FR2741070B1 - Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique - Google Patents

Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique

Info

Publication number
FR2741070B1
FR2741070B1 FR9513253A FR9513253A FR2741070B1 FR 2741070 B1 FR2741070 B1 FR 2741070B1 FR 9513253 A FR9513253 A FR 9513253A FR 9513253 A FR9513253 A FR 9513253A FR 2741070 B1 FR2741070 B1 FR 2741070B1
Authority
FR
France
Prior art keywords
oxadiazol
piperidin
phenyl
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9513253A
Other languages
English (en)
Other versions
FR2741070A1 (fr
Inventor
Samir Jegham
Alistair Lochead
Frederic Galli
Alain Nedelec
Axelle Solignac
Cruz Laurence De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9513253A priority Critical patent/FR2741070B1/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to IL12436496A priority patent/IL124364A/xx
Priority to CA002236357A priority patent/CA2236357C/fr
Priority to CZ19981421A priority patent/CZ287268B6/cs
Priority to CN96198208A priority patent/CN1077891C/zh
Priority to HU0001168A priority patent/HUP0001168A3/hu
Priority to NZ321626A priority patent/NZ321626A/xx
Priority to SI9630092T priority patent/SI0863897T1/xx
Priority to US09/068,390 priority patent/US5929089A/en
Priority to SK599-98A priority patent/SK282335B6/sk
Priority to RU98110976/04A priority patent/RU2167160C2/ru
Priority to PCT/FR1996/001730 priority patent/WO1997017345A1/fr
Priority to ES96937390T priority patent/ES2135934T3/es
Priority to JP51791797A priority patent/JP4263240B2/ja
Priority to EP96937390A priority patent/EP0863897B1/fr
Priority to BR9611311A priority patent/BR9611311A/pt
Priority to EE9800155A priority patent/EE03487B1/xx
Priority to PL96326671A priority patent/PL186204B1/pl
Priority to DE69602970T priority patent/DE69602970T2/de
Priority to AT96937390T priority patent/ATE181328T1/de
Priority to UA98031589A priority patent/UA50748C2/uk
Priority to AU75001/96A priority patent/AU707325B2/en
Priority to TR1998/00827T priority patent/TR199800827T2/xx
Priority to KR1019980703468A priority patent/KR100474454B1/ko
Priority to TW085113594A priority patent/TW371303B/zh
Priority to ZA969418A priority patent/ZA969418B/xx
Priority to CO96059097A priority patent/CO4770968A1/es
Priority to ARP960105098A priority patent/AR004708A1/es
Publication of FR2741070A1 publication Critical patent/FR2741070A1/fr
Application granted granted Critical
Publication of FR2741070B1 publication Critical patent/FR2741070B1/fr
Priority to BG102412A priority patent/BG63463B1/bg
Priority to NO982092A priority patent/NO309606B1/no
Priority to MX9803696A priority patent/MX9803696A/es
Priority to HK99101069A priority patent/HK1016165A1/xx
Priority to GR990401913T priority patent/GR3030823T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR9513253A 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique Expired - Fee Related FR2741070B1 (fr)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FR9513253A FR2741070B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
EE9800155A EE03487B1 (et) 1995-11-09 1996-11-05 5-fenüül-3-(piperidin-4-üül)-1,3,4-oksadiasol-2(3H)-ooni derivaadid kasutamiseks 5-HT4 - või H3- retseptorite ligandidena
CZ19981421A CZ287268B6 (en) 1995-11-09 1996-11-05 Derivatives of 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one, process of their preparation and pharmaceutical preparation in which they are comprised
AT96937390T ATE181328T1 (de) 1995-11-09 1996-11-05 5-(phenyl)-3-(4-piperidinyl)-1,3,4-oxadiazol- 2(3h)-on-derivate verwendbar als 5-ht4- oder h3- rezeptorliganden
HU0001168A HUP0001168A3 (en) 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht4 or h3 receptor ligands, process for their preparation and pharmaceuticals containing the same
NZ321626A NZ321626A (en) 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht4 or h3 receptor ligands
SI9630092T SI0863897T1 (en) 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht4- or h3-receptor ligands
US09/068,390 US5929089A (en) 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivatives for use as 5-Ht4 or H3 receptor ligands
SK599-98A SK282335B6 (sk) 1995-11-09 1996-11-05 Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje
