AP129A - Expression of retrovirus gag protein eukaryotic cells - Google Patents
Expression of retrovirus gag protein eukaryotic cells Download PDFInfo
- Publication number
- AP129A AP129A APAP/P/1989/000126A AP8900126A AP129A AP 129 A AP129 A AP 129A AP 8900126 A AP8900126 A AP 8900126A AP 129 A AP129 A AP 129A
- Authority
- AP
- ARIPO
- Prior art keywords
- cells
- gag
- precursor protein
- recombinant
- dna molecule
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20227188A | 1988-06-03 | 1988-06-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP8900126A0 AP8900126A0 (en) | 1989-07-31 |
| AP129A true AP129A (en) | 1991-04-17 |
Family
ID=22749175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1989/000126A AP129A (en) | 1988-06-03 | 1989-05-22 | Expression of retrovirus gag protein eukaryotic cells |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0345242A3 (fr) |
| AP (1) | AP129A (fr) |
| AU (2) | AU627465B2 (fr) |
| IL (1) | IL90381A0 (fr) |
| NZ (1) | NZ229297A (fr) |
| PT (1) | PT90731A (fr) |
| WO (1) | WO1991000904A1 (fr) |
| ZA (1) | ZA894137B (fr) |
Families Citing this family (289)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2003794C (fr) * | 1988-12-01 | 2000-02-08 | Hanne R. Johansen | Expression de proteines de vih dans des cellules de drosophiles |
| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| US5786464C1 (en) * | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| US6290969B1 (en) | 1995-09-01 | 2001-09-18 | Corixa Corporation | Compounds and methods for immunotherapy and diagnosis of tuberculosis |
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| US6114148C1 (en) * | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
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| US6696291B2 (en) | 1997-02-07 | 2004-02-24 | Merck & Co., Inc. | Synthetic HIV gag genes |
| JP2001512308A (ja) * | 1997-02-07 | 2001-08-21 | メルク エンド カンパニー インコーポレーテッド | 合成ｈｉｖ ｇａｇ遺伝子 |
| US6261562B1 (en) | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US7087713B2 (en) | 2000-02-25 | 2006-08-08 | Corixa Corporation | Compounds and methods for diagnosis and immunotherapy of tuberculosis |
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| KR20010041992A (ko) | 1998-03-18 | 2001-05-25 | 길리스 스티브 | 폐암의 치료와 진단을 위한 화합물 및 이를 위한 방법 |
| US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
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| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
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| US7625859B1 (en) | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
| US7393823B1 (en) | 1999-01-20 | 2008-07-01 | Oregon Health And Science University | HER-2 binding antagonists |
| BR0009505A (pt) | 1999-04-02 | 2002-06-11 | Corixa Corp | Compostos e processos para terapia e diagnóstico de câncer de pulmão |
| US8143386B2 (en) | 1999-04-07 | 2012-03-27 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| WO2000066741A2 (fr) | 1999-04-30 | 2000-11-09 | Chiron S.P.A. | Antigenes de neisseria conserves |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| JP2003510370A (ja) | 1999-10-07 | 2003-03-18 | コリクサ コーポレイション | Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓの融合タンパク質 |
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| CA2392103A1 (fr) | 1999-11-18 | 2001-05-25 | Chiron Corporation | Gene humain fgf-21 et produits d'expression genique |
| PT1248647E (pt) | 2000-01-17 | 2010-11-18 | Novartis Vaccines & Diagnostics Srl | Vacina de vesícula da membrana externa (omv) compreendendo proteínas de membrana externa de n. meningitidis do serogrupo b |
| EP1854476A3 (fr) | 2000-02-09 | 2008-05-07 | Bas Medical, Inc. | Utilisation de la relaxine pour traiter des maladies associées à la vasoconstriction |
| SI1265915T1 (sl) | 2000-02-23 | 2011-02-28 | Glaxosmithkline Biolog Sa | Nove spojine |
| ES2299476T3 (es) | 2000-02-28 | 2008-06-01 | Novartis Vaccines And Diagnostics S.R.L. | Expresion hibrida de proteinas de neisseria. |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| WO2001066595A2 (fr) | 2000-03-08 | 2001-09-13 | Chiron Corporation | Gene humain fgf-23 et produits d'expression associes |
| ATE389020T1 (de) | 2000-04-21 | 2008-03-15 | Corixa Corp | Verbindungen und verfahren zur behandlung und diagnose von chlamydia-infektionen |
| AU2001269695B2 (en) | 2000-05-19 | 2007-02-15 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious, autoimmune and allergic diseases with mono and disaccharide-based compounds |
| EP1950297A2 (fr) | 2000-05-31 | 2008-07-30 | Novartis Vaccines and Diagnostics, Inc. | Compositions et procédés de traitement de maladie néoplastique utilisant la chimiothérapie et des sensibilisateurs à rayonnement |
