ES2084914T3 - Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su preparacion. - Google Patents

Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su preparacion.

Info

Publication number
ES2084914T3
ES2084914T3 ES92121028T ES92121028T ES2084914T3 ES 2084914 T3 ES2084914 T3 ES 2084914T3 ES 92121028 T ES92121028 T ES 92121028T ES 92121028 T ES92121028 T ES 92121028T ES 2084914 T3 ES2084914 T3 ES 2084914T3
Authority
ES
Spain
Prior art keywords
rest
triaminobenzene
procedure
preparation
hidroxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92121028T
Other languages
English (en)
Inventor
Hans-Reinhold Dr Dieter
Jurgen Prof Engel
Bernhard Dr Kutscher
Emmanuel Dr Polymeropoulos
Stefan Prof Szelenyi
Bernd Dr Nickel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2084914T3 publication Critical patent/ES2084914T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPUESTOS ACTIVOS FARMACOLOGICOS DERIVADOS 1,2,4 TRIAMINOBENZOL DE LA FORMULA GENERAL: DONDE LOS SIMBOLOS R1, R2, R3, R4, R5, AR TIENEN EL SIGUIENTE SIGNIFICADO: R1: HIDROGENO, C1 O C1 LAMINO, C1 DIO DEL RESTO AR, C1 ALQUINIL, EL RESTO AR O EL RESTO ARO-; R4: HIDROGENO, C1 ESTO AR; ALK: UN GRUPO ALQUILENO DE CADENA RECTA O RAMIFICADA CON 1 ES DEL RESTO AR; AR: RESTO FENIL, QUE ES SUSTITUIDO POR MEDIO DEL RESTO R6, R7 Y/O R8, DONDE LOS RESTOS R6, R7 Y R8 SON IGUALES O DIFERENTES Y SIGNIFICAN C1 OALQUIL, HIDROXI, C1 C6 ENO, HIDROXI, C1 -C6 HALOGENOALQUIL, UIL, ONH NH O2 SO2 ON ACIDA ACEPTABLES FARMACEUTICAMENTE.
ES92121028T 1992-01-08 1992-12-10 Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su preparacion. Expired - Lifetime ES2084914T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4200259A DE4200259A1 (de) 1992-01-08 1992-01-08 Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES2084914T3 true ES2084914T3 (es) 1996-05-16

Family

ID=6449201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92121028T Expired - Lifetime ES2084914T3 (es) 1992-01-08 1992-12-10 Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su preparacion.

Country Status (13)

Country Link
US (1) US5384330A (es)
EP (1) EP0554543B1 (es)
JP (1) JP3145220B2 (es)
AT (1) ATE134611T1 (es)
CA (1) CA2086654C (es)
DE (3) DE4200259A1 (es)
DK (1) DK0554543T3 (es)
ES (1) ES2084914T3 (es)
GR (1) GR3019653T3 (es)
LU (1) LU91869I2 (es)
MX (1) MX9300014A (es)
SG (1) SG48046A1 (es)
ZA (1) ZA9311B (es)

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US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
WO1997049286A1 (en) 1996-06-27 1997-12-31 Smithkline Beecham Corporation Il-8 receptor antagonists
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US7205307B2 (en) 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
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DK1578740T3 (da) * 2002-12-27 2007-07-30 Lundbeck & Co As H 1,2,4-triaminobenzenderivater, der er egnede til behandling af lidelser i centralnervesystemet
US7906537B2 (en) 2003-03-21 2011-03-15 H. Lundbeck A/S Substituted p-diaminobenzene derivatives
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US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
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WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
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AU2006239942A1 (en) * 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
EP1874292A2 (en) * 2005-04-24 2008-01-09 Wyeth Methods for modulating bladder function
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US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) * 2006-08-18 2008-02-21 Valeant Pharmaceuticals North America Derivatives of 1,3-diamino benzene as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
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US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
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CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
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Also Published As

Publication number Publication date
DE59205496D1 (de) 1996-04-04
DE4200259A1 (de) 1993-07-15
JPH05345752A (ja) 1993-12-27
DK0554543T3 (da) 1996-03-18
US5384330A (en) 1995-01-24
GR3019653T3 (en) 1996-07-31
DE122011100044I1 (de) 2012-01-19
MX9300014A (es) 1993-07-01
CA2086654A1 (en) 1993-07-09
EP0554543A3 (en) 1993-10-27
SG48046A1 (en) 1998-04-17
EP0554543A2 (de) 1993-08-11
ZA9311B (en) 1993-08-05
LU91869I2 (fr) 2011-11-14
EP0554543B1 (de) 1996-02-28
CA2086654C (en) 2003-09-23
ATE134611T1 (de) 1996-03-15
JP3145220B2 (ja) 2001-03-12

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