RU98110976/04A RU2167160C2 (ru) 1995-11-09 1996-11-05 Производные 5-фенил-3-(пиперидин-4-ил)-1,3,4-оксадиазол-2(3н)-она, способ их получения, фармацевтическая композиция на их основе и лекарственное средство
PCT/FR1996/001730 WO1997017345A1 (fr) 1995-11-09 1996-11-05 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h¿3?
ES96937390T ES2135934T3 (es) 1995-11-09 1996-11-05 Compuesto eventualmente bajo la forma de isomero optico puro o de mezcla de tales isomeros.
JP51791797A JP4263240B2 (ja) 1995-11-09 1996-11-05 ５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途
EP96937390A EP0863897B1 (fr) 1995-11-09 1996-11-05 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h3
BR9611311A BR9611311A (pt) 1995-11-09 1996-11-05 Derivados de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona úteis como ligantes dos receptores 5-ht4 ou h3
CA002236357A CA2236357C (fr) 1995-11-09 1996-11-05 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h3
IL12436496A IL124364A (en) 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol -2(3h)- one derivatives, their preparation and pharmaceutical compositions comprising them
DE69602970T DE69602970T2 (de) 1995-11-09 1996-11-05 5-(phenyl)-3-(4-piperidinyl)-1,3,4-oxadiazol-2(3h)-on-derivate verwendbar als 5-ht4- oder h3-rezeptorliganden
CN96198208A CN1077891C (zh) 1995-11-09 1996-11-05 作为5-ht4或h3受体配位体有效的5-苯基-3-(哌啶-4-基)-1,3,4-噁二唑-2(3h)-酮衍生物
UA98031589A UA50748C2 (uk) 1995-11-09 1996-11-05 Похідні 5-феніл-3(піперидин-4-іл)-1,3,4-оксадіазол-2(3н)ону та фармацевтична композиція
TR1998/00827T TR199800827T2 (xx) 1995-11-09 1996-11-05 5-HT4, H3 resept�r ligandlar� olarak 5-fenil-3-(piperidin-4-il)-1,3,4-oksadiyazol-2(3H)-on t�revleri.
AU75001/96A AU707325B2 (en) 1995-11-09 1996-11-05 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivatives for use as 5-HT4 or H3 receptor ligands
KR1019980703468A KR100474454B1 (ko) 1995-11-09 1996-11-05 5-ht₄또는h₃수용체리간드로서사용하기위한5-페닐-3-(피페리딘-4-일)-1,3,4-옥사디아졸-2(3h)-온유도체
PL96326671A PL186204B1 (pl) 1995-11-09 1996-11-05 Pochodne 5-fenylo-3-(piperydyn-4-ylo)-1,3,4-oksadiazol-2(3H)-onu do stosowania jako ligandy receptora 5-HT lub H
TW085113594A TW371303B (en) 1995-11-09 1996-11-07 5-phenyl-3-(piperidin-4-YL)-1,3,4-oxadiazol-2(3H)-one derivatives, their preparation and their application in therapeutics
ZA969418A ZA969418B (en) 1995-11-09 1996-11-08 5-Phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol 2(3H)-one derivatives their preparation and their application in therapeutics
CO96059097A CO4770968A1 (es) 1995-11-09 1996-11-08 Derivados de 5-fenil-3-(piperidin-4-il)-1,3,4-oxidiazol- 2(3h)-ona, su preparacion y su aplicacion en terapeutica
ARP960105098A AR004708A1 (es) 1995-11-09 1996-11-08 Un derivado de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion de dicho derivado.
BG102412A BG63463B1 (bg) 1995-11-09 1998-04-28 Производни на 5-фенил-3-/пиперидин-4-ил/-1,3,4-оксадиазол- 2-/3н/-он полезни като лиганди на рецепторите 5-нт4 или н3
NO982092A NO309606B1 (no) 1995-11-09 1998-05-07 5-fenyl-3-(piperidin-4-yl)-1,3,4-oksadiazol-2(3H)-on- derivater, deres fremstilling, og medikamenter og farmasöytiske preparater
MX9803696A MX9803696A (es) 1995-11-09 1998-05-08 Derivados de 5-fenil-3-(piperidin-4-il)-1,3,4-oxadiazol-2(3h)-ona para utilizarse como ligandos de 5-ht4o h3.
HK99101069A HK1016165A1 (en) 1995-11-09 1999-03-16 5-Phenyl-3-(peperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht4 or h3 receptor ligands
GR990401913T GR3030823T3 (en) 1995-11-09 1999-07-20 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one derivatives for use as 5-ht 4? or h 3? receptor ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9513253A FR2741070B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2741070A1 FR2741070A1 (fr) 1997-05-16
FR2741070B1 true FR2741070B1 (fr) 1997-12-12

Family

ID=9484380

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9513253A Expired - Fee Related FR2741070B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique

Country Status (2)

Country Link
FR (1) FR2741070B1 (fr)
ZA (1) ZA969418B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
JPH06157518A (ja) * 1992-11-27 1994-06-03 Yamanouchi Pharmaceut Co Ltd 新規なオキサジアゾール誘導体又はその塩

Also Published As

Publication number Publication date
ZA969418B (en) 1997-06-02
FR2741070A1 (fr) 1997-05-16

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Effective date: 20140731