ZA928878B - New oligodeoxybonucleotides having anti-ischemic activity and methods of preparation thereof. - Google Patents

New oligodeoxybonucleotides having anti-ischemic activity and methods of preparation thereof.

Info

Publication number
ZA928878B
ZA928878B ZA9228878A ZA9228878A ZA928878B ZA 928878 B ZA928878 B ZA 928878B ZA 9228878 A ZA9228878 A ZA 9228878A ZA 9228878 A ZA9228878 A ZA 9228878A ZA 928878 B ZA928878 B ZA 928878B
Authority
ZA
South Africa
Prior art keywords
oligodeoxybonucleotides
preparation
new
methods
ischemic activity
Prior art date
Application number
ZA9228878A
Other languages
English (en)
Inventor
Ennio Lanzarotti
Marisa Mantovani
Guiseppe Prino
Roberto Porta
Armando Cedro
Danilo Moltrasio
Original Assignee
Crinos Industria Farmaco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco
Publication of ZA928878B publication Critical patent/ZA928878B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
ZA9228878A 1991-12-09 1992-11-17 New oligodeoxybonucleotides having anti-ischemic activity and methods of preparation thereof. ZA928878B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913294A IT1252174B (it) 1991-12-09 1991-12-09 Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento

Publications (1)

Publication Number Publication Date
ZA928878B true ZA928878B (en) 1993-06-22

Family

ID=11361289

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9228878A ZA928878B (en) 1991-12-09 1992-11-17 New oligodeoxybonucleotides having anti-ischemic activity and methods of preparation thereof.

Country Status (17)

Country Link
US (3) US6046172A (ja)
EP (1) EP0558833A3 (ja)
JP (1) JPH05247083A (ja)
CN (1) CN1073448A (ja)
AU (1) AU655087B2 (ja)
BE (1) BE1008163A5 (ja)
BR (1) BR9204931A (ja)
CA (1) CA2083416A1 (ja)
CH (1) CH685298A5 (ja)
FR (1) FR2684675B1 (ja)
GR (1) GR1002143B (ja)
IL (1) IL103757A (ja)
IT (1) IT1252174B (ja)
LU (1) LU88197A1 (ja)
MX (1) MX9207137A (ja)
PT (1) PT101113A (ja)
ZA (1) ZA928878B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271685B (it) * 1994-08-03 1997-06-04 Crinos Industria Farmaco Impiego dei polidesossiribonucleotidi nelle neuropati diabetiche
AU754242B2 (en) * 1997-04-28 2002-11-07 Arsinur Burcoglu Method of treating HIV infection and related secondary infections thereof
EP1059092B1 (en) * 1999-06-08 2005-12-07 Gentium S.p.A. Use of complexes among cationic liposomes and polydeoxyribonucleotides as medicaments
US7070310B2 (en) * 2002-10-01 2006-07-04 Truck-Lite Co., Inc. Light emitting diode headlamp
US7270723B2 (en) * 2003-11-07 2007-09-18 Kimberly-Clark Worldwide, Inc. Microporous breathable elastic film laminates, methods of making same, and limited use or disposable product applications
ITMI20031714A1 (it) * 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
ITMI20050336A1 (it) * 2005-03-03 2006-09-04 Gentium Spa Formulazione ad attivita' anti-tumorale
KR20070121001A (ko) * 2005-03-03 2007-12-26 젠티엄 에스피에이 신혈관 형성-의존성 종양 치료용 약학적 제제
EP1872787A1 (en) * 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
EP1982722A1 (en) * 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
EP2103689A1 (en) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
WO2012063272A1 (en) 2010-11-12 2012-05-18 Gentium S.P.A. Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd).
CN110079580B (zh) 2012-06-22 2022-12-06 真蒂奥姆责任有限公司 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
AU2018309068A1 (en) 2017-08-03 2020-02-20 Jazz Pharmaceuticals Ireland Limited Formulations comprising a nucleic acid in a high concentration
KR20210008478A (ko) 2018-04-12 2021-01-22 재즈 파마슈티칼즈, 인코포레이티드 면역고갈과 관련된 사이토카인 방출 증후군 및 신경독성의 예방 및 치료를 위한 데피브로타이드
WO2020118165A1 (en) 2018-12-07 2020-06-11 Jazz Pharmaceuticals Ireland Limited Subcutaneous delivery of high concentration formulations
WO2021174039A1 (en) 2020-02-28 2021-09-02 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
US20230086833A1 (en) 2020-04-17 2023-03-23 Jazz Pharmaceuticals Ireland Limited Defibrotide treatment for the prevention of organ rejection and injury
TW202308659A (zh) 2021-05-06 2023-03-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB808296A (en) * 1955-10-05 1959-02-04 Roland Vercambre Process for the extraction of nucleic acid and for the preparation of the salts thereof
DE1142365B (de) * 1955-10-05 1963-01-17 Roland Vercambre Verfahren zur Gewinnung von Nucleinsaeure und deren Salze aus Fischmilch
FR1245818A (fr) * 1959-11-27 1960-10-03 Procédé de préparation d'acides désoxyribonucléiques à haut degré de polymérisation
FR1408585A (fr) * 1964-09-22 1965-08-13 Schwarz Biores Isolement et purification de bases hétérocycliques
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
JPS5217040B2 (ja) * 1972-12-07 1977-05-12
SU780444A1 (ru) * 1979-06-25 1985-04-23 Специальное Конструкторско-Технологическое Бюро Биологически Активных Веществ Главного Управления Микробиологической Промышленности При Совете Министров Ссср Способ получени дезоксирибонуклеиновой кислоты
US4417046A (en) * 1981-08-24 1983-11-22 Eli Lilly And Company Process for isolating oligonucleotide product from a coupling reaction mixture
DE3308932A1 (de) * 1983-03-12 1984-09-13 Hoechst Ag, 6230 Frankfurt Verfahren zur abtrennung von ribonukleinsaeuren aus einer loesung, die desoxyribonukleinsaeuren enthaelt
SU1161511A1 (ru) * 1983-07-01 1985-06-15 Институт биоорганической химии АН БССР Способ осаждени нуклеиновых кислот из растворов,содержащих фосфатный буфер
JPS6036493A (ja) * 1983-08-08 1985-02-25 Nippon Zeon Co Ltd 保護された核酸関連物質の分離法
IT1206341B (it) * 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4605644A (en) * 1985-02-07 1986-08-12 Regents Of The University Of Minnesota Method for stimulating recovery from ischemia employing ribose and adenine
IT1190313B (it) * 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
NZ222051A (en) * 1986-10-06 1990-07-26 Univ Virginia Solution containing adenosine or hypoxanthine and optionally ribose for heart protection during surgery
US4833239A (en) * 1987-01-29 1989-05-23 Genetics Institute, Inc. Method for the isolation and purification of DNA molecules
US5063162A (en) * 1987-04-24 1991-11-05 Hoffmann-La Roche Inc. Process for isolating nucleic acids utilizing protease digestion
WO1990014416A1 (en) * 1989-05-22 1990-11-29 Genetics Institute, Inc. Improved composition for isolating and purifying nucleic acid and improved method using same
IT1232318B (it) * 1989-09-07 1992-01-28 Crinos Industria Farmaco Composizioni ad uso topico contenenti acidi nucleici depolimerizzati per la cosmesi della pelle e del corpo.
US4997932A (en) * 1989-11-13 1991-03-05 Boehringer Mannheim Corporation Method and kit for purifying nucleic acids

