AP438A - "6-(Substituted-methylene) penems and derivatives thereof and their use in pharmaceutical compositions". - Google Patents
"6-(Substituted-methylene) penems and derivatives thereof and their use in pharmaceutical compositions". Download PDFInfo
- Publication number
- AP438A AP438A APAP/P/1993/000585A AP9300585A AP438A AP 438 A AP438 A AP 438A AP 9300585 A AP9300585 A AP 9300585A AP 438 A AP438 A AP 438A
- Authority
- AP
- ARIPO
- Prior art keywords
- formula
- compound
- group
- dihydro
- carboxylate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Ink Jet (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929222700A GB9222700D0 (en) | 1992-10-29 | 1992-10-29 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9300585A0 AP9300585A0 (en) | 1993-10-31 |
| AP438A true AP438A (en) | 1995-11-24 |
Family
ID=10724235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1993/000585A AP438A (en) | 1992-10-29 | 1993-10-28 | "6-(Substituted-methylene) penems and derivatives thereof and their use in pharmaceutical compositions". |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US5602250A (cs) |
| EP (1) | EP0666862B1 (cs) |
| JP (1) | JP3488457B2 (cs) |
| KR (1) | KR100295710B1 (cs) |
| CN (3) | CN1044247C (cs) |
| AP (1) | AP438A (cs) |
| AT (1) | ATE191914T1 (cs) |
| AU (1) | AU687365B2 (cs) |
| BR (1) | BR1100542A (cs) |
| CA (1) | CA2147755C (cs) |
| CZ (1) | CZ293106B6 (cs) |
| DE (1) | DE69328436T2 (cs) |
| DK (1) | DK0666862T3 (cs) |
| ES (1) | ES2145064T3 (cs) |
| FI (1) | FI114638B (cs) |
| GB (1) | GB9222700D0 (cs) |
| GR (1) | GR3033448T3 (cs) |
| HU (1) | HUT71467A (cs) |
| IL (1) | IL107431A (cs) |
| MA (1) | MA23017A1 (cs) |
| MX (1) | MX9306679A (cs) |
| MY (1) | MY117265A (cs) |
| NO (1) | NO306903B1 (cs) |
| NZ (1) | NZ257109A (cs) |
| PH (1) | PH30919A (cs) |
| PL (1) | PL177840B1 (cs) |
| PT (1) | PT666862E (cs) |
| RU (1) | RU2133750C1 (cs) |
| SA (1) | SA93140373B1 (cs) |
| SI (1) | SI9300574A (cs) |
| SK (1) | SK281870B6 (cs) |
| TW (1) | TW400332B (cs) |
| WO (1) | WO1994010178A1 (cs) |
| ZA (1) | ZA937993B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| GB9326248D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Plc | Pharmaceutical formulations |
| MX9605149A (es) * | 1994-04-25 | 1997-12-31 | Smithkline Beecham Plc | Formulaciones farmaceuticas que contienen una penema inhibidora de beta-lactamasa en combinacion con un antibiotico de beta-lactama y su uso en el tratamiento de infecciones bacterianas. |
| US6472383B1 (en) | 1994-04-25 | 2002-10-29 | Smithkline Beecham P.L.C. | Pharmaceutical formulations |
| US6969303B1 (en) * | 1994-10-12 | 2005-11-29 | Nextec, Inc. | Method and composition for removing coatings which contain hazardous elements |
| AU2001225605A1 (en) * | 2000-10-03 | 2002-04-15 | Elena Alexandrovna Izakson | Thiazine derivatives |
| ES2438985T3 (es) | 2001-09-14 | 2014-01-21 | Glaxo Group Limited | Formulación de inhalación que comprende derivados de fenetanolamina para el tratamiento de enfermedades respiratorias |
| AR039475A1 (es) | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| FR2844807B1 (fr) * | 2002-09-23 | 2005-11-11 | Rambach Alain | Procede de detection de microorganismes resistants a la meticilline |
| JP2007501635A (ja) * | 2003-05-16 | 2007-02-01 | ワイス・ホールディングズ・コーポレイション | β−ラクタマーゼ阻害剤中間体を合成するための方法 |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| WO2007063384A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| EP2316821A1 (en) * | 2009-10-27 | 2011-05-04 | Novartis AG | Process for the manufacture of organic compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987000525A1 (en) * | 1985-07-22 | 1987-01-29 | Beecham Group P.L.C. | 6-alkylidene penems |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2541924A (en) * | 1948-09-17 | 1951-02-13 | Lilly Co Eli | Synthesis of substituted imidazoles |
| GB1403841A (en) * | 1973-03-22 | 1975-08-28 | Ici Ltd | Imidazo heterocyclic derivatives |
| US4137320A (en) * | 1974-02-07 | 1979-01-30 | Plantex, Ltd. | Pharmaceutical compositions containing imidazo(2,1-b)thiazoles and process for reducing blood sugar levels therewith |
