AP3607A - Substituted imidazopyridazines - Google Patents

Substituted imidazopyridazines

Info

Publication number
AP3607A
AP3607A AP2013006790A AP2013006790A AP3607A AP 3607 A AP3607 A AP 3607A AP 2013006790 A AP2013006790 A AP 2013006790A AP 2013006790 A AP2013006790 A AP 2013006790A AP 3607 A AP3607 A AP 3607A
Authority
AP
ARIPO
Prior art keywords
substituted imidazopyridazines
imidazopyridazines
substituted
Prior art date
Application number
AP2013006790A
Other languages
English (en)
Other versions
AP2013006790A0 (en
Inventor
Ulrich Klar
Marcus Koppitz
Rolf Jautelat
Dirk Kosemund
Rolf Bohlmann
Philip Lienau
Gerhard Siemeister
Antje Margret Wengner
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of AP2013006790A0 publication Critical patent/AP2013006790A0/xx
Application granted granted Critical
Publication of AP3607A publication Critical patent/AP3607A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)
AP2013006790A 2010-09-10 2011-09-06 Substituted imidazopyridazines AP3607A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10176134 2010-09-10
EP11075022 2011-02-04
EP11170771 2011-06-21
EP11170775 2011-06-21
PCT/EP2011/065368 WO2012032031A1 (en) 2010-09-10 2011-09-06 Substituted imidazopyridazines

Publications (2)

Publication Number Publication Date
AP2013006790A0 AP2013006790A0 (en) 2013-04-30
AP3607A true AP3607A (en) 2016-02-26

Family

ID=44545741

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013006790A AP3607A (en) 2010-09-10 2011-09-06 Substituted imidazopyridazines

Country Status (38)

Country Link
US (1) US9255100B2 (ru)
EP (1) EP2614063B1 (ru)
JP (1) JP5824050B2 (ru)
KR (1) KR20140032337A (ru)
CN (1) CN103370318B (ru)
AP (1) AP3607A (ru)
AR (1) AR082946A1 (ru)
AU (1) AU2011298844B2 (ru)
BR (1) BR112013005679A2 (ru)
CA (1) CA2810755A1 (ru)
CO (1) CO6720961A2 (ru)
CR (1) CR20130102A (ru)
CU (1) CU24187B1 (ru)
CY (1) CY1117352T1 (ru)
DK (1) DK2614063T3 (ru)
DO (1) DOP2013000054A (ru)
EA (1) EA023420B1 (ru)
EC (1) ECSP13012752A (ru)
ES (1) ES2568220T3 (ru)
HK (1) HK1187623A1 (ru)
HR (1) HRP20160360T1 (ru)
HU (1) HUE028771T2 (ru)
IL (1) IL225058A (ru)
MA (1) MA34516B1 (ru)
ME (1) ME02389B (ru)
MX (1) MX2013002713A (ru)
MY (1) MY185139A (ru)
NZ (1) NZ607904A (ru)
PE (1) PE20131164A1 (ru)
PL (1) PL2614063T3 (ru)
RS (1) RS54661B1 (ru)
SA (1) SA111320735B1 (ru)
SG (1) SG188417A1 (ru)
SI (1) SI2614063T1 (ru)
TW (1) TWI541243B (ru)
UY (1) UY33598A (ru)
WO (1) WO2012032031A1 (ru)
ZA (1) ZA201301756B (ru)

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ME02651B (me) 2012-06-13 2017-06-20 Incyte Holdings Corp Substituisana triciklična jedinjenja kao inhibitori fgfr
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US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
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US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
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MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
CN107567503B (zh) 2015-04-17 2022-03-22 荷兰转化研究中心有限责任公司 用于ttk抑制剂化疗的预后生物标记
WO2016187028A1 (en) * 2015-05-15 2016-11-24 Celgene Avilomics Research, Inc. Heteroaryl compounds, synthesis thereof, and intermediates thereto
EP3383796B1 (en) * 2015-12-04 2020-09-16 ExxonMobil Research and Engineering Company Emm-28, a novel synthetic crystalline material, its preparation and use
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
ES2945108T3 (es) 2016-07-18 2023-06-28 Univ Health Network Formas sólidas de inhibidor de TTK
CN110753560B (zh) * 2017-04-11 2022-07-26 斯特劳曼控股公司 牙科植入物
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
WO2019213544A2 (en) 2018-05-04 2019-11-07 Incyte Corporation Solid forms of an fgfr inhibitor and processes for preparing the same
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
AU2020221247A1 (en) 2019-02-12 2021-08-05 Sumitomo Pharma Oncology, Inc. Formulations comprising heterocyclic protein kinase inhibitors
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
CN111978325B (zh) * 2019-05-22 2023-11-17 中国药科大学 咪唑并哒嗪类mnk1/mnk2激酶抑制剂及其制备方法和应用
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JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Fgfr阻害剤としての三環式複素環
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Also Published As

Publication number Publication date
AU2011298844A1 (en) 2013-03-28
PL2614063T3 (pl) 2016-06-30
RS54661B1 (en) 2016-08-31
EA201390339A1 (ru) 2013-09-30
MY185139A (en) 2021-04-30
ES2568220T3 (es) 2016-04-28
SI2614063T1 (sl) 2016-05-31
MX2013002713A (es) 2013-05-22
JP5824050B2 (ja) 2015-11-25
CN103370318B (zh) 2016-04-20
HUE028771T2 (en) 2016-12-28
CO6720961A2 (es) 2013-07-31
DK2614063T3 (en) 2016-04-18
TWI541243B (zh) 2016-07-11
HK1187623A1 (zh) 2014-04-11
WO2012032031A1 (en) 2012-03-15
UY33598A (es) 2012-04-30
AR082946A1 (es) 2013-01-23
EP2614063A1 (en) 2013-07-17
KR20140032337A (ko) 2014-03-14
CY1117352T1 (el) 2017-04-26
DOP2013000054A (es) 2013-07-31
CN103370318A (zh) 2013-10-23
ECSP13012752A (es) 2014-01-31
AP2013006790A0 (en) 2013-04-30
SG188417A1 (en) 2013-04-30
NZ607904A (en) 2015-02-27
CU20130033A7 (es) 2013-08-29
JP2013537174A (ja) 2013-09-30
HRP20160360T1 (hr) 2016-05-06
TW201211049A (en) 2012-03-16
CR20130102A (es) 2013-04-17
PE20131164A1 (es) 2013-10-30
US20130338133A1 (en) 2013-12-19
US9255100B2 (en) 2016-02-09
EP2614063B1 (en) 2016-01-13
CU24187B1 (es) 2016-07-29
IL225058A (en) 2017-03-30
AU2011298844B2 (en) 2015-02-19
CA2810755A1 (en) 2012-03-15
MA34516B1 (fr) 2013-09-02
ME02389B (me) 2016-09-20
BR112013005679A2 (pt) 2016-05-03
EA023420B1 (ru) 2016-06-30
SA111320735B1 (ar) 2015-10-21
ZA201301756B (en) 2016-06-29

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