ZA958081B - N-substituted piperidinyl bicyclic benzoate derivatives - Google Patents

N-substituted piperidinyl bicyclic benzoate derivatives

Info

Publication number
ZA958081B
ZA958081B ZA958081A ZA958081A ZA958081B ZA 958081 B ZA958081 B ZA 958081B ZA 958081 A ZA958081 A ZA 958081A ZA 958081 A ZA958081 A ZA 958081A ZA 958081 B ZA958081 B ZA 958081B
Authority
ZA
South Africa
Prior art keywords
6alkyl
substituted
halo
hydrogen
alk
Prior art date
Application number
ZA958081A
Other languages
English (en)
Inventor
Georges Henri Paul Van Daele
Jean-Paul Rene Marie A Bosmans
Frans Maria Alfons Van Keybus
Original Assignee
Janssen Pharmaceuica N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuica N V filed Critical Janssen Pharmaceuica N V
Publication of ZA958081B publication Critical patent/ZA958081B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA958081A 1994-09-27 1995-09-26 N-substituted piperidinyl bicyclic benzoate derivatives ZA958081B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31

Publications (1)

Publication Number Publication Date
ZA958081B true ZA958081B (en) 1997-03-26

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA958081A ZA958081B (en) 1994-09-27 1995-09-26 N-substituted piperidinyl bicyclic benzoate derivatives

Country Status (23)

Country Link
EP (1) EP0784620B1 (ja)
JP (1) JP3953097B2 (ja)
CN (1) CN1068880C (ja)
AT (1) ATE187453T1 (ja)
AU (1) AU699152B2 (ja)
BR (1) BR9509036A (ja)
CA (1) CA2200578C (ja)
CZ (1) CZ289031B6 (ja)
DE (1) DE69513846T2 (ja)
DK (1) DK0784620T3 (ja)
ES (1) ES2141383T3 (ja)
FI (1) FI119640B (ja)
GR (1) GR3032646T3 (ja)
HU (1) HU218698B (ja)
IL (1) IL115413A (ja)
MY (1) MY113202A (ja)
NO (1) NO313238B1 (ja)
NZ (1) NZ293605A (ja)
PL (1) PL182502B1 (ja)
PT (1) PT784620E (ja)
RU (1) RU2154064C2 (ja)
WO (1) WO1996010027A1 (ja)
ZA (1) ZA958081B (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332275A1 (en) * 1998-05-14 1999-11-18 Zoltan Tamas Nagy Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
ATE295845T1 (de) * 2002-01-16 2005-06-15 Janssen Pharmaceutica Nv Prucaloprid-n-oxid
ATE457309T1 (de) 2003-12-23 2010-02-15 Serodus As Modulatoren von peripheren 5-ht-rezeptoren
MXPA06014574A (es) 2004-06-24 2007-03-12 Incyte Corp Piperidinas n-sustituidas y su uso como farmaceuticos.
ES2439736T3 (es) 2005-11-08 2014-01-24 Vertex Pharmaceuticals Incorporated Moduladores heterocíclicos de transportadores de casete de unión a ATP
CN104447716A (zh) 2007-05-09 2015-03-25 沃泰克斯药物股份有限公司 Cftr调节剂
CN101910156B (zh) 2007-12-07 2013-12-04 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式
CA2989620C (en) 2007-12-07 2022-05-03 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
EP2271622B1 (en) 2008-02-28 2017-10-04 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as CFTR Modulators
DK3150198T3 (da) 2010-04-07 2021-11-01 Vertex Pharma Farmaceutiske sammensætninger af 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-yl)-cyclopropancarboxamido)-3-methylpyriodin-2-yl)benzoesyre og indgivelse deraf
BR112012026257A2 (pt) * 2010-04-07 2017-03-14 Vertex Pharma formas sólidas de ácido 3-(6-(1-(2-,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzóico
US10231932B2 (en) 2013-11-12 2019-03-19 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
JP6494757B2 (ja) 2014-11-18 2019-04-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ハイスループット試験高速液体クロマトグラフィーを行うプロセス

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
CA2116024A1 (en) * 1991-08-20 1993-03-04 Francis David King 5-ht4 receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
CZ289031B6 (cs) 2001-10-17
EP0784620B1 (en) 1999-12-08
CA2200578C (en) 2006-11-07
ES2141383T3 (es) 2000-03-16
PL319997A1 (en) 1997-09-01
CZ91897A3 (en) 1997-12-17
MY113202A (en) 2001-12-31
NO971376L (no) 1997-05-05
PL182502B1 (pl) 2002-01-31
JP3953097B2 (ja) 2007-08-01
NZ293605A (en) 1998-07-28
CA2200578A1 (en) 1996-04-04
DE69513846D1 (de) 2000-01-13
CN1068880C (zh) 2001-07-25
JPH10506118A (ja) 1998-06-16
ATE187453T1 (de) 1999-12-15
FI971274A (fi) 1997-03-26
GR3032646T3 (en) 2000-06-30
NO971376D0 (no) 1997-03-24
HU218698B (hu) 2000-11-28
HUT77173A (hu) 1998-03-02
AU699152B2 (en) 1998-11-26
BR9509036A (pt) 1997-10-14
RU2154064C2 (ru) 2000-08-10
WO1996010027A1 (en) 1996-04-04
FI971274A0 (fi) 1997-03-26
CN1166171A (zh) 1997-11-26
PT784620E (pt) 2000-05-31
DK0784620T3 (da) 2000-05-22
FI119640B (fi) 2009-01-30
IL115413A0 (en) 1995-12-31
IL115413A (en) 2000-02-17
EP0784620A1 (en) 1997-07-23
AU3608195A (en) 1996-04-19
MX9702363A (es) 1997-10-31
DE69513846T2 (de) 2000-07-06
NO313238B1 (no) 2002-09-02

Similar Documents

Publication Publication Date Title
ZA958081B (en) N-substituted piperidinyl bicyclic benzoate derivatives
TW369526B (en) Diazabicyclic neurokinin antagonists
ES449191A1 (es) Un procedimiento de preparacion de derivados de 4,5,6,7-te- trahidro-tieno-(2,3-c)-piridina.
MY101359A (en) 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, their starting compounds and their preparation
YU95102A (sh) Supstituisani biciklični derivati u lečenju abnormalnog rasta ćelija
CA2036876A1 (fr) Derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RS20050180A (en) Novel benzoimidazole derivatives useful as antiproliferative agensts
CA2037575A1 (en) N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives
MY132062A (en) Apolipoprotein-b synthesis inhibitors
BG104983A (en) Aryl fused azapolycyclic compounds
ZW9791A1 (en) New heterocyclic chemistry
MY122731A (en) 4-phenyl-pyrimidine derivatives
PL322872A1 (en) Novel triazolones - inhibitors of b apolipoprotein synthesis
MY101775A (en) Substituted dipeptides, methods for their production, pharmaceutical, compositions containing them, method for making such pharmaceutical compositions
TW360653B (en) A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
AP1396A (en) 1-Trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives.
MXPA04004365A (es) Novedosas sales mandelato de derivados de tetrahidrofurano tetraciclico sustituido.
JO1648B1 (en) Nitrogen compounds
JO1697B1 (en) Pyridine derivatives
ATE178064T1 (de) Phenyl-oxo-alkyl-(4-piperidinyl) benzoatderivate
MX9703074A (es) Inhibidores de sintesis de apoliproteina-b.
NO932513L (no) N-alkyl-kinuklidinium-salter