| US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
| EP1370684B1 (fr) | 2000-06-15 | 2008-05-28 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides lies au cancer du colon |
| JP5139618B2 (ja) | 2000-06-20 | 2013-02-06 | コリクサ コーポレイション | Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓの融合タンパク質 |
| WO2002000174A2 (fr) | 2000-06-28 | 2002-01-03 | Corixa Corporation | Compositions et methodes pour le traitement et le diagnostic du cancer du poumon |
| US7691821B2 (en) | 2001-09-19 | 2010-04-06 | University Of South Florida | Inhibition of SHIP to enhance stem cell harvest and transplantation |
| US20020165192A1 (en) | 2000-09-19 | 2002-11-07 | Kerr William G. | Control of NK cell function and survival by modulation of ship activity |
| NZ560966A (en) | 2000-10-27 | 2010-06-25 | Novartis Vaccines & Diagnostic | Nucleic acids and proteins from streptococcus groups A & B |
| JP2004535765A (ja) | 2000-12-07 | 2004-12-02 | カイロン コーポレイション | 前立腺癌においてアップレギュレートされた内因性レトロウイルス |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| AU2002303261A1 (en) | 2001-04-06 | 2002-10-21 | Georgetown University | Gene brcc2 and diagnostic and therapeutic uses thereof |
| AU2002305151A1 (en) | 2001-04-06 | 2002-10-21 | Georgetown University | Gene scc-112 and diagnostic and therapeutic uses thereof |
| WO2002081642A2 (fr) | 2001-04-06 | 2002-10-17 | Georgetown University | Gene brcc-3 et ses utilisations diagnostiques et therapeutiques |
| WO2002089747A2 (fr) | 2001-05-09 | 2002-11-14 | Corixa Corporation | Compositions et procedes pour la therapie et le diagnostic du cancer de la prostate |
| CA2452119C (fr) | 2001-07-05 | 2013-10-15 | Chiron Corporation | Polynucleotides codant pour des polypeptides antigeniques du vih de sous-type b et/ou de sous-type c, polypeptides et leurs utilisations |
| US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
| CA2465953A1 (fr) | 2001-11-09 | 2003-05-15 | Georgetown University | Nouveaux isoformes de l'inhibiteur de la croissance de cellules endotheliales vasculaires |
| KR100982204B1 (ko) | 2001-12-12 | 2010-09-14 | 노바티스 백신즈 앤드 다이아그노스틱스 에스.알.엘. | 클라미디아 트라코마티스에 대한 면역화 |
| CA2476755C (fr) | 2001-12-17 | 2014-08-26 | Corixa Corporation | Compositions et procedes applicables a la therapie et au diagnostic pour la maladie intestinale inflammatoire |
| ES2323456T3 (es) | 2002-01-08 | 2009-07-16 | Novartis Vaccines And Diagnostics, Inc. | Productos genicos diferencialmente expresados en celulas de pecho cancerosas y sus metodos de uso. |
| WO2003070187A2 (fr) | 2002-02-15 | 2003-08-28 | Corixa Corporation | Proteines de fusion de mycobacterium tuberculosis |
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| US7138512B2 (en) | 2002-04-10 | 2006-11-21 | Georgetown University | Gene SHINC-2 and diagnostic and therapeutic uses thereof |
| US7244565B2 (en) | 2002-04-10 | 2007-07-17 | Georgetown University | Gene shinc-3 and diagnostic and therapeutic uses thereof |
| US20030206916A1 (en) | 2002-05-03 | 2003-11-06 | Rush-Presbyterian-St. Luke's Medical Center | Immunogenic peptides |
| ATE545651T1 (de) | 2002-06-13 | 2012-03-15 | Novartis Vaccines & Diagnostic | Vektoren zur expression von hml-2-polypeptiden |
| CA2492598C (fr) | 2002-07-18 | 2013-12-17 | University Of Washington | Purification rapide et efficace de t-lymphocytes specifiques au hsv et antigenes a hsv identifies par ce procede |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| AU2003304238A1 (en) | 2002-10-08 | 2005-01-13 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| MXPA05003502A (es) | 2002-10-08 | 2005-09-30 | Rinat Neuroscience Corp | Metodo para tratar dolor post-quirurgico al administrar un antagonista del factor de crecimiento de nervios y composiciones que contienen el mismo. |
| PT2263692T (pt) | 2002-12-24 | 2018-11-28 | Rinat Neuroscience Corp | Anticorpos anti-ngf e métodos de utilização dos mesmos |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| RU2389732C2 (ru) | 2003-01-06 | 2010-05-20 | Корикса Корпорейшн | Некоторые аминоалкилглюкозаминидфосфатные производные и их применение |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| US20040170982A1 (en) | 2003-02-14 | 2004-09-02 | Morris David W. | Novel therapeutic targets in cancer |
| CA2516138A1 (fr) | 2003-02-14 | 2004-09-02 | Sagres Discovery, Inc. | Nouveaux cibles therapeutiques du recepteur de couplage a la proteine g dans le cancer |
| US7767387B2 (en) | 2003-06-13 | 2010-08-03 | Sagres Discovery, Inc. | Therapeutic targets in cancer |
| US7655231B2 (en) | 2003-02-19 | 2010-02-02 | Pfizer Inc. | Methods for treating pain by administering a nerve growth factor antagonist and an NSAID |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| JP2006524057A (ja) | 2003-04-21 | 2006-10-26 | エペイウス バイオテクノロジーズ， インコーポレイテッド | 疾患を処置するための方法および組成物 |
