FR2684675B1 - Nouveaux oligodesoxyribonucleotides presentant des proprietes anti-ischemiques et leur procede de preparation. - Google Patents

Nouveaux oligodesoxyribonucleotides presentant des proprietes anti-ischemiques et leur procede de preparation.

Info

Publication number
FR2684675B1
FR2684675B1 FR9214810A FR9214810A FR2684675B1 FR 2684675 B1 FR2684675 B1 FR 2684675B1 FR 9214810 A FR9214810 A FR 9214810A FR 9214810 A FR9214810 A FR 9214810A FR 2684675 B1 FR2684675 B1 FR 2684675B1
Authority
FR
France
Prior art keywords
oligodesoxyribonucleotides
novel
preparation process
ischemic properties
ischemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9214810A
Other languages
English (en)
Other versions
FR2684675A1 (fr
Inventor
Ennio Lanzarotti
Guiseppe Prino
Armando Cedro
Marisa Mantovani
Roberto Porta
Danilo Moltrasio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Crinos Industria Farmacobiologica SpA
Original Assignee
Crinos Industria Farmacobiologica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmacobiologica SpA filed Critical Crinos Industria Farmacobiologica SpA
Publication of FR2684675A1 publication Critical patent/FR2684675A1/fr
Application granted granted Critical
Publication of FR2684675B1 publication Critical patent/FR2684675B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR9214810A 1991-12-09 1992-12-09 Nouveaux oligodesoxyribonucleotides presentant des proprietes anti-ischemiques et leur procede de preparation. Expired - Fee Related FR2684675B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913294A IT1252174B (it) 1991-12-09 1991-12-09 Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento

Publications (2)

Publication Number Publication Date
FR2684675A1 FR2684675A1 (fr) 1993-06-11
FR2684675B1 true FR2684675B1 (fr) 1996-10-18

Family

ID=11361289

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9214810A Expired - Fee Related FR2684675B1 (fr) 1991-12-09 1992-12-09 Nouveaux oligodesoxyribonucleotides presentant des proprietes anti-ischemiques et leur procede de preparation.

Country Status (17)

Country Link
US (3) US6046172A (fr)
EP (1) EP0558833A3 (fr)
JP (1) JPH05247083A (fr)
CN (1) CN1073448A (fr)
AU (1) AU655087B2 (fr)
BE (1) BE1008163A5 (fr)
BR (1) BR9204931A (fr)
CA (1) CA2083416A1 (fr)
CH (1) CH685298A5 (fr)
FR (1) FR2684675B1 (fr)
GR (1) GR1002143B (fr)
IL (1) IL103757A (fr)
IT (1) IT1252174B (fr)
LU (1) LU88197A1 (fr)
MX (1) MX9207137A (fr)
PT (1) PT101113A (fr)
ZA (1) ZA928878B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271685B (it) * 1994-08-03 1997-06-04 Crinos Industria Farmaco Impiego dei polidesossiribonucleotidi nelle neuropati diabetiche
EP1202750A4 (fr) * 1997-04-28 2002-10-16 Arsinur Burcoglu Traitement de l'infection par vih et de ses infections opportunistes
DE69928778T2 (de) * 1999-06-08 2006-07-06 Gentium S.P.A., Villa Guardia Anwendung von Komplexen von kationischen Liposomen und Polydeoxyribonukleotiden wie Arzneimitteln
MXPA05003469A (es) * 2002-10-01 2005-06-03 Truck Lite Co Faro delantero con diodo emisor de luz y montaje de faro delantero.
US7270723B2 (en) * 2003-11-07 2007-09-18 Kimberly-Clark Worldwide, Inc. Microporous breathable elastic film laminates, methods of making same, and limited use or disposable product applications
ITMI20031714A1 (it) * 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
ITMI20050336A1 (it) * 2005-03-03 2006-09-04 Gentium Spa Formulazione ad attivita' anti-tumorale
KR20070120953A (ko) * 2005-03-03 2007-12-26 젠티엄 에스피에이 항암활성을 갖는 제제
EP1872787A1 (fr) * 2006-06-27 2008-01-02 Gentium S.p.A. Utilisation de defibrotide pour l'inhibition de l'heparanase
EP1982722A1 (fr) * 2007-04-16 2008-10-22 Gentium S.p.A. Utilisation de oligotide pour le traitement de maladies rénales
EP2103689A1 (fr) 2008-03-19 2009-09-23 Gentium S.p.A. Oligonucléotides phosphodiesters synthétiques et leurs utilisations thérapeutiques
US8980862B2 (en) 2010-11-12 2015-03-17 Gentium S.P.A. Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD)
CN110079580B (zh) 2012-06-22 2022-12-06 真蒂奥姆责任有限公司 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法
EP3026122A1 (fr) 2014-11-27 2016-06-01 Gentium S.p.A. Procédé à base cellulaire pour déterminer la puissance de défibrotide
CA3071544A1 (fr) 2017-08-03 2019-02-07 Jazz Pharmaceuticals Ireland Limited Formulations comprenant un acide nucleique a haute concentration
EP3773608A1 (fr) 2018-04-12 2021-02-17 Jazz Pharmaceuticals, Inc. Défibrotide pour la prévention et le traitement du syndrome de libération de cytokines et de la neurotoxicité associée à l'immunodéplétion
WO2020118165A1 (fr) 2018-12-07 2020-06-11 Jazz Pharmaceuticals Ireland Limited Administration sous-cutanée de formulations à haute concentration
EP4110287A1 (fr) 2020-02-28 2023-01-04 Jazz Pharmaceuticals Ireland Limited Administration de formulations de faible viscosité
US20230086833A1 (en) 2020-04-17 2023-03-23 Jazz Pharmaceuticals Ireland Limited Defibrotide treatment for the prevention of organ rejection and injury
WO2022234101A1 (fr) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Défibrotide pour le traitement et la prévention du syndrome de détresse respiratoire aiguë

