ITMI913294A0 - Nuovi oligodessossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento - Google Patents
Nuovi oligodessossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimentoInfo
- Publication number
- ITMI913294A0 ITMI913294A0 IT91MI3294A ITMI913294A ITMI913294A0 IT MI913294 A0 ITMI913294 A0 IT MI913294A0 IT 91MI3294 A IT91MI3294 A IT 91MI3294A IT MI913294 A ITMI913294 A IT MI913294A IT MI913294 A0 ITMI913294 A0 IT MI913294A0
- Authority
- IT
- Italy
- Prior art keywords
- oligodexoxybonucleotides
- obtainment
- procedures
- new
- antiischemic activity
- Prior art date
Links
- 230000002253 anti-ischaemic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI913294A IT1252174B (it) | 1991-12-09 | 1991-12-09 | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
IL10375792A IL103757A (en) | 1991-12-09 | 1992-11-16 | Oligodeoxyribonucleotides their preparation and pharmaceutical compositions containing them |
ZA9228878A ZA928878B (en) | 1991-12-09 | 1992-11-17 | New oligodeoxybonucleotides having anti-ischemic activity and methods of preparation thereof. |
CA002083416A CA2083416A1 (en) | 1991-12-09 | 1992-11-20 | Oligodeoxyribonucleotides having anti-ischemic activity and methods of preparation thereof |
GR920100527A GR1002143B (en) | 1991-12-09 | 1992-11-26 | New oligodeoxyribonucleotides having anti-ischemic activity and methods of preparation thereof. |
AU29685/92A AU655087B2 (en) | 1991-12-09 | 1992-11-27 | New oligodeoxyribonucleotides having anti-ischemic activity and methods of preparations thereof |
EP92203723A EP0558833A3 (en) | 1991-12-09 | 1992-12-02 | New oligodeoxyribonucleotides having anti-ischemic activity and methods of preparation thereof |
US07/985,726 US6046172A (en) | 1991-12-09 | 1992-12-04 | Hydrolytically processed oligodeoxyribonucleotides and their pharmaceutical compositions |
PT101113A PT101113A (pt) | 1991-12-09 | 1992-12-07 | Novos oligodesoxirribonucleotides tendo actividade anti-isquemica e processos para a sua preparacao |
BR9204931A BR9204931A (pt) | 1991-12-09 | 1992-12-08 | Oligodesoxirribonucleotideos de origem natural,processo para a obtencao dos mesmos,seus usos e composicoes farmaceuticas |
BE9201080A BE1008163A5 (fr) | 1991-12-09 | 1992-12-08 | Nouveaux oligodesoxyribonucleotides a activite anti-ischemique et leur preparation. |
CH3759/92A CH685298A5 (fr) | 1991-12-09 | 1992-12-08 | Oligodésoxyribo-nucléotides présentant des propriétés anti-ischémiques et leur procédé de préparation. |
LU88197A LU88197A1 (fr) | 1991-12-09 | 1992-12-08 | Nouveaux oligodesoxyribonacleotides ayant une activite anti-ischemique et methode de preparation de ceux-ci. |
MX9207137A MX9207137A (es) | 1991-12-09 | 1992-12-09 | Nuevos oligodesoxirribonucleotidos, que tienen una actividad anti-isquemica, y metodos para su preparacion |
CN92113711A CN1073448A (zh) | 1991-12-09 | 1992-12-09 | 具有抗局部缺血活性的新的寡脱氧核糖核苷酸及其制备 |
FR9214810A FR2684675B1 (fr) | 1991-12-09 | 1992-12-09 | Nouveaux oligodesoxyribonucleotides presentant des proprietes anti-ischemiques et leur procede de preparation. |
JP4329713A JPH05247083A (ja) | 1991-12-09 | 1992-12-09 | 抗虚血活性を有する新規なオリゴデオキシリボヌクレオチド類およびその製造方法 |
US08/510,622 US5646127A (en) | 1991-12-09 | 1995-08-03 | Treatment of cardiac ischemia by administration of a fraction of partially depolymerized DNA |
US08/594,522 US5646268A (en) | 1991-12-09 | 1996-01-31 | Process producing lower molecular weight range oligodeoxyribonucleotides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI913294A IT1252174B (it) | 1991-12-09 | 1991-12-09 | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI913294A0 true ITMI913294A0 (it) | 1991-12-09 |
ITMI913294A1 ITMI913294A1 (it) | 1993-06-09 |
IT1252174B IT1252174B (it) | 1995-06-05 |
Family
ID=11361289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI913294A IT1252174B (it) | 1991-12-09 | 1991-12-09 | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
Country Status (17)
Country | Link |
---|---|
US (3) | US6046172A (it) |
EP (1) | EP0558833A3 (it) |
