ZA9610741B - 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists - Google Patents
4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonistsInfo
- Publication number
- ZA9610741B ZA9610741B ZA9610741A ZA9610741A ZA9610741B ZA 9610741 B ZA9610741 B ZA 9610741B ZA 9610741 A ZA9610741 A ZA 9610741A ZA 9610741 A ZA9610741 A ZA 9610741A ZA 9610741 B ZA9610741 B ZA 9610741B
- Authority
- ZA
- South Africa
- Prior art keywords
- substituted piperidine
- pct
- piperidine analogs
- analogs
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US919295P | 1995-12-22 | 1995-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9610741B true ZA9610741B (en) | 1997-06-24 |
Family
ID=21736135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9610741A ZA9610741B (en) | 1995-12-22 | 1996-12-19 | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
Country Status (22)
Country | Link |
---|---|
US (4) | US6130234A (de) |
EP (1) | EP0869791B1 (de) |
JP (1) | JP2000502352A (de) |
AT (1) | ATE239473T1 (de) |
AU (1) | AU719430B2 (de) |
BG (1) | BG63424B1 (de) |
BR (1) | BR9612153A (de) |
CA (1) | CA2240038A1 (de) |
CZ (1) | CZ177898A3 (de) |
DE (1) | DE69628035T2 (de) |
DK (1) | DK0869791T3 (de) |
EA (1) | EA001133B1 (de) |
ES (1) | ES2196196T3 (de) |
IL (1) | IL125060A (de) |
MX (1) | MX9805032A (de) |
NO (1) | NO312028B1 (de) |
NZ (1) | NZ325735A (de) |
PL (1) | PL327413A1 (de) |
PT (1) | PT869791E (de) |
SK (1) | SK82398A3 (de) |
WO (1) | WO1997023214A1 (de) |
ZA (1) | ZA9610741B (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
WO1998010757A2 (en) * | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | The use of functional n-methyl-d-aspartate antagonists to ameliorate or prevent aminoglycoside-induced ototoxicity |
GB9704948D0 (en) * | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
HUP0004900A3 (en) | 1997-10-24 | 2002-03-28 | Warner Lambert Co | Pharmaceutical compositions for treating disease-related or drug-induced dyskinesias containing piperidine derivatives as nmda receptor antagonist as active ingredient |
US6960577B2 (en) * | 1998-05-22 | 2005-11-01 | Eli Lilly And Company | Combination therapy for treatment of refractory depression |
PE20000728A1 (es) * | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
US8008283B2 (en) * | 1998-12-23 | 2011-08-30 | Neurotherapeutics Pharma, Inc. | Methods and compositions for the treatment of neuropsychiatric disorders |
US20060025387A1 (en) * | 1998-12-23 | 2006-02-02 | Cytoscan Sciences Llc | Compositions and methods for the treatment of disorders of the central and peripheral nervous systems |
US7214711B2 (en) * | 1998-12-23 | 2007-05-08 | Neurotherapeutics Pharma Llc | Method of treating migraine headache without aura |
US8722668B2 (en) * | 1998-12-23 | 2014-05-13 | Daryl W. Hochman | Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders |
US6316474B1 (en) * | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
JP2004506900A (ja) * | 2000-08-11 | 2004-03-04 | アジリックス・コーポレイション | 超高感度検出システム |
EP1186303A3 (de) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Ein Neutrophilhemmender Faktor und ein selektive NMDA-NR2B Rezeptor Antagonisten enthaltende Kombinationspräparate zur Behandlung von Schlaganfällen und traumatischen Gehirnschäden |
ZA200108038B (en) * | 2000-10-02 | 2003-04-01 | Pfizer Prod Inc | Prophylactic use of n-methyl-d-asparrate (NMDA) antagonists. |
IL145584A0 (en) * | 2000-10-02 | 2002-06-30 | Pfizer Prod Inc | Nmda nr2b antagonists for treatment |
EP1674087A1 (de) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Prophylaktische Verwendung von N-Methyl-D-Aspartat Rezeptor (NMDA) Antagonisten |
AU2002223968A1 (en) | 2000-12-21 | 2002-07-01 | Warner Lambert Company Llc | Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists |