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1142365B (de) * 1955-10-05 1963-01-17 Roland Vercambre Verfahren zur Gewinnung von Nucleinsaeure und deren Salze aus Fischmilch
GB808296A (en) * 1955-10-05 1959-02-04 Roland Vercambre Process for the extraction of nucleic acid and for the preparation of the salts thereof
FR1245818A (fr) * 1959-11-27 1960-10-03 Procédé de préparation d'acides désoxyribonucléiques à haut degré de polymérisation
FR1408585A (fr) * 1964-09-22 1965-08-13 Schwarz Biores Isolement et purification de bases hétérocycliques
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
JPS5217040B2 (fr) * 1972-12-07 1977-05-12
SU780444A1 (ru) * 1979-06-25 1985-04-23 Специальное Конструкторско-Технологическое Бюро Биологически Активных Веществ Главного Управления Микробиологической Промышленности При Совете Министров Ссср Способ получени дезоксирибонуклеиновой кислоты
US4417046A (en) * 1981-08-24 1983-11-22 Eli Lilly And Company Process for isolating oligonucleotide product from a coupling reaction mixture
DE3308932A1 (de) * 1983-03-12 1984-09-13 Hoechst Ag, 6230 Frankfurt Verfahren zur abtrennung von ribonukleinsaeuren aus einer loesung, die desoxyribonukleinsaeuren enthaelt
SU1161511A1 (ru) * 1983-07-01 1985-06-15 Институт биоорганической химии АН БССР Способ осаждени нуклеиновых кислот из растворов,содержащих фосфатный буфер
JPS6036493A (ja) * 1983-08-08 1985-02-25 Nippon Zeon Co Ltd 保護された核酸関連物質の分離法
IT1206341B (it) * 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4605644A (en) * 1985-02-07 1986-08-12 Regents Of The University Of Minnesota Method for stimulating recovery from ischemia employing ribose and adenine
IT1190313B (it) * 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
EP0290496B2 (fr) * 1986-10-06 1995-12-20 The University Of Virginia Alumni Patents Foundation Utilisation d'une solution contenant de l'adenosine, de l'hypoxanthine et du ribose pour ameliorer la protection du coeur au cours d'une operation chirurgicale
US4833239A (en) * 1987-01-29 1989-05-23 Genetics Institute, Inc. Method for the isolation and purification of DNA molecules
US5063162A (en) * 1987-04-24 1991-11-05 Hoffmann-La Roche Inc. Process for isolating nucleic acids utilizing protease digestion
ATE104338T1 (de) * 1989-05-22 1994-04-15 Genetics Inst Verbesserte zusammensetzung zur isolierung und anreicherung von nukleinsaeure und dadurch verbessertes verfahren.
IT1232318B (it) * 1989-09-07 1992-01-28 Crinos Industria Farmaco Composizioni ad uso topico contenenti acidi nucleici depolimerizzati per la cosmesi della pelle e del corpo.
US4997932A (en) * 1989-11-13 1991-03-05 Boehringer Mannheim Corporation Method and kit for purifying nucleic acids

Also Published As

Publication number Publication date
GR1002143B (en) 1996-02-16
IT1252174B (it) 1995-06-05
BE1008163A5 (fr) 1996-02-06
ITMI913294A0 (it) 1991-12-09
CH685298A5 (fr) 1995-05-31
US5646127A (en) 1997-07-08
ZA928878B (en) 1993-06-22
AU2968592A (en) 1993-06-10
BR9204931A (pt) 1993-06-15
CA2083416A1 (fr) 1993-06-10
US6046172A (en) 2000-04-04
ITMI913294A1 (it) 1993-06-09
MX9207137A (es) 1993-08-01
EP0558833A2 (fr) 1993-09-08
AU655087B2 (en) 1994-12-01
IL103757A (en) 1997-02-18
GR920100527A (el) 1994-03-31
JPH05247083A (ja) 1993-09-24
FR2684675A1 (fr) 1993-06-11
US5646268A (en) 1997-07-08
CN1073448A (zh) 1993-06-23
PT101113A (pt) 1994-02-28
LU88197A1 (fr) 1993-05-17
EP0558833A3 (en) 1995-09-06

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