| US20070178066A1 (en) | 2003-04-21 | 2007-08-02 | Hall Frederick L | Pathotropic targeted gene delivery system for cancer and other disorders |
| WO2005007673A2 (fr) | 2003-07-03 | 2005-01-27 | Rush University Medical Center | Peptides immunogenes |
| US7807646B1 (en) | 2003-11-20 | 2010-10-05 | University Of South Florida | SHIP-deficiency to increase megakaryocyte progenitor production |
| US7763592B1 (en) | 2003-11-20 | 2010-07-27 | University Of South Florida | SHIP-deficiency to increase megakaryocyte progenitor production |
| BRPI0417270A (pt) | 2003-12-23 | 2007-03-27 | Rinat Neuroscience Corp | anticorpos agonistas antitrkc e métodos para utilização dos mesmos |
| DK1736541T3 (da) | 2004-03-29 | 2013-05-06 | Galpharma Co Ltd | Nyt modificeret galectin 9-protein og anvendelse heraf |
| KR101637908B1 (ko) | 2004-04-07 | 2016-07-11 | 리나트 뉴로사이언스 코프. | 신경성장인자 길항제의 투여에 의한 골암 통증의 치료방법 |
| EP2261672B1 (fr) | 2004-07-14 | 2014-09-03 | The Regents of The University of California | Biomarqueur pour détecter de manière précoce un cancer des ovaires |
| US20060024677A1 (en) | 2004-07-20 | 2006-02-02 | Morris David W | Novel therapeutic targets in cancer |
| MX2007000998A (es) | 2004-07-30 | 2007-07-11 | Rinat Neuroscience Corp | Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos. |
| CA2579764A1 (fr) | 2004-08-10 | 2006-02-23 | Institute For Multiple Myeloma And Bone Cancer Research | Procedes pour reguler la differenciation et traiter le myelome multiple |
| EP2181714A3 (fr) | 2004-09-22 | 2010-06-23 | GlaxoSmithKline Biologicals S.A. | Composition immunogène pour la vaccination contre des staphylocoques |
| WO2006091517A2 (fr) | 2005-02-18 | 2006-08-31 | Novartis Vaccines And Diagnostics Inc. | Immunogenes d'escherichia coli uropathogene |
| EP1701165A1 (fr) | 2005-03-07 | 2006-09-13 | Johannes Dr. Coy | Utilisation thérapeutique et diagnostique de TKTL1, ses inhibiteurs et ses activateurs |
| SG158145A1 (en) | 2005-03-31 | 2010-01-29 | Glaxosmithkline Biolog Sa | Vaccines against chlamydial infection |
| WO2006110585A2 (fr) | 2005-04-07 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | Genes lies au cancer (prlr) |
| JP2008535857A (ja) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 癌の診断、検出および処置におけるｃａｃｎａ１ｅ |
| SI1877426T1 (sl) | 2005-04-29 | 2012-06-29 | Glaxosmithkline Biolog Sa | Postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis |
| PE20061323A1 (es) | 2005-04-29 | 2007-02-09 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos |
| RU2486204C2 (ru) | 2005-07-22 | 2013-06-27 | Уай'З Терапьютикс Ко., Лтд. | Антитела против сd26 и способы их применения |
| RS20080200A (sr) | 2005-11-14 | 2009-07-15 | Rinat Neuroscience Corp., | Antagonistička antitela usmerena protiv kalcitonina, peptida povezanog sa genom, i postupak njihovog korišćenja |
| AU2007239095B2 (en) | 2006-01-09 | 2012-05-03 | The Regents Of The University Of California | Immunostimulatory combinations for vaccine adjuvants |
| US9259463B2 (en) | 2006-01-16 | 2016-02-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chlamydia vaccine |
| US7935342B2 (en) | 2006-02-02 | 2011-05-03 | Rinat Neuroscience Corp. | Methods for treating obesity by administering a trkB antagonist |
| JP5524610B2 (ja) | 2006-04-07 | 2014-06-18 | ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク | トランスコバラミン受容体ポリペプチド、核酸およびその調節因子、ならびに細胞の増殖の調節ならびにガンおよびコバラミン欠損症の処置に使用する関連方法 |
| ES2718952T3 (es) | 2006-06-07 | 2019-07-05 | Bioalliance Cv | Anticuerpos que reconocen un epítopo que contiene carbohidratos en CD-43 y CEA expresados en células cancerosas y métodos que los usan |
| ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
| CA2659552A1 (fr) | 2006-08-16 | 2008-02-21 | Novartis Ag | Immunogenes pour escherichia coli uropathogene |
| EP2139447A2 (fr) | 2007-03-20 | 2010-01-06 | Harold Brem | Compositions gm-csf cosméceuticales et leurs procédés d'utilisation |
| DK2170384T3 (en) | 2007-07-02 | 2016-07-25 | Etubics Corp | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| CN102216329A (zh) | 2007-12-17 | 2011-10-12 | 辉瑞有限公司 | 间质性膀胱炎的治疗 |
| AU2008338313B2 (en) | 2007-12-18 | 2014-01-16 | Bioalliance C.V. | Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same |
| EP3023502A1 (fr) | 2008-04-10 | 2016-05-25 | Cell Signaling Technology, Inc. | Compositions et procédés pour détecter des mutations egfr dans le cancer |
| WO2009150623A1 (fr) | 2008-06-13 | 2009-12-17 | Pfizer Inc | Traitement de la prostatite chronique |
| TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Ｐｃｓｋ９拮抗劑類 |
| EP2352841A2 (fr) | 2008-09-23 | 2011-08-10 | President and Fellows of Harvard College | Sirt4 et utilisations de celui-ci |
