ZA955646B - Process for the preparation of 4-acetoxy-2alpha-benzoyloxy-5beta 20-epoxy-1,7beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-phenylpropionate trihydrate - Google Patents

Process for the preparation of 4-acetoxy-2alpha-benzoyloxy-5beta 20-epoxy-1,7beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Info

Publication number
ZA955646B
ZA955646B ZA955646A ZA955646A ZA955646B ZA 955646 B ZA955646 B ZA 955646B ZA 955646 A ZA955646 A ZA 955646A ZA 955646 A ZA955646 A ZA 955646A ZA 955646 B ZA955646 B ZA 955646B
Authority
ZA
South Africa
Prior art keywords
beta
benzoyloxy
trihydroxy
tax
acetoxy
Prior art date
Application number
ZA955646A
Other languages
English (en)
Inventor
Jean Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA955646(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA955646B publication Critical patent/ZA955646B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ZA955646A 1994-07-08 1995-07-06 Process for the preparation of 4-acetoxy-2alpha-benzoyloxy-5beta 20-epoxy-1,7beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-phenylpropionate trihydrate ZA955646B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
ZA955646B true ZA955646B (en) 1996-02-21

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA955646A ZA955646B (en) 1994-07-08 1995-07-06 Process for the preparation of 4-acetoxy-2alpha-benzoyloxy-5beta 20-epoxy-1,7beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl (2R,3S)-3-tert-butoxy-carbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Country Status (38)

Country Link
US (1) US6022985A (no)
EP (1) EP0770070B1 (no)
JP (1) JP3753155B2 (no)
KR (1) KR100391753B1 (no)
CN (1) CN1067996C (no)
AT (1) ATE171702T1 (no)
AU (1) AU706519B2 (no)
BR (1) BR9508789A (no)
CA (1) CA2193531C (no)
CO (1) CO4410189A1 (no)
CZ (1) CZ284695B6 (no)
DE (1) DE69505128T2 (no)
DK (1) DK0770070T3 (no)
DZ (1) DZ1905A1 (no)
ES (1) ES2121404T3 (no)
FI (1) FI119246B (no)
FR (1) FR2722191B1 (no)
GR (1) GR3027558T3 (no)
HU (1) HU220634B1 (no)
IL (1) IL114274A (no)
IN (1) IN183947B (no)
IS (1) IS2032B (no)
MA (1) MA23606A1 (no)
MX (1) MX9700173A (no)
MY (1) MY118481A (no)
NO (1) NO314500B1 (no)
NZ (1) NZ289455A (no)
PE (1) PE8697A1 (no)
PL (1) PL179876B1 (no)
RU (1) RU2126397C1 (no)
SI (1) SI0770070T1 (no)
SK (1) SK280520B6 (no)
TN (1) TNSN95071A1 (no)
TW (1) TW419473B (no)
UA (1) UA51624C2 (no)
UY (1) UY23991A1 (no)
WO (1) WO1996001815A1 (no)
ZA (1) ZA955646B (no)

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BR9808697A (pt) 1997-04-28 2000-07-11 Rhone Poulenc Rorer Sa Processo para inibir o crescimento de um tumor, vetor de adenovìrus defeituoso, vetor de vìrus, uso do mesmo, e, composição farmacêutica
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
US7838551B2 (en) 2003-12-12 2010-11-23 Quiral Quimica do Basil S.A. Process for the preparation of concentrated, sterile injectable solutions containing docetaxel
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
KR101643416B1 (ko) 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 증가된 안정성을 가진 수 난용성 약물의 조성물 및 제조방법
CA2620585C (en) * 2005-08-31 2015-04-28 Abraxis Bioscience, Llc Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
CA2620308A1 (en) * 2005-10-12 2007-04-19 Sicor Inc. Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
BRPI0706580A2 (pt) * 2006-01-20 2011-03-29 Landmark Graphics Corp gerenciamento dinámico de sistema de produção
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
NZ576355A (en) * 2006-10-20 2012-04-27 Scinopharm Singapore Pte Ltd Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
US20100197944A1 (en) * 2007-07-04 2010-08-05 Dr. Reddy's Laboratories Limited Docetaxel process and polymorphs
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
CN109745287A (zh) 2010-05-03 2019-05-14 帝国制药美国公司 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
PT2753355T (pt) 2011-09-08 2019-02-01 Univ New York Vírus herpes simplex oncolítico e suas utilizações terapêuticas
WO2013096455A1 (en) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
AU2013243873B2 (en) 2012-04-04 2016-08-25 Halozyme, Inc. Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2968406A4 (en) 2013-03-14 2016-10-26 Icahn School Med Mount Sinai AUTOLOGOUS TUMOR LYSAT-FILLED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
WO2016205429A1 (en) 2015-06-15 2016-12-22 New York University Method of treatment using oncolytic viruses
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
NO970007D0 (no) 1997-01-02
IN183947B (no) 2000-05-20
FI119246B (fi) 2008-09-15
EP0770070A1 (fr) 1997-05-02
SK280520B6 (sk) 2000-03-13
KR970704721A (ko) 1997-09-06
US6022985A (en) 2000-02-08
IS2032B (is) 2005-08-15
PL179876B1 (pl) 2000-11-30
PE8697A1 (es) 1997-03-26
CA2193531C (fr) 2006-12-05
MX9700173A (es) 1997-04-30
DZ1905A1 (fr) 2002-02-17
MY118481A (en) 2004-11-30
SK697A3 (en) 1997-06-04
HUT76833A (en) 1997-11-28
HU220634B1 (hu) 2002-03-28
FI970069A0 (fi) 1997-01-07
FR2722191B1 (fr) 1996-08-23
FR2722191A1 (fr) 1996-01-12
AU2930595A (en) 1996-02-09
UY23991A1 (es) 1995-09-20
JP3753155B2 (ja) 2006-03-08
IL114274A0 (en) 1995-10-31
SI0770070T1 (en) 1998-12-31
IL114274A (en) 1999-04-11
ES2121404T3 (es) 1998-11-16
NO970007L (no) 1997-01-02
KR100391753B1 (ko) 2004-02-11
EP0770070B1 (fr) 1998-09-30
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
CZ3597A3 (en) 1997-04-16
FI970069A (fi) 1997-01-07
JPH10502627A (ja) 1998-03-10
TNSN95071A1 (fr) 1996-02-06
WO1996001815A1 (fr) 1996-01-25
PL318195A1 (en) 1997-05-26
AU706519B2 (en) 1999-06-17
GR3027558T3 (en) 1998-11-30
BR9508789A (pt) 1997-10-21
ATE171702T1 (de) 1998-10-15
IS4411A (is) 1997-01-07
RU2126397C1 (ru) 1999-02-20
CA2193531A1 (fr) 1996-01-25
CO4410189A1 (es) 1997-01-09
DE69505128D1 (de) 1998-11-05
HU9700041D0 (en) 1997-02-28
TW419473B (en) 2001-01-21
NZ289455A (en) 1997-12-19
CZ284695B6 (cs) 1999-02-17
DK0770070T3 (da) 1999-03-01
UA51624C2 (uk) 2002-12-16
CN1151741A (zh) 1997-06-11
CN1067996C (zh) 2001-07-04
DE69505128T2 (de) 1999-04-01

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