ZA952477B - Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt - Google Patents

Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt

Info

Publication number
ZA952477B
ZA952477B ZA952477A ZA952477A ZA952477B ZA 952477 B ZA952477 B ZA 952477B ZA 952477 A ZA952477 A ZA 952477A ZA 952477 A ZA952477 A ZA 952477A ZA 952477 B ZA952477 B ZA 952477B
Authority
ZA
South Africa
Prior art keywords
aminoethyl
benzo
bis
amino
dione
Prior art date
Application number
ZA952477A
Other languages
English (en)
Inventor
Silvano Spinelli
Roberto Didomenico
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ZA952477B publication Critical patent/ZA952477B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA952477A 1994-03-28 1995-03-27 Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt ZA952477B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/220,007 US5506232A (en) 1994-03-28 1994-03-28 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Publications (1)

Publication Number Publication Date
ZA952477B true ZA952477B (en) 1996-09-27

Family

ID=22821665

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA952477A ZA952477B (en) 1994-03-28 1995-03-27 Method of synthesis for 6,9-bis[(2-aminoethyl)-amino]benzo[g]soquinoline,5-10-dione and its dimaleate salt

Country Status (24)

Country Link
US (3) US5506232A (ru)
EP (1) EP0752857B1 (ru)
JP (2) JP3151462B2 (ru)
KR (1) KR100224153B1 (ru)
CN (2) CN1130199C (ru)
AT (1) ATE203408T1 (ru)
AU (1) AU679627B2 (ru)
BR (1) BR9507257A (ru)
CA (1) CA2186485C (ru)
CZ (2) CZ598A3 (ru)
DE (1) DE69521887T2 (ru)
DK (1) DK0752857T3 (ru)
ES (1) ES2159313T3 (ru)
FI (1) FI113861B (ru)
GR (1) GR3037014T3 (ru)
HU (1) HU223311B1 (ru)
LU (1) LU92089I2 (ru)
NO (2) NO307564B1 (ru)
NZ (1) NZ282480A (ru)
PT (1) PT752857E (ru)
RU (1) RU2144028C1 (ru)
TW (1) TW397826B (ru)
WO (1) WO1995026189A1 (ru)
ZA (1) ZA952477B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
SK281254B6 (sk) * 1995-07-13 2001-01-18 Smithkline Beecham Corporation Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
WO2005097128A1 (en) * 2004-03-30 2005-10-20 Novacea, Inc. 1,4-bis-n-oxide azaanthracenediones and the use thereof
US20080081041A1 (en) * 2006-09-29 2008-04-03 Jeffrey Nemeth Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) * 2018-09-04 2022-05-17 北京凯莱天成医药科技有限公司 一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920754A1 (en) * 1991-03-08 1992-09-09 Univ Vermont 6,9 BIS(SUBSTITUTED-AMINO) BENZO[g]-ISOQUINOLINE-5,10-DIONES
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
WO1995026189A1 (en) 1995-10-05
JP3151462B2 (ja) 2001-04-03
CA2186485A1 (en) 1995-10-05
NO964082L (no) 1996-09-27
NZ282480A (en) 1997-04-24
FI963864A (fi) 1996-09-27
HU9602655D0 (en) 1996-11-28
HU223311B1 (hu) 2004-05-28
US5506232A (en) 1996-04-09
HUT75654A (en) 1997-05-28
PT752857E (pt) 2001-11-30
AU1958995A (en) 1995-10-17
JP3548099B2 (ja) 2004-07-28
DE69521887T2 (de) 2001-11-22
MX9603994A (es) 1997-12-31
NO2012020I2 (no) 2013-11-11
US5616709A (en) 1997-04-01
CZ285139B6 (cs) 1999-05-12
CN1130199C (zh) 2003-12-10
GR3037014T3 (en) 2002-01-31
RU2144028C1 (ru) 2000-01-10
CA2186485C (en) 1999-12-14
LU92089I2 (fr) 2012-12-27
CN1282738A (zh) 2001-02-07
NO964082D0 (no) 1996-09-27
TW397826B (en) 2000-07-11
FI113861B (fi) 2004-06-30
ATE203408T1 (de) 2001-08-15
JP2001089454A (ja) 2001-04-03
CZ284937B6 (cs) 1999-04-14
DK0752857T3 (da) 2001-09-24
NO2012020I1 (no) 2012-12-27
CZ598A3 (cs) 1999-05-12
NO307564B1 (no) 2000-04-25
EP0752857B1 (en) 2001-07-25
CZ276796A3 (en) 1997-02-12
AU679627B2 (en) 1997-07-03
JPH09507674A (ja) 1997-08-05
DE69521887D1 (de) 2001-08-30
CN1145028A (zh) 1997-03-12
KR100224153B1 (ko) 1999-10-15
EP0752857A1 (en) 1997-01-15
ES2159313T3 (es) 2001-10-01
US5717099A (en) 1998-02-10
FI963864A0 (fi) 1996-09-27
BR9507257A (pt) 1997-10-07

Similar Documents

Publication Publication Date Title
NO2012020I2 (no) Piksantron dimaleatsalt
CA2160447A1 (en) Amino(thio)ether derivatives
EP0629608A3 (en) N-acyl-N, N ', N'-ethylenediamine triacetic acid derivatives and process for their preparation.
IL131755A0 (en) Crystalline amine salt of cefdinir
DK0582790T3 (da) Ny fremgangsmåde til fremstilling af 7-substituerede-9-[(substitueret glycyl)-amino]-6-demethyl-6-deoxytetracycliner
HU9503370D0 (en) N-alkylthio polyamine derivatives as radioprotective agents
CA2179712A1 (en) Crosslinked polymeric ammonium salts
TW230775B (ru)
PL308202A1 (en) Synthesis of n-acetloneuraminic acid derivatives
MX9602812A (es) Sales de amonio polimericas, reticuladas.
BG103289A (en) Method for yohexene preparation
TW252979B (ru)
GR3018038T3 (en) Antitumor amino acid and peptide derivatives of 1,4-bis[ (aminoalkyl and hydroxyaminoalkyl)- amino]-5,8 dihydroxyanthraquinones.
TW333533B (en) Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
EA200200389A1 (ru) Липосомный препарат 6,9-бис[(2-аминоэтил)-амино]бензо[g]изохинолин-5,10-диона дималеата
UA41890C2 (ru) Способ получения производных 2-перфторалкил-3-оксазолин-5-она (варианты), перфторалканоиламинонитрильные промежуточные соединения
TW340108B (en) 1,1-difluoro-1,4-dichlorobutane and process for its preparation
SG47459A1 (en) Process for preparing enantiomerically pure imidazo(4,5,1)(1,4)benzodiazepin-2(1H)-thiones
HUT65917A (en) Process for producing asparatic acid and glutamic acid derivatives and pharmaceutical preparations containing them
FI945414A (fi) Menetelmä N,N-disubstituoidun aminofenolin valmistamiseksi
EA199600048A3 (ru) N,n-диэтил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанамин дималеат, фармацевтическая композиция на его основе и способ индуцирования иммуномодуляции
PL312966A1 (en) Derivatives of thiocarbamoil
CA2155802A1 (en) Enantiomerically pure pyridylcycloalkylethylamines and the salts thereof and processes for preparing them
PT90831A (pt) Processo para a preparacao de eteres da 2-amino-7-hidroxitetralina
MX9605668A (es) Sal de estilbazolio, su preparacion y uso.