AP2000001742A0 - Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands. - Google Patents

Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands.

Info

Publication number
AP2000001742A0
AP2000001742A0 APAP/P/2000/001742A AP2000001742A AP2000001742A0 AP 2000001742 A0 AP2000001742 A0 AP 2000001742A0 AP 2000001742 A AP2000001742 A AP 2000001742A AP 2000001742 A0 AP2000001742 A0 AP 2000001742A0
Authority
AP
ARIPO
Prior art keywords
substituted
napthyridine
carboxamides
oxo
agonists
Prior art date
Application number
APAP/P/2000/001742A
Other languages
English (en)
Inventor
Pamela Albaugh
Robert W Desimone
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of AP2000001742A0 publication Critical patent/AP2000001742A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
APAP/P/2000/001742A 1997-08-25 2000-02-01 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands. AP2000001742A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
AP2000001742A0 true AP2000001742A0 (en) 2000-02-24

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2000/001742A AP2000001742A0 (en) 1997-08-25 2000-02-01 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands.

Country Status (24)

Country Link
EP (1) EP1007526A1 (sk)
JP (1) JP2001514181A (sk)
KR (1) KR20010023313A (sk)
CN (1) CN1268136A (sk)
AP (1) AP2000001742A0 (sk)
AU (1) AU753800B2 (sk)
BG (1) BG104192A (sk)
BR (1) BR9811362A (sk)
CA (1) CA2301599C (sk)
EG (1) EG21717A (sk)
HU (1) HUP0003258A3 (sk)
IL (1) IL134291A0 (sk)
IS (1) IS5382A (sk)
LV (1) LV12539B (sk)
NO (1) NO20000822L (sk)
NZ (1) NZ502548A (sk)
OA (1) OA11293A (sk)
PE (1) PE130999A1 (sk)
PL (1) PL338783A1 (sk)
SI (1) SI20270A (sk)
SK (1) SK2162000A3 (sk)
TW (1) TW574221B (sk)
WO (1) WO1999010347A1 (sk)
YU (1) YU10500A (sk)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE289593T1 (de) * 1999-05-06 2005-03-15 Neurogen Corp Substituierte 4-oxo-chinolin-3-carboxamide als gaba gehirnrezeptorliganden
US6448246B1 (en) 1999-05-25 2002-09-10 Neurogen Corporation Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
ES2274913T3 (es) 2000-10-12 2007-06-01 MERCK & CO., INC. Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de vih integrada.
WO2002030426A1 (en) 2000-10-12 2002-04-18 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
CZ20031028A3 (cs) 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CN1494422A (zh) * 2001-03-01 2004-05-05 �Ʒ� Gabaa反相激动剂与烟碱受体不完全激动剂、雌激素、选择性雌激素调节剂、或维生素e联合用于认知障碍的用途
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
JP4523281B2 (ja) 2002-01-17 2010-08-11 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
AU2003218130A1 (en) 2002-03-15 2003-09-29 Merck And Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
PT2074123E (pt) * 2006-10-16 2013-01-22 Bionomics Ltd Novos compostos ansiolíticos
JP2010510314A (ja) * 2006-11-22 2010-04-02 シーサイド セラピューティクス，エルエルシー 精神遅滞、ダウン症候群、脆弱ｘ症候群および自閉症の治療方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (es) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampicilina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
CA2301599A1 (en) 1999-03-04
SK2162000A3 (en) 2001-03-12
IS5382A (is) 2000-02-22
HUP0003258A2 (en) 2001-03-28
EG21717A (en) 2002-02-27
CA2301599C (en) 2003-03-25
PE130999A1 (es) 1999-12-16
IL134291A0 (en) 2001-04-30
HUP0003258A3 (en) 2001-05-28
AU753800B2 (en) 2002-10-31
LV12539A (en) 2000-10-20
SI20270A (sl) 2000-12-31
AU9117398A (en) 1999-03-16
BG104192A (en) 2001-05-31
NO20000822L (no) 2000-04-13
BR9811362A (pt) 2000-08-22
YU10500A (sh) 2002-10-18
KR20010023313A (ko) 2001-03-26
PL338783A1 (en) 2000-11-20
WO1999010347A1 (en) 1999-03-04
NO20000822D0 (no) 2000-02-18
CN1268136A (zh) 2000-09-27
EP1007526A1 (en) 2000-06-14
LV12539B (en) 2001-01-20
OA11293A (en) 2002-11-19
NZ502548A (en) 2002-06-28
TW574221B (en) 2004-02-01
JP2001514181A (ja) 2001-09-11

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