparacion de un medicamento.
AR049405A1 (es) Compuesto de dicetopiperazina, composicion farmaceutica que lo comprende, uso del compuesto para la fabricacion de un medicamento y procedimiento para la preparacion del mismo
UY26513A1 (es) Nuevas piperidinas sustituidas, medicamentos que contienen estos compuestos y procedimiento para su preparación.
ES2097490T3 (es) Composiciones farmaceuticas a base de ebastina o de sus analogos.
TR200102811T2 (tr) Oral uygulama için, tolpersiyon içeren farmasötik preparat.
CO5160242A1 (es) UTILIZACION DE DERIVADOS DE PIRIDAZINO [4,5-b] INDOL-1- ACETAMIDA, PARA LA PREPARACION DE MEDICAMENTOS DESTINADOS A LAS ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL
AR002016A1 (es) Derivados de 3-fenilisoquinoleina-1-(2h)-ona, procedimiento para su preparacion y medicamento y composicion farmaceutica que los contienen.
BRPI0413013A (pt) composto, seus sais, solvatos, e derivados farmaceuticamente funcionais, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou profilaxia de condições ou distúrbios, e de doenças
UY24429A1 (es) Acetidinas
BR0100234A (pt) Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos
RU2218334C2 (ru) Замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцин-10-олы и фармацевтическая композиция на их основе
ES2062165T3 (es) Derivado de piperidina, metodo para su preparacion, y una composicion farmaceutica que comprende el mismo.
CA2442210A1 (en) Aryl oxime-piperazines useful as ccr5 antagonists
AR012097A1 (es) UN COMPUESTO DERIVADO DE 2,3-DIHIDROFURO[3,2-B]PIRIDINA, UN PROCEDIMIENTO DE PREPARACIoN DE DICHO COMPUESTO Y UN MEDICAMENTO Y UNA COMPOSICONFARMACEUTICA QUE LO COMPRENDEN.
KR870005641A (ko) 고혈압 치료용 조성물
AR013192A1 (es) Un compuesto derivado de 6-pirrolidin-2-ilpiridina, en forma de isomero optico puro o de mezcla de dichos isomeros, un procedimiento para supreparacion, un medicamento que consiste en dicho compuesto y una composicion farmaceutica que contiene a dicho compuesto
CR6503A (es) Derivados de- 1-trifluorometil-4-hidroxi-7-piperidinil-aminometiclcromano
HUP0002456A2 (hu) 5-Aril-3-(8-azabiciklo[3.2.2]okt-3-il)-1,3,4-oxadiazol-2(3H)-on-származékok mint 5-HT4 receptor ligandumok, eljárás ezek előállítására, valamint ezeket hatóanyagként tartalmazó gyógyszerkészítmények
FR2650505B1 (fr) Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
DE60031557D1 (de) Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen

Legal Events

Date Code Title Description
FG Grant, registration