ZA9311B - Novel pharmaceutically active 1,2,4,-triaminobenzene derivatives, processes for their preparation and pharmacuetical compositions containing them - Google Patents

Novel pharmaceutically active 1,2,4,-triaminobenzene derivatives, processes for their preparation and pharmacuetical compositions containing them

Info

Publication number
ZA9311B
ZA9311B ZA9311A ZA9311A ZA9311B ZA 9311 B ZA9311 B ZA 9311B ZA 9311 A ZA9311 A ZA 9311A ZA 9311 A ZA9311 A ZA 9311A ZA 9311 B ZA9311 B ZA 9311B
Authority
ZA
South Africa
Prior art keywords
alkyl
radical
nhco
alkoxy
hydrogen
Prior art date
Application number
ZA9311A
Other languages
English (en)
Inventor
Hans-Reinhold Dieter
Jurgen Engel
Bernbard Kutscher
Emmanuel Polymeropoulos
Stefan Szelenyi
Bernd Nickel
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of ZA9311B publication Critical patent/ZA9311B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA9311A 1992-01-08 1993-01-04 Novel pharmaceutically active 1,2,4,-triaminobenzene derivatives, processes for their preparation and pharmacuetical compositions containing them ZA9311B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4200259A DE4200259A1 (de) 1992-01-08 1992-01-08 Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ZA9311B true ZA9311B (en) 1993-08-05

Family

ID=6449201

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9311A ZA9311B (en) 1992-01-08 1993-01-04 Novel pharmaceutically active 1,2,4,-triaminobenzene derivatives, processes for their preparation and pharmacuetical compositions containing them

Country Status (13)

Country Link
US (1) US5384330A (xx)
EP (1) EP0554543B1 (xx)
JP (1) JP3145220B2 (xx)
AT (1) ATE134611T1 (xx)
CA (1) CA2086654C (xx)
DE (3) DE4200259A1 (xx)
DK (1) DK0554543T3 (xx)
ES (1) ES2084914T3 (xx)
GR (1) GR3019653T3 (xx)
LU (1) LU91869I2 (xx)
MX (1) MX9300014A (xx)
SG (1) SG48046A1 (xx)
ZA (1) ZA9311B (xx)

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US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
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DE19701694A1 (de) * 1997-01-20 1998-07-23 Asta Medica Ag Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung
DE19752748A1 (de) 1997-11-28 1999-06-02 Bayer Ag Substituierte Phenyluracile
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US7906537B2 (en) 2003-03-21 2011-03-15 H. Lundbeck A/S Substituted p-diaminobenzene derivatives
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UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
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JP5237643B2 (ja) 2005-03-03 2013-07-17 ハー・ルンドベック・アクチエゼルスカベット 置換されたピリジン誘導体
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GT200600158A (es) * 2005-04-22 2006-11-28 Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2,3-dihidro-1-benzofurano-2-il]metil}amina
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GT200600164A (es) * 2005-04-22 2007-03-14 Derivados de dihidrobenzofuranos y usos de los mismos
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US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
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CN103373941B (zh) * 2012-04-11 2016-08-17 浙江九洲药物科技有限公司 瑞替加滨及其中间体的制备方法
KR20150053257A (ko) * 2012-04-30 2015-05-15 사이플루어 라이프 사이언시즈, 엘엘씨 플루오르화 2-아미노-4-(벤질아미노)페닐카르바메이트 유도체
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CN103664678B (zh) * 2013-11-06 2015-10-28 河北科技大学 一种n1-(4-氟苄基)-4-硝基苯基-1,3-二胺的中间体及其制备方法
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CN109641836A (zh) * 2016-06-10 2019-04-16 赛弗卢尔生命科学公司 氟化的2-氨基-4-(取代的氨基)苯基氨基甲酸酯衍生物
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US11358930B2 (en) 2018-04-20 2022-06-14 University of Pittsburgh—of the Commonwealth System of Higher Education Selective potassium channel agonists
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CN114760990A (zh) 2019-12-02 2022-07-15 泽农医药公司 钾通道开放剂埃佐加滨的儿科即释制剂
KR20230159531A (ko) * 2021-03-19 2023-11-21 자이자겐, 인크. Kv7 통로 개방제의 전구약물
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WO2023121992A1 (en) 2021-12-22 2023-06-29 Icagen, Llc Cyclopropyl compounds
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Also Published As

Publication number Publication date
ATE134611T1 (de) 1996-03-15
DE59205496D1 (de) 1996-04-04
SG48046A1 (en) 1998-04-17
CA2086654C (en) 2003-09-23
DK0554543T3 (da) 1996-03-18
CA2086654A1 (en) 1993-07-09
ES2084914T3 (es) 1996-05-16
DE122011100044I1 (de) 2012-01-19
GR3019653T3 (en) 1996-07-31
EP0554543A2 (de) 1993-08-11
EP0554543A3 (en) 1993-10-27
LU91869I2 (fr) 2011-11-14
MX9300014A (es) 1993-07-01
JP3145220B2 (ja) 2001-03-12
US5384330A (en) 1995-01-24
JPH05345752A (ja) 1993-12-27
EP0554543B1 (de) 1996-02-28
DE4200259A1 (de) 1993-07-15

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