ZA924386B - Oral presentation forms for acid-unstable active compounds - Google Patents

Oral presentation forms for acid-unstable active compounds

Info

Publication number
ZA924386B
ZA924386B ZA924386A ZA924386A ZA924386B ZA 924386 B ZA924386 B ZA 924386B ZA 924386 A ZA924386 A ZA 924386A ZA 924386 A ZA924386 A ZA 924386A ZA 924386 B ZA924386 B ZA 924386B
Authority
ZA
South Africa
Prior art keywords
acid
active compounds
presentation forms
oral presentation
unstable active
Prior art date
Application number
ZA924386A
Other languages
English (en)
Inventor
Rango Dietrich
Dietrich Rango
Hartmut Ney
Ney Hartmut
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4218617&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA924386(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of ZA924386B publication Critical patent/ZA924386B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
ZA924386A 1991-06-17 1992-06-16 Oral presentation forms for acid-unstable active compounds ZA924386B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH178891 1991-06-17

Publications (1)

Publication Number Publication Date
ZA924386B true ZA924386B (en) 1993-02-24

Family

ID=4218617

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA924386A ZA924386B (en) 1991-06-17 1992-06-16 Oral presentation forms for acid-unstable active compounds

Country Status (34)

Country Link
US (1) US5997903A (uk)
EP (2) EP0519365A1 (uk)
JP (1) JP3338052B2 (uk)
KR (1) KR100254021B1 (uk)
CN (1) CN1037932C (uk)
AT (1) ATE144416T1 (uk)
AU (1) AU683411B2 (uk)
BG (1) BG61796B1 (uk)
CA (2) CA2109697C (uk)
CZ (1) CZ281697B6 (uk)
DE (2) DE4219390A1 (uk)
DK (1) DK0589981T3 (uk)
ES (1) ES2096080T3 (uk)
FI (1) FI101598B1 (uk)
GR (1) GR3022154T3 (uk)
HK (1) HK1005851A1 (uk)
HR (1) HRP920162B1 (uk)
IE (1) IE77640B1 (uk)
IL (1) IL102096A (uk)
LV (1) LV11982B (uk)
MX (1) MX9202961A (uk)
NO (1) NO303714B1 (uk)
NZ (1) NZ243147A (uk)
PL (1) PL169951B1 (uk)
RO (1) RO117502B1 (uk)
RU (1) RU2089180C1 (uk)
SI (1) SI9200111A (uk)
SK (1) SK278566B6 (uk)
TW (1) TW224429B (uk)
UA (1) UA32525C2 (uk)
WO (1) WO1992022284A1 (uk)
YU (1) YU48263B (uk)
ZA (1) ZA924386B (uk)
ZW (1) ZW9392A1 (uk)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4504000A (en) * 1993-04-27 2000-09-07 Sepracor, Inc. Methods and compositions for treating gastric disorders using optically pure (-) pantoprazole
SE9301489D0 (sv) * 1993-04-30 1993-04-30 Ab Astra Veterinary composition
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
DE4324014C2 (de) * 1993-07-17 1995-06-08 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung einer in Wasser rekonstituierbaren Zubereitung
TW280770B (uk) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
RU2160094C2 (ru) * 1994-07-08 2000-12-10 Астра Актиеболаг Таблетированная многоединичная лекарственная форма, способ ее получения, упаковка и способ ингибирования секреции желудочной кислоты и/или лечения желудочно-кишечных воспалительных заболеваний
ES2094694B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5945124A (en) * 1995-07-05 1999-08-31 Byk Gulden Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
US6207198B1 (en) * 1995-09-21 2001-03-27 Schwarz Pharma Ag Composition containing an acid-labile omeprazole and process for its preparation
SI9700186B (sl) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
ES2137862B1 (es) * 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
DE69831504T2 (de) * 1997-12-08 2006-06-14 Altana Pharma Ag Orale verabreichungsform enthaltend einen protonenpumpeninhibitor (z.b.pantoprazole)
DK173431B1 (da) 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