Also Published As

Publication number Publication date
AU655087B2 (en) 1994-12-01
FR2684675A1 (fr) 1993-06-11
ITMI913294A0 (it) 1991-12-09
EP0558833A3 (en) 1995-09-06
ITMI913294A1 (it) 1993-06-09
AU2968592A (en) 1993-06-10
CN1073448A (zh) 1993-06-23
CA2083416A1 (en) 1993-06-10
IT1252174B (it) 1995-06-05
LU88197A1 (fr) 1993-05-17
US5646127A (en) 1997-07-08
EP0558833A2 (en) 1993-09-08
FR2684675B1 (fr) 1996-10-18
PT101113A (pt) 1994-02-28
CH685298A5 (fr) 1995-05-31
BR9204931A (pt) 1993-06-15
GR920100527A (el) 1994-03-31
GR1002143B (en) 1996-02-16
US6046172A (en) 2000-04-04
IL103757A (en) 1997-02-18
JPH05247083A (ja) 1993-09-24
BE1008163A5 (fr) 1996-02-06
US5646268A (en) 1997-07-08
MX9207137A (es) 1993-08-01

Similar Documents

Publication Publication Date Title
ZA928878B (en) New oligodeoxybonucleotides having anti-ischemic activity and methods of preparation thereof.
GR3017062T3 (en) Piperidine compounds and their preparation and use.
ZA923516B (en) New thiopyranopyrrole derivatives and their preparation
EP0572025A3 (en) Furniture construction and manufacturing method.
CS20091A2 (en) Basic calciumaluminiumhydroxidedicarboxylate, method of its preparation and its application
PL296034A2 (en) Composition exibiting-fgf activity and method of obtaining same
EP0454726A4 (en) Hindered linking agents and methods
JPS6479170A (en) Halogenated 1,3-dioxolane and derivatives
EP0344110A3 (en) Substituted naphthacenes-5,12-diones and their use
EP0421436A3 (en) Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity
EP0604505A4 (en) PRODUCTION OF SELENIUM-72 AND ARSEN-72.
PL297839A1 (en) Novel hetaryloxy-beta-carbolines, method of obtaining them and their use in drugs
JPS6468346A (en) Substituted anilinophenylthiourea, anilinophenylisothiourea and anilinophenylcarbodiimide
IL92281A0 (en) Polyimidesiloxanes,their preparation and use
IL88880A0 (en) Cyano-dienes and halopyridines and their preparation
EP0344109A3 (en) Substituted naphthacene-5,12-diones and their use
IL102467A0 (en) Substituted pyridines and their preparation
IL87779A0 (en) 4-azasaccharines,4-aza-dihydro-and-tetrahydro-saccharines and their preparation
ZA889251B (en) 8,9-annelated-beta-carbolines and 8,9-annelated-3,4-dihydro-beta-carbolines
GR3017784T3 (en) Substituted dibenzofurans and methods of using same.
ZA882852B (en) Pyrrolealdehydes,their preparation and their use
PL297872A1 (en) Substituted sulfonylbenzyloimidazopyridines, method of obtaining them and drugs containing them
EP0393339A3 (en) Preparation of pre-caseinates, and use
HU9401351D0 (en) Alkylthiophenes and alkylthiopolyhiophenes, methods of preparing them, and their use
IL92781A0 (en) Preparation of 5-acylamino-1,2,4-triazole-3-sulfonamides and intermediates