JP (1) | JPH05247083A (it) |
CN (1) | CN1073448A (it) |
AU (1) | AU655087B2 (it) |
BE (1) | BE1008163A5 (it) |
BR (1) | BR9204931A (it) |
CA (1) | CA2083416A1 (it) |
CH (1) | CH685298A5 (it) |
FR (1) | FR2684675B1 (it) |
GR (1) | GR1002143B (it) |
IL (1) | IL103757A (it) |
IT (1) | IT1252174B (it) |
LU (1) | LU88197A1 (it) |
MX (1) | MX9207137A (it) |
PT (1) | PT101113A (it) |
ZA (1) | ZA928878B (it) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1271685B (it) * | 1994-08-03 | 1997-06-04 | Crinos Industria Farmaco | Impiego dei polidesossiribonucleotidi nelle neuropati diabetiche |
CA2259041A1 (en) * | 1997-04-28 | 1998-11-05 | Arsinur Burcoglu | Method of treating hiv infection and related secondary infections thereof |
DE69928778T2 (de) | 1999-06-08 | 2006-07-06 | Gentium S.P.A., Villa Guardia | Anwendung von Komplexen von kationischen Liposomen und Polydeoxyribonukleotiden wie Arzneimitteln |
CA2500996C (en) * | 2002-10-01 | 2010-11-09 | Truck-Lite Co., Inc. | Light emitting diode headlamp and headlamp assembly |
US7270723B2 (en) * | 2003-11-07 | 2007-09-18 | Kimberly-Clark Worldwide, Inc. | Microporous breathable elastic film laminates, methods of making same, and limited use or disposable product applications |
ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
JP5714203B2 (ja) * | 2005-03-03 | 2015-05-07 | ゲンチウム エスピーエー | 血管新生依存性腫瘍を治療するためのデフィブロチドおよび/またはオリゴデオキシリボヌクレオチド |
ITMI20050336A1 (it) * | 2005-03-03 | 2006-09-04 | Gentium Spa | Formulazione ad attivita' anti-tumorale |
EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
EP1982722A1 (en) * | 2007-04-16 | 2008-10-22 | Gentium S.p.A. | Use of oligotide for the treatment of renal diseases |
EP2103689A1 (en) | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
JP6069209B2 (ja) | 2010-11-12 | 2017-02-01 | ジェンティウム ソシエタ ア レスポンサビリタ リミタータ | 移植片対宿主病(gvhd)の予防および/または治療に使用するためのデフィブロタイド |
RU2627177C2 (ru) | 2012-06-22 | 2017-08-03 | Джентиум С.Р.Л. | Способ определения биологической активности дефибротида, основанный на применении эуглобулина |
EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
JP2020530004A (ja) | 2017-08-03 | 2020-10-15 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 核酸を高濃度で含む製剤 |
WO2019200251A1 (en) | 2018-04-12 | 2019-10-17 | Jazz Pharmaceuticals, Inc. | Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion |
US20220023533A1 (en) | 2018-12-07 | 2022-01-27 | Jazz Phrmaceticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
US20230190783A1 (en) | 2020-02-28 | 2023-06-22 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
US20230086833A1 (en) | 2020-04-17 | 2023-03-23 | Jazz Pharmaceuticals Ireland Limited | Defibrotide treatment for the prevention of organ rejection and injury |
WO2022234101A1 (en) | 2021-05-06 | 2022-11-10 | Jazz Pharmaceuticals Ireland Limited | Defibrotide for the treatment and prevention of acute respiratory distress syndrome |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB808296A (en) * | 1955-10-05 | 1959-02-04 | Roland Vercambre | Process for the extraction of nucleic acid and for the preparation of the salts thereof |
DE1142365B (de) * | 1955-10-05 | 1963-01-17 | Roland Vercambre | Verfahren zur Gewinnung von Nucleinsaeure und deren Salze aus Fischmilch |
FR1245818A (fr) * | 1959-11-27 | 1960-10-03 | Procédé de préparation d'acides désoxyribonucléiques à haut degré de polymérisation | |
FR1408585A (fr) * | 1964-09-22 | 1965-08-13 | Schwarz Biores | Isolement et purification de bases hétérocycliques |
US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
IT1043823B (it) * | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
JPS5217040B2 (it) * | 1972-12-07 | 1977-05-12 | ||
SU780444A1 (ru) * | 1979-06-25 | 1985-04-23 | Специальное Конструкторско-Технологическое Бюро Биологически Активных Веществ Главного Управления Микробиологической Промышленности При Совете Министров Ссср | Способ получени дезоксирибонуклеиновой кислоты |
