IL113010A
(en)
*
|
1994-03-31 |
1999-10-28 |
Pharmacia & Upjohn Ab |
Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
|
SE9403915D0
(sv)
*
|
1994-11-14 |
1994-11-14 |
Annelie Almstedt |
Process A
|
GB9501040D0
(en)
*
|
1995-01-19 |
1995-03-08 |
Quadrant Holdings Cambridge |
Dried composition
|
US7253262B2
(en)
|
1995-01-19 |
2007-08-07 |
Quandrant Drug Delivery Limited |
Dried blood factor composition comprising trehalose
|
US7244824B2
(en)
|
1995-01-19 |
2007-07-17 |
Quadrant Drug Delivery Limited |
Dried blood factor composition comprising trehalose
|
SE9502285D0
(sv)
*
|
1995-06-22 |
1995-06-22 |
Pharmacia Ab |
Improvements related to injections
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
US7560107B2
(en)
*
|
1996-06-26 |
2009-07-14 |
Emory University |
Modified factor VIII
|
US5763401A
(en)
*
|
1996-07-12 |
1998-06-09 |
Bayer Corporation |
Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
|
US7223845B2
(en)
|
1998-06-16 |
2007-05-29 |
The Board Of Regents Of The University Of Oklahoma |
Synthetic glycosulfopeptides and methods of synthesis thereof
|
US20030143662A1
(en)
|
1998-06-16 |
2003-07-31 |
Cummings Richard D. |
Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
|
MXPA00012586A
(es)
*
|
1998-06-16 |
2004-05-21 |
Univ Oklahoma |
Glicosulfopeptidos y metodos de sintesis y uso de los mismos.
|
RU2244556C2
(ru)
|
1999-02-22 |
2005-01-20 |
Юниверсити Оф Коннектикут |
Новые не содержащие альбумин составы фактора viii
|
GB0207092D0
(en)
|
2002-03-26 |
2002-05-08 |
Sod Conseils Rech Applic |
Stable pharmaceutical composition containing factor VIII
|
CA2788505C
(en)
*
|
2003-02-26 |
2018-09-04 |
Nektar Therapeutics |
Polymer-factor viii moiety conjugates
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
CA2465004A1
(en)
*
|
2003-05-19 |
2004-11-19 |
National Institute For Biological Standards And Control |
Composition
|
CN1266144C
(zh)
*
|
2003-09-01 |
2006-07-26 |
上海凯曼生物科技有限公司 |
黄芩甙和黄芩甙元的用途和剂型
|
ES2229931B1
(es)
*
|
2003-10-03 |
2006-01-16 |
Grifols, S.A. |
Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos.
|
DE102004005095A1
(de)
|
2004-01-27 |
2005-09-22 |
Coty B.V. |
Kosmetische Zusammensetzung mit wasserbeständiger Parfümkomponente
|
EP1750733B1
(en)
*
|
2004-05-03 |
2013-12-11 |
Emory University |
METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII
|
SI3130601T1
(sl)
*
|
2004-11-12 |
2020-11-30 |
Bayer Healthcare Llc |
Usmerjena modifikacija FVIII
|
TWI264608B
(en)
*
|
2005-04-08 |
2006-10-21 |
Delta Electronics Inc |
Light tunnel module
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
US8637007B2
(en)
|
2006-12-15 |
2014-01-28 |
Baxter International Inc. |
Factor VIIa-polysialic acid conjugate having prolonged in vivo half-life
|
CA2690218C
(en)
|
2007-06-13 |
2017-02-28 |
Csl Behring Gmbh |
Use of vwf stabilized fviii preparations and of vwf preparations without fviii for extravascular administration in the therapy and prophylactic treatment of bleeding disorders
|
JP5779780B2