| WO2010080985A1 (fr) | 2009-01-08 | 2010-07-15 | Dana-Farber Cancer Institute, Inc. | Compositions et procédés pour induire la différenciation du tissu adipeux brun |
| WO2010086828A2 (fr) | 2009-02-02 | 2010-08-05 | Rinat Neuroscience Corporation | Anticorps monoclonaux agonistes anti-trkb |
| EP3549602A1 (fr) | 2009-03-06 | 2019-10-09 | GlaxoSmithKline Biologicals S.A. | Antigènes de chlamydia |
| WO2010118243A2 (fr) | 2009-04-08 | 2010-10-14 | Genentech, Inc. | Utilisation d'antagonistes de il-27 pour traiter le lupus |
| CA2758490C (fr) | 2009-04-14 | 2023-05-02 | Novartis Ag | Compositions pour l'immunisation contre le staphylococcus aureus |
| WO2010146511A1 (fr) | 2009-06-17 | 2010-12-23 | Pfizer Limited | Traitement d'une vessie hyperactive |
| MX2012000734A (es) | 2009-07-16 | 2012-01-27 | Novartis Ag | Inmunogenos destoxificados de escherichia coli. |
| US8563261B2 (en) | 2009-09-28 | 2013-10-22 | The Trustees Of The University Of Pennsylvania | Method of diagnosing and treating interstitial cystitis |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| EP2526205A1 (fr) | 2010-01-21 | 2012-11-28 | Dana-Farber Cancer Institute, Inc. | Plate-forme de criblage génétique spécifique du contexte pour assister la découverte de gènes et la validation de cibles |
| WO2011092253A1 (fr) | 2010-01-27 | 2011-08-04 | Glaxosmithkline Biologicals S.A. | Antigènes modifiés de la tuberculose |
| US8298535B2 (en) | 2010-02-24 | 2012-10-30 | Rinat Neuroscience Corp. | Anti-IL-7 receptor antibodies |
| GB201003333D0 (en) | 2010-02-26 | 2010-04-14 | Novartis Ag | Immunogenic proteins and compositions |
| AU2011225716A1 (en) | 2010-03-11 | 2012-09-27 | Pfizer Inc. | Antibodies with pH dependent antigen binding |
| GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| WO2011133931A1 (fr) | 2010-04-22 | 2011-10-27 | Genentech, Inc. | Utilisation d'antagonistes d'il-27 pour traiter une maladie intestinale inflammatoire |
| EP2598126A2 (fr) | 2010-07-30 | 2013-06-05 | Saint Louis University | Méthodes de traitement de la douleur |
| US9539427B2 (en) | 2010-11-08 | 2017-01-10 | The Johns Hopkins University | Methods for improving heart function |
| EP2663868A2 (fr) | 2010-12-01 | 2013-11-20 | The University of North Carolina at Chapel Hill | Procédés et compositions destinés à cibler des sites de croissance néovasculaire |
| WO2012072769A1 (fr) | 2010-12-01 | 2012-06-07 | Novartis Ag | Epitopes rrgb de pneumocoque et combinaisons de variantes |
| US9267112B2 (en) | 2011-05-10 | 2016-02-23 | The Regents Of The University Of California | Adenovirus isolated from Titi Monkeys |
| US10221218B2 (en) | 2011-05-10 | 2019-03-05 | The Regents Of The University Of California | Adenovirus isolated from titi monkeys |
| MX2013013627A (es) | 2011-06-21 | 2014-04-25 | Oncofactor Corp | Composiciones y metodos para la terapia y diagnostico de cancer. |
| US20130071375A1 (en) | 2011-08-22 | 2013-03-21 | Saint Louis University | Compositions and methods for treating inflammation |
| WO2013028527A1 (fr) | 2011-08-23 | 2013-02-28 | Indiana University Research And Technology Corporation | Compositions et procédés pour traiter le cancer |
| CA2846865A1 (fr) | 2011-08-29 | 2013-03-07 | The Regents Of The University Of California | Utilisation de molecules associees au hdl pour traiter et prevenir des etats pro-inflammatoires |
| US10093705B2 (en) | 2011-09-13 | 2018-10-09 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using FNDC5 |
| WO2013055911A1 (fr) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Biomarqueur znf365/zfp365 pouvant prévoir une réponse anticancéreuse |
| WO2013068946A2 (fr) | 2011-11-11 | 2013-05-16 | Rinat Neuroscience Corp. | Anticorps spécifiques de trop-2 et leurs utilisations |
| WO2013093693A1 (fr) | 2011-12-22 | 2013-06-27 | Rinat Neuroscience Corp. | Anticorps spécifiques de staphylococcus aureus et leurs utilisations |
| HK1204328A1 (en) | 2011-12-22 | 2015-11-13 | 瑞纳神经科学公司 | Human growth hormone receptor antagonist antibodies and methods of use thereof |
| US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
| US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| KR20150082503A (ko) | 2012-11-09 | 2015-07-15 | 화이자 인코포레이티드 | 혈소판 유래 성장 인자 b 특이적 항체, 및 그의 조성물 및 용도 |
| CA2902975C (fr) | 2013-03-14 | 2021-05-11 | Epeius Biotechnologies Corporation | Dosage diagnostique des thymidine kinases pour applications de therapie genique |
| WO2014144521A1 (fr) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Peptide d'origine mitochondriale mots3 régule le métabolisme et la survie cellulaire |
| WO2014144844A1 (fr) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Petits arn dérivés d'arnt (arnts) impliqués dans la viabilité cellulaire |