JP4127740B2 (ja) * 1998-04-20 2008-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定化したベンズイミダゾール系化合物含有組成物
US20020039597A1 (en) * 1998-04-20 2002-04-04 Koji Ukai Stabilized compositions containing benzimidazole-type compounds
ES2274625T3 (es) 1998-05-18 2007-05-16 Takeda Pharmaceutical Company Limited Comprimidos desintegrables en la boca que comprenden un bencimidazol.
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
DE69930648T2 (de) * 1998-08-12 2006-12-21 Altana Pharma Ag Orale darreichungsform für pyridin-2-ylmethylsulfinyl-1h-benzimidazole
DE19843413C1 (de) * 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol
HUP0201637A3 (en) 1999-06-07 2004-05-28 Altana Pharma Ag Novel preparation and administration form comprising an acid-labile active compound
ES2168043B1 (es) * 1999-09-13 2003-04-01 Esteve Labor Dr Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
ES2288876T3 (es) 1999-10-20 2008-02-01 EISAI R&D MANAGEMENT CO., LTD. Procedimiento para estabilizar compuestos de bencimidazol.
DE19959419A1 (de) 1999-12-09 2001-06-21 Ratiopharm Gmbh Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung
EP1108425B1 (en) * 1999-12-16 2005-06-08 Laboratorio Medinfar-Produtos Farmaceuticos, S.A. New stable multi-unitary pharmaceutical preparations containing substituted benzimidazoles
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
AU2277101A (en) * 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
KR20030059318A (ko) * 2000-12-07 2003-07-07 알타나 파마 아게 산 불안정성 활성 성분을 포함하는 현탁액 형태의 약학 제제
EP1429742B1 (en) 2001-09-28 2011-05-04 McNeil-PPC, Inc. Modified release dosage forms
US20050163846A1 (en) * 2001-11-21 2005-07-28 Eisai Co., Ltd. Preparation composition containing acid-unstable physiologically active compound, and process for producing same
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
CA2518780C (en) * 2003-03-12 2014-05-13 Takeda Pharmaceutical Company Limited Drug composition having active ingredient adhered at high concentration to spherical core
WO2004098573A1 (en) * 2003-05-08 2004-11-18 Natco Pharma Limited An improved and stable pharmaceutical composition containing substituted benzimidazoles and a process for its preparation
PE20050150A1 (es) * 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
CL2004000983A1 (es) * 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
US20050147663A1 (en) * 2003-07-17 2005-07-07 Mohan Mailatur S. Method of treatment for improved bioavailability
CA2532310A1 (en) * 2003-07-17 2005-02-03 Dr. Reddy's Laboratories, Inc. Pharmaceutical compositions having a swellable coating
US20050042277A1 (en) * 2003-07-17 2005-02-24 Irukulla Srinivas Pharmaceutical compositions having a swellable coating
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2538910A1 (en) * 2003-09-18 2005-03-24 Altana Pharma Ag Use of known active ingredients as radical scavengers
TWI372066B (en) * 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
AU2003272086A1 (en) * 2003-10-14 2005-04-27 Natco Pharma Limited Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation
US20050175689A1 (en) * 2003-10-27 2005-08-11 Yamanouchi Pharmaceutical Co., Ltd. Coated fine particles containing drug for intrabuccally fast disintegrating tablet
US20070065513A1 (en) * 2003-10-31 2007-03-22 Avi Avramoff Stable lansoprazole formulation
WO2005046634A2 (de) * 2003-11-14 2005-05-26 Siegfried Generics International Ag Magensaftresistente verabreichungsform
HU227317B1 (en) * 2003-11-25 2011-03-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Enteric coated tablet containing pantoprazole