MXPA04000737A (es) | 2001-07-24 | 2004-07-08 | Richter Gedeon Vegyeszet | Derivados de piperidina como antagonistas receptores de nmda. |
WO2003017764A1 (de) * | 2001-08-23 | 2003-03-06 | Bayer Cropscience S.A. | Substituierte propargylamine |
WO2003035641A1 (fr) * | 2001-10-22 | 2003-05-01 | Shionogi & Co., Ltd. | Nouveau derive carbamoyl-pyrrolidone |
AU2002365271B2 (en) * | 2001-11-06 | 2008-12-11 | Agilix Corporation | Sensitive coded detection systems |
DE10201550A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
WO2005037286A1 (en) * | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
DE602004028150D1 (de) * | 2003-11-26 | 2010-08-26 | Pfizer Prod Inc | Aminopyrazolderivate als gsk-3-inhibitoren |
JP2008529035A (ja) * | 2005-02-03 | 2008-07-31 | パーキンエルマー エルエーエス,インク. | 多次元シグナルを用いる超高感度検出システム |
DK1864666T3 (da) * | 2005-03-31 | 2012-10-29 | Asahi Glass Co Ltd | Beskyttelsesmiddel til en retinal neuronal celle indeholdende prostaglandin-F2-alfa-derivat som aktiv ingrediens |
WO2006112313A1 (ja) * | 2005-04-13 | 2006-10-26 | Ube Industries, Ltd. | インダゾール誘導体を有効成分として含む網膜神経細胞保護剤 |
DE602006008945D1 (de) | 2005-06-28 | 2009-10-15 | Sanofi Aventis | Isochinolinderivate als inhibitoren von rho-kinase |
NI200800025A (es) | 2005-07-26 | 2009-03-03 | Derivados de isoquinolona sustituidos con piperidinilo en calidad de inhibidores de rho-quinasa | |
NZ565669A (en) | 2005-07-26 | 2010-05-28 | Sanofi Aventis | Cyclohexylamin isoquinolone derivatives as Rho-kinase inhibitors |
JP2009511629A (ja) * | 2005-10-17 | 2009-03-19 | ニューロセラピューティクス ファーマ, インコーポレイテッド | 中枢神経系疾患の調節に有用な利尿薬様化合物類似体 |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
CA2673917C (en) | 2006-12-27 | 2015-01-27 | Sanofi-Aventis | Cycloalkylamine substituted isoquinolone derivatives |
WO2008077550A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
MY151953A (en) | 2006-12-27 | 2014-07-31 | Sanofi Aventis | Cycloalkylamine substituted isoquinoline derivatives |
DK2132194T3 (da) | 2006-12-27 | 2011-06-27 | Sanofi Aventis | Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer |
PL2102164T3 (pl) | 2006-12-27 | 2011-05-31 | Sanofi Aventis | Pochodne izochinoliny i izochinolinonu podstawione cykloalkiloaminami |
WO2008077552A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
DK2303846T3 (en) | 2008-06-24 | 2015-08-03 | Sanofi Sa | SUBSTITUTED isoquinolines AND ISOQUINOLINONER AS RHO kinase inhibitors |
MX2010013974A (es) | 2008-06-24 | 2011-01-14 | Sanofi Aventis | Isoquinolinas e isoquinolinonas 6-sustituidas. |
RU2532481C2 (ru) | 2008-06-24 | 2014-11-10 | Санофи-Авентис | Би- и полициклические замещенные производные изохинолина и изохинолинона, полезные в качестве ингибиторов rho-киназы |
US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
EP2542549B1 (de) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Glutaminylcyclase-hemmer |
BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
EP2705024B1 (de) * | 2011-05-03 | 2015-12-16 | Merck Sharp & Dohme Corp. | Alkin-Benzotriazol-Derivate |
SG10201800159QA (en) | 2011-11-22 | 2018-02-27 | Univ California | Cysteamine and/or cystamine for treating ischemic injury |
EP3090260A1 (de) * | 2014-01-02 | 2016-11-09 | John P. Jasper | Verfahren zur kontinuierlichen überwachung chemischer oder biologischer prozesse |
US11066366B2 (en) | 2015-09-03 | 2021-07-20 | Allegheny-Singer Research Institute | Hydrophilic fentanyl derivatives |
SI25272A (sl) * | 2016-09-23 | 2018-03-30 | Univerza V Ljubljani | Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
CN108250058B (zh) * | 2018-01-19 | 2022-02-11 | 上海怡立舍生物技术有限公司 | Ppar激动剂及其在治疗老年痴呆及其他疾病中的用途 |
US20240270705A1 (en) * | 2021-05-25 | 2024-08-15 | Vividion Therapeutics, Inc. | Compounds selective for jak1 and methods of use |