| CN111704672B (zh) | 2013-03-15 | 2024-06-04 | 武田药品工业株式会社 | 抗血浆激肽释放酶抗体 |
| EP2986717A1 (fr) | 2013-04-19 | 2016-02-24 | The Regents of The University of California | Virus d'amblyomma americanum |
| HK1218421A1 (zh) | 2013-05-07 | 2017-02-17 | 瑞纳神经科学公司 | 抗胰高血糖素受体抗体和其使用方法 |
| US10231993B2 (en) | 2013-06-27 | 2019-03-19 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
| US20160129017A1 (en) | 2013-07-01 | 2016-05-12 | The Research Foundation for the State University New York | Ship inhibition to combat obesity |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| TWI671317B (zh) | 2013-08-02 | 2019-09-11 | 輝瑞大藥廠 | 抗ｃｘｃｒ４抗體及抗體-藥物結合物 |
| CN113150144A (zh) | 2013-11-13 | 2021-07-23 | 辉瑞大药厂 | 肿瘤坏死因子样配体1a特异性抗体及其组合物和用途 |
| WO2015087187A1 (fr) | 2013-12-10 | 2015-06-18 | Rinat Neuroscience Corp. | Anticorps anti-sclérostine |
| WO2015109212A1 (fr) | 2014-01-17 | 2015-07-23 | Pfizer Inc. | Anticorps anti-il-2 et compositions et utilisations de ceux-ci |
| KR102274964B1 (ko) | 2014-03-21 | 2021-07-09 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 칼시토닌 유전자-관련 펩티드에 대한 길항제 항체 및 그의 사용 방법 |
| JP6719384B2 (ja) | 2014-03-27 | 2020-07-15 | ダイアックス コーポレーション | 糖尿病黄斑浮腫の治療のための組成物および方法 |
| CA2944903A1 (fr) | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Suppresseur de tumeur et biomarqueurs oncogenes predictifs de reponse a un inhibiteur de point de controle anti-immunitaire |
| EP3139955B1 (fr) | 2014-04-30 | 2024-03-20 | President and Fellows of Harvard College | Protéines de fusion pour le traitement du cancer et procédés associés |
| MX2016014824A (es) | 2014-05-13 | 2017-03-23 | Bioatla Llc | Proteinas biologicas condicionalmente activas. |
| US20170128461A1 (en) | 2014-06-17 | 2017-05-11 | The Research Foundation For The State University Of New York | Ship inhibition to induce expression of granulocyte colony stimulating factor in a subject |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| DK4074735T3 (da) | 2014-08-28 | 2025-07-14 | Bioatla Inc | Betinget aktive kimæriske antigenreceptorer til modificerede t-celler |
| WO2016036916A1 (fr) | 2014-09-03 | 2016-03-10 | Bioatla, Llc | Découverte et production de protéines biologiques conditionnellement actives dans les mêmes cellules hôtes eucaryotes de production |
| SG11201701775VA (en) | 2014-09-09 | 2017-04-27 | Unum Therapeutics | Chimeric receptors and uses thereof in immune therapy |
| US20170248603A1 (en) | 2014-10-06 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response |
| JP6941561B2 (ja) | 2014-10-09 | 2021-09-29 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| AU2015373910B2 (en) | 2015-01-02 | 2021-11-18 | Takeda Pharmaceutical Company Limited | Bispecific antibodies against plasma kallikrein and factor XII |
| WO2016144673A1 (fr) | 2015-03-06 | 2016-09-15 | Dana-Farber Cancer Institute, Inc. | Biomarqueurs pd-l2 prédictifs de réponses d'inhibiteurs de la voie pd-1 dans les cancers oesophagogastriques |
| US20180071380A1 (en) | 2015-03-20 | 2018-03-15 | The Regents Of The University Of Michigan | Immunogenic compositions for use in vaccination against bordetella |
| US9758575B2 (en) | 2015-04-06 | 2017-09-12 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof |
| SG10201912823PA (en) | 2015-04-13 | 2020-02-27 | Pfizer | Therapeutic antibodies and their uses |
| CN108137705B (zh) | 2015-07-21 | 2022-11-08 | 武田药品工业株式会社 | 一种因子xiia的单克隆抗体抑制剂 |
| WO2017015334A1 (fr) | 2015-07-21 | 2017-01-26 | Saint Louis University | Compositions et méthodes pour diagnostiquer et traiter l'infertilité associée à l'endométriose |
| US11066481B2 (en) | 2015-07-23 | 2021-07-20 | The Regents Of The University Of California | Antibodies to coagulation factor XIa and uses thereof |
| KR20230074843A (ko) | 2015-08-19 | 2023-05-31 | 화이자 인코포레이티드 | 조직 인자 경로 억제제 항체 및 그의 용도 |
| RS66913B1 (sr) | 2015-09-15 | 2025-07-31 | Scholar Rock Inc | Anti-pro/latentna antitela miostatina i njihova upotreba |
| EP3359651A1 (fr) | 2015-10-05 | 2018-08-15 | THE UNITED STATES OF AMERICA, represented by the S | Souche de rotavirus humain g9p[6]et utilisation comme vaccin |
| IL300420B2 (en) | 2015-10-16 | 2024-09-01 | Univ Columbia | Compositions and methods for inhibition of lineage specific antigens |
| US11207393B2 (en) | 2015-10-16 | 2021-12-28 | President And Fellows Of Harvard College | Regulatory T cell PD-1 modulation for regulating T cell effector immune responses |
| AU2016340989B2 (en) | 2015-10-23 | 2023-09-14 | Pfizer Inc. | Anti-IL-2 antibodies and compositions and uses thereof |
| WO2017075037A1 (fr) | 2015-10-27 | 2017-05-04 | Scholar Rock, Inc. | Facteurs de croissance amorcés et leurs utilisations |