EP1694300A4 (en) * 2003-12-09 2009-04-29 Pharmasset Inc DOSAGE PROCESS FOR BETA-D-2 ', 3'-DIDEOXY-2', 3'-DIDEHYDRO-5-FLUOROCYTIDINE ANTIVIRAL THERAPY
EP1718303A4 (en) * 2004-02-10 2010-09-01 Santarus Inc COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG
CZ23088U1 (cs) * 2004-03-25 2011-12-19 Astellas Pharma Inc. Kompozice pevného farmaceutického prípravku solifenacinu nebo jeho soli
JPWO2005092336A1 (ja) * 2004-03-26 2008-02-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 溶出制御製剤とその製造方法
EP1746980B1 (en) * 2004-05-07 2011-11-02 Nycomed GmbH Pharmaceutical dosage form comprising pellets as well as its manufacturing process
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20050281876A1 (en) * 2004-06-18 2005-12-22 Shun-Por Li Solid dosage form for acid-labile active ingredient
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
DE102004042139B4 (de) * 2004-08-31 2009-06-10 Aristocon Verwaltungs- Gmbh Perorale Darreichungsformen zur Erzielung eines Retardierungseffektes nach der Arzneimitteleinnahme mit einer Mahlzeit
EP1830822A1 (en) * 2004-12-24 2007-09-12 LEK Pharmaceuticals D.D. Stable pharmaceutical composition comprising an active substance in the form of solid solution
AU2005320672B2 (en) * 2004-12-27 2011-01-06 Astellas Pharma Inc. Stable particulate pharmaceutical composition of solifenacin or salt thereof
AU2006213439A1 (en) * 2005-01-03 2006-08-17 Lupin Limited Pharmaceutical composition of acid labile substances
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
WO2007029124A2 (en) * 2005-05-13 2007-03-15 Combino Pharm, S.L. Formulations containing pantoprazole free acid and its salts
US7815939B2 (en) * 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
EP1747776A1 (en) * 2005-07-29 2007-01-31 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising granular pantoprazole
US20090148519A1 (en) * 2005-09-29 2009-06-11 Yasuhiro Zaima Pulsed-release preparation having improved disintegration properties in vivo
CN101309917B (zh) * 2005-10-06 2013-09-11 奥斯拜客斯制药有限公司 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂
JP5053865B2 (ja) 2005-12-28 2012-10-24 武田薬品工業株式会社 口腔内崩壊性固形製剤の製造法
WO2007080601A1 (en) * 2006-01-16 2007-07-19 Jubilant Organosys Limited Stable pharmaceutical formulation of an acid labile compound and process for preparing the same
CA2654402A1 (en) * 2006-06-01 2007-12-06 Adel Penhasi Multiple unit pharmaceutical formulation
EP2068841B1 (en) 2006-10-05 2018-09-26 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
WO2008062320A2 (en) * 2006-10-06 2008-05-29 Eisai R&D Management Co., Ltd Extended release formulations of a proton pump inhibitor
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
SI2124884T1 (sl) 2006-12-22 2019-09-30 Ironwood Pharmaceuticals, Inc. Pripravki, ki obsegajo sekvestrante žolčnih kislin, za zdravljenje motenj požiralnika
EP2471515A3 (en) 2007-09-14 2012-12-26 Wockhardt Limited Rhein or diacerein compositions
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
DE102010052847A1 (de) 2010-11-29 2012-05-31 Temmler Werke Gmbh Verfahren zur Herstellung einer PPI-haltigen pharmazeutischen Zubereitung
CA2898362C (en) 2013-01-15 2020-09-01 Ironwood Pharmaceuticals, Inc. Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant
WO2016126625A1 (en) 2015-02-03 2016-08-11 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN108065443B (zh) * 2017-12-30 2020-02-28 厦门金达威维生素有限公司 斥水型双包被微胶囊及其制备方法
CN114569579B (zh) 2020-12-02 2023-10-31 丽珠医药集团股份有限公司 肠溶微丸、其制备方法和包含它的制剂
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
JPH0768125B2 (ja) * 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤

