ZA938705B - Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid - Google Patents

Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid

Info

Publication number
ZA938705B
ZA938705B ZA938705A ZA938705A ZA938705B ZA 938705 B ZA938705 B ZA 938705B ZA 938705 A ZA938705 A ZA 938705A ZA 938705 A ZA938705 A ZA 938705A ZA 938705 B ZA938705 B ZA 938705B
Authority
ZA
South Africa
Prior art keywords
pct
chloro
thiophenecarboxylic acid
compound
regioselective synthesis
Prior art date
Application number
ZA938705A
Other languages
English (en)
Inventor
Laurence E Burgess
Gary R Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA938705B publication Critical patent/ZA938705B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
ZA938705A 1992-11-23 1993-11-21 Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid ZA938705B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97998392A 1992-11-23 1992-11-23

Publications (1)

Publication Number Publication Date
ZA938705B true ZA938705B (en) 1995-05-22

Family

ID=25527268

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA938705A ZA938705B (en) 1992-11-23 1993-11-21 Regioselective synthesis of 4-chloro-2-thiophenecarboxylic acid

Country Status (26)

Country Link
US (1) US5648502A (hu)
EP (1) EP0669924B1 (hu)
JP (2) JP2706573B2 (hu)
KR (1) KR950704727A (hu)
CN (4) CN1036001C (hu)
AT (1) ATE146181T1 (hu)
AU (1) AU670454B2 (hu)
BR (1) BR9307503A (hu)
CA (1) CA2148616C (hu)
CZ (1) CZ131695A3 (hu)
DE (1) DE69306595T2 (hu)
DK (1) DK0669924T3 (hu)
EG (1) EG20200A (hu)
ES (1) ES2095080T3 (hu)
FI (1) FI935168A (hu)
GR (1) GR3022396T3 (hu)
HU (1) HUT68757A (hu)
IL (2) IL107612A0 (hu)
MX (1) MX9307292A (hu)
MY (1) MY109037A (hu)
NO (1) NO952021L (hu)
NZ (1) NZ256279A (hu)
PL (1) PL174312B1 (hu)
RU (1) RU2114854C1 (hu)
WO (1) WO1994012505A1 (hu)
ZA (1) ZA938705B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045282A1 (en) * 1997-04-04 1998-10-15 Pfizer Inc. Processes and intermediates for preparing 2-fluorothiophene derivatives
CN100413861C (zh) * 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
US7560551B2 (en) 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
AU2008299220B2 (en) * 2007-09-10 2011-07-21 Calcimedica, Inc. Compounds that modulate intracellular calcium
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
MX2011002149A (es) 2008-08-27 2011-04-05 Calcimedica Inc Compuestos que modulan el calcio intracelular.
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
EP2477982A4 (en) 2009-09-16 2013-04-03 Calcimedica Inc COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
CN103180316A (zh) 2010-08-27 2013-06-26 钙医学公司 调节细胞内钙的化合物
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN109096245A (zh) * 2018-09-27 2018-12-28 上海雅本化学有限公司 一种5-氯噻吩-2-甲酸的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4432974A (en) * 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
DE3534286A1 (de) * 1985-09-26 1987-04-02 Hoechst Ag Verfahren zur herstellung von halogenthiophen-2-carbonsaeuren
SK278175B6 (en) * 1988-10-18 1996-03-06 Pfizer 3-acyl-2-oxindole-1-carboxamides and method of their preparation
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
FR2655655A1 (fr) * 1989-12-07 1991-06-14 Rhone Poulenc Chimie Procede de preparation de polysilthiophenediyle et polymeres obtenus a l'issue de ce procede.
PL170837B1 (pl) * 1991-10-18 1997-01-31 Monsanto Co S rod ek g r zybobó j c zy PL PL PL PL PL PL