(ja)
|
2008-11-07 |
2015-09-16 |
バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated |
第viii因子製剤
|
CA2748314C
(en)
|
2009-02-03 |
2018-10-02 |
Amunix Operating Inc. |
Extended recombinant polypeptides and compositions comprising same
|
US10172949B2
(en)
|
2009-06-09 |
2019-01-08 |
Prolong Pharmaceuticals, LLC |
Hemoglobin compositions
|
PL3266463T3
(pl)
|
2009-06-09 |
2024-03-18 |
Prolong Pharmaceuticals, LLC |
Kompozycje hemoglobiny
|
US10172950B2
(en)
|
2009-06-09 |
2019-01-08 |
Prolong Pharmaceuticals, LLC |
Hemoglobin compositions
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
ES2856055T3
(es)
|
2009-07-27 |
2021-09-27 |
Baxalta GmbH |
Glicopolisialilación de proteínas diferentes de las proteínas de coagulación de la sangre
|
ES2590679T3
(es)
|
2009-07-27 |
2016-11-23 |
Lipoxen Technologies Limited |
Glicopolisialilación de proteínas diferentes a proteínas de coagulación de la sangre
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
CA2769326A1
(en)
|
2009-07-27 |
2011-02-10 |
Baxter International Inc. |
Blood coagulation protein conjugates
|
KR20120061898A
(ko)
*
|
2009-08-20 |
2012-06-13 |
체에스엘 베링 게엠베하 |
출혈성 장애의 치료요법 및 예방 치료에 있어서의 비정맥내 투여를 위한 알부민 융합 응고 인자
|
WO2011028229A1
(en)
|
2009-08-24 |
2011-03-10 |
Amunix Operating Inc. |
Coagulation factor ix compositions and methods of making and using same
|
CA2782424C
(en)
|
2009-12-06 |
2021-07-27 |
Biogen Idec Hemophilia Inc. |
Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
|
GB201007356D0
(en)
|
2010-04-30 |
2010-06-16 |
Leverton Licence Holdings Ltd |
Conjugated factor VIIa
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
US20130216513A1
(en)
|
2010-07-09 |
2013-08-22 |
Biogen Idec Hemophilia Inc. |
Chimeric Clotting Factors
|
CN104788557A
(zh)
*
|
2010-09-15 |
2015-07-22 |
诺沃—诺迪斯克有限公司 |
具有减少的细胞摄取的因子viii变体
|
SG10201509149VA
(en)
|
2010-11-05 |
2015-12-30 |
Baxter Int |
A new variant of antihemophilic factor viii having increased specific activity
|
KR102025442B1
(ko)
|
2010-12-22 |
2019-09-25 |
박스알타 인코퍼레이티드 |
단백질에 수용성 지방산 유도체를 접합하기 위한 물질 및 방법
|
EP2709648A4
(en)
|
2011-05-19 |
2015-04-08 |
Geysen Hendrik M |
COMPOUNDS FOR BINDING TO THE ERYTHROPOIETIN RECEPTOR
|
HUE039317T2
(hu)
*
|
2011-06-10 |
2018-12-28 |
Baxalta GmbH |
Koagulációs betegség kezelése rekombináns VWF adagolásával
|
US9486507B2
(en)
|
2011-06-10 |
2016-11-08 |
Biogen Ma Inc. |
Pro-coagulant compounds and methods of use thereof
|
WO2013009627A2
(en)
|
2011-07-08 |
2013-01-17 |
Biogen Idec Hemophilia Inc. |
Factor viii chimeric and hybrid polypeptides, and methods of use thereof
|
US10656167B2
(en)
|
2011-07-25 |
2020-05-19 |
Bioverativ Therapeutics Inc. |
Assays to monitor bleeding disorders
|
AU2012318303B2
(en)
|
2011-10-18 |
2015-09-03 |
Csl Behring Gmbh |
Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of Factor VIII
|
KR20140083036A
(ko)
|
2011-10-18 |
2014-07-03 |
체에스엘 베링 게엠베하 |
인자 viii의 생체이용률을 향상시키기 위한 황산화 글리코사미노글리칸의 용도
|
PT2804623T
(pt)
|
2012-01-12 |
2019-11-18 |