| WO2017075329A2 (fr) | 2015-10-29 | 2017-05-04 | Dana-Farber Cancer Institute, Inc. | Procédés pour identifier, évaluer, prévenir et traiter des troubles métaboliques au moyen de pm20d1 et d'acides aminés n-lipidés |
| CN106699889A (zh) | 2015-11-18 | 2017-05-24 | 礼进生物医药科技（上海）有限公司 | 抗pd-1抗体及其治疗用途 |
| NZ783685A (en) | 2015-12-30 | 2025-09-26 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
| DK3405490T3 (da) | 2016-01-21 | 2022-01-10 | Pfizer | Mono- og bispecifikke antistoffer mod epidermal vækstfaktorreceptor variant iii og cd3 og anvendelser deraf |
| CA3018332A1 (fr) | 2016-03-21 | 2017-09-28 | Dana-Farber Cancer Institute, Inc. | Regulateurs de l'expression genique specifiques a l'etat d'epuisement des lymphocytes t et leurs utilisations |
| JP7099967B2 (ja) | 2016-07-01 | 2022-07-12 | リサーチ ディベロップメント ファウンデーション | 幹細胞由来移植片からの増殖性細胞の排除 |
| WO2018057618A1 (fr) | 2016-09-20 | 2018-03-29 | Dana-Farber Cancer Institute, Inc. | Compositions et méthodes pour l'identification, l'évaluation, la prévention et le traitement de la lma au moyen de biomarqueurs usp10 et de modulateurs |
| US20180119141A1 (en) | 2016-10-28 | 2018-05-03 | Massachusetts Institute Of Technology | Crispr/cas global regulator screening platform |
| US20190345501A1 (en) | 2017-02-07 | 2019-11-14 | Massachusetts Institute Of Technology | Methods and compositions for rna-guided genetic circuits |
| RU2019127550A (ru) | 2017-03-03 | 2021-04-05 | Ринат Ньюросайенс Корп. | Анти-gitr антитела и способы их использования |
| WO2018167621A1 (fr) | 2017-03-16 | 2018-09-20 | Pfizer Inc. | Prototrophie à la tyrosine |
| WO2018191548A2 (fr) | 2017-04-14 | 2018-10-18 | Kodiak Sciences Inc. | Anticorps antagonistes du facteur d du complément et leurs conjugués |
| US11279755B2 (en) | 2017-04-25 | 2022-03-22 | Lbl Biotechnology, Inc. | Use of IL-20 antagonists for treating eye diseases |
| AU2018275359C1 (en) | 2017-06-02 | 2022-02-03 | Pfizer Inc. | Antibodies specific for FLT3 and their uses |
| AU2018284077B2 (en) | 2017-06-13 | 2021-09-23 | Bostongene Corporation | Systems and methods for identifying responders and non-responders to immune checkpoint blockade therapy |
| CN110997002A (zh) | 2017-07-13 | 2020-04-10 | 麻省理工学院 | 靶向hdac2-sp3复合体以增强突触功能 |
| WO2019016784A1 (fr) | 2017-07-21 | 2019-01-24 | Universidade De Coimbra | Anticorps anti-nucléoline |
| EP4088783A1 (fr) | 2017-08-01 | 2022-11-16 | Ab Studio Inc. | Anticorps bispécifiques et leurs utilisations |
| US11970707B2 (en) | 2017-09-18 | 2024-04-30 | Children's Hospital Medical Center | Strong insulator and uses thereof in gene delivery |
| EP3684812A4 (fr) | 2017-09-21 | 2021-09-08 | Eucure (Beijing) Biopharma Co., Ltd | Anticorps anti-ctla4 et utilisations associées |
| JP2020536115A (ja) | 2017-10-04 | 2020-12-10 | オプコ ファーマシューティカルズ、エルエルシー | 癌の個別化療法に関する物品および方法 |
| EP3625263B8 (fr) | 2017-10-27 | 2025-05-28 | New York University | Anticorps anti-galectine-9 et leurs utilisations |
| AU2017440393B2 (en) | 2017-11-24 | 2025-02-20 | Eucure (Beijing) Biopharma Co., Ltd | Anti-OX40 antibodies and uses thereof |
| KR20250040087A (ko) | 2018-02-01 | 2025-03-21 | 화이자 인코포레이티드 | Cd70을 표적으로 하는 키메라 항원 수용체 |
| PE20251579A1 (es) | 2018-02-01 | 2025-06-16 | Pfizer | Anticuerpos especificos para cd70 y sus usos |
| US11912736B2 (en) | 2018-02-21 | 2024-02-27 | The University Of Montana | Diaryl trehalose compounds and uses thereof |
| AU2018409906B2 (en) | 2018-02-23 | 2025-06-05 | Eucure (Beijing) Biopharma Co. , Ltd | Anti-PD-1 antibodies and uses thereof |
| EP3759129A1 (fr) | 2018-02-28 | 2021-01-06 | Pfizer Inc | Variants d'il-15 et leurs utilisations |
| US20210032334A1 (en) | 2018-02-28 | 2021-02-04 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer using combinations of anti-btnl2 and immune checkpoint blockade agents |
| SG11202008242XA (en) | 2018-03-02 | 2020-09-29 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof |
| WO2019169313A1 (fr) | 2018-03-02 | 2019-09-06 | The University Of Montana | Composés de tréhalose immunogènes et leurs utilisations |
| US12103972B2 (en) | 2018-04-06 | 2024-10-01 | Dana-Farber Cancer Institute, Inc. | KIR3DL3 as an HHLA2 receptor, anti-HHLA2 antibodies, and uses thereof |
| BR112020022897A2 (pt) | 2018-05-23 | 2021-02-23 | Pfizer Inc. | anticorpos específicos para cd3 e usos dos mesmos |
| KR102584675B1 (ko) | 2018-05-23 | 2023-10-05 | 화이자 인코포레이티드 | GUCY2c에 특이적인 항체 및 이의 용도 |
| CA3104862A1 (fr) | 2018-07-03 | 2020-01-09 | Sotio, LLC | Recepteurs chimeriques en association avec des molecules de metabolisme trans ameliorant l'importation de glucose et leurs utilisations therapeutiques |
| SG11202100510PA (en) | 2018-07-20 | 2021-02-25 | Eucure Beijing Biopharma Co Ltd | Anti-cd40 antibodies and uses thereof |