Also Published As

Publication number Publication date
NO303714B1 (no) 1998-08-24
NZ243147A (en) 1995-12-21
ATE144416T1 (de) 1996-11-15
PL169951B1 (pl) 1996-09-30
DK0589981T3 (da) 1997-03-17
RO117502B1 (ro) 2002-04-30
BG98286A (bg) 1994-08-30
CA2109697A1 (en) 1992-12-23
EP0589981B1 (de) 1996-10-23
FI935677A (fi) 1993-12-16
DE59207438D1 (de) 1996-11-28
KR100254021B1 (ko) 2000-05-01
ES2096080T3 (es) 1997-03-01
CZ281697B6 (cs) 1996-12-11
IL102096A (en) 1996-06-18
YU48263B (sh) 1997-09-30
CN1037932C (zh) 1998-04-08
HRP920162A2 (en) 1996-08-31
LV11982B (lv) 1998-09-20
YU57692A (sh) 1995-03-27
AU683411B2 (en) 1997-11-13
IE77640B1 (en) 1997-12-31
UA32525C2 (uk) 2001-02-15
HK1005851A1 (en) 1999-01-29
GR3022154T3 (en) 1997-03-31
ZW9392A1 (en) 1993-02-17
KR940701256A (ko) 1994-05-28
EP0519365A1 (de) 1992-12-23
JPH06508118A (ja) 1994-09-14
CA2109697C (en) 2005-11-22
NO934648D0 (no) 1993-12-16
EP0589981A1 (de) 1994-04-06
CZ276493A3 (en) 1994-07-13
SK278566B6 (en) 1997-10-08
DE4219390A1 (de) 1992-12-24
JP3338052B2 (ja) 2002-10-28
IE921733A1 (en) 1992-11-18
FI101598B (fi) 1998-07-31
HRP920162B1 (en) 1998-08-31
TW224429B (uk) 1994-06-01
WO1992022284A1 (de) 1992-12-23
SK128793A3 (en) 1994-06-08
CA2524168A1 (en) 1992-12-23
IL102096A0 (en) 1993-01-14
SI9200111A (en) 1992-12-31
NO934648L (no) 1993-12-16
RU2089180C1 (ru) 1997-09-10
CN1067809A (zh) 1993-01-13
US5997903A (en) 1999-12-07
AU1974692A (en) 1993-01-12
FI935677A0 (fi) 1993-12-16
MX9202961A (es) 1993-02-01
LV11982A (lv) 1998-03-20
FI101598B1 (fi) 1998-07-31
BG61796B1 (bg) 1998-06-30

Similar Documents

Publication Publication Date Title
ZW9392A1 (en) Oral presentation forms for acid-unstable active compounds
HK57196A (en) Cyclosporin compositions for oral administration
IL136249A0 (en) Suppository containing an acid-labile active compound
DE3874250T2 (de) Anaesthesiemittel enthaltende kaugummi-zusammensetzungen.
EP0676957A4 (en) CHEWING GUM COATED WITH ORAL COMPOSITION.
HUP9903308A3 (en) Granuls for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
EP0652770A4 (en) ORAL ADMINISTRATION OF ANTIGENS.
DE69330428D1 (de) Verbesserter wachsfreier feuchtigkeitsarmer kaugummi
EP0687464A3 (de) Verfahren zur Herstellung von Brausetabletten und Brausetabletten
HUT71131A (en) Paramycin formulations for oral administration
ZA884418B (en) Pharmaceutical dosage unit
AU2293892A (en) Enzyme-sensitive enteric preparation for oral administration
GR3032649T3 (en) CATALASE-BASED ANTI--i(HELICOBACTER PYLORI) IMMUNISING COMPOSITION
IL70990A0 (en) Pharmaceutical compositions containing glyceryl mononitrates
GR1002181B (en) Method for the preparation of oral compositions containing quinolones.
MX9102419A (es) Compuestos novedosos, composiciones farmaceuticas que contienen a los mismos y un procedimiento parala preparacion de los mismos.
NO923593D0 (no) Fremgangsmaate til fremstilling av 5-amino-1-(hydroksymetyl)cyklopentan-1,2,3,4-tetraol