Bioverativ Therapeutics Inc |
Polipéptidos quiméricos do fator viii e suas utilizações
|
ES2899848T3
(es)
|
2012-01-12 |
2022-03-15 |
Bioverativ Therapeutics Inc |
Reducción de la inmunogenicidad contra el factor VIII en individuos sometidos a una terapia con factor VIII
|
LT3564260T
(lt)
|
2012-02-15 |
2023-01-10 |
Bioverativ Therapeutics Inc. |
Viii faktoriaus kompozicijos ir jų gamybos bei panaudojimo būdai
|
CA2864126A1
(en)
|
2012-02-15 |
2013-08-22 |
Biogen Idec Ma Inc. |
Recombinant factor viii proteins
|
JP2015525222A
(ja)
|
2012-06-08 |
2015-09-03 |
バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. |
キメラ性凝固因子
|
EP4079316A1
(en)
|
2012-06-08 |
2022-10-26 |
Bioverativ Therapeutics Inc. |
Procoagulant compounds
|
EP3404105A1
(en)
|
2012-07-06 |
2018-11-21 |
Bioverativ Therapeutics Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
BR112015000267B1
(pt)
|
2012-07-11 |
2023-01-24 |
Bioverativ Therapeutics Inc. |
Proteínas quiméricas, e composição farmacêutica
|
EP2877202A4
(en)
|
2012-07-25 |
2016-06-01 |
Biogen Ma Inc |
BLOOD FACTOR MONITORING TEST AND USES THEREOF
|
EP2908847B1
(en)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Methods of using a fixed dose of a clotting factor
|
EP3943102A1
(en)
|
2012-10-30 |
2022-01-26 |
Bioverativ Therapeutics Inc. |
Methods of using fviii polypeptide
|
FI2956477T4
(fi)
|
2013-02-15 |
2024-04-24 |
Bioverativ Therapeutics Inc |
Optimoitu tekijä viii:n geeni
|
UY35462A
(es)
|
2013-03-15 |
2014-10-31 |
Biogen Idec Inc |
Formulación de un polipéptido del factor viii.
|
SG11201505926VA
(en)
|
2013-03-15 |
2015-09-29 |
Biogen Ma Inc |
Factor ix polypeptide formulations
|
EP2989123A4
(en)
*
|
2013-04-22 |
2016-10-12 |
Scripps Research Inst |
METHODS AND COMPOSITIONS FOR TREATING COAGULATION DISORDERS
|
EP2796145B1
(en)
|
2013-04-22 |
2017-11-01 |
CSL Ltd. |
A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
|
NZ713904A
(en)
|
2013-06-28 |
2022-02-25 |
Bioverativ Therapeutics Inc |
Thrombin cleavable linker with xten and its uses thereof
|
EP3875106A1
(en)
|
2013-08-08 |
2021-09-08 |
Bioverativ Therapeutics Inc. |
Purification of chimeric fviii molecules
|
TW202003554A
(zh)
|
2013-08-14 |
2020-01-16 |
美商百歐維拉提夫治療公司 |
因子viii-xten融合物及其用途
|
EP3065769A4
(en)
|
2013-11-08 |
2017-05-31 |
Biogen MA Inc. |
Procoagulant fusion compound
|
WO2015085276A1
(en)
|
2013-12-06 |
2015-06-11 |
Biogen Idec Ma Inc. |
Population pharmacokinetics tools and uses thereof
|
CN116621991A
(zh)
|
2014-01-10 |
2023-08-22 |
比奥贝拉蒂治疗公司 |
因子viii嵌合蛋白及其用途
|
EP3102589A1
(en)
|
2014-02-04 |
2016-12-14 |
Biogen MA Inc. |
Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
|
CN106414492B
(zh)
|
2014-06-06 |
2021-07-06 |
奥克塔法马股份有限公司 |
包含因子viii和冯·维勒布兰德因子肽的制剂
|
US9987241B2
(en)
|
2014-09-25 |
2018-06-05 |
The Board Of Regents Of The University Of Oklahoma |
Enzyme conjugate and prodrug cancer therapy
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
EA201890423A1
(ru)
|
2015-08-03 |
2018-07-31 |