| WO2020037066A1 (fr) | 2018-08-14 | 2020-02-20 | Unum Therapeutics Inc. | Récepteurs d'antigène chimériques en association avec des molécules de trans-métabolisme modulant le cycle de krebs et leurs utilisations thérapeutiques |
| WO2020047164A1 (fr) | 2018-08-28 | 2020-03-05 | Vor Biopharma, Inc | Cellules souches hématopoïétiques génétiquement modifiées et utilisations associées |
| JP7387743B2 (ja) | 2018-09-12 | 2023-11-28 | ユーカー（ベンジン） バイオファーマ カンパニー，リミテッド | 抗ｔｎｆｒｓｆ９抗体及びその使用 |
| WO2020078270A1 (fr) | 2018-10-15 | 2020-04-23 | Elixiron Immunotherapeutics (hong Kong) Limited | Anticorps dirigés contre le facteur de croissance des granulocytes et des macrophages et leurs utilisations |
| EP3883969A4 (fr) | 2018-11-19 | 2022-11-16 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anticorps anti-pd-1 et leurs utilisations |
| WO2020132190A1 (fr) | 2018-12-21 | 2020-06-25 | Multitude Inc. | Anticorps spécifiques à muc18 |
| EP4434541A3 (fr) | 2019-01-23 | 2025-02-26 | New York University | Anticorps spécifiques de la chaîne delta 1 du récepteur des lymphocytes t |
| CN113660956B (zh) | 2019-01-28 | 2024-10-29 | Ab诊疗公司 | 双特异性抗体及其用途 |
| AU2020226445B2 (en) | 2019-02-18 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| US20220289854A1 (en) | 2019-04-30 | 2022-09-15 | Dana-Farber Cancer Institute, Inc. | Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents |
| KR20220018503A (ko) | 2019-05-23 | 2022-02-15 | 더 유니버시티 오브 몬타나 | Tlr 수용체 리간드에 기반한 백신 애주번트 |
| EP4567125A3 (fr) | 2019-07-03 | 2025-09-17 | BostonGene Corporation | Systèmes et procédés pour la préparation d'échantillons, le séquençage d'échantillons, la correction de biais de données de séquençage et le contrôle de qualité |
| AU2020363372A1 (en) | 2019-10-07 | 2022-05-19 | University Of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US20240092935A1 (en) | 2019-10-11 | 2024-03-21 | Beth Israel Deaconess Medical Center, Inc. | Anti-tn antibodies and uses thereof |
| US20230067811A1 (en) | 2020-01-24 | 2023-03-02 | University Of Virginia Patent Foundation | Modulating lymphatic vessels in neurological disease |
| US20230075965A1 (en) | 2020-01-24 | 2023-03-09 | Constantine S. Mitsiades | Uses of biomarkers for improving immunotherapy |
| WO2021205325A1 (fr) | 2020-04-08 | 2021-10-14 | Pfizer Inc. | Anticorps anti-gucy2c et leurs utilisations |
| WO2021224850A1 (fr) | 2020-05-06 | 2021-11-11 | Crispr Therapeutics Ag | Peptides masques et anticorps anti-ptk7 masqués les comprenant |
| AU2021283564B2 (en) | 2020-06-02 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| US20230235007A1 (en) | 2020-06-15 | 2023-07-27 | Ming-Che Shih | Humanized ace2-fc fusion protein for treatment and prevention of sars-cov-2 infection |
| WO2022013775A1 (fr) | 2020-07-17 | 2022-01-20 | Pfizer Inc. | Anticorps thérapeutiques et leurs utilisations |
| EP4189093A1 (fr) | 2020-07-30 | 2023-06-07 | Pfizer Inc. | Cellules ayant des duplications de gènes et leurs utilisations |
| WO2022086852A2 (fr) | 2020-10-19 | 2022-04-28 | Dana-Farber Cancer Institute, Inc. | Biomarqueurs germinaux de la réponse clinique et du bénéfice d'un traitement par inhibiteur de points de contrôle immunitaire |
| WO2022104104A2 (fr) | 2020-11-13 | 2022-05-19 | Dana-Farber Cancer Institute, Inc. | Vaccins à cellules de fusion personnalisés |
| WO2022120256A2 (fr) | 2020-12-04 | 2022-06-09 | Bostongene Corporation | Techniques d'apprentissage machine hiérarchique permettant d'identifier des catégories moléculaires à partir de données d'expression |
| WO2022159793A2 (fr) | 2021-01-25 | 2022-07-28 | Dana-Farber Cancer Institute, Inc. | Procédés et compositions pour identifier un cancer de la prostate neuroendocrinien |
| US20220372580A1 (en) | 2021-04-29 | 2022-11-24 | Bostongene Corporation | Machine learning techniques for estimating tumor cell expression in complex tumor tissue |
| US20240280561A1 (en) | 2021-06-08 | 2024-08-22 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers |
| US20240327496A1 (en) | 2021-08-02 | 2024-10-03 | Pfizer Inc. | Improved Expression Vectors and Uses Thereof |
| MX2024004009A (es) | 2021-09-27 | 2024-06-19 | Sotio Biotech Inc | Polipéptidos receptores quiméricos en combinación con moléculas transmetabólicas que redirigen metabolitos de glucosa fuera de la vía de la glucólisis y usos terapéuticos de estos. |
| CA3237201A1 (fr) | 2021-11-16 | 2023-05-25 | Sotio Biotech Inc. | Traitement de patients atteints de liposarcome myxoide/a cellules rondes |
| US20250381241A1 (en) | 2021-11-29 | 2025-12-18 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to modulate riok2 |
| CA3249858A1 (fr) | 2022-01-31 | 2023-08-03 | Bostongene Corporation | Techniques d'apprentissage automatique pour cytométrie |