US4417046A (en) * | 1981-08-24 | 1983-11-22 | Eli Lilly And Company | Process for isolating oligonucleotide product from a coupling reaction mixture |
DE3308932A1 (de) * | 1983-03-12 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | Verfahren zur abtrennung von ribonukleinsaeuren aus einer loesung, die desoxyribonukleinsaeuren enthaelt |
SU1161511A1 (ru) * | 1983-07-01 | 1985-06-15 | Институт биоорганической химии АН БССР | Способ осаждени нуклеиновых кислот из растворов,содержащих фосфатный буфер |
JPS6036493A (ja) * | 1983-08-08 | 1985-02-25 | Nippon Zeon Co Ltd | 保護された核酸関連物質の分離法 |
IT1206341B (it) * | 1984-02-16 | 1989-04-14 | Crinos Industria Farmaco | Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. |
US4605644A (en) * | 1985-02-07 | 1986-08-12 | Regents Of The University Of Minnesota | Method for stimulating recovery from ischemia employing ribose and adenine |
IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
AU618723B2 (en) * | 1986-10-06 | 1992-01-09 | University Of Virginia Alumni Patents Foundation, The | Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery |
US4833239A (en) * | 1987-01-29 | 1989-05-23 | Genetics Institute, Inc. | Method for the isolation and purification of DNA molecules |
US5063162A (en) * | 1987-04-24 | 1991-11-05 | Hoffmann-La Roche Inc. | Process for isolating nucleic acids utilizing protease digestion |
WO1990014416A1 (en) * | 1989-05-22 | 1990-11-29 | Genetics Institute, Inc. | Improved composition for isolating and purifying nucleic acid and improved method using same |
IT1232318B (it) * | 1989-09-07 | 1992-01-28 | Crinos Industria Farmaco | Composizioni ad uso topico contenenti acidi nucleici depolimerizzati per la cosmesi della pelle e del corpo. |
US4997932A (en) * | 1989-11-13 | 1991-03-05 | Boehringer Mannheim Corporation | Method and kit for purifying nucleic acids |
-
1991
- 1991-12-09 IT ITMI913294A patent/IT1252174B/it active IP Right Grant
-
1992
- 1992-11-16 IL IL10375792A patent/IL103757A/xx not_active IP Right Cessation
- 1992-11-17 ZA ZA9228878A patent/ZA928878B/xx unknown
- 1992-11-20 CA CA002083416A patent/CA2083416A1/en not_active Abandoned
- 1992-11-26 GR GR920100527A patent/GR1002143B/el unknown
- 1992-11-27 AU AU29685/92A patent/AU655087B2/en not_active Ceased
- 1992-12-02 EP EP92203723A patent/EP0558833A3/en not_active Withdrawn
- 1992-12-04 US US07/985,726 patent/US6046172A/en not_active Expired - Lifetime
- 1992-12-07 PT PT101113A patent/PT101113A/pt not_active Application Discontinuation
- 1992-12-08 BE BE9201080A patent/BE1008163A5/fr not_active IP Right Cessation
- 1992-12-08 CH CH3759/92A patent/CH685298A5/fr not_active IP Right Cessation
- 1992-12-08 BR BR9204931A patent/BR9204931A/pt not_active Application Discontinuation
- 1992-12-08 LU LU88197A patent/LU88197A1/fr unknown
- 1992-12-09 FR FR9214810A patent/FR2684675B1/fr not_active Expired - Fee Related
- 1992-12-09 CN CN92113711A patent/CN1073448A/zh active Pending
- 1992-12-09 MX MX9207137A patent/MX9207137A/es unknown
- 1992-12-09 JP JP4329713A patent/JPH05247083A/ja active Pending
-
1995
- 1995-08-03 US US08/510,622 patent/US5646127A/en not_active Expired - Lifetime
-
1996
- 1996-01-31 US US08/594,522 patent/US5646268A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GR1002143B (en) | 1996-02-16 |
US6046172A (en) | 2000-04-04 |
PT101113A (pt) | 1994-02-28 |
FR2684675A1 (fr) | 1993-06-11 |
MX9207137A (es) | 1993-08-01 |
EP0558833A2 (en) | 1993-09-08 |
ITMI913294A1 (it) | 1993-06-09 |
JPH05247083A (ja) | 1993-09-24 |
CN1073448A (zh) | 1993-06-23 |
CH685298A5 (fr) | 1995-05-31 |
BE1008163A5 (fr) | 1996-02-06 |
BR9204931A (pt) | 1993-06-15 |
GR920100527A (el) | 1994-03-31 |
AU655087B2 (en) | 1994-12-01 |
US5646127A (en) | 1997-07-08 |
IL103757A (en) | 1997-02-18 |
FR2684675B1 (fr) | 1996-10-18 |
US5646268A (en) | 1997-07-08 |
EP0558833A3 (en) | 1995-09-06 |
CA2083416A1 (en) | 1993-06-10 |
LU88197A1 (fr) | 1993-05-17 |
ZA928878B (en) | 1993-06-22 |
AU2968592A (en) | 1993-06-10 |
IT1252174B (it) | 1995-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |