AR004699A1 - Derivados de 2-quinolina inhibidores de la farnesil transferasa, composicion farmaceutica, proceso para preparar dicha composicion, y proceso para preparar dichos derivados. - Google Patents
Derivados de 2-quinolina inhibidores de la farnesil transferasa, composicion farmaceutica, proceso para preparar dicha composicion, y proceso para preparar dichos derivados.Info
- Publication number
- AR004699A1 AR004699A1 ARP960104942A ARP960104942A AR004699A1 AR 004699 A1 AR004699 A1 AR 004699A1 AR P960104942 A ARP960104942 A AR P960104942A AR P960104942 A ARP960104942 A AR P960104942A AR 004699 A1 AR004699 A1 AR 004699A1
- Authority
- AR
- Argentina
- Prior art keywords
- 6alkyl
- 6alkyloxy
- prepare
- derivatives
- aminoc1
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 229950008696 farnesil Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003558 transferase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- -1 C1-6alkyloalkyloxy Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de 2-quinolona que comprenden la fórmula (I) una forma estereoisomérica del mismo, una sal de adición de acido o basefarmacéuticamente aceptable y las formas estereoquímicamente isoméricas del mismo, en los cuales la línea de puntorepresenta un enlace optativo; X esoxígeno o azufre; R1 es H, alquilo C1-2, Ar1, Ar2C1-6alquilo, quinolinilC1-6 alquilo, piridilC1-6alquilo, hidroxiC1-6alquilo, C1-6alquiloxiC1-6alquilo,mono-ó di(C1-6alquilo)aminoC1-6alquilo, aminoC1-6alqui lo, oun radical de la fórmula -Alk1-C(=O)-R9 ó Alk1-S(O)2-R9, donde Alk1 es alcanodiiloC1-6alquilo;R9 es hidroxi, C1-6alquilo, C1-6alquiloalquiloxi, amino, C1-8alquilamino o C1-8alquilamino sustituido con C1-6alquiloxicarbonilo; R2 y R3,independientemente son H, hidroxi, halo, ciano, C1-6alquilo,C1-6alquiloxi, hidroxiC1-6alquiloxi, C1-6alquiloxiC1-6alquiloxi, amino C1-6alquiloxi, mono- odi(C1-6alquil)aminoC1-6alquiloxi, Ar1, Ar2C1-6alquilo, Ar2oxi, Ar2C1-6 alquiloxi,hidroxicarbonilo, C1-6alquiloxocarbonilo, trihalometilo,trihalo-metoxi, C2-6alquenilo; o cuando están en posiciones adyacentes, R2 y R3 juntos pueden formar un radical bivalente de la fórmula:-O-CH2-O- (a-1) -O-CH2-CH2-O- (a-2)-O-CH=CH- (a-3)-O-CH2-CH2- (a-4)-O-CH2-CH2-CH2- (a-5), ó -CJ=CH-CH=CH- (a-6);cada uno de R4 y R5, alquiloindependientemente, es H,C1-6alquilo, C1-6alquiloxiC1-6 , C1-6alquiloxi, C-16alquiltio, amino, hidroxicarbonilo, C1-6
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95202945 | 1995-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004699A1 true AR004699A1 (es) | 1999-03-10 |
Family
ID=8220785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104942A AR004699A1 (es) | 1995-10-31 | 1996-10-28 | Derivados de 2-quinolina inhibidores de la farnesil transferasa, composicion farmaceutica, proceso para preparar dicha composicion, y proceso para preparar dichos derivados. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5968952A (es) |
| EP (2) | EP1019395B1 (es) |
| JP (1) | JP4257869B2 (es) |
| KR (1) | KR100417620B1 (es) |
| CN (1) | CN1101391C (es) |
| AR (1) | AR004699A1 (es) |
| AT (2) | ATE212627T1 (es) |
| AU (1) | AU712435B2 (es) |
| CA (1) | CA2231143C (es) |
| CY (1) | CY2287B1 (es) |
| CZ (1) | CZ290954B6 (es) |
| DE (2) | DE69632751T2 (es) |
| DK (1) | DK1019395T3 (es) |
| EA (1) | EA000719B1 (es) |
| ES (2) | ES2233557T3 (es) |
| HK (2) | HK1027576A1 (es) |
| HU (1) | HU224032B1 (es) |
| IL (1) | IL123567A (es) |
| MY (1) | MY116577A (es) |
| NO (1) | NO314037B1 (es) |
| NZ (1) | NZ321576A (es) |
| PL (1) | PL184168B1 (es) |
| PT (1) | PT1019395E (es) |
| SI (1) | SI1019395T1 (es) |
| SK (1) | SK282642B6 (es) |
| TR (1) | TR199800720T2 (es) |
| TW (1) | TW349948B (es) |
| WO (1) | WO1997016443A1 (es) |
| ZA (1) | ZA969087B (es) |
Families Citing this family (91)
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|---|---|---|---|---|
| US3900501A (en) * | 1970-12-23 | 1975-08-19 | Hoffmann La Roche | Benzophenone intermediates for 7-lower alkanoyl benzodiazepines |
| IL65709A (en) * | 1981-05-18 | 1986-01-31 | Chevron Res | Electroactive polymers |
| JPS63275548A (ja) * | 1987-05-02 | 1988-11-14 | Res Inst For Prod Dev | ｏ−アミノベンゾイル化合物の製造方法 |
| CA2002859C (en) * | 1988-11-29 | 1998-12-29 | Jean P. F. Van Wauwe | Method of treating epithelial disorders |
| CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| EP0574992A1 (en) * | 1992-06-17 | 1993-12-22 | Glaxo Group Limited | 5-(1,2,4-Triazol-1-ylmethyl)-3H-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors |
| ES2134971T3 (es) * | 1994-04-15 | 1999-10-16 | Takeda Chemical Industries Ltd | Derivado de acido octahidro-2-naftaleno-carboxilico, su produccion y uso. |
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