Also Published As

Publication number Publication date
PL174312B1 (pl) 1998-07-31
FI935168A0 (fi) 1993-11-22
ES2095080T3 (es) 1997-02-01
CN1158853A (zh) 1997-09-10
CN1158851A (zh) 1997-09-10
NO952021D0 (no) 1995-05-22
DK0669924T3 (da) 1997-06-16
AU670454B2 (en) 1996-07-18
MY109037A (en) 1996-11-30
NO952021L (no) 1995-05-22
JP2706573B2 (ja) 1998-01-28
CN1036001C (zh) 1997-10-01
GR3022396T3 (en) 1997-04-30
CN1093704A (zh) 1994-10-19
US5648502A (en) 1997-07-15
DE69306595T2 (de) 1997-04-03
CN1156725A (zh) 1997-08-13
EG20200A (en) 1997-10-30
FI935168A (fi) 1994-05-24
EP0669924B1 (en) 1996-12-11
KR950704727A (ko) 1995-11-20
DE69306595D1 (en) 1997-01-23
ATE146181T1 (de) 1996-12-15
PL309048A1 (en) 1995-09-18
CA2148616C (en) 1998-02-03
RU2114854C1 (ru) 1998-07-10
JPH1081683A (ja) 1998-03-31
BR9307503A (pt) 1999-06-29
IL120461A0 (en) 1997-07-13
HUT68757A (en) 1995-07-28
CZ131695A3 (en) 1996-05-15
AU4858793A (en) 1994-06-22
IL107612A0 (en) 1994-02-27
JP2795642B2 (ja) 1998-09-10
NZ256279A (en) 1996-11-26
EP0669924A1 (en) 1995-09-06
WO1994012505A1 (en) 1994-06-09
JPH07508761A (ja) 1995-09-28
CA2148616A1 (en) 1994-06-09
MX9307292A (es) 1994-05-31

Similar Documents

Publication Publication Date Title
EG20200A (en) Regioselective synthesis of 4- chloro -2- thiophenecarboxylic acid
CA2304713A1 (en) Biphenyl-5-alkanoic acid derivatives and use thereof
HK1055726A1 (en) Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants
IL114726A0 (en) Noribogaine derivatives and pharmaceutical compositions containing the same
MY115679A (en) Process for preparing intermediates to florfenicol
MX9604020A (es) Arilalquildiazinonas.
FR2668063B1 (hu)
TW263499B (hu)
IL64905A (en) Process for the preparation of 2-penems,carbapenems,carbacephams,oxapenems,and azapenems,some novel such compounds and pharmaceutical compositions containing them
HUP0004731A2 (hu) 2-Aril-benzo[b]tiofének alkalmazása ösztrogén elvonási szindróma kezelésére alkalmas gyógyszerkészítmények előállítására
IL112432A0 (en) Fatty acid derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
IL93989A0 (en) Pharmaceutical compositions comprising heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases
HU9402761D0 (en) Bis-aryl-carbinol derivatives, pharmaceutical compositions containing them and process for producing
FI950892A0 (fi) Entsymaattinen asymmetrinen pelkistysmenetelmä 4-H-tieno-(2,3-6) tiopyraanijohdannaisten tuottamiseksi
IL107520A0 (en) Substituted ortho-ethenylphenylacetic acid derivatives and pharmaceutical compositions containing them
GR1002355B (el) Μιγμα για την ρυθμιση της αναπτυξης των φυτων.
MX9604078A (es) Preparacion de esteres de alquilo de acido (met)acrilico.
MY102090A (en) Compounds with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom
FR2696454B1 (fr) Procédé de préparation stéréosélective d'un dérivé de la beta-phénylisosérine et son utilisation pour la préparation de dérivés du Taxane.
GR3025116T3 (en) Process for the preparation of n-carbonylarylimines useful for the synthesis of therapeutically active taxoids
MY109729A (en) Benzofuranylimidazole derivatives, a process for the preparation and therapeutical compositions containing the same
HU9602228D0 (en) Condenzed azepine-derivatives of mercaptoacetylamide disulfides useful as inhibitors of enkephalinase, pharmaceutical compositions containing the same and process for producing them
AU7130496A (en) Disubstituted piperidine derivatives
TW334422B (en) The synthesis of novel antineoplasic and antimicrobial naphthol derivatives
AU4544096A (en) New derivatives of glycylanilides, preparation and therapeutical application