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US3255196A (en) | 1966-06-07 | Phenoxyalkyl piperidine derivatives | ||
CA696999A (en) | 1964-11-03 | Ayerst, Mckenna And Harrison | Therapeutic compounds and their preparation | |
GB1052302A (de) * | 1963-04-22 | |||
GB1055548A (en) | 1965-08-23 | 1967-01-18 | Acraf | New substituted 1-aryl-3-aminopropynes and process for their preparation |
US3632767A (en) | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
US3686187A (en) * | 1970-05-25 | 1972-08-22 | Abbott Lab | 4-anilino-1-(4-p-fluorophenyl-1-butyl) piperidine compounds |
AR206937A1 (es) * | 1974-09-06 | 1976-08-31 | Lilly Co Eli | Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina |
DE2651574A1 (de) | 1976-11-12 | 1978-05-18 | Boehringer Mannheim Gmbh | Ein neues aminopropanol-derivat und verfahren zu dessen herstellung |
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-
1996
- 1996-12-19 ZA ZA9610741A patent/ZA9610741B/xx unknown
- 1996-12-20 ES ES96944537T patent/ES2196196T3/es not_active Expired - Lifetime
- 1996-12-20 EA EA199800591A patent/EA001133B1/ru not_active IP Right Cessation
- 1996-12-20 CZ CZ981778A patent/CZ177898A3/cs unknown
- 1996-12-20 US US09/091,594 patent/US6130234A/en not_active Expired - Fee Related
- 1996-12-20 SK SK823-98A patent/SK82398A3/sk unknown
- 1996-12-20 NZ NZ325735A patent/NZ325735A/en unknown
- 1996-12-20 AU AU14310/97A patent/AU719430B2/en not_active Ceased
- 1996-12-20 AT AT96944537T patent/ATE239473T1/de not_active IP Right Cessation
- 1996-12-20 DK DK96944537T patent/DK0869791T3/da active
- 1996-12-20 EP EP96944537A patent/EP0869791B1/de not_active Expired - Lifetime
- 1996-12-20 PT PT96944537T patent/PT869791E/pt unknown
- 1996-12-20 PL PL96327413A patent/PL327413A1/xx unknown
- 1996-12-20 CA CA002240038A patent/CA2240038A1/en not_active Abandoned
- 1996-12-20 WO PCT/US1996/020766 patent/WO1997023214A1/en not_active Application Discontinuation
- 1996-12-20 JP JP09523881A patent/JP2000502352A/ja not_active Ceased
- 1996-12-20 IL IL12506096A patent/IL125060A/xx not_active IP Right Cessation
- 1996-12-20 BR BR9612153-0A patent/BR9612153A/pt not_active Application Discontinuation
- 1996-12-20 DE DE69628035T patent/DE69628035T2/de not_active Expired - Fee Related
-
1998
- 1998-06-19 MX MX9805032A patent/MX9805032A/es not_active IP Right Cessation
- 1998-06-19 NO NO19982869A patent/NO312028B1/no unknown
- 1998-06-19 BG BG102561A patent/BG63424B1/bg unknown
-
2000
- 2000-06-13 US US09/592,883 patent/US6448270B1/en not_active Expired - Fee Related
-
2002
- 2002-07-29 US US10/206,578 patent/US20030105133A1/en not_active Abandoned
- 2002-08-06 US US10/172,525 patent/US20030100018A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030100018A1 (en) | 2003-05-29 |
AU1431097A (en) | 1997-07-17 |
DE69628035D1 (de) | 2003-06-12 |
EP0869791A1 (de) | 1998-10-14 |
ES2196196T3 (es) | 2003-12-16 |
CZ177898A3 (cs) | 1998-12-16 |
IL125060A0 (en) | 1999-01-26 |
WO1997023214A1 (en) | 1997-07-03 |
DK0869791T3 (da) | 2003-06-10 |
US6130234A (en) | 2000-10-10 |
BG102561A (en) | 1999-04-30 |
JP2000502352A (ja) | 2000-02-29 |
NO982869D0 (no) | 1998-06-19 |
BG63424B1 (bg) | 2002-01-31 |
US20030105133A1 (en) | 2003-06-05 |
AU719430B2 (en) | 2000-05-11 |
CA2240038A1 (en) | 1997-07-03 |
SK82398A3 (en) | 1999-03-12 |
US6448270B1 (en) | 2002-09-10 |
PL327413A1 (en) | 1998-12-07 |
MX9805032A (es) | 1998-11-30 |
EA001133B1 (ru) | 2000-10-30 |
EP0869791B1 (de) | 2003-05-07 |
NO982869L (no) | 1998-08-24 |
EA199800591A1 (ru) | 1999-02-25 |
PT869791E (pt) | 2003-08-29 |
IL125060A (en) | 2003-07-31 |
BR9612153A (pt) | 1999-12-28 |
NZ325735A (en) | 2000-02-28 |
ATE239473T1 (de) | 2003-05-15 |
EP0869791A4 (de) | 1999-04-28 |
DE69628035T2 (de) | 2004-02-12 |
NO312028B1 (no) | 2002-03-04 |
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