Биовератив Терапьютикс Инк. |
Слитые белки фактора ix, способы их получения и применения
|
CN108884145B
(zh)
|
2015-11-13 |
2023-08-22 |
武田药品工业株式会社 |
用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体
|
JP6695426B2
(ja)
|
2015-11-13 |
2020-05-20 |
バクスアルタ インコーポレイテッド |
組換えfviii変異型をコードする血友病a遺伝子治療用高発現ウイルスベクター
|
PL3411478T3
(pl)
|
2016-02-01 |
2022-10-03 |
Bioverativ Therapeutics Inc. |
Geny zoptymalizowanego czynnika VIII
|
WO2017222337A1
(ko)
|
2016-06-24 |
2017-12-28 |
재단법인 목암생명과학연구소 |
Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도
|
JP2020504082A
(ja)
|
2016-11-11 |
2020-02-06 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
血液凝固障害の処置又は予防における血管外投与のための切断型フォン・ヴィルブランド因子ポリペプチド
|
EP3548066A1
(en)
|
2016-12-02 |
2019-10-09 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
MX2019006446A
(es)
|
2016-12-02 |
2019-12-11 |
Bioverativ Therapeutics Inc |
Métodos para inducir tolerancia inmunológica a factores de coagulación.
|
SG11202000764RA
(en)
|
2017-08-09 |
2020-02-27 |
Bioverativ Therapeutics Inc |
Nucleic acid molecules and uses thereof
|
US11446365B2
(en)
|
2017-08-09 |
2022-09-20 |
The Board Of Regents Of The University Of Oklahoma |
Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same
|
US20210038744A1
(en)
|
2018-02-01 |
2021-02-11 |
Bioverativ Therapeutics Inc. |
Use of lentiviral vectors expressing factor viii
|
IL277713B2
(en)
|
2018-04-04 |
2024-09-01 |
Sigilon Therapeutics Inc |
Implantable particles and related methods
|
SG11202010767SA
(en)
|
2018-05-18 |
2020-11-27 |
Bioverativ Therapeutics Inc |
Methods of treating hemophilia a
|
TW202006141A
(zh)
|
2018-07-16 |
2020-02-01 |
美商巴克斯歐塔公司 |
使用編碼具有增加表現的重組fviii變異體之病毒載體的a型血友病之基因療法
|
BR112021002017A2
(pt)
|
2018-08-09 |
2021-05-11 |
Bioverativ Therapeutics Inc. |
moléculas de ácido nucleico e usos das mesmas para terapia genética não viral
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
EA202191977A1
(ru)
|
2019-01-16 |
2021-12-15 |
Баксалта Инкорпорейтед |
Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии а
|
BR112021025426A2
(pt)
|
2019-06-19 |
2022-06-21 |
Bioverativ Therapeutics Inc |
Fator recombinante viii-fc para tratamento de hemofilia e baixa densidade mineral óssea
|
US20230023826A1
(en)
|
2019-12-12 |
2023-01-26 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
WO2021165226A1
(en)
|
2020-02-17 |
2021-08-26 |
Biotest Ag |
Subcutaneous administration of factor viii
|
WO2022159414A1
(en)
|
2021-01-22 |
2022-07-28 |
University Of Rochester |
Erythropoietin for gastroinfestinal dysfunction
|
EP4355768A1
(en)
|
2021-06-14 |
2024-04-24 |
Takeda Pharmaceutical Company Limited |
Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
|
WO2023028456A1
(en)
|
2021-08-23 |
2023-03-02 |
Bioverativ Therapeutics Inc. |
Optimized factor viii genes
|
WO2023056331A1
(en)
|
2021-09-30 |
2023-04-06 |
Bioverativ Therapeutics Inc. |
Nucleic acids encoding factor viii polypeptides with reduced immunogenicity
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|