| DE2949167A1 (de) * | 1978-12-08 | 1980-06-26 | Ciba Geigy Ag | Photographisches material fuer das silberfarbbleichverfahren |
| FI82471C (fi) * | 1984-01-26 | 1991-03-11 | Beecham Group Plc | Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater. |
| US5015473A (en) * | 1984-01-30 | 1991-05-14 | Pfizer Inc. | 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof |
| GB8518421D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| EP1019397A4 (en) | 1995-11-08 | 2001-01-17 | Smithkline Beecham Corp | PROCESS FOR PRODUCING 3-PHENYL-1-METHYLENEDIOXYPHENYL-INDANE-2-CARBOXYLIC ACID DERIVATIVES |
-
1992
- 1992-10-29 GB GB929222700A patent/GB9222700D0/en active Pending
-
1993
- 1993-10-15 PH PH47096A patent/PH30919A/en unknown
- 1993-10-20 US US08/428,101 patent/US5602250A/en not_active Expired - Lifetime
- 1993-10-20 DE DE69328436T patent/DE69328436T2/de not_active Expired - Fee Related
- 1993-10-20 HU HU9501226A patent/HUT71467A/hu unknown
- 1993-10-20 EP EP93923504A patent/EP0666862B1/en not_active Expired - Lifetime
- 1993-10-20 CA CA002147755A patent/CA2147755C/en not_active Expired - Fee Related
- 1993-10-20 PT PT93923504T patent/PT666862E/pt unknown
- 1993-10-20 WO PCT/EP1993/002894 patent/WO1994010178A1/en not_active Ceased
- 1993-10-20 PL PL93308643A patent/PL177840B1/pl not_active IP Right Cessation
- 1993-10-20 NZ NZ257109A patent/NZ257109A/en not_active IP Right Cessation
- 1993-10-20 CZ CZ19951053A patent/CZ293106B6/cs not_active IP Right Cessation
- 1993-10-20 JP JP51063794A patent/JP3488457B2/ja not_active Expired - Fee Related
- 1993-10-20 ES ES93923504T patent/ES2145064T3/es not_active Expired - Lifetime
- 1993-10-20 KR KR1019950701652A patent/KR100295710B1/ko not_active Expired - Fee Related
- 1993-10-20 AT AT93923504T patent/ATE191914T1/de not_active IP Right Cessation
- 1993-10-20 SK SK540-95A patent/SK281870B6/sk not_active IP Right Cessation
- 1993-10-20 RU RU95110049A patent/RU2133750C1/ru active
- 1993-10-20 AU AU53355/94A patent/AU687365B2/en not_active Ceased
- 1993-10-20 DK DK93923504T patent/DK0666862T3/da active
- 1993-10-27 MA MA23323A patent/MA23017A1/fr unknown
- 1993-10-27 MX MX9306679A patent/MX9306679A/es not_active IP Right Cessation
- 1993-10-27 ZA ZA937993A patent/ZA937993B/xx unknown
- 1993-10-27 MY MYPI93002250A patent/MY117265A/en unknown
- 1993-10-28 CN CN93119574A patent/CN1044247C/zh not_active Expired - Fee Related
- 1993-10-28 IL IL10743193A patent/IL107431A/en not_active IP Right Cessation
- 1993-10-28 AP APAP/P/1993/000585A patent/AP438A/en active
- 1993-10-29 SI SI9300574A patent/SI9300574A/sl unknown
- 1993-10-30 TW TW082109081A patent/TW400332B/zh not_active IP Right Cessation
- 1993-11-27 SA SA93140373A patent/SA93140373B1/ar unknown
-
1995
- 1995-04-28 NO NO951634A patent/NO306903B1/no not_active IP Right Cessation
- 1995-04-28 FI FI952063A patent/FI114638B/fi active IP Right Grant
- 1995-05-24 US US08/448,730 patent/US6037469A/en not_active Expired - Fee Related
- 1995-05-24 US US08/448,941 patent/US6600035B1/en not_active Expired - Fee Related
-
1997
- 1997-05-13 BR BR1100542-4A patent/BR1100542A/pt active IP Right Grant
-
1998
- 1998-08-11 CN CN98118447A patent/CN1102595C/zh not_active Expired - Fee Related
- 1998-08-11 CN CNB001068075A patent/CN1143851C/zh not_active Expired - Fee Related
-
2000
- 2000-05-19 GR GR20000401136T patent/GR3033448T3/el not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987000525A1 (en) * | 1985-07-22 | 1987-01-29 | Beecham Group P.L.C. | 6-alkylidene penems |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP438A (en) | "6-(Substituted-methylene) penems and derivatives thereof and their use in pharmaceutical compositions". | |
| EP0758240B1 (en) | Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections | |
| EP0231244A1 (en) | 6-alkylidene penems | |
| AU715163B2 (en) | 6-(substituted methylene) penems and intermediates | |
| CA2188695C (en) | Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections | |
| HK1012375B (en) | 6-(substituted methylene) penems and intermediates | |
| US6472383B1 (en) | Pharmaceutical formulations |