| EP4473096A1 (fr) | 2022-02-02 | 2024-12-11 | Pfizer Inc. | Prototrophie cystéinique |
| WO2023158732A1 (fr) | 2022-02-16 | 2023-08-24 | Dana-Farber Cancer Institute, Inc. | Procédés de diminution de l'alpha-synucléine pathologique à l'aide d'agents qui modulent fndc5 ou des fragments biologiquement actifs de celui-ci |
| WO2024015561A1 (fr) | 2022-07-15 | 2024-01-18 | Bostongene Corporation | Techniques de détection d'une déficience de recombinaison homologue (hrd) |
| WO2024040208A1 (fr) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Cellules immunitaires génétiquement modifiées avec des polypeptides récepteurs chimériques en combinaison avec de multiples molécules du métabolisme trans et leurs utilisations thérapeutiques |
| WO2024040207A1 (fr) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Cellules tueuses naturelles (nk) génétiquement modifiées avec des polypeptides récepteurs chimériques en combinaison avec des molécules de trans-métabolisme et leurs utilisations thérapeutiques |
| WO2024215987A1 (fr) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | CELLULES IMMUNITAIRES POUR LE TRAITEMENT DU CANCER EN COMBINAISON AVEC DES CONJUGUÉS IL-15/IL-15Rα |
| WO2024215989A1 (fr) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | CELLULES IMMUNITAIRES MODIFIÉES POUR LE TRAITEMENT D'UN CANCER EN COMBINAISON AVEC DES AGONISTES βγ DU RÉCEPTEUR IL-2/IL-15 |
| WO2025030010A1 (fr) | 2023-08-01 | 2025-02-06 | Vor Biopharma Inc. | Compositions comprenant des cellules souches hématopoïétiques génétiquement modifiées et leurs méthodes d'utilisation |
| WO2025034542A1 (fr) | 2023-08-04 | 2025-02-13 | Cornell University | Panel de signature génique prédisant une réponse cancéreuse à un blocage de point de contrôle immunitaire et radiothérapie |
| WO2025096811A1 (fr) | 2023-10-31 | 2025-05-08 | Bostongene Corporation | Technique d'apprentissage automatique pour identifier des sujets répondant à un inhibiteur de point de contrôle immunitaire (ici) et des sujets n'y répondant pas |
| US20250253011A1 (en) | 2024-02-02 | 2025-08-07 | Seven Bridges Genomics Inc. | Techniques for improved tumor mutational burden (tmb) determination using a population-specific genomic reference |
| WO2025202359A1 (fr) | 2024-03-27 | 2025-10-02 | Adcendo Aps | Anticorps anti-gpc1 et leurs utilisations |
| TW202543672A (zh) | 2024-03-27 | 2025-11-16 | 丹麥商阿德森多私人有限公司 | 抗gpc1抗體及其用途 |
| WO2025223455A1 (fr) | 2024-04-24 | 2025-10-30 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anticorps anti-ptk7/b7h3 et leurs utilisations |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0230222A1 (fr) * | 1986-01-06 | 1987-07-29 | F. Hoffmann-La Roche Ag | Expression du gène gag de HTLV-III |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5931799A (ja) * | 1982-08-16 | 1984-02-20 | Science & Tech Agency | Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド |
| US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| NZ217645A (en) * | 1985-09-25 | 1991-11-26 | Oncogen | Recombinant viruses expressing lav/htlv-iii related epitopes and vaccine formulations |
| WO1988006185A1 (fr) * | 1987-02-11 | 1988-08-25 | Scripps Clinic And Research Foundation | Vecteurs retroviraux d'expression et procedes de production d'antigenes du virus d'hepatite b |
| IL90048A0 (en) * | 1988-04-25 | 1989-12-15 | Merck & Co Inc | Recombinant gag precursor of hiv,its preparation and its use as aids vaccine |
-
1989
- 1989-05-22 AP APAP/P/1989/000126A patent/AP129A/en active
- 1989-05-23 IL IL90381A patent/IL90381A0/xx unknown
- 1989-05-26 NZ NZ229297A patent/NZ229297A/en unknown
- 1989-06-01 ZA ZA894137A patent/ZA894137B/xx unknown
- 1989-06-02 PT PT90731A patent/PT90731A/pt not_active Application Discontinuation
- 1989-06-02 EP EP89870082A patent/EP0345242A3/fr not_active Withdrawn
- 1989-06-30 AU AU37256/89A patent/AU627465B2/en not_active Ceased
- 1989-07-11 WO PCT/US1989/002415 patent/WO1991000904A1/fr not_active Ceased
- 1989-07-11 AU AU43206/89A patent/AU4320689A/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0230222A1 (fr) * | 1986-01-06 | 1987-07-29 | F. Hoffmann-La Roche Ag | Expression du gène gag de HTLV-III |
Non-Patent Citations (1)
| Title |
|---|
| SCIENCE (March 28, 1986) Vol. 231, pp. 1580-1584: * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991000904A1 (fr) | 1991-01-24 |
| IL90381A0 (en) | 1989-12-15 |
| AU627465B2 (en) | 1992-08-27 |
| NZ229297A (en) | 1992-01-29 |
| EP0345242A3 (fr) | 1990-05-30 |
| EP0345242A2 (fr) | 1989-12-06 |
| PT90731A (pt) | 1989-12-29 |
| ZA894137B (en) | 1990-06-27 |
| AU4320689A (en) | 1991-02-06 |
| AP8900126A0 (en) | 1989-07-31 |
| AU3725689A (en) | 1991-01-03 |
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