MX9802067A - Derivados de la 2-quinolona inhibidores de la farnesil transferasa. - Google Patents

Derivados de la 2-quinolona inhibidores de la farnesil transferasa.

Info

Publication number
MX9802067A
MX9802067A MX9802067A MX9802067A MX9802067A MX 9802067 A MX9802067 A MX 9802067A MX 9802067 A MX9802067 A MX 9802067A MX 9802067 A MX9802067 A MX 9802067A MX 9802067 A MX9802067 A MX 9802067A
Authority
MX
Mexico
Prior art keywords
6alkyl
6alkyloxy
hydrogen
aminoc1
ar2c1
Prior art date
Application number
MX9802067A
Other languages
English (en)
Other versions
MXPA98002067A (es
Inventor
David William End
Marc Gaston Venet
Patrick Rene Angibaud
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX9802067A publication Critical patent/MX9802067A/es
Publication of MXPA98002067A publication Critical patent/MXPA98002067A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a compuestos de la formula (I) (Ver Formula), las formas estereoisoméricas de los mismos y las sales de adicion de ácido o base farmacéuticamente aceptable de los mismos, en los cuales la línea de puntos representa un enlace optativo; x es oxígeno o azufre; R1 es hidrogeno, alquilo C1-&, Ar1, Ar2C1-6alquilo, quinolinilC1-6aqluilo, piridilC1-6alquilo, hidroxiC1-6alquilo, C1-6alquiloxiC1-6alquilo, mono- o di(C1-6alquilo)aminoC1-6alquilo, amonoC1-6alquilo, o un radical de la formula -A1k1-C(=0)- R9 o A1k1-S(O)2-R9; R9 y R1 y R3, independientemente, son hidrogeno, hidroxi, halo, ciano, halo, ciano, C1-6alquilo, C1-6alquiloxi, hidroxiC1-6alquiloxi, C1-6alquiloxiC1-6alquiloxi, aminoC1-6alquiloxi, mono- o di(C1-6alquilo)aminoC1-6alquiloxi, Ar1, Ar2C1-6alquilo, Ar2oxi, Ar2C1-6aqluiloxi, hidroxicarbonilo, C1-6alquiloxicarbonilo, trihalometilo, trihalometoxi, C2-6alquenilo; o cuando están en posiciones adyacentes, R2 y R3 juntos pueden formar un radical bivalente; cada uno de R4 y R5, independientemente, es hidrogeno, C1-6alquilo, C1-6alquiloxiC1-6alquilo, C1-6alquiloxi, C1-6alquitio, amino, hidroxicarbonilo, C1-6alquiloxicarbonilo, C1-6alquilS(O)C1-6alquilo o C1-6alquilos(O)(2(c1-alquilo; cada uno de R6 y R7; independientemente, es hidrogeno, halo, ciano, C1-6alquilo, C1-6alquiloxi o Ar2ox1; R8 es hidrogeno, C1-6alquilo, ciano, hidroxicarbonilo, C1-6alquiloxicarbonilo, C1-6alquilcarboniloC1-6alquilo, cianoC1-6alquilo, C1-6alquiloxicarbonil C1-6alquilo, hidroxicarbonilC1-6alquilo, hidroxiC1-6aqluilo, aminoC1-6alquilo, mono- o di(C1-6alquil)-aminoC1-6alquilo, haloC1-6alquilo, C1-6aqluiloxiC1-6alquilo, aminocarboniloC1-6alquilo, Ar1C1-6alquiloxiC1-6alquilo, C1-6alquiltioC1-6alquilo; R10 es hidrogeno, C1-6alquilo; C1-6alquiloxi o halo; R11 es hidrogeno o C1-6alquilo; que tienen actividad inhibidora de la farnesiltransfereasa; su preparacion las composiciones que los contienen y su uso como medicamento.
MXPA/A/1998/002067A 1995-10-31 1998-03-16 Derivados de la 2-quinolona inhibidores de la farnesil transferasa MXPA98002067A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95202945 1995-10-31
EP95202945.2 1995-10-31

Publications (2)

Publication Number Publication Date
MX9802067A true MX9802067A (es) 1998-08-30
MXPA98002067A MXPA98002067A (es) 1998-11-12

Family

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Also Published As

Publication number Publication date
CN1101391C (zh) 2003-02-12
DE69618999T2 (de) 2002-09-26
ZA969087B (en) 1998-04-29
EP1106610B1 (en) 2004-06-16
MY116577A (en) 2004-02-28
JP4257869B2 (ja) 2009-04-22
NO980928D0 (no) 1998-03-04
NZ321576A (en) 1999-05-28
AU7493396A (en) 1997-05-22
IL123567A0 (en) 1998-10-30
DK1019395T3 (da) 2002-05-06
HUP9802424A3 (en) 2003-02-28
SK55698A3 (en) 1999-02-11
ATE269322T1 (de) 2004-07-15
IL123567A (en) 2002-11-10
CZ127298A3 (cs) 1998-12-16
EA199800395A1 (ru) 1998-10-29
DE69632751T2 (de) 2005-08-04
CY2287B1 (en) 2003-07-04
CA2231143C (en) 2005-06-21
HK1036064A1 (en) 2001-12-21
TR199800720T2 (xx) 1998-09-21
US5968952A (en) 1999-10-19
CZ290954B6 (cs) 2002-11-13
TW349948B (en) 1999-01-11
PT1019395E (pt) 2002-07-31
JPH11514635A (ja) 1999-12-14
DE69618999D1 (de) 2002-03-14
ES2233557T3 (es) 2005-06-16
AU712435B2 (en) 1999-11-04
WO1997016443A1 (en) 1997-05-09
KR19990063639A (ko) 1999-07-26
DE69632751D1 (de) 2004-07-22
KR100417620B1 (ko) 2004-05-27
HK1027576A1 (en) 2001-01-19
EP1019395B1 (en) 2002-01-30
CA2231143A1 (en) 1997-05-09
HU224032B1 (hu) 2005-05-30
AR004699A1 (es) 1999-03-10
EP1106610A1 (en) 2001-06-13
CN1200732A (zh) 1998-12-02
PL328230A1 (en) 1999-01-18
EA000719B1 (ru) 2000-02-28
EP1019395A1 (en) 2000-07-19
ES2171736T3 (es) 2002-09-16
NO980928L (no) 1998-04-29
HUP9802424A2 (hu) 1999-10-28
NO314037B1 (no) 2003-01-20
SK282642B6 (sk) 2002-10-08
ATE212627T1 (de) 2002-02-15
PL184168B1 (pl) 2002-09-30
SI1019395T1 (en) 2002-06-30

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